[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kaiser Permanente\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":593},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,42,68,93,123,150,177,213,242,266,289,316,345,372,396,422,447,471,494,523,544,563],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100588447","addressing-social-needs-to-improve-health-in-adults-with-multiple-chronic-conditions-100588447",false,"NCT06941519","Addressing Social Needs to Improve Health in Adults With Multiple Chronic Conditions","Inclusion Criteria:\n\n* Two or more chronic medical conditions from a defined list of 24 chronic conditions\n* One or more gaps in evidence-based care (related to condition-specific risk factor management, evidence-based screening and preventive care, missed appointments, and medication non-adherence),\n* At least one self-reported social-related barrier to care or \"social need\" (e.g., transportation, food, housing, utilities, and\u002For financial insecurity).\n\nExclusion Criteria:\n\n* major cognitive barriers (dementia, psychosis).\n* multiple prior year hospitalizations (\"extremely high utilizers\")","ALL","18 Years",{"count":18,"type":19},800,"ESTIMATED","INTERVENTIONAL",[22],"NA","The investigators will conduct a comparative effectiveness randomized clinical trial with two \"active comparator\" arms. The investigators will evaluate the two current, usual care strategies (higher intensity \"telephonic navigation\" vs. lower intensity \"virtual outreach\") for addressing social needs among patients with multiple chronic conditions.",[25,26,27,28],"Multiple Chronic Conditions","Social Needs","Care Gaps","Navigation","RECRUITING","2026-06-03",{"date":32,"type":33},"2026-06-05","ACTUAL",{"date":35,"type":33},"2025-09-01",{"date":37,"type":19},"2029-12-01",{"name":39,"class":40},"Kaiser Permanente","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100628283","evaluation-of-a-novel-mhealth-intervention-for-people-who-are-ambivalent-about-quitting-smoking-100628283","NCT07459621","Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking","Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking: A Randomized Controlled Trial","GEMS","Inclusion Criteria:\n\n* 18 years of age and older\n* Current cigarette smoker who is ambivalent about smoking\n* Not actively using any treatment to quit smoking\n* Own and regularly use a smartphone\n* State willingness to install and use their assigned app\n* Willingness to receive study communications\n* Smoke at least half a pack a day\n* Meet geolocation requirements\n\nExclusion Criteria:\n\n* A lifetime history of dementia or psychosis\n* Visual impairments that prevent viewing phone content and they lack adaptive devices\n* Report medical contra-indications for over-the-counter NRT use\n* Due to the potential for bias introduced by fraudulent participants, other exclusions will be applied to deter fraudulent enrollment.",{"count":18,"type":19},[22],"The goal of this study is to compare the effectiveness of two smoking cessation programs to determine which better helps people change their smoking behavior, the control or the experimental intervention? Both interventions include access to a mHealth app and other publicly available stop-smoking resources. The two app versions each include best practice advice and guidance for quitting smoking, but one includes additional content designed for people who aren't ready to quit smoking.\n\nThe investigators hypothesize that people who receive the experimental intervention will be more likely to request additional stop-smoking resources offered through the intervention and report smoking abstinence after 6 months.\n\nThe investigators also hypothesize people assigned to the experimental app will have better app engagement and be more likely to report positive changes in their smoking behavior and use of other evidence-based stop smoking treatments that are publicly available.",[54],"Smoking Behaviors",[56,57,58,59],"Smoking","mHealth","motivation","ambivalent smokers","2026-04-24",{"date":62,"type":33},"2026-04-30",{"date":64,"type":33},"2026-03-29",{"date":66,"type":19},"2028-12",{"name":39,"class":40},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":15,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":20,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":41},"100634801","stride-supporting-early-diabetes-self-management-for-parents-100634801","NCT07544407","STRIDE: Supporting Early Diabetes Self-Management for Parents","A Pilot Trial of an Intervention to Support Initial Type 2 Diabetes Self-management Among Younger Adults With Children (STRIDE)","STRIDE","Inclusion Criteria:\n\n* Kaiser Permanente Northern California members newly diagnosed with T2D (within the past 5 years)\n* Proficient in English\n* Primary caregivers to ≥1 child (ages 2-14 years at time of enrollment)\n* Can receive text messages\n* Able to participate in a virtual session\n\nExclusion Criteria:\n\n* Pregnant women\n* Type 1 Diabetes\n* Unable to receive text messages\n* Unable to participate in a virtual session","21 Years","44 Years",{"count":79,"type":19},150,[22],"This study will test STRIDE (SupporTing paRents with DiabEtes), a virtually delivered program that helps adults ages 21-44 who were recently diagnosed with type 2 diabetes and are caring for a child ages 2-14 within Kaiser Permanente Northern California. STRIDE focuses on practical skills for everyday life, with sessions on Prioritizing Self-Care, Eating Well Together, and Getting Active as a Family.",[83],"Diabetes Mellitus Type 2","NOT_YET_RECRUITING","2026-04-23",{"date":87,"type":33},"2026-04-29",{"date":89,"type":19},"2026-04",{"date":91,"type":19},"2027-12",{"name":39,"class":40},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":20,"phases":103,"briefSummary":104,"conditions":105,"keywords":108,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":41},"100633127","adherence-to-dyslipidemia-therapy-harnessing-evidence-from-randomized-evaluations-in-atherosclerotic-cardiovascular-disease-100633127","NCT07522645","Adherence to Dyslipidemia Therapy: Harnessing Evidence From Randomized Evaluations in AtheroSclerotic CardioVascular Disease","Adherence to Dyslipidemia Therapy: Harnessing Evidence From Randomized Evaluations in AtheroSclerotic CardioVascular Disease (ADHERE-ASCVD)","ADHERE-ASCVD","Inclusion Criteria\n\n1. Age ≥18 years\n2. Active Kaiser Permanente Northern California (KPNC) membership\n3. Diagnosis of atherosclerotic cardiovascular disease (ASCVD) or diabetes and inclusion in the Preventing Heart Attacks and Strokes Everyday (PHASE) Registry\n4. No statin prescription fill within the prior 3 months\n5. Statin adherence \\\u003C80% in the prior 12 months\n6. Active kp.org account within the past 12 months\n7. Valid email address and text-capable phone number on file\n\nExclusion Criteria\n\n1. Documented allergic reaction or contraindication to statin therapy\n2. Receiving hospice care\n3. Medicare beneficiaries\n4. Other exclusions applied per operational standard practice",{"count":102,"type":19},22000,[22],"The goal of the ADHERE-ASCVD study is to evaluate and optimize patient-facing messaging strategies to improve statin refill and adherence among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes.