[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Johannes Kepler University of Linz\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":172},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,49,76,104,127,149],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100637689","brain-connectivity-changes-in-glioma-patients-during-treatment-100637689",false,"NCT07612917","Brain Connectivity Changes in Glioma Patients During Treatment","Functional Reorganization and Connectivity in Glioma Patients During the Therapeutic Trajectory","GliRecon","Inclusion Criteria:\n\n* Patients with diffuse gliomas (WHO grade 2-4).\n* Age \\>18 years and \\\u003C65 years.\n* Written participant information and informed consent provided and signed.\n* Signed informed consent for functional magnetic resonance imaging (fMRI).\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>65 years.\n* Pregnancy.\n* Contraindications to MRI, including but not limited to:\n\n  * Active medical implants (e.g., pain pump, defibrillator, cardiac pacemaker),\n  * Orthodontic braces,\n  * Metallic tattoos,\n  * Non-removable piercings,\n  * Known metallic foreign bodies,\n  * Claustrophobia.\n* Cerebral metastases from secondary (non-primary) tumors.\n* Absence of baseline BOLD functional MRI and\u002For baseline neurocognitive assessment.\n* Failure to provide written participant information and informed consent.\n* Karnofsky Performance Status (KPS) \\\u003C60, unless feasibility of clinical-psychological testing and BOLD fMRI is confirmed by the investigator in consultation with clinical psychology, radiology staff, and the patient.","ALL","18 Years","64 Years",{"count":21,"type":22},20,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as movement, language, or sensation, as well as the nerve fiber pathways that connect these areas.\n\nThe main question this study aims to answer is:\n\nHow do important brain areas and their connections adapt and reorganize over the course of glioma treatment?\n\nPatients with glioma will undergo repeated brain imaging examinations as part of their regular medical care. These images will be analyzed over time to observe changes in brain activity and structure during different stages of therapy.\n\nBy studying these changes, researchers hope to gain new insights into the brain's ability to adapt (neuroplasticity) throughout the entire course of glioma treatment.",[26,27,28,29],"Glioma (Any Grade) in the Brain","Gliomas, Malignant","fMRI Research","Neurocognitive Function",[31,32,33,34,35],"Glioma,","Magnetic Resonance Imaging, Functional","Brain Mapping","Neural Plasticity","Cognition","RECRUITING","2026-05-28",{"date":39,"type":40},"2026-05-29","ACTUAL",{"date":42,"type":22},"2026-05",{"date":44,"type":22},"2029-12",{"name":46,"class":47},"Johannes Kepler University of Linz","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100615600","improving-visual-quality-in-patients-with-irregular-corneas-using-asymmetrical-toric-intraocular-lenses-100615600","NCT07294716","Improving Visual Quality in Patients With Irregular Corneas Using Asymmetrical Toric Intraocular Lenses","VITAL - \"Visual Improvement With Toric Asymmetrical Lenses\": Enhancing Vision in Irregular Corneas","VITAL","Inclusion Criteria:\n\n* Age 21 years or older\n* Scheduled cataract surgery\n* At least 1.75 D of total astigmatism in the CASIA2 measurement\n* At least 0.75 D of asymmetry or higher order irregularity within the 6mm zone of the real (total) index corneal refractive map of the CASIA2 measurements\n\nExclusion Criteria:\n\n* Relevant central corneal scars\n* PEX, previous ocular surgery, severe trauma or any pathology that could lead to an unstable capsular bag\n* Combined surgery (cataract plus glaucoma\u002Fvitreoretinal\u002Fcorneal surgery)\n* Postoperative best corrected distance visual acuity below 0.3 Snellen decimal\n* Pregnancy","21 Years",{"count":59,"type":22},15,"INTERVENTIONAL",[62],"NA","Cataract surgery in patients with irregular corneas presents unique challenges, primarily due to the high variability in keratometry and corneal tomography measurements, which complicates accurate intraocular lens (IOL) calculations. In these patients, therapeutic options are currently limited to either non-toric IOLs and rigid contact lenses postoperatively or conventional toric IOLs for the reduction of total astigmatism within cataract surgery. While conventional toric