[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jun Zhang\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100618424","external-oblique-intercostal-plane-block-for-postoperative-analgesia-after-major-upper-abdominal-surgery-100618424",false,"NCT07331441","External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery","External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Obtain written informed consent from participants or their legal representatives\n* Age between 18 and 85 years\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Scheduled for elective laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery)\n* Expected surgical duration ≥ 2 hours\n* Ability to use the intravenous patient-controlled analgesia (IV PCA) system\n\nExclusion Criteria:\n\n* Hepatic disease (liver enzyme levels ≥ 2× the upper limit of normal)\n* Renal disease (serum creatinine levels ≥ 2× the upper limit of normal)\n* Allergy to local anesthetics or known study-related drugs\n* Pregnancy or lactation\n* Low surgical incision site (not involving the upper abdominal wall innervated by T6-T10 nerves)\n* Coagulopathy or current use of anticoagulant medications\n* Opioid use for more than 2 weeks in the past 6 months","ALL","18 Years","85 Years",{"count":20,"type":21},78,"ESTIMATED","INTERVENTIONAL",[24],"NA","Postoperative pain after laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) is often severe, and inadequate analgesia may lead to increased opioid use, opioid dependence, and poor functional recovery. Current analgesic techniques such as neuraxial block have safety concerns (e.g., hypotension, neurological injury), while transversus abdominis plane (TAP) block is ineffective for blocking the lateral cutaneous branches of intercostal nerves in the upper abdomen. The External Oblique Intercostal Plane Block (EOIB) is a novel regional block technique that has shown promise in reducing postoperative opioids and pain in small-scale studies, but evidence for its use in major upper abdominal surgery is limited. This randomized controlled trial (RCT) aims to evaluate the analgesic efficacy and safety of bilateral EOIB combined with standard multimodal analgesia versus standard multimodal analgesia alone in patients undergoing elective laparoscopic major upper abdominal surgery. The primary outcome is the total postoperative opioid consumption (measured as Morphine Milligram Equivalents, MME) within 24 hours. Secondary and additional outcomes include pain scores (Verbal Rating Scale, VRS), recovery quality (QoR-15 scale), incidence of adverse events, and hospital stay.",[27,28],"Abdominal Surgery","Postoperative Pain",[30,28,31,32,33],"External Oblique Intercostal Plane Block","Laparoscopic Surgery","Pain Management","Randomized Controlled Trial","RECRUITING","2026-06-21",{"date":37,"type":38},"2026-06-25","ACTUAL",{"date":40,"type":38},"2026-02-01",{"date":42,"type":21},"2026-08-31",{"name":44,"class":45},"Jun Zhang","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100628411","perioperative-prophylactic-positive-pressure-ventilation-reduces-postoperative-pulmonary-complications-100628411","NCT07461285","Perioperative Prophylactic Positive Pressure Ventilation Reduces Postoperative Pulmonary Complications.","Inclusion Criteria:\n\n* Patients who have signed the informed consent form and are willing to comply with the study protocol;\n* Age ≥ 18 years and ≤ 90 years;\n* ASA physical status classification I to III;\n* Scheduled for major elective abdominal surgery;\n* Undergoing general anesthesia with endotracheal intubation;\n* ARISCAT (Assessement of Respiratory Risk in Surgical Patients in Catalonia) score ≥ 45;\n* Anticipated surgery duration ≥ 2 hours.\n\nExclusion Criteria:\n\n* Untreated ischemic heart disease; severe cardiovascular or cerebrovascular disease;\n* Severe asthma, pulmonary bullae\u002Fbullous lung disease, pneumothorax, bronchopleural fistula, etc.;\n* Severe underlying hepatic or renal disease;\n* Age \\\u003C 18 years or \\> 90 years;\n* Refusal to participate in the clinical study.","90 Years",{"count":55,"type":21},206,[24],"The incidence of postoperative pulmonary complications (PPCs) ranges from 5% to 33%. PPCs significantly prolong hospital stay, increase the economic burden, and are associated with postoperative mortality at 30 days and 1 year. The occurrence of PPCs is associated with multiple perioperative factors. A multimodal approach may provide better prevention against PPCs. We hypothesize that perioperative prophylactic positive pressure ventilation can reduce the incidence of PPCs in patients undergoing high-risk abdominal surgery.",[59],"Postoperative Pulmonary Complications (PPCs)",[61,62,63],"Postoperative pulmonary complications","positive pressure ventilation","abdominal surgery","NOT_YET_RECRUITING","2026-03-07",{"date":67,"type":38},"2026-03-10",{"date":69,"type":21},"2026-03-20",{"date":71,"type":21},"2026-09-30",{"name":44,"class":45},""]