[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jorge Gonzalez-Martinez\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":91},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100539440","deep-brain-stimulation-motor-ventral-thalamus-vopvim-for-restoration-of-speech-and-upper-limb-function-in-people-with-subcortical-stroke-100539440",false,"NCT06303869","Deep Brain Stimulation Motor Ventral Thalamus (VOP\u002FVIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke","Inclusion Criteria:\n\n1. Participants must have suffered a single, ischemic, or hemorrhagic stroke more than 6 months before the time of enrollment with dysarthria as a result.\n2. Participants must be between the ages of 18 and 75 years old. (Participants outside this age range may be at an increased medical risk and have an increased risk of fatigue during testing).\n3. English speaker.\n4. Participant must score ≤ 80% in at least 4 categories of the perceptual speech assessment (speech intelligibility, listener effort, speech naturalness, articulatory precision, speech rate, overall voice quality, and\u002For overall speech severity). OR ≤ 80% in at least 3 categories of the perceptual speech assessment AND ≤ 27 on the Communicative Participation Item Bank.\n\nExclusion Criteria:\n\n1. Patients who refuse participation in the study.\n2. Patients with gross anatomical variances in MR imaging or cerebral vascular accidents involving thalamic and cerebellar areas.\n3. Patients with no clinical condition to undergo DBS implantation or highly dependent on anticoagulation therapy.\n4. Patients who cannot undergo pre-operative MRIs or could not complete the pre-operative assessments.\n5. Participants must not have any serious disease or disorder (ex. neurological condition other than stroke, cancer, severe cardiac or respiratory disease, renal failure, etc.) or cognitive impairments that could affect their ability to participate in this study.\n6. Female participants of child-bearing age must not be pregnant, planning to become pregnant for the next 9 months, or breast feeding.\n7. Participants must not be receiving anticoagulants.\n8. Severe claustrophobia.\n9. Participants must not be on anti-spasticity or anti-epileptic medications for the duration of the study.\n10. Participants who have been deemed inappropriate for participation based upon results from the Brief Symptoms Inventory (BSI-18) and discussions with the Principal Investigator and a study physician\n11. Evaluation to sign consent form score \\<12.\n12. MRI contraindications (excluding subjects who are pregnant, who have metal in any portion of their body, have medical complications, cardiac pacemaker, cochlear implant, aneurysm clip, certain IUDs, or known problems of claustrophobia).\n13. Medications with common cognitive side-effects.\n14. Bleeding disorders or platelet dysfunction (e.g., from regular aspirin usage).\n15. Patients must not have any lesions in the lower motoneuron causing flaccid dysarthria.","ALL","18 Years","75 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this study is to verify whether the use of deep brain stimulation can improve motor function of the hand and arm and speech abilities for people following a stroke. Participants will undergo a surgical procedure to implant deep brain stimulation electrode leads. The electrodes will be connected to external stimulators and a series of experiments will be performed to identify the types of movements that the hand and arm can make and how speech abilities are affected by the stimulation. The implant will be removed after less than 30 days. Results of this study will provide the foundation for future studies evaluating the efficacy of a minimally-invasive neuro-technology that can be used in clinical neuro-rehabilitation programs to restore speech and upper limb motor functions in people with subcortical strokes, thereby increasing independence and quality of life.",[26,27,28,29,30],"Stroke","Brain Disease","Central Nervous System Diseases","Nervous System Diseases","Cardiovascular Diseases","RECRUITING","2026-05-05",{"date":34,"type":35},"2026-05-08","ACTUAL",{"date":37,"type":35},"2025-06-20",{"date":39,"type":20},"2029-12",{"name":41,"class":42},"Jorge Gonzalez-Martinez","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":15,"minAge":16,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100597273","long-term-brain-stimulation-of-the-motor-ventral-thalamus-vopvim-to-improve-motor-function-100597273","NCT07056348","Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP\u002FVIM) to Improve Motor Function","Chronic Stimulation of the Motor Ventral Thalamus (VOP\u002FVIM) for Motor Control in Humans","Inclusion Criteria:\n\n* Movement disorder patients ≥18 years of age and \\\u003C 80 years of age, who will be implanted with DBS for treatment of motor symptoms.\n* Subject has provided written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization, where applicable, prior to any study-related procedures.\n\nExclusion Criteria:\n\n* History of seizure disorders\n* Vasovagal response history and loss of consciousness history\n* Severe behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator would impact participation in the study.\n* Any serious disease or disorder (e.g. cancer, severe cardiac or respiratory disease, neurological conditions other than current movement disorder) or cognitive impairments that could impair ability to participate in this study.\n* Females who are pregnant or breastfeeding.",true,"80 Years",{"count":54,"type":20},60,[23],"This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patients would then participate in multiple sessions performing contralateral upper extremity movement tasks measuring movement speed, grip strength, and strength modulation, facial movement, swallowing, and speech tasks.",[58,26,27,59,60,61,62],"Traumatic Brain Injury","Movement Disorders (Incl Parkinsonism)","Central Nervous System Disease","Essential Tremor, Movement Disorders","Essential Tremor of Voice","2025-12-08",{"date":65,"type":35},"2025-12-16",{"date":67,"type":35},"2022-05-10",{"date":69,"type":20},"2030-12-31",{"name":41,"class":42},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":90,"locationsCount":43},"100597274","stimulating-specific-brain-areas-vopvim-with-electricity-to-improve-movement-and-muscle-control-100597274","NCT07056361","Stimulating Specific Brain Areas (VOP\u002FVIM) With Electricity to Improve Movement and Muscle Control","VOP\u002FVIM Direct Electrical Stimulation Increases Motor Cortex Excitability and Motor Output","Inclusion Criteria:\n\n* Essential tremor patients who are scheduled to undergo deep brain stimulation surgery at UPMC Presbyterian with asymmetric essential tremor symptoms will be included, with the tested limb corresponding to the least affected arm to better approximate normal function. These patients are implanted bilaterally regardless of symptom laterality, as the natural history of essential tremor indicates eventual bilateral symptoms.\n* Parkinson's Disease patients who are scheduled to undergo deep brain stimulation surgery at UPMC Presbyterian with a history of Parkinson's Disease will also be recruited for intra-operative stimulation of their STN-targeted implants, to assess if VIM\u002FVOP has high specificity for improving motor output.\n\nConfirmation that subjects' terms of insurance coverage for their standard of care procedure will not be altered by study enrollment.\n\nExclusion Criteria:\n\n* Patients will be excluded from the study if there is any seizure history, to avoid the increased epileptogenic risk of intraoperative stimulation.\n* Patients with significant bilateral tremor that precludes completion of motor tasks.",{"count":54,"type":20},[23],"In this study the investigators aim to enroll patients scheduled to undergo deep brain stimulation (DBS) implantation for movement disorders for intra-operative testing. In addition to standard-of-care surgical procedure to implant deep brain stimulation electrode leads, participants will also be stimulated and recorded from cortical areas by a temporary strip electrode (1X6) in the subdural space. The electrodes will be connected to external stimulators and a series of experiments will be performed to assess effects of the DBS on movement quality and electrophysiology measures. Results of this study will elucidate the biological mechanisms related to deep brain stimulation in modulating motor and speech function in patients with abnormal movement disorders.",[59,26,58,82,83,61],"Brain Diseases","Parkinson Disease","2025-11-05",{"date":86,"type":35},"2025-11-10",{"date":88,"type":35},"2022-12-16",{"date":69,"type":20},{"name":41,"class":42},""]