IOLs may be beneficial in selected cases with a stable astigmatic pattern and clear axis, their effectiveness is largely limited, as significant irregularity and higher order aberrations reduce predictability, accuracy of formulae, and refractive outcomes. Therefore, the development of a reliable method to reduce total astigmatism - including irregular components - would represent a major advancement, potentially improving both visual function and patient quality of life. The aim of this exploratory study is to evaluate the effectiveness of customized toric intraocular lenses (AMILens Individual, AMIPLANT GmbH, Germany) in reducing total corneal astigmatism in patients with a significant irregular astigmatic component. These lenses are designed to address corneal aberrations up to the 6th Zernike order, thereby extending correction beyond the capabilities of conventional toric IOLs. To our knowledge, no clinical study has yet investigated this novel approach.",[65,66,67],"Irregular Astigmatism","Astigmatism","Cataract and IOL Surgery","2026-01-22",{"date":70,"type":40},"2026-01-26",{"date":72,"type":40},"2026-01-20",{"date":74,"type":22},"2027-06",{"name":46,"class":47},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":60,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100612435","iobbat---impact-of-basic-body-awareness-therapy-on-body-awareness-100612435","NCT07253545","IOBBAT - Impact of Basic Body Awareness Therapy on Body Awareness","IOBBAT","Inclusion Criteria:\n\n* Students in the 5th semester of the Bachelor's degree program in physiotherapy at FH JOANNEUM in Graz\n* Signed informed consent for participation\n\nExclusion Criteria:\n\n* Pregnancy\n* Current illnesses or injuries that represent a contraindication for participating in the BBAT session",true,{"count":85,"type":22},60,[62],"Body awareness (BA) is an essential factor for health and well-being. In 2021, the IOBA (Impact on Body Awareness) study was conducted at the Institute of Physical Medicine \\& Rehabilitation at Kepler University Hospital (Clinical Trials NCT05004272). This study investigated the effects of massage and gymnastics on BA in healthy individuals. The protocol provides a solid foundation for further research projects on BA. The aim of the present study is to examine the immediate effects of a Basic Body Awareness Therapy (BBAT) session compared to a lecture (control group) on BA and well-being, and to explore correlations with BA.\n\nIn a randomized controlled study with 60 physiotherapy students in two groups (BBAT and control group) the use of the ABC questionnaire and further German questionnaires (Short questionnaire on self-perception of the body, self-rating mood scale - revised) concerning body awareness and well-being should analyse the following hypothesis: There is a difference in the change of BA between intervention (BBAT) and control group, Before interventions demographic data and further questionnaires concerning health conditions of the participants (e.g. Simple Physical Activity Questionnaire, Short Form Health Survey, Brief Symptom Inventory) are administered. Correlations between BA and the results of these tests will be investigated too. All these analyses can provide insights into the effects of BBAT on BA. The identification of patterns in BA among students can be used for future comparisons with patient cohorts.",[89,90,91],"Perception, Self","Body Awareness","Self-Assessment",[93,94],"Basic Body Awareness Therapy","Body awareness","NOT_YET_RECRUITING","2025-11-19",{"date":98,"type":40},"2025-11-28",{"date":100,"type":22},"2025-11",{"date":102,"type":22},"2025-12",{"name":46,"class":47},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":48},"100608531","intraocular-lens-calculation-using-artificial-intelligence-100608531","NCT07202767","Intraocular Lens Calculation Using Artificial Intelligence","Inclusion criteria\n\n* age 21 years and older\n* planned uncomplicated bilateral cataract surgery\n* availability, willingness, ability and sufficient cognitive awareness to comply with examination procedures and study visits\n* ability to consent to the participation in the study\n* signed informed consent\n\nExclusion criteria\n\n* multifocal IOL\n* combined surgery (cataract plus glaucoma\u002Fvitreoretinal\u002Fcorneal surgery)\n* PEX, previous ocular surgery, severe trauma or any pathology that could lead to an unstable capsular