\n\nThe main questions it aims to answer are:\n\n1. Do different outreach methods (such as text messages, secure portal messages, or email) increase short-term statin refill compared to usual care?\n2. Among patients who do not initially refill their prescription, does changing the outreach method improve refill rates?\n\nThe team with operational partners will evaluate the comparitive effectivessness of multiple messaging strategies delivered through existing health system communication channels, including SMS (text messaging), secure patient portal messages, non-secure email, and usual care (no additional outreach).\n\nParticipants\n\n* Receive an initial outreach message encouraging statin refill (or usual care) Be monitored for statin refill within 14 days\n* Potentially receive a second outreach message using the same or a different communication method if they do not initially refill their prescription\n* Have their medication refill patterns tracked over time, including longer-term adherence outcomes",[106,107],"ASCVD","Diabetes",[106,109,110,111,112,113,114],"ASCVD management","statin therapy","statin","SMART design","messaging strategies","patient outreach","2026-04-13",{"date":117,"type":33},"2026-04-15",{"date":119,"type":19},"2026-04-14",{"date":121,"type":19},"2028-12-31",{"name":39,"class":40},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":130,"sex":15,"minAge":131,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":20,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":149},"100543972","promoting-physical-activity-in-older-hispaniclatinoa-adults-100543972","NCT06362824","Promoting Physical Activity in Older Hispanic\u002FLatino(a) Adults","De Pie y a Movernos Study: Promoting Physical Activity in Older Hispanic\u002FLatino(a) Adults","Inclusion Criteria:\n\n* be 55-89 and self-identify as Hispanic\u002FLatino(a)\n* able to participate for up to 20 weeks in the study\n* willing to be randomized to the intervention or active comparison program\n* willing to follow study procedures depending on program assignment\n* available M-F for study phone calls between 8am-5pm\n* able to walk one block unassisted,\n* able to speak and can read Spanish or English,\n* have a smartphone (85% of the Hispanic\u002FLatino(a) population has a smartphone)\n* willing to wear an ActiGraph for up to 2 weeks, twice during the course of the study\n* willing to complete study questionnaires via weblink, paper, or phone call\n* have an email address and be willing to share it with the team\n* have a US mailing address where they receive mail regularly (confirmed in pre-screen)\n\nExclusion criteria are as follows:\n\n* score less than or equal to 4 on the Six-Item Screener (Callahan et al., 2002)\n* unable to hear phone conversation, even with a hearing aid\n* planned surgeries or travel that would interfere with participation\n* had a fall in the last year that resulted in hospitalization\n* had a cancer diagnosis that requires treatment in the past year (other than skin cancer)\n* had a diagnosis of heart attack or irregular heart beat (arrythmia) in the past year\n* been advised recently by their doctor to avoid physical activity\n* does not want to share cognitive health information collected during the study with researchers at UCSD\n* unwilling to share their email address\n* unwilling to obtain an email address if they do not already have one\n* currently participating in another institution's physical activity study",true,"55 Years","89 Years",{"count":134,"type":19},130,[22],"In this randomized controlled trial, study staff will randomize 130 Hispanic\u002FLatino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington (State) to either the culturally adapted De Pie physical activity intervention or an active comparison program focusing on general brain health topics. The purpose of this study is to determine if 12 weeks of the culturally adapted and fully remote De Pie y a Movernos intervention improves self-efficacy, habit strength, social support, and enjoyment for physical activity (PA), thus promoting adherence to moderate-intensity physical activity (MIPA) guidelines (150 minutes\u002Fweek).",[138,139,140],"Sedentary Behavior","Physical Inactivity","Alzheimer Disease, Protection Against","2026-04-02",{"date":143,"type":33},"2026-04-08",{"date":145,"type":33},"2024-09-24",{"date":147,"type":19},"2027-05-31",{"name":39,"class":40},2,{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":20,"phases":159,"briefSummary":160,"conditions":161,"keywords":166,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":176,"locationsCount":41},"100628901","infusing-needed-iron-to-target-insufficiency-in-adults-treated-for-evidence-of-heart-failure-100628901","NCT07467668","Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure","INITIATE-HF","Inclusion Criteria:\n\nAdults (age \\>18 years); Diagnosed heart failure with most recent left ventricular ejection fraction \\\u003C50%; Hospitalized for any reason for the index admission; Documented iron deficiency defined as TSAT \\\u003C20% during the index hospitalization; At least 6 months of health plan coverage and prescription drug benefit before admission\n\nExclusion Criteria:\n\nA documented allergy to IV iron in the Kaiser Permanente Northern California (KPNC) electronic health record (EHR) system; A history of hemochromatosis (i.e., iron overload) based on KPNC EHR data; End-stage kidney disease (defined as receiving chronic dialysis or a prior kidney transplant) or advanced chronic kidney disease (i.e., estimated glomerular filtration rate \\[eGFR\\] \\\u003C30 mL\u002Fmin\u002F1.73 m2) based on most recent pre-admission outpatient laboratory results or the KPNC regional End-Stage Kidney Disease Treatment Registry; Serum ferritin \\>300 ng\u002FmL based on KPNC EHR data; Diagnosed with metastatic cancer and\u002For receiving systemic chemotherapy based on KPNC EHR data; Institutionalized (e.g., prison) and\u002For receiving palliative care per KPNC EHR data",{"count":158,"type":19},3000,[22],"The INITIATE-HF study is a cluster randomized controlled trial that aims to find out if reminding doctors about treatment guidelines for iron deficiency in adults with heart failure who are hospitalized and have evidence of iron deficiency changes the subsequent use of intravenous (IV) iron.