[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"KK Women's and Children's Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":683},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,28,0,25,[9,52,80,128,150,179,207,237,264,293,315,337,356,386,412,437,460,489,517,544,566,592,612,636,660],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100637305","phase-2-folinic-acid-as-a-treatment-for-autism-spectrum-disorder-in-children-100637305",false,"NCT07630506","Folinic Acid as a Treatment for Autism Spectrum Disorder in Children","Folinic Acid as a Treatment for Autism Spectrum Disorder in Children: A Double-blind Randomised Placebo-controlled Trial With Open Label Extension (FOLIN-A Trial)","FOLIN-A","Inclusion Criteria:\n\n* Children aged 3 years 0 months to 10 years 11 months at the time of enrolment\n* Weight ≥ 10 kg and ≤ 30 kg at the time of enrolment\n* Confirmed diagnosis of Autism Spectrum Disorder (ASD) based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) or Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria, supported by standardized diagnostic assessments\n* Stable on regular behavioral interventions and any medications for at least 6 months prior to enrolment\n* At least one parent or legal guardian able to understand and complete study questionnaires in English\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* Known allergy or intolerance to folinic acid\n* Current or prior supplementation with folinic acid or other folate preparations (folic acid supplementation permitted)\n* Vitamin B12 (cobalamin) deficiency or pernicious anemia\n* Concurrent use of medications known to interfere with folate metabolism (e.g., methotrexate, trimethoprim, fluorouracil, capecitabine, glucarpidase)\n* Known genetic, metabolic, or chromosomal disorder, or structural brain abnormalities\n* History of epilepsy or seizures (except simple febrile seizures) or current use of antiepileptic or antipsychotic medication\n* Significant sensory (hearing or visual) or motor impairment\n* Participation in another interventional clinical trial for autism within the past 6 months\n* Unable or unwilling to comply with study visits and procedures","ALL","3 Years","10 Years",{"count":22,"type":23},184,"ESTIMATED","INTERVENTIONAL",[26],"PHASE2","Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects communication, behavior, and social interaction in children. Current treatments are limited and mainly focus on managing symptoms. This study aims to evaluate whether folinic acid is safe and effective in improving symptoms of autism spectrum disorder in children. Participants will be randomly assigned to receive either folinic acid or a placebo during the double-blind treatment phase. After this phase, all participants will have the option to receive folinic acid in an open-label extension. The results of this study may help determine whether folinic acid could be a potential treatment option for children with autism spectrum disorder.",[29],"Autism Spectrum Disorder",[29,31,32,33,34,35,36,37,38],"ASD","Folinic Acid","Leucovorin","Children","Pediatric","Randomized Controlled Trial","Placebo-Controlled","Open-Label Extension","RECRUITING","2026-06-01",{"date":42,"type":43},"2026-06-05","ACTUAL",{"date":45,"type":43},"2025-05-19",{"date":47,"type":23},"2027-06-30",{"name":49,"class":50},"KK Women's and Children's Hospital","OTHER_GOV",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100578502","surviving-the-pediatric-intensive-care-unit-picu-100578502","NCT06812130","Surviving the Pediatric Intensive Care Unit (PICU)","Surviving the Pediatric Intensive Care Unit (PICU): Long-term Study to Understand and Improve Outcomes of PICU Survivors and Their Families","Inclusion Criteria:\n\n\\[HOPE Cohort\\]\n\n1. Between 28 days - 16 years of age at PICU admission\n2. Have an expected PICU stay \\> 48 hours\\*\n\n\\[SHACK-S Cohort\\]\n\n1. Healthy children (aged 4 -16 years old) with critically ill sibling between 28 days - 16 years of age at PICU admission\n2. Has a critically ill sibling who has an expected PICU stay \\> 48 hours\n3. Lives in the same household as the critically ill sibling and parents prior to admission\n\nExclusion Criteria:\n\n\\[HOPE Cohort\\]\n\n1. Do-Not-Resuscitate status\n2. Lack of informed consent\n3. Prior enrolment in this study\n\n\\[SHACK-S Cohort\\]\n\n1. Children of critically ill sibling with Do-Not-Resuscitate status\n2. Children with condition listed on paediatric Complex Chronic Conditions (CCC) system Version 3.0 or with neurocognitive\u002Fneurodevelopmental delays or disorders\n3. Previous admission to PICU\n4. Lack of informed consent\n5. Prior enrolment in this study\n\n   * Note: For participating study sites without a dedicated PICU (e.g., sites where patients are managed in a combined ward under High Dependency (HD) or ICU status), PICU stay will be defined as the duration during which the patient is assigned an ICU status. The determination of ICU status will be made at the discretion of the respective site's study team and Site-PI.","28 Days","16 Years",{"count":62,"type":23},404,"OBSERVATIONAL","Improvement in pediatric intensive care unit (PICU) supportive care has led to improvement in clinical outcomes and decreased mortality in pediatric critical illness. However, PICU survivors are at risk of long-term health sequalae. Given the increased recognition of physical, cognitive, and psychological sequelae in PICU survivors, the concept of post-intensive care syndrome-pediatrics (PICS-p) has been proposed. Besides the PICU patient\u002Fsurvivor, the PICS-p framework also highlights the impacts of a child's critical illness has on the family. The impact of a PICU admission extends beyond the patient and parents, potentially affecting healthy siblings who are navigating their own developmental challenges. Healthy siblings may face emotional distress, increased responsibilities, and disruptions in their daily routines, all of which can contribute to long-term negative outcomes if unaddressed. Thus, this study consists of two cohorts to understand the long-term physical, cognitive, and psychological outcomes in PICU survivors and their families, and the short-term impacts on siblings of critically ill children.",[66],"Post Intensive Care Syndrome (PICS)",[68,69,70],"PICS-p","Prospective Observational Cohort Study","Post Intensive Care Syndrome in Paediatrics (PICS-p)","2026-04-29",{"date":73,"type":43},"2026-05-05",{"date":75,"type":43},"2025-02-11",{"date":77,"type":23},"2027-12",{"name":49,"class":50},2,{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":24,"phases":93,"briefSummary":95,"conditions":96,"keywords":113,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":127,"locationsCount":51},"100634052","early-pregnancy-lifestyle-and-glucose-patterns-a-substudy-of-tofffy-100634052","NCT07534670","Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY","Early-Pregnancy Chronobehavioural Profiles and Continuous Glucose Dynamics: A Nested Randomised Pilot Study of TOFFFY","Inclusion Criteria:\n\n* Enrolled in the Towards Optimal Fertility, Fathering and Fatherhood studY (TOFFFY) (NCT06293235)\n* Females who are currently pregnant and with viable intrauterine pregnancy at ≤13 weeks gestation at enrolment\n\nExclusion Criteria:\n\n* Females with pre-existing diabetes mellitus (Type 1 or Type 2) and\u002For chronic medical conditions affecting glucose metabolism\n* Females who are taking medications known to significantly affect glucose metabolism\n* Females with multiple pregnancy (e.g., twins or higher-order gestation)\n* Females who are unable to comply with study procedures, including: Inability to use smartphone-based applications and inability to wear wrist actigraphy device",true,"FEMALE","21 Years","39 Years",{"count":92,"type":23},140,[94],"NA","The goal of this clinical trial is to examine how daily behavioral patterns in early pregnancy, including sleep, physical activity, and meal timing, influence continuous glucose dynamics and subsequent risk of gestational diabetes mellitus (GDM) in pregnant women without pre-existing diabetes.