[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"John Muir Health\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100492836","barotrauma-in-hyperbaric-oxygen-therapy-100492836",false,"NCT05697328","Barotrauma in Hyperbaric Oxygen Therapy","Pseudoephedrine Prophylaxis for Prevention of Middle Ear Barotrauma in Hyperbaric Oxygen Therapy","HBOT","Inclusion Criteria:\n\n* New patient requiring HBOT (either inpatient or outpatient)\n* Age greater than or equal to 18 years and less than 80 years\n* Fluent in English\n* Full decision capacity\n* Able and medically cleared to swallow a pill\n\nExclusion Criteria:\n\n* Enrollment would delay hyperbaric therapy more than 30 minutes in patients with emergent indications (example: Central Retinal Arterial Occlusion, Carbon Monoxide, Air Gas Embolism)\n* Contraindication to pseudoephedrine (monoamine oxidase inhibitors (MAOI) use, pregnancy, glaucoma, heart disease, allergy to drug class)\n* Systolic Blood Pressure \\>160\n* Diastolic Blood Pressure \\> 90\n* Heart Rate \\>100\n* Decongestant\u002Fantihistamine\u002Fpseudoephedrine\u002Fnasal steroid\u002Foxymetazoline use within 12 hours.\n* Prisoner\n* Intubated\n* Unable to swallow oral medications","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research is to study whether the use of pseudoephedrine can help prevent middle ear trauma during HBOT. Pseudoephedrine is an approved drug that is used for temporary relief of nasal or sinus pain and pressure.",[27],"Barotrauma",[29],"hyperbaric oxygen therapy","RECRUITING","2025-08-25",{"date":33,"type":34},"2025-08-27","ACTUAL",{"date":36,"type":34},"2023-01-31",{"date":38,"type":21},"2026-07",{"name":40,"class":41},"John Muir Health","OTHER",""]