\n\nTwo groups of hospitalized adult patients with known heart failure and iron deficiency will be compared:\n\n* Group 1 will include doctors who receive a notification with their patient's iron storage test results and guideline recommendations related to the use of IV iron.\n* Group 2 will include doctors who do not receive this notification and continue with usual standard of care.\n\nThe study will measure if this provider-facing notification affects physician use of recommended IV iron treatment in eligible patients with heart failure, left ventricular ejection fraction less than 50%, and iron deficiency. Secondarily, if there is an increased use of IV iron observed in the intervention group, this study will evaluate whether there are differential health outcomes (i.e., fewer subsequent hospital visits and lower risk of death) of patients whose providers were assigned to the intervention group.",[162,163,164,165],"Iron Deficiency (ID)","Heart Failure","Heart Failure and Reduced Ejection Fraction","Heart Failure and Mildly Reduced Ejection Fraction",[167,168,169],"IV iron","iron deficiency","heart failure","2026-03-11",{"date":172,"type":33},"2026-03-12",{"date":174,"type":19},"2026-03-09",{"date":121,"type":19},{"name":39,"class":40},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":15,"minAge":76,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":20,"phases":187,"briefSummary":188,"conditions":189,"keywords":199,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":4},"100624165","navigation-intervention-for-adolescent-and-young-adult-cancer-survivors-100624165","NCT07406087","Navigation Intervention for Adolescent and Young Adult Cancer Survivors","Adaptation and Implementation of an Evidence-Based Patient Navigation Intervention for Adolescent and Young Adult Cancer Survivors","Inclusion Criteria:\n\n* Received diagnosis of local or regional breast, ovarian, cervical, testicular, colon\u002Frectal, melanoma, endometrial, sarcoma, or thyroid cancer between the ages of 15-39 years (\"index cancer\")\n* Current age 21-45 years\n* Diagnosed and treated for index cancer within Kaiser Permanente Southern California\n* Current Kaiser Permanente insurance coverage\n\nExclusion Criteria:\n\n* Patients with a history of or current diagnosis of leukemia or lymphoma\n* Patients with metastatic disease at diagnosis","45 Years",{"count":186,"type":19},25,[22],"The investigators propose to: 1) Adapt an evidence-based cancer-focused patient navigation (PN) program for the Adolescent and Young Adult (AYA) cancer survivor population; and 2) Plan and conduct an effectiveness-implementation trial of this program within Kaiser Permanente Southern California (KPSC). PLEASE NOTE: This study is awarded in two phases. The UG3 phase has been awarded for the first two years; upon successful completion of this phase by meeting pre-defined milestones, the National Cancer Institute (NCI) will provide funding for the second phase of the study (Years 3-6), which will allow our team to conduct a trial to determine the effectiveness of the implementation of the adapted PN program for the AYA cancer survivor population. This application is focused on the initial UG3 phase and will update the protocol for the UH3 trial upon successful completion of the UG3 milestones and receipt of the UH3 award.\n\nThe primary objectives in the UG3 phase of the study are to adapt and tailor an existing PN program to meet the needs of AYA cancer survivors and the local clinical context via (a) interviews with key stakeholders (patients, clinicians, administrators) and (b) guidance from our AYA Primary Care Survivorship Council. The investigators will conduct a pilot study of the adapted PN program and refine the program to enhance acceptability to patients and clinicians, enhance feasibility and effectiveness, and develop and pilot evaluation tools and methods prior to the start of the UH3 phase of the trial, which will be a larger trial. Objectives will be updated for the UH3 phase once awarded.",[190,191,192,193,194,195,196,197,198],"Breast Cancer","Ovarian Cancer","Cervical Cancer","Testicular Cancer","Colon Rectal Cancer","Melanoma (Skin Cancer)","Endometrial Cancer","Sarcoma","Thyroid Cancer",[200,201,202,203,204],"Adolescent and Young Adult","Cancer Survivors","Patient Navigation","Adaptations","Implementation Science","2026-02-23",{"date":207,"type":33},"2026-02-25",{"date":209,"type":19},"2026-11-01",{"date":211,"type":19},"2027-08",{"name":39,"class":40},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":130,"sex":15,"minAge":221,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":20,"phases":224,"briefSummary":225,"conditions":226,"keywords":230,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":41},"100559835","filipino-family-health-initiative-10-100559835","NCT06569303","Filipino Family Health Initiative 1.0","Virtual Positive Parenting Intervention to Promote Filipino Family Wellness: A Randomized Controlled Trial : Filipino Family Health Initiative 1.0","FFHI","Inclusion Criteria:\n\n* Parent or legal guardian of at least one child 8-12 years of age\n* Parent or legal guardian is of Filipino descent\n* Parent or legal guardian and child are English speaking\n* Pregnant women or legal guardians may be included if they have a child who meets the inclusion and exclusion criteria\n\nExclusion Criteria:\n\n* Family plans to move out of the state of California within the next 6 months\n* Family has previously participated in the Incredible Years (IY) curriculum\n* Parent or legal guardian are not fluent in English\n* Adults unable to consent or children unable to assent\n* Prisoners\n\nNote: All parent participants in the study are 18 years or older. Youth participants are 8-12 years old.","8 Years",{"count":223,"type":19},500,[22],"The goal of this clinical trial is to test the effectiveness of an online parenting program on Filipino parents living in California. The main aims are to:\n\n* Test the effectiveness of the online Incredible Years® model of parent training and its impact on primary outcomes.\n* Determine the impact of intervention engagement (i.e., higher attendance) on parenting practices and child behavior outcomes.\n* Describe Intervention delivery and its online implementation in real-world community settings.\n\nThe study involves two phases:\n\n* Phase 1: Participants will receive the Online Incredible Years® School Age Basic \\& Advanced Parent Training Program (intervention) and complete parent-reported and child-reported measures at baseline, 3 months and 6 months.