\n\nThe main questions it aims to answer are:\n\n1. Do early-pregnancy chronobehavioral patterns (e.g., irregular sleep, night eating, and unstable rest-activity rhythms) relate to continuous glucose patterns measured using continuous glucose monitoring (CGM)?\n2. Can early behavioral and CGM-derived measures predict glucose regulation and metabolic outcomes later in pregnancy (24-28 weeks)?\n3. Does real-time self-monitoring using wearable devices and food logging improve glycemic outcomes compared to usual care?\n\nThis study is a prospective, nested randomized pilot trial embedded within the ongoing Towards Optimal Fertility, Fathering and Fatherhood studY (TOFFFY) cohort (NCT06293235) at KK Women's and Children's Hospital, Singapore. A total of 140 pregnant women without pre-existing diabetes, recruited at ≤13 weeks gestation, will be randomized in a 1:1 ratio to either a pilot arm (wearable-based self-monitoring) or a control arm (usual care).\n\nParticipants in the pilot arm (n=70) will undergo intensive behavioral and metabolic monitoring over a 14-day period in early pregnancy, including continuous glucose monitoring using a CGM device, wrist actigraphy to assess sleep-wake and rest-activity patterns, and an AI-supported mobile application to record meal timing and dietary intake. Participants will have real-time access to their glucose data and behavioral feedback, enabling self-monitoring and potential behavioral adjustments.",[97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,36,112],"Continuous Glucose Monitoring","Diabetes, Gestational","Diet During Pregnancy","Meal Time","Actigraphy","Pregnancy","Glucose Intolerance During Pregnancy","Gestational Diabetes Mellitus in Pregnancy","Circadian Rhythm","Sleep","Chronobiology","Wearable Electronic Devices","Mobile Applications","Blood Glucose Profile","Metabolic Diseases","Pilot Study",[114,115,116,117,118,119],"Risk factor","Lifestyle","Early pregnancy","Chrono-disruptive behaviours","Maternal health","Lifestyle intervention","NOT_YET_RECRUITING","2026-04-22",{"date":123,"type":43},"2026-04-27",{"date":125,"type":23},"2026-05-01",{"date":47,"type":23},{"name":49,"class":50},{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":79},"100553096","asia-pediatric-intensive-care-epidemiology-and-outcomes-study-100553096","NCT06481644","Asia Pediatric Intensive Care Epidemiology and Outcomes Study","AsiaPedIC","Inclusion Criteria:\n\n* All patients admitted to the pediatric ICUs of participant hospitals\n\nExclusion Criteria:\n\n* No consent",{"count":136,"type":23},10000,"The overall objective of this study is to improve the standard of care of critically ill pediatric patients. The specific aims are to describe the clinical profile and outcomes of all admissions to Asian pediatric ICUs, determine the risk factors associated with poor outcomes, determine quality indicators for benchmarking ICU performance across sites and develop and train artificial intelligence algorithms to predict mortality, length of ICU stay and resource utilization.",[139,140,141],"Pediatrics","Intensive Care Unit","Critical Illness","2026-04-02",{"date":144,"type":43},"2026-04-08",{"date":146,"type":43},"2024-08-01",{"date":148,"type":23},"2027-12-31",{"name":49,"class":50},{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":87,"sex":18,"minAge":89,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":161,"conditions":162,"keywords":165,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":51},"100538622","towards-optimal-fertility-fathering-and-fatherhood-study-100538622","NCT06293235","Towards Optimal Fertility, Fathering and Fatherhood studY","Investigating Male Factors and Their Relationships With Reproductive Health Outcomes in Singapore: Towards Optimal Fertility, Fathering and Fatherhood studY","TOFFFY","Inclusion Criteria:\n\nSubfertile couples:\n\n* men aged ≥21-49 years\n* men with a female partner aged 21-39 years\n* couples who are not able to conceive for at least 12 months\n* couples who are Singapore citizen or permanent resident\n\nFertile couples:\n\n* men aged 21-49 years\n* men with a female partner aged 21-39 years\n* men with proven fertility defined as those female partners who are currently pregnant and with viable intrauterine pregnancy at gestational weeks of less or equal to 16 at the time of the study\n* couples with attempted time to conceive within 12 months to achieve this pregnancy or with unplanned pregnancy\n* couples who are Singapore citizen or permanent resident\n\nExclusion Criteria:\n\nSubfertile couples:\n\n* male infertility of a known aetiology including azoospermia, retrograde ejaculation, genetic disorders, cancer treatment, or testes trauma\n* female infertility diagnosis as confirmed by diagnostic imaging or having severe endometriosis\n* female partners with irregular menstrual cycle \\>35 days\n* couples with known chromosomal abnormalities\n\nFertile couples:\n\n* couples who achieve pregnancy after oocyte or spermatozoa donation\n* couples with known chromosomal abnormalities\n* female partners with known uterine abnormalities","49 Years",{"count":160,"type":23},960,"This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood, and examine how male factors relate to the semen physical and biological characteristics.",[163,164],"Reproductive Issues","Fertility Issues",[166,114,115,167,168,169,170],"Male","Semen analysis","Epigenetic","Oxidative stress","DNA fragmentation","2026-03-17",{"date":173,"type":43},"2026-03-20",{"date":175,"type":43},"2024-06-21",{"date":177,"type":23},"2027-09",{"name":49,"class":50},{"id":180,"slug":181,"hasResults":12,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":187,"enrollmentInfo":188,"targetDuration":4,"studyType":24,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":51},"100628834","the-ehealth-integrated-maternal-physical-activity-programme-in-prenatal-care-trial-e-impact-100628834","NCT07466797","The eHealth Integrated Maternal Physical Activity Programme in Prenatal Care Trial (E-IMPACT)","e-IMPACT: Evaluating an eHealth and Healthcare Professional Support Program to Promote Physical Activity During Pregnancy","e-IMPACT","Inclusion Criteria:\n\n1. Pregnant women (First trimester at least 4 weeks gestation)\n2. Age 21 years and above\n3. BMI 23 kg\u002Fm2 and above\n4. Physically fit to participate in moderate intensity exercise\n5. Singleton pregnancy\n\nExclusion Criteria:\n\n1. Women who have severe chronic disease such as chronic kidney disease, hypertension, asthma OR\n2. Obstetric or medical complications which might preclude women in normal levels of physical activity or exercise during pregnancy.\n3. Women who participated in other weight management programmes, or physical activity intervention studies recently (past 6 months) or concurrently\n4. Difficulty in understanding the English language","45 Years",{"count":189,"type":23},100,[94],"This will be a proof-of-concept randomised control trial (RCT) study, where 100 pregnant women will be recruited in the first trimester of pregnancy and followed-up until delivery. It aims to test these following hypotheses:\n\n1. pregnancy is a window of opportunity to implement good lifestyle habits of physical activity and exercise as pregnant women are in regular contact with health professionals and are likely motivated and be more confident to carry out these activities according to the guidelines\n2. this integrated programme will effective in a healthcare setting, and will bring Singapore's \"Guidelines on Physical Activity and Exercise in Pregnancy\" guidelines to implementation\n3. with enhanced self-efficacy and motivation, the proportion of women engaging in adequate physical activity during pregnancy will increase to meet recommended guidelines.",[193,194],"Physical Activity","Health Behavior",[196,197,198],"pregnancy","exercise in pregnancy","physical activity in