[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jinzhou Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100555447","a-study-on-the-efficacy-of-androgen-deprivation-therapy-combined-with-anti-pd-1-therapy-in-advanced-lung-cancer-100555447",false,"NCT06512207","A Study on the Efficacy of Androgen Deprivation Therapy Combined With Anti-PD-1 Therapy in Advanced Lung Cancer","A Clinical Investigation on the Efficacy of Leuprorelin Acetate (Androgen Deprivation Therapy) Combined With Sintilimab (Anti-PD-1) in Advanced Lung Cancer","3.Inclusion Criteria:\n\n1. Male patients aged ≥60 years.\n2. ECOG performance status score of 0 \\~1.\n3. Expected survival time of more than 3 months.\n4. Histologically or cytologically diagnosed advanced lung cancer according to the TNM staging system established by AJCC.\n5. Patients who have not previously received any anti-PD-1 treatment.\n6. Patients with adequate bone marrow function, no significant hepatic, renal, or coagulation dysfunction as per laboratory test criteria.\n7. At least one tumor lesion meeting the following criteria:\n\n   * No prior local treatments such as radiotherapy\n   * Not biopsied during the screening period (if biopsy needed, baseline tumor assessment at least 14 days after the screening biopsy).\n   * Measurable at baseline (longest diameter of the lesion ≥10 mm; For a lymph node, short diameter ≥15 mm).\n   * If only one measurable lesion, no prior local treatments such as radiotherapy.\n8. Ability to understand and voluntarily sign a written informed consent form.\n9. Willingness to follow the study protocol and follow-up examinations.\n\nExclusion Criteria:\n\n* Exclusion of cases that do not meet the inclusion criteria","MALE","60 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","Androgen Deprivation Therapy (ADT) triggers thymic revitalization and increases thymic output, enhancing baseline anti-tumor immunity and responses to immunotherapies. Anti-tumor synergism has been identified by combining ADT with anti-PD-1 immunotherapy for androgen-independent tumors. This study is to investigate the combination of Leuprorelin ADT and Sintilimab (anti-PD-1) therapy in patients with advanced lung cancer.",[26,27],"NSCLC, Stage III","NSCLC, Stage IV",[29,30,31,32],"Androgen Deprivation Therapy （ADT）","Leuprorelin acetate","NSCLC","PD-1 inhibitor","RECRUITING","2025-09-02",{"date":36,"type":37},"2025-09-09","ACTUAL",{"date":39,"type":37},"2023-12-03",{"date":41,"type":20},"2026-06",{"name":43,"class":44},"Jinzhou Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":5},"100599835","evaluation-of-a-pmt-rehabilitation-nursing-plan-for-the-older-adults-with-mci-to-promote-cognitive-health-100599835","NCT07089654","Evaluation of a PMT Rehabilitation Nursing Plan for the Older Adults With MCI to Promote Cognitive Health","Development and Evaluation of a Psychomotor Rehabilitation Nursing Plan for the Older Adults With Mild Cognitive Impairment to Promote Cognitive Health","Inclusion Criteria:\n\n1. Older adults are aged 50 years and above.\n2. Subjective cognitive complaints from the individual or caregiver.\n3. Screening for MCI using the Mini-Cog scores between 0-2 ( SN Abayomi, 2024).\n4. Basic language communication, listening, speaking, and understanding skills.\n5. Ability to provide informed consent.\n\nExclusion Criteria:\n\n1. Diagnosed with severe psychiatric conditions (e.g., schizophrenia, major depressive disorder).\n2. It is at the end stage of important functional organ diseases, such as malignant tumors, cardiac failure, etc.\n3. Limb dysfunction.\n4. Diagnosed with dementia.","ALL","50 Years",{"count":56,"type":20},76,[23],"With the aging of the population, the number of older adults with mild cognitive impairment (MCI) has increased year by year, which has caused serious social and family burdens. At present, the existing drug treatment effect is limited. Studies show the application value of non-drug treatment in the older adults with mild cognitive impairment. Psychomotor Therapy (PMT) is now widely used in European countries and has formed an independent scientific system. Therefore, this topic pays attention to older adults with mild cognitive impairment, intending to promote cognitive stimulation, using PMT methods to build a rehabilitation nursing plan. Relying on older adults care institutions, older adults with mild cognitive impairment in a certain period were divided into a control group (CG) and an experimental group (EG). Older adults will be engaged in a 12-week PMT rehabilitation nursing plan involving relaxation and breathing exercises, face exercises, hand exercises, and mind exercises to promote cognitive health. SPSS 28.0 software was used to analyze data. The comparison of scores of various scales are based on paired t-test statistical methods. The P value \\\u003C0.05 will be considered to indicate statistically significant with 95% confidence interval (CI). The rehabilitation effect of the two groups was evaluated according to cognitive assessments (Montreal Cognitive Assessment, MoCA), psychological assessment (Positive and Negative Syndrome Scale, PANSS), and emotional assessment (Hamilton Depression Rating Scale, HAMD-17; Hamilton Anxiety Rating Scale, HAMA-14) . The expected findings of this study may be useful for cognitive rehabilitation plans for the elderly in care institutions, rehabilitation hospitals, communities, and families.",[60],"Mild Cognitive Impairment (MCI)",[62],"PMT rehabilitation nursing plan","NOT_YET_RECRUITING","2025-08-26",{"date":66,"type":37},"2025-08-27",{"date":68,"type":20},"2025-09-10",{"date":70,"type":20},"2026-01-30",{"name":43,"class":44},""]