\n* Phase 2: Parenting Group Leaders will each participate in one semi-structured interview to inform the sustainability of the intervention in real world community settings. Researchers will compare 250 Filipino families, half of which will receive the intervention and the other half will receive the American Academy of Pediatrics' Bright Futures handouts (control) and be placed on a 3-month waitlist for the IY parenting program. Both groups will be followed for a minimum of 6 months with follow- up assessments that include parent-report and child report measures.",[227,228,229],"Depression","Anxiety","Parenting",[231,232,233],"Filipino Families","Incredible Years","Mental Health","2026-01-30",{"date":236,"type":33},"2026-02-03",{"date":238,"type":33},"2025-04-15",{"date":240,"type":19},"2028-03-31",{"name":39,"class":40},{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":15,"minAge":249,"maxAge":250,"enrollmentInfo":251,"targetDuration":4,"studyType":20,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":265,"locationsCount":41},"100521249","sleep-for-health-study-on-the-effects-of-cognitive-behavioral-therapy-for-insomnia-on-diabetes-risk-100521249","NCT06067139","Sleep for Health Study on the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk","Sleep for Health: A Randomized Clinical Trial Examining the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk","Inclusion Criteria:\n\n* Age ≥ 22 years and \\\u003C 80 years of age\n* Prediabetes\n* Insomnia\n* Regular access to device with internet access\n* Adequate data at baseline\n\nExclusion Criteria:\n\n* BMI \\> 40 kg\u002Fm2\n* Sleep comorbidities detected in medical record or via medical history\n* Shift work or significant, externally imposed irregular sleep schedule\n* moderate to severe OSA by home sleep apnea test as part of trial protocol\n* Received a full course of CBT-I in the last 12 months\n* Current use of medication with glycemic effects:\n* History of type 1 or type 2 diabetes or recent\u002Fplanned use of hypoglycemic agents (e.g., metformin, insulin)\n* Recent history of bariatric surgery or planning bariatric surgery in the next year\n* Current or recent use of weight loss meds\n* Unstable sleep medication regimen (recent change to schedule or dosage)\n* Significant comorbidity that may interfere with CBT-I uptake or increase risks\n* Unwilling or unable to limit heavy machinery use\u002Flong bouts of driving or unstable illness that would be worsened by sleep restriction\n* High risk of falls\n* Epilepsy\n* Medical conditions that interfere with dCBT-I or contribute to insomnia or diabetes risk (e.g., hyperthyroidism, significant kidney disease, active cancer treatment, any medical condition that requires chronic steroid use)\n* Significant alcohol or substance use disorder\n* Active or recent history of eating disorder, recent weight change of \\>10%\n* Women: pregnancy (current or planned), breastfeeding, \\\u003C 1 year postpartum\n* Use of hydroxyurea\n* Extensive skin changes or adhesive allergy making CGM sensor use problematic","22 Years","79 Years",{"count":252,"type":19},300,[22],"This study tests whether providing cognitive behavioral therapy for insomnia (CBT-I) to people with prediabetes results in a reduction in glucose levels compared to a patient education control program.",[256,257,258],"Diabetes Mellitus, Type 2","Prediabetic State","Sleep Initiation and Maintenance Disorders","2025-12-11",{"date":261,"type":33},"2025-12-15",{"date":263,"type":33},"2023-08-01",{"date":91,"type":19},{"name":39,"class":40},{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":20,"phases":275,"briefSummary":276,"conditions":277,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":288},"100609613","screening-cardiometabolic-opportunities-using-transformative-echocardiography-artificial-intelligence-scout-echo-ai-100609613","NCT07216859","Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT Echo-AI)","SCOUT Echo-AI","Inclusion Criteria:\n\n* Adults ≥18 years.\n* Underwent routine TTE within site defined recent timeframe and flagged as high risk for MASLD and\u002For cirrhosis by the AI model using pre specified threshold.\n* Able to provide informed consent; reachable for follow up.\n\nExclusion Criteria:\n\n* Inability to consent or communicate.\n* Enrollment in hospice or life expectancy so limited that additional evaluation would not be appropriate per clinician judgment.\n* Clinical circumstances where immediate alternative diagnostic pathways supersede study procedures (e.g., acute decompensation requiring urgent management).\n* Prior liver or kidney transplant.\n* Patient unwilling to undergo prospective testing for liver disease.",{"count":274,"type":19},2000,[22],"The goal of this prospective, multicenter, open-label, blinded end-point pragmatic study is to evaluate an artificial intelligence (AI)-augmented echocardiography screening approach for early detection of metabolic dysfunction associated steatotic liver disease (MASLD) and\u002For cirrhosis, in patients undergoing routine transthoracic echocardiograms (TTEs).\n\nThe main question it aims to answer is to:\n\n1. Evaluate notification responsiveness and rates of confirmatory testing for patients identified as high risk for having liver disease to determine whether optimized notifications increase timely confirmatory testing and treatment initiation versus standard of care assessment.\n2. Compare time to diagnosis, treatment uptake, and clinical outcomes (hospitalizations, incident ASCVD, mortality) between cohorts identified as high risk by the AI algorithm and comparison groups to determine whether AI guided screening shortens time to diagnosis and increases appropriate treatment.",[278,279],"MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease","Cirrhosis","2025-11-13",{"date":282,"type":33},"2025-11-17",{"date":284,"type":19},"2026-01-01",{"date":286,"type":19},"2027-11-01",{"name":39,"class":40},4,{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":130,"sex":15,"minAge":297,"maxAge":221,"enrollmentInfo":298,"targetDuration":4,"studyType":20,"phases":300,"briefSummary":301,"conditions":302,"keywords":304,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":41},"100450300","motivational-wellness-coaching-to-reduce-childhood-obesity-in-families-and-kids-100450300","NCT05143697","Motivational Wellness Coaching to Reduce Childhood Obesity in Families and Kids","Integrated Motivational Interviewing to Reduce Childhood Obesity in a Large Health Maintenance Organization","WC4K","24 Eligible Intervention Clinics will provide motivational interview counseling and referrals to Wellness Coaching.