pregnancy","2026-03-08",{"date":201,"type":43},"2026-03-12",{"date":203,"type":43},"2026-03-09",{"date":205,"type":23},"2028-12-31",{"name":49,"class":50},{"id":208,"slug":209,"hasResults":12,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":215,"enrollmentInfo":216,"targetDuration":218,"studyType":63,"phases":4,"briefSummary":219,"conditions":220,"keywords":223,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":236},"100623519","early-sepsis-recognition-tool-100623519","NCT07397689","Early Sepsis Recognition Tool","Sepsis Optimal Recognition Toolkit in Children (SORT): An Early Recognition Tool for Children in Asia","SORT","Inclusion Criteria:\n\n* Children \\\u003C 18 years old\n* Suspected infection defined by (1) blood culture performed (irrespective of result), AND (2) use of broad-spectrum anti-microbial agents, in the first 24 hours of admission\n\nExclusion Criteria:\n\n* 18 years and older\n* Patients who discharge At Own Risk (AOR) without outcome data","18 Years",{"count":217,"type":23},40000,"30 Days","This study seeks to develop early recognition tools specially designed for children meeting the Phoenix definition and explore implementation science aspects by investigating facilitators and barriers to adopting Phoenix sepsis criteria in clinical practice. This addresses the critical need for systemic, evidence-based approaches to paediatric sepsis identification across diverse healthcare settings in Asia.",[221,222],"Infection","Sepsis",[224,225,226,227],"Phoenix sepsis score","early recognition","infection","child","2026-02-08",{"date":230,"type":43},"2026-02-11",{"date":232,"type":23},"2026-02",{"date":234,"type":23},"2028-12",{"name":49,"class":50},19,{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":87,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":24,"phases":246,"briefSummary":247,"conditions":248,"keywords":250,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":51},"100551258","anthropometric-outcomes-of-a-mobile-health-intervention-for-eating-behaviour-and-lifestyle-in-infancy-100551258","NCT06457750","Anthropometric Outcomes of a Mobile Health Intervention for Eating Behaviour and Lifestyle in Infancy","Anthropometric and Body Composition Outcomes of a Mobile Health Intervention to Improve Eating Behaviours and Lifestyle Habits During Infancy","Inclusion Criteria:\n\n* Women\n* 34-36 weeks' pregnant, or 3 days post-delivery.\n* Pre-pregnancy BMI of at least 23 kg\u002Fm\\^2, and\u002For with the diagnosis of gestational diabetes mellitus or type 2 diabetes mellitus.\n\nExclusion Criteria:\n\n* Women less than 21 years old\n* Unable to understand English\n* Not planning to reside in Singapore until baby is at least 1 year old\n* Premature birth of baby (defined as below 37 weeks' gestation)\n* Birth of a baby with congenital abnormalities, physical or neurodevelopmental disabilities",{"count":245,"type":23},440,[94],"Lifestyle, activity, and feeding behaviours during early childhood set the foundation for subsequent lifelong metabolic health as an adult. The investigators have developed a digital tool, called Feeding, Lifestyle, Activity Goals (FLAGs) to assess lifestyle and feeding behaviours of young infants, simultaneously providing guidance and tailored advice for parents on ideal practices specific to their children. The investigators aim to assess its usability, acceptability, and feasibility , before proceeding to determine efficacy of the FLAGs intervention through conducting a randomized controlled trial, enrolling 440 infants from KK Women's and Children's Hospital. Half of them will receive standard routine infant care, whereas the other half will additionally receive the digital FLAGs assessment and advisory tool, complete with mobile nudges. The follow-up period will be over 12 months, with the main outcomes being i) indicators of good feeding and lifestyle behaviour at 12 months old, and ii) physical growth trends, body fat proportions. Demonstrating the benefits of using FLAGs will underscore the importance of integrating this digitalized tool into the screening and evaluation of well children, with the potential to be upscaled and adopted across hospitals, primary care, and community-based health programmes.",[249],"Childhood Obesity Prevention",[251,252,253,254,255],"Developmental origins of health and disease","childhood obesity","life course approach","population health","paediatrics","2025-08-28",{"date":258,"type":43},"2025-09-05",{"date":260,"type":23},"2025-11-01",{"date":262,"type":23},"2026-12-30",{"name":49,"class":50},{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":12,"sex":18,"minAge":271,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":24,"phases":275,"briefSummary":276,"conditions":277,"keywords":280,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":79},"100575313","effect-of-tele-exercise-on-cardiorespiratory-fitness-in-paediatrics-100575313","NCT06770660","Effect of Tele-exercise on Cardiorespiratory Fitness in Paediatrics","Evaluating the Effectiveness of Telemedicine-based Exercise Programme in Improving Cardiorespiratory Fitness in Asian Paediatric Population: a Randomised Controlled Trial","Inclusion Criteria:\n\n* 12 to 17 years (secondary school students)\n* able to participate in school physical education lessons\n\nExclusion Criteria:\n\n* less than 12 years or older than 17 years (non-secondary school students)\n* has medical or musculoskeletal condition(s) preventing participation in school physical education lessons or exercise","12 Years","17 Years",{"count":274,"type":23},122,[94],"The goal of this clinical trial is to learn if telemedicine exercise programme can improve the cardiorespiratory fitness (how well your body delivers oxygen to muscles and organs) and insulin resistance in Asian children with low cardiorespiratory fitness levels. The main questions it aims to answers are:\n\n* Does telemedicine exercise programme improve the number of 20-metre laps the participant is able to run?\n* Does telemedicine exercise programme improve the insulin sensitivity using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) formula?\n\nResearchers will compare the telemedicine exercise programme to current active lifestyle programme (e.g., daily step count monitoring) to see if telemedicine exercise programme is more effective in improving cardiorespiratory fitness.\n\nParticipants will:\n\n* participate in weekly telemedicine exercise programme or adhere to current active lifestyle recommendations through daily step count reporting for 10 weeks\n* visit the clinic for pre- and post-programme cardiorespiratory fitness assessments and blood taking",[278,279],"Cardiorespiratory Fitness","Insulin Resistance",[281,282,283,284],"paediatric","cardiorespiratory fitness","telemedicine","insulin resistance","2025-08-27",{"date":287,"type":43},"2025-09-04",{"date":289,"type":43},"2025-05-02",{"date":291,"type":23},"2027-01",{"name":49,"class":50},{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":87,"sex":18,"minAge":300,"maxAge":301,"enrollmentInfo":302,"targetDuration":4,"studyType":24,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":314,"locationsCount":79},"100519827","saline-enema-administration-in-meconium-obstruction-of-prematurity-and-impact-on-the-resolution-feeds-microbiome-and-gut-brain-axis-100519827","NCT06048614","Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.","The Administration of Saline Enema Versus Glycerin Suppository as a Treatment Intervention for Meconium Obstruction of Prematurity (MOP) and to Study the Impact on the Resolution of MOP, Time to Reach Full Enteral Feeds, Gut Microbiome, and Gut-brain Axis, a Randomised Control Trial.","Inclusion Criteria:\n\n* Criteria A: For infant presenting with early onset of MOP\n\n  1. Birth weight 500 - 1250 gram\n  2. ≥ 23 weeks gestation\n  3. No BO for 48 hours\n  4. BO present but with a small amount or stain of meconium\n  5. Feeds intolerance or abdominal X-ray showing dilated loops of bowel\n* Criteria B: For infant presenting