[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jubilee Mission Medical College and Research Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":71},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100599026","a-prospective-observational-study-to-determine-the-predictive-accuracy-of-snakebite-severity-score-sss-in-identifying-syndrome-specific-core-outcome-parameters-amongst-envenomated-patients-presenting-to-the-emergency-department-100599026",false,"NCT07079137","A Prospective Observational Study to Determine the Predictive Accuracy of Snakebite Severity Score (SSS) in Identifying Syndrome-Specific Core Outcome Parameters Amongst Envenomated Patients Presenting to the Emergency Department.","SCOPE-Snake","Inclusion Criteria:\n\n* All patients 'clinically suspected snakebite'\n* Presenting within 24 hours of the event\n* Age ≥18 years\n* Providing written informed consent\n\nExclusion Criteria:\n\n* Stings or bites other than snake\n* All patients who received antivenom or blood products at another institute\n* All patients with known hematological malignancies, coagulation disorders, chronic liver or renal failure\n* All patients known to be on warfarin, heparin or any newer oral or injectable anticoagulants\n* Individuals withdrawing a consent later on.","ALL","18 Years",{"count":19,"type":20},220,"ESTIMATED","OBSERVATIONAL","India reports \\~58,000 snakebite deaths\u002Fyear, over 50% of global mortality. Clinical outcomes of antivenom may vary due to regional venom differences, delayed access to care, ineffective use of existing polyvalent antivenom. There is a need for an India-specific severity assessment tool because it improves risk stratification \\& clinical decisions ,guides antivenom use, supports rural healthcare infrastructure, reduces morbidity, mortality, and financial burden.\n\nExisting scoring systems lack validation for Indian envenomation patterns. Variability in venom (both inter- and intra-species) leads to inconsistent clinical outcomes.Misapplication of non-Indian tools may cause: Inaccurate severity grading, inappropriate antivenom use, poor patient outcomes.\n\nPRIMARY OBJECTIVE:\n\n● To determine the predictive accuracy of Snakebite Severity Score (SSS) done at the time of presentation in identifying syndrome specific core outcomes for snakebites.\n\nSECONDARY OBJECTIVES:\n\n* To evaluate the predictive accuracy of SSS in identifying patients at risk of mortality at 6 weeks\n* To determine the predictive accuracy of modified Snakebite Severity Score (mSSS) done at the time of presentation in identifying syndrome specific core outcomes for snakebites\n\nMETHODOLOGY Study Duration: 18 months (Proposed)\n\n* Setting: Emergency Dept, Jubilee Mission Medical College\n* Sampling method :consecutive sampling\n* Sample Size Calculation:\n\nn = Z₍₁-α\u002F₂)2 x SN (100-SN ) \u002F l2 x P = 220\n\n* Confidence Level: 95% (Z₍₁-α\u002F₂₎ = 1.96)\n* Expected Sensitivity: 97%\n* Relative Allowable Error: 5% (l = 0.05)\n* Proportion: Based on core outcome occurrence = 0.22\n* Drop-out Rate Assumed: 20%\n* minimum sample size = 264 Reference: Based on data from Dart et al.\"Validation of a Severity Score for the Assessment of Crotalid Snakebite,1999\"\n\nINCLUSION AND EXCLUSION CRITERIA\n\nInclusion Criteria:\n\n* All patients 'clinically suspected snakebite'\n* Presenting within 24 hours of the event\n* Age ≥18 years\n* Providing written informed consent\n\nExclusion Criteria\n\n* Stings or bites other than snake\n* All patients who received antivenom or blood products at another institute\n* All patients with known hematological malignancies, coagulation disorders, chronic liver or renal failure\n* All patients known to be on warfarin, heparin or any newer oral or injectable anticoagulants\n* Individuals withdrawing a consent later on.\n\nSTUDY FLOW AND DATA MANAGEMENT\n\nStudy Flow:\n\nEnrollment \\& Initial ED Assessment:\n\nHistory, examination, bite documentation, SSS scoring Baseline labs as per institutional protocol\n\nMonitoring \\& Follow-Up Timepoints:\n\nT0: At presentation T+3h, +6h, +12h: Direct proforma, records review T+48h: Medical records Day 30 and Day 42 : Medical records \\& telephonic follow-up Outcomes Monitored: Neurotoxicity, haemotoxicity , coagulopathy, local damage, AKI, hypotension No interference with clinical care or treatment decisions.\n\nDATA ANALYSIS PLAN:\n\nSoftware: SPSS v29 Continuous variables are measured by using Mean+\u002F-SD or median IQR Categorical variables are reported as frequencies and percentages. ROC curve analysis for SSS and mSSS. Logistic regression for mortality. Subgroup and domain-wise analysis.\n\nETHICAL CONSIDERATIONS:\n\nEthics approval to be obtained. Informed consent will be ensured. Data anonymized and securely stored. No interference with patient treatment.",[24],"Snake Bite",[26,27,28,29],"snakebite","antivenom","snakebite severety score","modified snakebite severety score","NOT_YET_RECRUITING","2025-07-13",{"date":33,"type":34},"2025-07-22","ACTUAL",{"date":36,"type":20},"2025-07-14",{"date":38,"type":20},"2027-06-30",{"name":40,"class":41},"Jubilee Mission Medical College and Research Institute","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":21,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100596545","predictive-accuracy-of-plr-and-pnr-in-detecting-etic-100596545","NCT07046858","Predictive Accuracy of PLR and PNR in Detecting ETIC","Predictive Accuracy of Platelet Lymphocyte Ratio & Platelet Neutrophil Ratio in Detecting Early Trauma Induced Coagulopathy","ETIC","Inclusion Criteria:\n\n* All patients with trauma AND\n* Presenting to ED within 6 hours of the event AND\n* The ED Physician sends coagulation profile\n\nExclusion Criteria:\n\n* Treated with intravenous fluids, drugs, whole blood and blood products elsewhere\n* Patients admitted with a non-mechanical mechanism of injury, specifically drowning, hanging,or burns, as these mechanisms may result in a different biologic response than mechanical trauma\n* Patients on known medications affecting coagulation profile or hemogram\n* Patients with known chronic liver disease, chronic renal failure, malignancy, hematological disorders\n* Patients not consenting for the study",true,"12 Years",{"count":54,"type":20},250,"1 Day","Observational study to know what is the predictive accuracy of platelet-neutrophil ratio (PNR) and platelet-lymphocyte ratio (PLR) done in patients presenting to ED( emergency department)within 6 hours of trauma; in detecting early trauma induced coagulopathy during hospital admission",[58,59],"Trauma Injury","Coagulopathy",[61],"Early trauma induced coagulopathy","RECRUITING","2025-06-23",{"date":65,"type":34},"2025-07-02",{"date":67,"type":34},"2023-10-17",{"date":69,"type":20},"2025-11-27",{"name":40,"class":41},""]