\n\nInclusion criteria:\n\n* Children age 2-8 years\n* Body mass index in the 85 percentile or higher\n\nExclusion criteria:\n\n• Families that don't speak English or Spanish as a primary language","2 Years",{"count":299,"type":19},6600,[22],"Primary care settings lack interventions to address the childhood obesity epidemic that are feasible and sustainable without requiring significant resources. The investigators propose to modify and test an intervention shown to lower children's body mass index(BMI) so that it is feasible, sustainable, and easily disseminated in a real-world clinical setting. If successful, the investigators will be able to provide recommendations to providers and health care systems that help prioritize future intervention strategies and research investments to reduce obesity in children that can be quickly translated into other settings and widely adopted after the study period, with the goal of halting and reversing the childhood obesity epidemic.",[303],"Obesity",[305,306,307],"Motivational Interviewing","Wellness","Coaching","2025-08-27",{"date":310,"type":33},"2025-09-04",{"date":312,"type":33},"2022-05-16",{"date":314,"type":19},"2026-06-30",{"name":39,"class":40},{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":15,"minAge":76,"maxAge":324,"enrollmentInfo":325,"targetDuration":4,"studyType":20,"phases":327,"briefSummary":328,"conditions":329,"keywords":331,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":344,"locationsCount":41},"100467306","provider-recommendation-and-hpv-vaccination-100467306","NCT05365048","Provider Recommendation and HPV Vaccination","Effectiveness and Mechanisms of Multilevel Implementation Strategies to Improve Provider Recommendation and Advance HPV Vaccination: a Cluster Randomized Trial","HPVV","Inclusion Criteria:\n\n* All KPSC pediatric clinics.\n* All providers (physicians, nurses, and medical assistants) and department administrators from the pediatric department.\n* Parents of HPV vaccine-eligible children (9-12 years old).\n\nExclusion Criteria:\n\n* Providers and administrators who do not work for the pediatric department\n* Parents of children older than 12 years and\u002For who did not have a clinic visit in the study period.","70 Years",{"count":326,"type":19},301201,[22],"In the United State, there are millions of US teens who are not vaccinated against the human papillomavirus (HPV) putting them at risk of getting HPV-related cancers. Although there are clinical guidelines recommending the HPV vaccine and interventions encouraging parents to vaccinate their children to prevent HPV-related cancers, the vaccination rate for teens remains low according to a 2018 national survey. Survey data shows that HPV vaccine complete series coverage for teens aged 13-15 years was 50%, far below the 80% target of Healthy People 2020. Receiving a strong provider recommendation is the most powerful strategy for improving HPV vaccine rates. Yet, little is known about how to include provider recommendations and other important factors into an intervention to improve the HPV vaccination rates. Studies show there are provider, patient and system-level barriers in the initiation and completion of HPV vaccine series among 9-12 years old children. Barriers to the HPV vaccine also differ across demographic subgroups, communities, and clinics. Interventions that address only one component are not responsive to site barriers and as effective as one that addresses multiple components and site-specific barriers. This study uses a 3-arm cluster randomized controlled trial (RCT) to compare three implementation strategies to improve provider recommendations on the HPV vaccine. Two of the implementation strategies (local-tailored and prescribed strategy) utilize a multilevel approach. The three implementation strategies of interest are (1) a \"local-tailored\" implementation strategy, co-designed with local care teams to address local barriers and contexts (2) A \"prescribed\" strategy, most commonly used by health systems, that involves pre-specified interventions addressing pre-selected vaccination barriers and (3) usual standard of care where there are no research-led activities. We will use surveys, interviews, and electronic health records to evaluate the three implementation strategies and their impact on improving HPV vaccination rates. The study surveys and interviews will include pediatric providers, nurses, administrators, staff members, and parents of HPV vaccine-eligible children (9-12 years old). Successful implementation will be defined as improvement in HPV vaccination rates (primary outcome), strengthening provider recommendation (secondary outcome), and the cost-effectiveness of the implementation strategy.",[330],"Human Papillomavirus",[330,332,333,334,335,336,337],"Vaccine","Local Tailoring","4 Pillars","Prescribed Strategy","Implementation Strategy","Provider Recommendation","2025-05-15",{"date":340,"type":33},"2025-05-20",{"date":342,"type":33},"2022-03-21",{"date":314,"type":19},{"name":39,"class":40},{"id":346,"slug":347,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":351,"targetDuration":4,"studyType":20,"phases":353,"briefSummary":354,"conditions":355,"keywords":358,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":41},"100540529","systematic-implementation-of-patient-centered-care-for-alcohol-use-trial-beyond-referral-to-treatment-100540529","NCT06318026","Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment","Inclusion Criteria:\n\n1. Adult primary care patients ≥18 years old on the day of a primary care appointment; and\n2. ≥4 symptoms on the Alcohol Symptom Checklist, or 2-3 symptoms on the Alcohol Symptom Checklist with at least one symptom associated with high risk of progression to severe symptoms, documented in the electronic health record associated with the primary care appointment; and\n3. high-risk drinking on the alcohol screening questionnaire (AUDIT-C ≥7) on the day of the Alcohol Symptom Checklist or in the prior 30 days documented in the electronic health record.\n\nExclusion Criteria:\n\n1. Documented request to not participate in research, or\n2. Patient was eligible for the Vanguard pilot study.",{"count":352,"type":19},1500,[22],"The Systematic Implementation of Patient-centered Care for Alcohol Use Trial is a pragmatic, cluster-randomized, effectiveness-implementation trial testing two interventions in Kaiser Permanente Washington to systematically implement shared decision-making with primary care patients with symptoms due to alcohol use: a primary care intervention and a centralized intervention. An anticipated 25 primary care clinics will be randomized to one of three conditions: usual care or the primary care or centralized interventions.",[356,357],"Alcohol Use Disorder","Unhealthy Alcohol Use",[359,360,361,362,363],"Patient-centered care","Shared decision-making","Population-based management","Quality improvement","Decision aid","2025-05-05",{"date":366,"type":33},"2025-05-06",{"date":368,"type":33},"2025-03-25",{"date":370,"type":19},"2029-02",{"name":39,"class":40},{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":378,"eligibilityCriteria":379,"healthyVolunteers":130,"sex":15,"minAge":297,"maxAge":4,"enrollmentInfo":380,"targetDuration":4,"studyType":20,"phases":382,"briefSummary":384,"conditions":385,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":41},"100463031","phase-3-food-prescriptions-to-promote-affordable-diets-100463031","NCT05309395","Food Prescriptions to Promote Affordable Diets","Food Prescriptions to Promote Affordable Diets That Meet RDAs Among Multi-generational Latino Households","FoodRx","Inclusion Criteria:\n\n* Multigenerational Latino household that has at least 2 adults with a BMI \\>27 kg\u002Fm2 and who both want to lose weight and at least one child under age 18; \\[Multi-generational is defined as having household members in two or three age groups: a) less than 18 years; b) 18-64 years; c) 65 years or older\\]; The household should have between 3-5 residents.