with Late onset of MOP\n\n  1. Birth weight 500 - 1250 gram\n  2. ≥ 23 weeks gestation\n  3. Infants who passed meconium initially and develop evidence of meconium obstruction at a later age (feed intolerance or vomiting and abnormal abdominal X-ray with or without abdominal distension)\n\nExclusion Criteria:\n\nInfants that:\n\n1. Neuromuscular disorder\n2. Moderate or severe asphyxia\n3. Inability to start enteral feeding, which continued for 3 consecutive days before 2 weeks of post-natal age for reasons unrelated to meconium inspissation or its complication\n4. Without parental consent\n5. Aggravated medical instability\n6. Single mothers \\\u003C 21 years","1 Day","36 Weeks",{"count":303,"type":23},95,[94],"The goal of this clinical trial is to study the effect of twice-daily saline enema (SE) in the treatment obstruction of prematurity (MOP) in infants with the birth weight ≤1.25kg. The main questions, the trial aims to answer are\n\n1. To validate the finding of our pilot study which had shown that twice-daily SE reduces the time to reach full enteral feeds in premature infant as compared to premature infant treated with Glycerine Suppository (GS), in a larger cohort. Infant with MOP fails to pass meconium in the first 48 hours of life and develop symptoms and signs like abdominal distension and feed intolerance.\n2. The other aims of this study are to test whether the intervention is\n\n   1. Effective treatment for MOP\n   2. Reduce the duration of ICU stay\n   3. Reduce the rate of necrotizing enterocolitis, sepsis, Total Parenteral Nutrition (TPN) days and number of intravenous catheter days\n3. The study also wants to explore the impact of this intervention on the gut microbiome, gut-brain interaction and immune response of the new-born.",[307],"Meconium Obstruction of Prematurity","2025-05-20",{"date":310,"type":43},"2025-05-23",{"date":312,"type":43},"2024-01-02",{"date":148,"type":23},{"name":49,"class":50},{"id":316,"slug":317,"hasResults":12,"nctId":318,"briefTitle":319,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":87,"sex":18,"minAge":271,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":323,"conditions":324,"keywords":325,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":51},"100588131","survey-on-patient-and-parental-perceptions-of-eeg-monitoring-during-paediatric-anaesthesia-care-100588131","NCT06937398","Survey on Patient and Parental Perceptions of EEG-monitoring During Paediatric Anaesthesia Care","Inclusion Criteria:\n\n* All parents of children 1-16 years old and patients 12-16 years old coming for elective surgery requiring GA at KK Women's and Children's Hospital will be invited to voluntarily participate in an electronic survey on Form SG.\n\nExclusion Criteria:\n\n* Parents and patients coming for emergency surgery will not be invited for the survey.",{"count":322,"type":23},400,"Electroencephalographic (EEG) monitoring during general anaesthesia (GA) is not typically part of standard care during GA. The recent availability of non-invasive commercial EEG monitors for children has made EEG monitoring more popular. Several studies have shown that monitoring EEG while under GA allows customization and titration of GA. However, the usefulness of EEG monitoring in children have not been established. It is a relatively new technology for some and will involve additional costs. The investigators aim to understand the perceptions of participants regarding EEG monitoring during paediatric anaesthesia care by administering a survey before and after GA.",[319],[326,327,328],"EEG","Survey","Perception","2025-04-22",{"date":331,"type":43},"2025-04-27",{"date":333,"type":43},"2022-05-01",{"date":335,"type":23},"2025-09-30",{"name":49,"class":50},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":187,"enrollmentInfo":344,"targetDuration":4,"studyType":24,"phases":345,"briefSummary":346,"conditions":347,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":51},"100493759","integrating-smart-ring-wearable-technology-in-pregnancy-health-monitoring-i-smart-100493759","NCT05709327","Integrating Smart Ring Wearable Technology in Pregnancy Health Monitoring (I-SMART)","I-SMART","Inclusion criteria:\n\n1. From the first to third trimester of pregnancy (4-39 weeks of gestational age)\n2. Mobile phone's operating system supported by the smart ring application.\n3. Aged 21 and above\n\nExclusion criteria:\n\n1. Can't read or speak English\n2. Below 21 years of age\n3. Below or above gestational age limit\n4. Limited mobility\n5. Diagnosed with severe unstable mental conditions\n6. Diagnosed with severe chronic disorders\n7. Mobile device not compatible with smart ring",{"count":189,"type":23},[94],"This study aims to test the following hypotheses in a single-arm observational study in 70-100 healthy pregnant multi-ethnic women who will be followed-up from the first trimester of pregnancy to the third trimester of pregnancy.\n\nAim 1: To assess the applicability, acceptability and compliance with the use of a wearable smart ring together with smart digital devices (e.g., smart phone) during pregnancy.\n\nHypothesis 1: The investigators hypothesize that participants will respond favorably to the use of the smart ring to monitor their physical activity and sleep during pregnancy.\n\nAim 2: To assess the association between maternal characteristics (age, pre-pregnancy BMI, pregnancy weight gain, stress, anxiety and depression symptoms) with physical activity markers (energy expenditure, and step count) and sleep markers (duration, quality, sleep onset latency, wake after sleep onset, time in bed and heart rate variability) collected from the smart ring in the second trimester of pregnancy.\n\nHypothesis 2: The investigators hypothesize that specific maternal characteristics will be associated with physical activity markers (energy expenditure, and step count), as well as sleep markers (duration, quality, sleep onset latency, wake after sleep onset, time in bed and heart rate variability).",[102],"2025-04-21",{"date":350,"type":43},"2025-04-25",{"date":352,"type":43},"2023-09-03",{"date":354,"type":23},"2025-12-03",{"name":49,"class":50},{"id":357,"slug":358,"hasResults":12,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":12,"sex":88,"minAge":89,"maxAge":364,"enrollmentInfo":365,"targetDuration":4,"studyType":24,"phases":367,"briefSummary":369,"conditions":370,"keywords":373,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":51},"100568094","early-phase-1-benzydamine-hydrochloride-and-post-operative-sore-throat-100568094","NCT06676748","Benzydamine Hydrochloride and Post-operative Sore Throat","The Effect of Benzydamine Hydrochloride Spray on Post-operative Sore Throat: a Randomized Controlled Study","DIFFLAM","Inclusion Criteria:\n\n1. American Society of Anaesthesiologists (ASA) physical status 1-2\n2. Female patients having laryngeal mask airway (LMA) for airway management for surgery in KKH;\n3. BMI \\\u003C 40 kg\u002Fm2.