bag\n* glaucoma or any other retinal disease that may affect visual acuity significantly\n* pregnancy\n* pre-operative visual acuity below 0.1 Snellen decimal (1.0 Log MAR)\n* pupil diameter \\\u003C4mm",{"count":111,"type":22},170,"The aim of this study is to investigate the lens diameter (LD) as a useful parameter in intraocular lens (IOL) power calculation by using several different non-invasive imaging techniques. The aim is to establish an accurate model for lens diameter estimation and subsequently evaluate the influence of the LD on the effective postoperative lens position. The comparability of the different devices in terms of variability between the biometric measurements will also be assessed.\n\nBy then combining these two approaches with artificial intelligence, the aim is to develop a new approach to effectively incorporate the LD in IOL power calculation and improve patient's outcome in the long run.",[114],"Cataract",[116,117,118],"cataract","lens diameter","artificial intelligence","2025-10-01",{"date":121,"type":40},"2025-10-02",{"date":123,"type":22},"2025-11-01",{"date":125,"type":22},"2028-10-30",{"name":46,"class":47},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":148,"locationsCount":48},"100583719","body-awareness-in-people-with-depressive-disorder-100583719","NCT06879977","Body Awareness in People With Depressive Disorder","ABC-D","Inclusion Criteria:\n\n* Age 18 - 69 years\n* Medical diagnosis of a depressive disorder, including depressive adjustment disorder and depressive episodes in the context of bipolar disorder, i.e. one of the following ICD-10 codes:\n* F32 Depressive Episode\n* F33 Recurrent Depressive Disorder\n* F31.3 Bipolar Affective Disorder, current mild or moderate depressive episode\n* F31.4 Bipolar Affective Disorder, current severe depressive episode without psychotic symptoms\n* F43.20 Adjustment Disorder with Brief Depressive Reaction\n* F43.21 Adjustment Disorder with Prolonged Depressive Reaction\n* Inpatient admission\n* Written informed consent\n\nExclusion Criteria:\n\n* Inability to fill out questionnaires with or without assistance due to language, physical, or cognitive limitations\n* Acute psychotic state\n* Known body schema disorders, e.g. due to significant neurological or malignant diseases, eating disorders, congenital or acquired physical limitations such as the absence of a body part\n* Deafness, blindness","69 Years",{"count":136,"type":22},125,"Body awareness plays a crucial role in health and well-being. However, too little research has been carried out on how it manifests in individuals with depressive disorders. The Awareness Body Chart (ABC), a tool developed in recent years to assess body awareness, may provide new insights into the physical experience of people with depression and may lead the way in the application of body-oriented therapies in this cohort. Information about the distribution properties of the Awareness Body Chart in people with depressive disorder will be collected and analysed in this observational study.",[139],"Depressive Disorder",[141,94],"Depression","2025-04-03",{"date":144,"type":40},"2025-04-08",{"date":146,"type":40},"2025-03-26",{"date":102,"type":22},{"name":46,"class":47},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":83,"sex":17,"minAge":155,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":48},"100521833","diagnostic-possibilities-in-ophthalmological-diseases-using-swept-source-optical-coherence-tomography-100521833","NCT06074731","Diagnostic Possibilities in Ophthalmological Diseases Using Swept Source Optical Coherence Tomography","Inclusion Criteria:\n\n* Age between 5 and 110 years\n* Ability to follow instructions during imaging procedure\n* Written Informed consent\n\nExclusion Criteria:\n\n* Dementia\n* Inability to follow instructions during imaging procedure\n* Patients who do not give informed consent","5 Years","110 Years",{"count":158,"type":22},500,"In this pilot study we want to investigate morphological features acquired by the novel image modality and gain information regarding disease pathomechanism, development and future possible influence on disease management for patients affected by those diseases.",[161,162,163],"Retinal Disease","Diabetic Retinopathy","Macular Degeneration","2023-10-03",{"date":166,"type":40},"2023-10-10",{"date":168,"type":40},"2017-06-01",{"date":170,"type":22},"2026-12",{"name":46,"class":47},""]