\n* Owns at least 1 smart phone, tablet or computer or has internet access;\n* No dietary exclusions or medical conditions (e.g. chronic kidney disease, or using insulin (those with type 2 diabetes mellitus without needing insulin can participate)\n* Plans to stay in the area for 12 months;\n* Must not be using medications that interfere with weight loss (e.g., steroids, certain anti-depressants, anti-seizure medications),\n* Willing to pay for groceries\n* If on Calfresh, must be willing to pick up groceries at the store.\n\nExclusion Criteria:\n\n* Chronic kidney disease,\n* insulin dependent diabetes,\n* dietary exclusions that are inconsistent with menus",{"count":381,"type":19},720,[383],"PHASE3","This is an Randomized controlled trial (RCT) to assess the impact of meal planning and affordable grocery delivery on weight loss, dietary quality and health on members of multigenerational Latino households.",[386,387],"Diet, Healthy","Overweight and Obesity","2025-04-25",{"date":390,"type":33},"2025-04-29",{"date":392,"type":33},"2021-08-21",{"date":394,"type":19},"2027-06-01",{"name":39,"class":40},{"id":397,"slug":398,"hasResults":11,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":402,"eligibilityCriteria":403,"healthyVolunteers":11,"sex":15,"minAge":404,"maxAge":4,"enrollmentInfo":405,"targetDuration":4,"studyType":20,"phases":407,"briefSummary":408,"conditions":409,"keywords":411,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":288},"100538872","safer-aging-with-diabetes-monitoring-100538872","NCT06296485","Safer Aging With Diabetes Monitoring","Pragmatic Clinical Trial of Continuous Glucose Monitoring-based Interventions for Safe Insulin Use in High-Risk Older Adults With Type 2 Diabetes","SAGE","Inclusion Criteria:\n\n* Age 75 years and older\n* Diagnosis of Type 2 Diabetes\n* Current treatment with insulin\n* Increased hypoglycemia risk (prior year hypoglycemia by self-report or utilization)\n* Able to communicate in English\n* Able to access email and the Internet\n\nExclusion Criteria:\n\n* On renal dialysis\n* Dementia\n* Pacemaker or Automatic Implantable Cardioverter Defibrillator\n* Using insulin pump\n* Severe Mental Illness\n* Severe Visual Impairment\n* In Hospice\n* Current or recent CGM use","75 Years",{"count":406,"type":19},360,[22],"Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin. This study proposes to evaluate, in a randomized clinical trial, a strategy of safe insulin prescribing based on an educational program that leverages continuous glucose monitoring to support older adults at high risk for hypoglycemia. If the aims of this project are achieved, this novel care strategy could be widely applied to reduce severe hypoglycemia episodes in older, high-risk adults with type 2 diabetes.",[256,410],"Hypoglycemia",[410,412,413],"Diabetes Education","Continuous Glucose Monitor","2025-04-21",{"date":416,"type":33},"2025-04-22",{"date":418,"type":33},"2024-05-01",{"date":420,"type":19},"2028-01-31",{"name":39,"class":40},{"id":423,"slug":424,"hasResults":11,"nctId":425,"briefTitle":426,"officialTitle":427,"acronym":428,"eligibilityCriteria":429,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":20,"phases":432,"briefSummary":434,"conditions":435,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":41},"100420121","phase-2-nad-augmentation-in-cardiac-surgery-associated-myocardial-injury-trial-100420121","NCT04750616","NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial","NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury (NACAM) Trial","NACAM","Inclusion Criteria\n\n* Informed consent before any study-related activities.\n* Men or women \\>18 years of age who are scheduled for non-emergent cardiac surgery procedures requiring CPB and are at increased risk for surgery-related adverse cardiovascular outcomes.\n\nProcedures include:\n\n* CABG\n* Aortic, mitral, tricuspid, or pulmonic valve replacement or repair\n* CABG with aortic, mitral, tricuspid, and\u002For pulmonic valve replacement\n\nRisk factors for surgery related to adverse cardiovascular outcomes include one or more of the following:\n\n* Valve surgery\n* eGFR \\\u003C 45 ml\u002Fmin\u002F1.73m2\n* Documented LVEF ≤ 35% within six months before surgery\n* Documented history of heart failure\n* Insulin-requiring diabetes\n* Non-insulin-requiring diabetes and the presence of ≥+2 proteinuria on urinalysis (or equivalent on urine protein-to-creatinine ratio or urine albumin-to-creatinine ratio)\n* Preoperative anemia (hemoglobin \\\u003C11g\u002Fdl for men and women)\n* History of prior CABG\n* Age ≥65\n\nExclusion Criteria\n\n* Preexisting AKI within seven days before surgery as defined by KDIGO stage ≥1 (serum creatinine-based)\n* Kidney transplant status\n* Off-pump cardiac surgery\n* ESRD\n* Emergent cardiac surgery\n* Pregnancy\n* Patient enrolled in competing research studies that may affect outcomes\n* Patients held in an institution by legal or official order",{"count":431,"type":19},304,[433],"PHASE2","A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery",[436,437,438],"Ischemia Reperfusion Injury","Myocardial Injury","Acute Kidney Injury","2025-03-10",{"date":441,"type":33},"2025-03-12",{"date":443,"type":33},"2021-09-13",{"date":445,"type":19},"2025-06-30",{"name":39,"class":40},{"id":448,"slug":449,"hasResults":11,"nctId":450,"briefTitle":451,"officialTitle":452,"acronym":453,"eligibilityCriteria":454,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":455,"enrollmentInfo":456,"targetDuration":4,"studyType":20,"phases":458,"briefSummary":459,"conditions":460,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":41},"100515467","mobile-intervention-for-simultaneous-alcohol-and-marijuana-use-in-young-adults-100515467","NCT05991882","Mobile Intervention for Simultaneous Alcohol and Marijuana Use in Young Adults","Mobile Adaptive Intervention to Reduce Negative Consequences Associated With