\n\nExclusion Criteria:\n\n1. Pregnant;\n2. Pre-existing sore throat, or history of upper respiratory tract infection\u002F abnormalities, hypertension, chronic pain or anti-inflammatory drugs and antihypertensive treatment;\n3. Allergies to benzydamine hydrochloride;\n4. Symptomatic hiatus hernia;\n5. Severe gastroesophageal reflux disease;\n6. Contraindications to the use of LMA.","80 Years",{"count":366,"type":23},106,[368],"EARLY_PHASE1","Postoperative sore throat (POST) after laryngeal mask airway (LMA) insertion is prevalent and unappealing. A significant cause of POST is mechanical injury to the airway mucosa during airway instrumentation, leading to mucosal injury and inflammation. The Difflam Forte Anti-Inflammatory Throat Spray (Difflam) contains benzydamine hydrochloride, a non-steroidal anti-inflammatory agent with topical analgesic properties. This study will randomize 106 women undergoing gynaecological surgery under general anaesthesia with LMA use at KK Women's and Children's Hospital (KKH) in 1:1 allocation ratio of study (Difflam spray) and control (usual practice; no intervention) groups. Demographic and intraoperative airway data collection will be conducted in perioperative period. Those allocated to study group will receive Difflam spray when awake in the post-anaesthesia care unit (PACU). The primary aim to determine if patients undergoing general anaesthesia with LMA use with the Difflam spray in PACU will have a lower incidence of POST in the immediate and 4 hours postoperative recovery period, as compared with those in the control group. Other outcome measures include the severity of pain of sore throat as measured by the visual analog scale, and incidence of side effects associated with the Difflam spray. This proposal will determine whether the use of Difflam spray is suitable to be implemented in local clinical setting and improve perioperative care.",[371,372],"Sore Throat","Postoperative Care",[374,375,376,377],"Sore throat","Posoperative care","benzydamine hydrochloride","laryngeal mask airway","2025-04-15",{"date":380,"type":43},"2025-04-17",{"date":382,"type":23},"2025-04",{"date":384,"type":23},"2026-12",{"name":49,"class":50},{"id":387,"slug":388,"hasResults":12,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":392,"eligibilityCriteria":393,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":187,"enrollmentInfo":394,"targetDuration":4,"studyType":24,"phases":396,"briefSummary":397,"conditions":398,"keywords":402,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":406,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":51},"100445484","integrated-hyperglycaemia-incentivised-postnatal-surveillance-study-i-hips-100445484","NCT05081037","Integrated Hyperglycaemia Incentivised Postnatal Surveillance Study (I-HIPS)","Lifestyle Interventions to Prevent Postpartum Type II Diabetes Mellitus in Asian Women With a History of Gestational Diabetes Mellitus","I-HIPS","Inclusion Criteria:\n\n1. Women diagnosed antenatally with GDM by IADPSG criteria (15)\n2. Normal 6 weeks post-natal OGTT\n3. BMI range from 20-40\n4. Physically fit to participate in moderate intensity walking\n\nExclusion Criteria:\n\n1. Women with serious skin conditions (e.g. eczema) that precludes wearing the sensor for 14 days\n2. Women who have any other serious chronic disease such as chronic kidney disease and heart disease",{"count":395,"type":23},300,[94],"This study aims to test the following hypotheses in a randomized controlled trial of post-partum women with a history of gestational diabetes mellitus (GDM) that will be followed up for up to 4 years:\n\n1. Post-partum pregnancy is ideal for behavioural modification and adopting a healthy lifestyle. Using the continous glucose monitoring (CGM) sensor and an exercise tracker will promote self-motivation and awareness by positive reinforcement and behavioural changes to improve diet, control body weight and increase physical activity in this group of post-partum women who are at high risk for developing Type II Diabetes.\n2. The use of the continous glycose monitoring (CGM) sensor and exercise tracker will motivate women to modify their dietary food intake and physical activity over time, reducing their cardiovascular risk factors for developing metabolic syndrome by lowering their baseline blood pressure, BMI, reducing their waist circumference and body fat mass, glycaemic levels and fasting lipids within the targeted healthy range.\n3. There will be an increase in the quality adjusted life years (QALYs) gained based on improvements in HbA1C and other proximal outcomes at the end of the trial.",[399,400,401],"Gestational Diabetes","Glucose Metabolism Disorders","Metabolic Disease",[403,404,405],"gestational diabetes","post-partum intervention","Body composition",{"date":380,"type":43},{"date":408,"type":43},"2021-09-06",{"date":410,"type":23},"2026-05-26",{"name":49,"class":50},{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":12,"sex":18,"minAge":89,"maxAge":419,"enrollmentInfo":420,"targetDuration":4,"studyType":24,"phases":422,"briefSummary":423,"conditions":424,"keywords":428,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":434,"leadSponsor":435,"locationsCount":436},"100587501","heart-rate-variability-and-music-listening-100587501","NCT06929208","Heart Rate Variability and Music Listening","Investigating the Association Between Heart Rate Variability and Music Listening Prior to Procedures: A Pilot Cohort Study","Inclusion Criteria:\n\n1. America Society of Anaesthesiologist (ASA) 1 to 3 adults undergoing procedures (surgery, pain procedures);\n2. Able to read and understand English and\u002For Chinese;\n3. Not receiving opioid prior to the procedures.\n\nExclusion Criteria:\n\n1. With chronic pain;\n2. Opioid and drug abuse;\n3. Scheduled postoperative Intensive care unit (ICU) admission;\n4. With baseline non-sinus heart rhythm or on pacemaker support.","90 Years",{"count":421,"type":23},120,[94],"High anxiety levels may lead to negative outcomes, and previous studies have shown that music listening could reduce periprocedural anxiety and depression. Recent evidence suggests that a lower heart rate variability (HRV) may be associated with anxiety and depression disorders, but the association of these HRV parameters with preoperative mood in the procedural settings are less defined.\n\nIn this prospective cohort pilot study, the study team will investigate the association between HRV and psychological vulnerability (anxiety, depression) in the presence of music listening before procedures. A total of 120 patients about to undergo procedures (surgery, procedures) will be recruited in three healthcare institutions in Singapore (KK Women's and Children's Hospital, Singapore General Hospital, Changi General Hospital). Patients will be asked to have their ECG readings recorded before, during, and after music listening. Preprocedural information (e.g., demographic, clinical) and psychological scores will be collected.",[425,426,427],"Heart Rate Variability","Anxiety","Depression",[426,427,429],"Heart rate variability","2025-04-12",{"date":432,"type":43},"2025-04-16",{"date":382,"type":23},{"date":77,"type":23},{"name":49,"class":50},3,{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":441,"acronym":4,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":18,"minAge":443,"maxAge":89,"enrollmentInfo":444,"targetDuration":4,"studyType":24,"phases":446,"briefSummary":447,"conditions":448,"keywords":450,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":459,"locationsCount":79},"100586911","a-novel-home-based-non-invasive-neuromodulation-therapy-for-children-and-adolescents-with-cerebral-palsy-100586911","NCT06921538","A Novel Home-based Non-invasive Neuromodulation Therapy for Children and Adolescents With Cerebral Palsy","Inclusion Criteria:\n\nChildren and adolescents aged between 2 to \\\u003C21 years old with mild to severe Spastic Cerebral Palsy (CP) classified on Gross Motor Function Classification System (GMFCS) II, III, IV, V. Families with at least one parent or caregiver has simple or conversational English language skill.\n\nTo be eligible for the qualitative interview components of this research study, the individuals should be recognised as one of the following:\n\n1. CP patients who participate in this research study,\n2. caregivers of the CP patients taking part in this research study,\n3. implementation staff\n4. qualified clinicians not involved in the intervention or refused to recommend the intervention device (AscenZion-IV stimulator) for management of CP.\n\nEligible individuals must agree to be audio-recorded.\n\nExclusion Criteria:\n\n1. CP patients with epilepsy with recent seizures (\\<12 months) will be excluded for safety given the theoretical risks of seizures (abnormal brain electrical discharges) with transcranial electrical stimulation. We will include those with well controlled epilepsy with no recent seizures (within 12 months).