Simultaneous Alcohol and Marijuana Use in Young Adults in Primary Care","SAFERR","Inclusion Criteria:\n\n* resident of state of Hawai'i and island of O'ahu\n* age 18-30 years\n* has sought services at Kaiser Permanente Hawaii within the past year\n* report marijuana use, heavy drinking, and simultaneous alcohol and marijuana use\n* report confidence in ability to use protective behavioral strategies\n* endorse at least 3 recent negative consequences from marijuana and\u002For alcohol\n* own a smartphone\n\nExclusion Criteria:\n\n• any substance use treatment within the past 3 months","30 Years",{"count":457,"type":19},136,[22],"The goal of this treatment development project is to develop an adaptive ecological momentary intervention (a-EMI) for young adults using marijuana and alcohol that is grounded in self-regulation and social cognitive theories. To determine the most efficacious intervention strategies, the investigators will test variations of intervention components to identify the best combination. The study will take place at the Center for Integrated Health Care Research at Kaiser Permanente Hawaii (KPHI), located in Honolulu (island of Oahu). Following pilot testing with 6 participants, the study team will assess the feasibility and efficacy of intervention components on two primary outcomes (negative consequences and protective behavioral strategies \\[PBS\\]) using a fractional factorial experimental design, with post-intervention assessment and one- and three-month follow-ups. 136 diverse young adults recruited from KPHI who report current simultaneous alcohol and marijuana (SAM) use will be randomly assigned to one of eight groups, representing experimental conditions that include or do not include intervention strategies focused on craving reduction and PBS. As a result of this process, individual and\u002For combined components that lead to improved outcomes will be retained in a subsequent randomized controlled trial, while ineffective components will be eliminated.",[461,462],"Alcohol Drinking","Cannabis Use","2025-03-07",{"date":465,"type":33},"2025-03-11",{"date":467,"type":33},"2024-04-01",{"date":469,"type":19},"2026-05-01",{"name":39,"class":40},{"id":472,"slug":473,"hasResults":11,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":477,"eligibilityCriteria":478,"healthyVolunteers":130,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":479,"targetDuration":4,"studyType":481,"phases":4,"briefSummary":482,"conditions":483,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":493,"locationsCount":41},"100515267","structural-conditions-and-health-after-release-from-prison-100515267","NCT05989282","Structural Conditions and Health After Release From Prison","Healthcare Organizational Structural Conditions and the Health of People Recently Released From Prison","SCHARP","Inclusion Criteria:\n\n* Recenlty released from state prison into the Denver\u002FAurora Colorado metro area\n* Age 18 and older\n* Ability to understand study procedures in English or Spanish\n* No plans to leave the area for six months\n\nExclusion Criteria:\n\n* On \"current inmate\" status or still under correctional observation (i.e., under locked confinement part of the day or night)\n* Plans to leave area within six months\n* Unable to consent",{"count":480,"type":19},400,"OBSERVATIONAL","People released from prison experience two times higher cardiovascular (CV) mortality than the general population, have a high prevalence of poor CV health and increased risk of CV events within 2 years of release. Access to high quality healthcare following release from prison is key to preventing poor health and CV outcomes. Our study team will investigate facilitators and barriers to health care access experienced by people released from prison.",[484,485],"Cardiovascular Diseases","Health Care Utilization","2025-02-26",{"date":488,"type":33},"2025-02-28",{"date":490,"type":33},"2023-08-05",{"date":492,"type":19},"2028-06-30",{"name":39,"class":40},{"id":495,"slug":496,"hasResults":11,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":500,"eligibilityCriteria":501,"healthyVolunteers":11,"sex":502,"minAge":184,"maxAge":4,"enrollmentInfo":503,"targetDuration":4,"studyType":20,"phases":505,"briefSummary":507,"conditions":508,"keywords":510,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":41},"100570675","phase-4-effect-of-tranexamic-acid-on-intraoperative-blood-loss-in-patients-undergoing-aquablation-100570675","NCT06710327","Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Aquablation","Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Aquablation for Benign Prostatic Hyperplasia: a Randomized Controlled Trial","TXA-AQ","Inclusion Criteria:\n\n1. Male participants diagnosed with BPH scheduled for Aquablation therapy.\n2. Aged 45 years or older\n3. Exhibiting clinically significant symptoms of BPH.\n\nExclusion Criteria:\n\n1. History of or high risk for thrombosis.\n2. Presence of preoperative heart or cerebrovascular diseases.\n3. Renal insufficiency.\n4. Ongoing anticoagulation therapy.\n5. Required extended preoperative resting period.\n6. Diagnosis of prostate cancer.\n7. Any form of blood coagulation dysfunction.\n8. Previous use of warfarin or aspirin before the surgery.\n9. Belonging to vulnerable populations such as prisoners (who are not treated in our clinics).","MALE",{"count":504,"type":19},56,[506],"PHASE4","This study aims to find out if tranexamic acid (TXA), a medication, works to decrease blood loss during a specific surgery called Aquablation therapy, which is a treatment for men with Benign Prostatic Hyperplasia (BPH). BPH is a common condition in men over the age of 45 that involves enlargement of the prostate gland and can lead to problems or discomfort with urination.\n\nThe main goal of this research is to see if TXA can help reduce the amount of blood loss during surgery compared to not using the drug. This is important because losing less blood during surgery can help patients recover faster and more safely. Researchers will monitor the safety of TXA and its effects on other outcomes, like the length of hospital stay and any possible changes in blood tests that check how well blood clots.\n\nParticipants in this study will:\n\n* Be males diagnosed with BPH who are already scheduled to undergo Aquablation therapy.\n* Be randomly assigned to either receive TXA or a placebo (a look-alike substance that contains no drug) right before their surgery.\n* Not know which treatment they are receiving to make sure the results are unbiased.\n\nResearchers hope to engage participants who meet the health criteria of the study. They will be carefully monitored before, during, and after the surgery for any health changes, and their blood loss during surgery will be measured.