\n2. CP patients who have contra-indications to the use of tPCS and\u002For TENS will be excluded from the study, include:\n\n   * Individuals with history of uncontrolled epileptic disorder, seizures, brain tumour or trauma, and mental disease\n   * Individuals with electrical implanted stimulatory device, such as pacemaker or defibrillator\n   * Individuals with medical devices that are affected by magnets, such as programmable shunts.\n   * Individuals with pregnancy\n3. CP patients who received any intramuscular botulinum toxin injections within less than 6 months (as anti-spasticity effect lasts for 4-6 months).\n4. CP patients who received any musculo-skeletal, brain or nerve-related surgery within less than 6 months, or major surgery requiring prolonged hospitalisation (\\>1week) within less than 3 months.\n\nThose who do not agree to be audio-recorded will be excluded for the qualitative interview components of this research study.","6 Years",{"count":445,"type":23},60,[94],"The aim of this study is to evaluate the clinical effectiveness, feasibility and acceptability of a novel home-based noninvasive neuromodulation therapy (AscenZ-IV Stimulator) that utilizes transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) for children and adolescents with cerebral palsy as a community-based intervention by families and healthcare providers.",[449],"Cerebral Palsy (CP)",[451],"neuromodulation","2025-04-08",{"date":454,"type":43},"2025-04-10",{"date":456,"type":43},"2024-10-11",{"date":458,"type":23},"2025-11",{"name":49,"class":50},{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":88,"minAge":89,"maxAge":4,"enrollmentInfo":467,"targetDuration":4,"studyType":24,"phases":469,"briefSummary":471,"conditions":472,"keywords":474,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":488,"locationsCount":51},"100465522","phase-4-the-use-of-letrozole-or-mifepristone-for-pretreatment-of-medical-termination-of-pregnancy-100465522","NCT05341817","The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy","The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy: a Randomized, Non-inferiority Trial","Inclusion Criteria:\n\n* 21 years and above\n* Patient requesting for medical termination of pregnancy (mTOP)\n* Patient eligible for legal abortion according to the Termination of Pregnancy Act (Chapter 324)\n* Gestational age ≤10 weeks (on day 1 of mifepristone or letrozole administration) as confirmed by the first trimester dating scan\n* Singleton pregnancy\n* Patient is agreeable to undergo surgical evacuation or repeat medical therapy if treatment fails\n* Willing and able to provide written, informed consent\n\nExclusion Criteria:\n\n* History or evidence of adrenal pathology, steroid-dependent cancer, porphyria, poorly controlled hypertension, bronchial asthma, thromboembolism and severe cardiac\u002Frenal\u002Fliver disease\n* Haemoglobin level of \\\u003C9.5 g\u002FL\n* Presence of an intrauterine contraceptive device\n* Breastfeeding\n* Reported allergic reaction to mifepristone, misoprostol or letrozole,\n* Participating in another trial of investigational medicinal products during the current pregnancy",{"count":468,"type":23},144,[470],"PHASE4","Medical termination of pregnancy (mTOP) generally involves using either a combined regimen consisting of mifepristone and misoprostol, or a misoprostol-only regimen. Complete abortion rates of first trimester mTOP with the use of misoprostol-only regimen varies between 74-88%. With the addition of mifepristone as pre-treatment drug, this improves success rates to 93-97%. Mifepristone, an anti-progesterone, is relatively expensive and is subject to stringent regulations for usage in addition to restricted access in many countries. Therefore, there is a need to find a cheaper and more readily available, yet effective alternative.\n\nThe use of letrozole (an aromatase inhibitor) in mTOP is postulated to suppress estradiol levels (an important factor in the maintenance of early pregnancy), therefore enhancing the effect of misoprostol in inducing abortion. Studies have shown that pre-treatment with letrozole achieves a complete abortion rate of 77-98%, similar to that in mifepristone-Misoprostol studies.\n\nThe investigators hypothesise that letrozole is equivalent to mifepristone for the pre-treatment of mTOP and propose to conduct a randomised, non-inferiority trial for mTOP up to 10 weeks gestation with two arms as detailed below:\n\n1. Oral letrozole 10mg daily for 3 days, followed by vaginal misoprostol on Day 3 (Intervention group)\n2. Oral mifepristone 200mg once on Day 1, followed by vaginal misoprostol 800mcg on Day 3. Then, 4 hours later, another dose of 400mcg PV misoprostol if no signs of abortion (Control group - current practice).\n\nThe investigators aim to include a total of 144 patients, 72 in each arm, to detect a non-inferiority margin of 15% with a power of 80% at 5% significance. The investigators primary outcome will be rate of complete abortion by Day 21-28 of mTOP.\n\nThis pilot RCT will provide preliminary data and preparation for larger grant application which will provide necessary evidence to enhance the care of women undergoing mTOP, with enhanced cost-savings and availability.",[473],"Abortion in First Trimester",[475,476,477,478,479,480,481],"Medical termination of pregnancy","Abortion","Induced","mTOP","letrozole","mifepristone","misoprostol","2025-01-20",{"date":484,"type":43},"2025-01-22",{"date":486,"type":43},"2022-11-22",{"date":458,"type":23},{"name":49,"class":50},{"id":490,"slug":491,"hasResults":12,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":4,"eligibilityCriteria":495,"healthyVolunteers":87,"sex":18,"minAge":443,"maxAge":271,"enrollmentInfo":496,"targetDuration":4,"studyType":24,"phases":497,"briefSummary":498,"conditions":499,"keywords":501,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":51},"100460852","integrating-community-lite-programme-as-an-online-family-based-intervention-to-combat-childhood-obesity-100460852","NCT05281016","Integrating Community LITE Programme as an Online Family-based Intervention to Combat Childhood Obesity","Integrating Community LITE Programme Into a School-clinic-community Partnership as an Online Family-based Intervention to Combat Childhood Obesity","Inclusion Criteria:\n\n* Overweight as defined by BMI percentile of above 90th percentile\n* Age 6- 12 years old\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Patients with secondary causes of obesity especially genetic syndromes e.g. Trisomy 21, Prader-Willi, and those who are taking medications that can affect weight status.\n* Intellectual disability, poor level of spoken English (including their parent\u002Fcarer)\n* Significant medical illness that precludes physical activity and significant psychiatric illness\n* Sibling who is already participating in the study",{"count":189,"type":23},[94],"Childhood obesity in Singapore is rising with a record prevalence of 13% in 2017 (1). Given that 70% of overweight children remain so into adulthood (2), this will further increase the public health epidemic of diabetes among Singaporeans. Early intervention is thus critical to improve the weight trajectory of overweight children and foster life long healthy lifestyle habits. Family-based interventions combining dietary, physical activity and behavioural interventions are currently recommended as the best practice in the management of childhood obesity in children younger than 12 years old (3-7). Our pilot study on family-based intervention in the tertiary setting demonstrated feasibility and short-term effectiveness. However, its outreach and sustainable results are limited. Currently, school-based screening, weight management clinics and community recreational facilities are operating in silos with limited effectiveness. Here, the investigators will integrate our family-based intervention into a school, clinic and community partnership to achieve an impactful and sustainable outcome for families with overweight children.\n\nThe community Lifestyle InTervention for Everyone (LITE) program is a structured, group family-based multicomponent lifestyle intervention. Community LITE program will introduce various exercise programs within the family based online sessions to reduce perceived barrier and promote self-efficacy of community sports facilities to increase physical activity. Children have minimal control over their food and physical activity choices especially in current obesogenic environment (8). Parents are the most important influencers(9) to impose interventions for childhood obesity through parental practices and parenting style(10). Therefore, they are the main focus of the community-based intervention program.",[500],"Pediatric Obesity",[502,503,504,505,506,507,508],"child health","Body Mass Index","Healthy Lifestyle","Community Networks","internet-based intervention","Diet, Food, and Nutrition","Parenting","2024-11-24",{"date":511,"type":43},"2024-11-27",{"date":513,"type":43},"2022-04-22",{"date":515,"type":23},"2025-12",{"name":49,"class":50},{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":522,"acronym":523,"eligibilityCriteria":524,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":364,"enrollmentInfo":525,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":527,"conditions":528,"keywords":533,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":538,"startDateStruct":540,"completionDateStruct":542,"leadSponsor":543,"locationsCount":51},"100363639","evaluation-of-central-sensitization-fear-avoidance-and-pain-pressure-threshold-with-chronic-pain-after-hysterectomy-100363639","NCT04014829","Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy","Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain in Post-Hysterectomy Patients: A Collaborative Cohort Study (EPOCH - Enhancing Post-operative Outcomes in Chronic Pain After Hysterectomy)","EPOCH","Inclusion Criteria:\n\n* Age 21 to 80 years old\n* American Society of Anesthesiologists Physical Scale (ASA) I to III\n* Benign gynaecological indications for hysterectomy\n* Elective abdominal or laparoscopic hysterectomy\n\nExclusion Criteria:\n\n* Vaginal hysterectomy\n* Uterine prolapse, endometriosis, malignant disease, or pelvic pain as main indication for surgery\n* History of drug dependence or recreational drug use\n* History of chronic pain syndrome\n* Current chronic daily treatment with corticosteroids, excluding inhaled steroids\n* Allergy to study drugs\n* Major heart surgery\n* Heart transplant\n* Pacemaker inserted\n* Baseline non-sinus cardiac rhythm",{"count":526,"type":23},436,"Phase 1 (started in July 2019):\n\nCentral Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete understanding on the development of CPHP is lacking. The study aims to identify clinically-relevant factors for CPHP that can be reliably assessed preoperatively.\n\n===\n\nPhase 2 (anticipated start May 2022):\n\nIn addition to above factors, the association between heart rate variability (HRV) parameters, anxiety level, anticipated pain, and anticipated analgesia requirement with significant postoperative pain and CPHP will be investigated.",[529,530,531,532],"Hysterectomy","Chronic Pain","Central Sensitisation","Anxiety Depression",[529,530,534,535,536,537,429],"Fear-Avoidance","Central Sensitization","Pain-Pressure Threshold","Mechanical Temporal Summation",{"date":539,"type":43},"2024-11-26",{"date":541,"type":43},"2019-07-23",{"date":77,"type":23},{"name":49,"class":50},{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":548,"acronym":4,"eligibilityCriteria":549,"healthyVolunteers":12,"sex":88,"minAge":4,"maxAge":4,"enrollmentInfo":550,"targetDuration":551,"studyType":63,"phases":4,"briefSummary":552,"conditions":553,"keywords":555,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":565,"locationsCount":79},"100568095","outcomes-of-a-novel-technique-minimal-scar-mastectomy-100568095","NCT06676761","Outcomes of a Novel Technique Minimal Scar Mastectomy","Inclusion Criteria: breast cancer patients who opted for minimal scar mastectomy -\n\nExclusion Criteria: breast cancer patients who underwent conventional mastectomy\n\n\\-",{"count":189,"type":23},"5 Years","Nipple sparing mastectomy is oncologically safe and has a good cosmetic outcome. However, nipple sparing mastectomy was conventionally performed with reconstruction. Minimal scar mastectomy (MSM) is a novel technique which could allow women, with non-ptotic breasts, who do not want reconstruction, to conserve their nipple areolar complex (NAC) and avoid the transverse scar associated with modified radical mastectomy. This is the first study on the oncologic and surgical outcomes of MSM.",[554],"Breast Cancer Early Stage Breast Cancer (Stage 1-3)",[556,557],"breast cancer","nipple sparing mastectomy","2024-11-05",{"date":560,"type":43},"2024-11-06",{"date":562,"type":43},"2017-03-01",{"date":564,"type":23},"2030-12-31",{"name":49,"class":50},{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":570,"acronym":571,"eligibilityCriteria":572,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":573,"enrollmentInfo":574,"targetDuration":4,"studyType":24,"phases":576,"briefSummary":577,"conditions":578,"keywords":582,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":591,"locationsCount":51},"100455170","healthy-early-life-moments-in-singapore-100455170","NCT05207059","Healthy Early Life Moments in Singapore","HELMS","Inclusion Criteria:\n\n1. Women aged 21-40 years\n2. BMI 25-40 kg\u002Fm2\n3. Intention to reside in Singapore for the next 4 years\n4. Chinese, Malay, Indian or any combination of these 3 ethnic groups\n5. Planning to conceive within 1 year\n6. Able to understand English\n7. Able to provide written, informed consent\n\nExclusion Criteria:\n\n1. Currently pregnant\n2. Known type 1 or type 2 diabetes\n3. On any anticonvulsant medication in the past 1 month\n4. On any oral steroid in the past 1 month (e.g. Prednisolone, Prednisone, Deltasone, Prelone, Methyl Prednisolone, Medrol, Hydrocortisone, Cortef, Dexamethasone, Decadron)\n5. On any oral, implanted contraception or intrauterine contraceptive device (IUCD) in situ in the past 1 month\n6. On any fertility medication (e.g. hormones injection, IVF treatments) other than Clomiphene\u002F Letrozole in the past 1 month\n7. On HIV or Hepatitis B or C medication in the past 1 month.","40 Years",{"count":575,"type":23},500,[94],"This study aims to assess whether an integrated continuum of care from the preconception period, across maternity until the first 18 months of life, can promote maternal metabolic and mental health, as well as offspring health, among overweight and obese women.",[401,579,580,581],"Mental Health Wellness 1","Lifestyle Risk Reduction","Maternal Obesity",[583,584,119],"Obesity","Mental health","2024-10-08",{"date":587,"type":43},"2024-10-10",{"date":589,"type":43},"2022-03-18",{"date":234,"type":23},{"name":49,"class":50},{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":4,"eligibilityCriteria":598,"healthyVolunteers":12,"sex":88,"minAge":89,"maxAge":599,"enrollmentInfo":600,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":601,"conditions":602,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":611,"locationsCount":51},"100438485","quality-of-recovery-after-childbirth-100438485","NCT04989894","Quality of Recovery After Childbirth","Investigating the Quality of Recovery After Childbirth","Inclusion Criteria:\n\n* Aged 21-50 years old;\n* Able to read and understand written Chinese;\n* Primiparous and having singleton pregnancy;\n* Delivered via spontaneous vaginal delivery, or elective cesarean delivery;\n* ≥38 gestational week.