\n\nThis study does not require any additional time commitment outside of the standard surgical process, and all treatments will be provided at no additional cost to the participants. The researchers will ensure that all participants understand the procedure and support their safety throughout the research.",[509],"Benign Prostatic Hyperplasia",[511,512,513,509,514],"BPH","TXA","Aquablation","Tranexamic Acid","2024-11-26",{"date":517,"type":33},"2024-11-29",{"date":519,"type":19},"2025-01",{"date":521,"type":19},"2025-08",{"name":39,"class":40},{"id":524,"slug":525,"hasResults":11,"nctId":526,"briefTitle":527,"officialTitle":527,"acronym":4,"eligibilityCriteria":528,"healthyVolunteers":130,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":529,"targetDuration":4,"studyType":481,"phases":4,"briefSummary":531,"conditions":532,"keywords":533,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":41},"100558858","collaborative-care-for-treatment-of-depression-and-anxiety-100558858","NCT06556589","Collaborative Care for Treatment of Depression and Anxiety","Inclusion Criteria:\n\n* 18+\n* Current membership and active on patient portal\n* Depression Diagnosis in the prior year\n* Overdue for PHQ9 Screening based on the following criteria:\n\n  * High Risk: Last PHQ9 screener was completed greater than 4 months ago AND total Score is greater than or equal 10 or item 9 is greater than 0.\n  * Low Risk: Last PHQ9 screener was completed greater than 12 months ago AND Last PHQ9 Total Score is less than 10 and item 9 is equal to 0.\n* Anxiety diagnoses in the prior year\n* Has a baseline GAD7 in the same prior year; score = 10+ (\\*Note: Provider referrals could be GAD7 score of 7 or higher)\n* No Behavioral Health (BH) engagement in the prior year\n* Patient is not in a Skilled Nursing Facility or Hospice\n* Patient has no record of psychiatric hospitalization in the last year\n* Patient does not need an interpreter (i.e., English speaking)\n* Primary care location is one of the intervention clinics\n\nExclusion Criteria:\n\n• Exclude individuals with any of the following diagnoses:\n\n* Psychosis\n* Dementia\n* Bipolar\n* Personality Disorders\n* Post Traumatic Stress Disorder (PTSD)\n* Obsessive Compulsive Disorder (OCD)\n* Panic Disorder\n* Cognitive Disorder",{"count":530,"type":19},200,"The goal of this project is to evaluate the effectiveness of a collaborative care model for primary care patients at Kaiser Permanente Colorado (KPCO) with depression and\u002For anxiety. Collaborative care uses evidence-based short-term treatments delivered to patients over the phone. We will explore the use of cost-efficient automated processes for patient outreach and follow-up, such as care pools of patients and using patient portal messaging, risk-based results routing to providers, and electronic health record (EHR) tools for patient tracking and outcome assessment. Using a cluster randomized design, we will compare results between clinics that are offering collaborative care to those that are not.",[227,228],[534,227,228,535],"Collaborative Care","Evaluation","2024-08-13",{"date":538,"type":33},"2024-08-16",{"date":540,"type":33},"2023-03-01",{"date":542,"type":19},"2025-03-31",{"name":39,"class":40},{"id":545,"slug":546,"hasResults":11,"nctId":547,"briefTitle":548,"officialTitle":549,"acronym":4,"eligibilityCriteria":550,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":551,"targetDuration":4,"studyType":20,"phases":553,"briefSummary":554,"conditions":555,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":559,"completionDateStruct":561,"leadSponsor":562,"locationsCount":41},"100482449","phase-2-food-prescription-app-100482449","NCT05562180","FOOD PRESCRIPTION APP","FOOD PRESCRIPTION APP TO EXTEND AND CUSTOMIZE HEALTHY MEALS FOR A BETTER DIET","Inclusion Criteria:\n\nAlready enrolled in FoodRx study \\>18 years BMI\\>27 and wants to lose weight -\n\nExclusion Criteria:\n\nNot enrolled in Food Rx\n\n\\-",{"count":552,"type":19},30,[433,383],"This study will develop and test and app that will create meal plans to improve diet quality and support weight loss. This app will allow participants to customize their meal plans and substitute recipes for nutritionally equivalent options that they find more appealing, thus potentially increasing adherence.",[386],"2024-07-08",{"date":558,"type":33},"2024-07-09",{"date":560,"type":33},"2024-04-08",{"date":445,"type":19},{"name":39,"class":40},{"id":564,"slug":565,"hasResults":11,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":11,"sex":15,"minAge":570,"maxAge":571,"enrollmentInfo":572,"targetDuration":4,"studyType":20,"phases":574,"briefSummary":575,"conditions":576,"keywords":581,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":41},"100553484","centralized-virtual-sbirt-for-pediatric-primary-care-100553484","NCT06486688","Centralized Virtual SBIRT for Pediatric Primary Care","Virtual SBIRT for Pediatric Primary Care: Increasing Access to Screening, Brief Intervention and Referral to Treatment for Alcohol and Other Drug Use Via Telehealth","Inclusion Criteria:\n\n• The sample will include all adolescents aged 12 through 17 years seen for a Well Visit, who are at risk of AOD use disorder defined as endorsing monthly or more frequent AOD use OR any AOD use and past-two-week depressive symptoms or suicidality.\n\nExclusion Criteria:\n\n• N\u002FA - all adolescents with a Well Visit are eligible","12 Years","17 Years",{"count":573,"type":19},22320,[22],"Adolescent alcohol and other drug (AOD) use is a significant public health problem which contributes to high levels of mortality, morbidity and healthcare costs in young people, and identification and early intervention for these problems is critical to improving outcomes. Screening, Brief Intervention and Referral to Treatment (SBIRT) in pediatric primary care is an evidence-based strategy for addressing these problems, but has not been widely and systematically implemented, for a variety of reasons, including lack of training and staffing resources to support its implementation. This pragmatic, Type 1 Hybrid Comparative Effectiveness Implementation study will examine whether a centralized, virtually-delivered modality of SBIRT, rapidly accessible by multiple pediatric primary care clinics, can be cost-effectively implemented to improve early identification and treatment for AOD use and comorbid mental health problems among adolescents identified as being at high or severe risk of AOD use disorder during adolescent Well Visits.",[577,578,579,580],"Adolescent Alcohol Use","Mental Health Issue","Alcohol Related Disorders","Adolescents",[580,582,583,584,585],"Alcohol","SBIRT","Screening","Drug","2024-07-04",{"date":556,"type":33},{"date":589,"type":33},"2024-02-13",{"date":591,"type":19},"2027-08-31",{"name":39,"class":40},""]