\n\nExclusion Criteria:\n\n* Failed neuraxial analgesia in those receiving elective cesarean delivery;\n* General anaesthesia;\n* Intrapartum cesarean delivery;\n* Women whose infants have died;\n* Mother or baby requiring ICU after delivery;\n* Assisted\u002F operative vaginal delivery.","50 Years",{"count":274,"type":23},"In this proposed study, the investigators hope to assess the quality of recovery after delivery in a local population that would take into account physiological and psychological parameters to better understand the recovery process after delivery. The investigators will identify risk factors, especially those that are modifiable and associated with a poorer ObsQoR score and hence a poor quality of recovery after delivery. This data may then be used to educate women and manage expectations in the postpartum period, and help develop potential therapeutic interventions.",[603,604,605],"Quality of Life","Childbirth","Maternal Health",{"date":607,"type":43},"2024-10-09",{"date":609,"type":43},"2021-12-20",{"date":384,"type":23},{"name":49,"class":50},{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":618,"eligibilityCriteria":619,"healthyVolunteers":12,"sex":88,"minAge":89,"maxAge":599,"enrollmentInfo":620,"targetDuration":4,"studyType":24,"phases":622,"briefSummary":624,"conditions":625,"keywords":628,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":630,"startDateStruct":631,"completionDateStruct":633,"leadSponsor":635,"locationsCount":51},"100363356","phase-3-development-of-variable-volume-automated-mandatory-boluses-for-patient-controlled-epidural-analgesia-during-labour-100363356","NCT04011150","Development of Variable Volume Automated Mandatory Boluses for Patient-controlled Epidural Analgesia During Labour","Development of Variable Volume Automated Mandatory Boluses (VVAMB) for Patient-controlled Epidural Analgesia During Labour and Delivery","VVAMB","Inclusion Criteria:\n\n* Healthy (American Society of Anesthesiologists (ASA) physical status 1 and 2) primiparous parturient at term (≥36 weeks gestation);\n* Singleton fetus;\n* In early labor stage (cervical dilation ≤5cm);\n* Request labor epidural analgesia and able to administer combined spinal epidural analgesia (CSEA) according to protocol.\n\nExclusion Criteria:\n\n* Non-cephalic fetal presentation;\n* Obstetric (e.g. pre-eclampsia, premature rupture of amniotic membranes for more than 48 hours, gestational diabetes on insulin, pregnancy-induced hypertension on medication) and uncontrolled medical (e.g. cardiac disease) complications;\n* Have contraindications to neuraxial blockade or have received parenteral opioids within last 2 hours;\n* Dural puncture\u002F suspected dural puncture at initiation of CSEA.",{"count":621,"type":23},216,[623],"PHASE3","A novel epidural delivery regimen was developed: Variable volume automated mandatory bolus (AMB) (VVAMB) will advance individualisation of labour epidural analgesia, by which a larger volume of bolus may contribute to better spread of the local anaesthetics within brief period and thereby reduces the chances of motor blockade that could reduce instrumental deliveries.",[626,627],"Labor Pain","Breakthrough Pain",[626,627,629],"Infusion pump",{"date":607,"type":43},{"date":632,"type":43},"2020-08-11",{"date":634,"type":23},"2026-08-31",{"name":49,"class":50},{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":641,"acronym":642,"eligibilityCriteria":643,"healthyVolunteers":12,"sex":88,"minAge":89,"maxAge":644,"enrollmentInfo":645,"targetDuration":4,"studyType":24,"phases":647,"briefSummary":648,"conditions":649,"keywords":651,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":655,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":659,"locationsCount":51},"100338511","an-ultrasound-guided-automated-spinal-landmark-identification-system-100338511","NCT03687411","An Ultrasound Guided Automated Spinal Landmark Identification System","Development of an Ultrasound Guided Automated Spinal Landmark Identification System (uSINE Study)","uSINE","Inclusion Criteria:\n\nFirst phase:\n\n* Age 21 - 75 years old patients who require neuraxial anesthesia for surgical procedure;\n* Normal body mass index (Weight 40-90 kg, Height 140-180cm).\n\nSecond-fourth phases:\n\n* Obese patients aged between 21-75 years old;\n* body mass index more than 30.\n\nExclusion Criteria:\n\n* History of scoliosis;\n* History of spinal instrumentation;\n* Drug allergy to ultrasound transmission gel;\n* Visible wound or injury in the lumbar spine.","75 Years",{"count":646,"type":23},200,[94],"Neuraxial ultrasonography has been shown a safe and effective technique to enhance the overall success rate of lumbar puncture and reduce the number of injection attempts. However, the current blind palpation landmark technique is known to be highly inaccurate and may increase the risk of multiple insertion attempts, patient suffering and complication rates such as spinal cord injury. Various clinical studies have confirmed the effectiveness of ultrasound imaging compared with the traditional palpation method. However, none of the present system can achieve real-time guidance.\n\nThe overall aim of this proposal is to develop an ultrasound guided automated spinal landmark identification with real-time neuraxial needle insertion system (uSINE) to improve patient safety and efficacy of neuraxial procedure needle insertion success. This will be achieved in 4 phases of technology development and clinical trial phases. The investigators will recruit 20 subjects in a prospective cohort study to investigate the spinal needle first attempt success rate as a clinically relevant outcome. The secondary aim is to develop an automated spinal landmark identification algorithm using image processing to identify spinal landmarks in 50 obese patients. Third phase objective will be to obtain clinical data, and evaluation and annotation of the clinical data of spinal ultrasonography in 65 obese patients (BMI \\> 30kg\u002Fm2), whereas the fourth phase will measure the uSINE identification accuracy and first-attempt puncture success rate of uSINE in a clinical study of 65 obese patients (BMI \\> 30kg\u002Fm2).",[650,583],"Spinal Anaesthesia",[652,653,654],"spinal anaesthesia","Neuraxial ultrasonography","landmark identification",{"date":607,"type":43},{"date":657,"type":43},"2018-05-24",{"date":148,"type":23},{"name":49,"class":50},{"id":661,"slug":662,"hasResults":12,"nctId":663,"briefTitle":664,"officialTitle":665,"acronym":4,"eligibilityCriteria":666,"healthyVolunteers":12,"sex":88,"minAge":89,"maxAge":667,"enrollmentInfo":668,"targetDuration":4,"studyType":24,"phases":670,"briefSummary":671,"conditions":672,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":677,"startDateStruct":678,"completionDateStruct":680,"leadSponsor":682,"locationsCount":51},"100317666","perioperative-music-listening-on-anxiety-pain-analgesia-use-and-patient-satisfaction-100317666","NCT03415620","Perioperative Music Listening on Anxiety, Pain, Analgesia Use and Patient Satisfaction","The Use of Perioperative Music Listening on Anxiety, Pain, Analgesia Use and Patient Satisfaction in Patients Undergoing Surgery","Inclusion Criteria:\n\n* Healthy participants who are American Society of Anesthesiologists (ASA) 1 and 2 (with well-controlled medical problems);\n* Undergo day surgery, same-day-admission gynecologic surgery or cesarean section;\n* No hearing impairment.\n\nExclusion Criteria:\n\n* Patients with significant respiratory disease and obstructive sleep apnea;\n* Patients who are unable to read and understand the hospital anxiety questionnaire.","70 Years",{"count":669,"type":23},410,[94],"The use of music to relieve pain has been studied in many forms of medicines and has been proven to reduce anxiety, pain and analgesic use in the perioperative setting. However, music listening as an inexpensive and duplicable method has not been investigated and implemented in the local context. The investigators hereby propose a prospective study to recruit patients undergoing surgery to evaluate the effectiveness of music in pain relief and post-operative recovery; as well as the implementation and operational readiness of music listening.",[673,674,426,675,676],"Music","Pain","Patient Satisfaction","Analgesia",{"date":587,"type":43},{"date":679,"type":43},"2018-01-03",{"date":681,"type":23},"2026-12-31",{"name":49,"class":50},""]