[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kantonsspital Aarau\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100565060","prospective-evaluation-of-proclarix-test-to-improve-risk-stratification-in-men-scheduled-for-mpmri-and-prostate-biopsy-in-cantonal-hospital-aarau-100565060",false,"NCT06637267","Prospective Evaluation of Proclarix® Test to Improve Risk Stratification in Men Scheduled for MpMRI and Prostate Biopsy in Cantonal Hospital Aarau","Inclusion Criteria:\n\n* Male patients between 45 and 80 years of age who are scheduled for an mpMRI followed by prostate biopsy (systematic and \u002F or TRUS fusion biopsy) - within the framework of standard of care\n* Signed ICE\n\nExclusion Criteria:\n\n* patients who had previous treatments of the prostate (TUR prostate, cryoablation, HIFU, IRE, radiation therapy, alcohol instillation, etc.) in the past 5 years.\n* acute urinary tract infections.\n* the use of 5-alpha reductase inhibitors.\n* mpMRI performed outside of the scope of Kantonsspital Aarau.","MALE","45 Years","80 Years",{"count":19,"type":20},480,"ESTIMATED","OBSERVATIONAL","The use of prostate-specific antigen (PSA) for the screening of prostate cancer has led to higher detection rates and a shift to lower and therefore potentially more curative disease stages at diagnosis and thus subsequently to a lower mortality. A suspicious digital rectal examination of the prostate or an increased PSA value are suspicious for PCa and indicate a confirmatory prostate biopsy . Almost 25% of all men report moderate to severe pain after the biopsy. Serious complications such as urosepsis requiring intensive medical monitoring are less common. There are also other predictors for the presence of prostate cancer: including positive family history in first-degree relatives, low PSA-ratio (= ratio between free to total PSA), older age and African-American race. In order to reduce the number of unnecessary prostate biopsies, numerous prostate-cancer risk calculators based on these predictors have been designed. Risk-calculators serve as an aid to clinical decision-making. For example, if the calculated risk of prostate cancer is low, a PSA follow-up can be a viable alternative to prostate biopsy. However, these risk calculators often have some shortcomings. The two most frequently used calculators are based on cohorts of men in whom the biopsies were performed as part of a study protocol regardless of the clinical context. These cohorts do not realistically represent the collective of patients to whom a prostate biopsy is indicated. Furthermore, the cohorts of these calculators are mostly very old and do not take into account the technical developments with improved sensitivity\u002Fspecificity in recent years. Nowadays, a multiparametric magnetic resonance imaging (mpMRI) of the prostate is being performed and suspicious areas in the prostate are explicitly targeted, leading to an improved detection of significant carcinoma.The possibility of determining novel laboratory predictors such as biomarkers has been lately under investigation. All of these biomarkers are not included in the currently available risk calculators or are poorly validated. A pathological grading system, the so-called Gleason score, is a pathological grading system differentiating between less versus more aggressive prostate cancer cells. The most frequently used risk calculators have been developed based on patient cohorts that were created at a time before the Gleason score was revised to its current status. Thus, many previously low-grade carcinomas would be classified as more aggressive ones according to current pathology guidelines. Based on these circumstances, the development of a new PCa risk stratification models is of major clinical importance. In addition, as all biomarker measurements rely heavily on analytical performance of laboratory equipment, the quality assurance is an important factor and should be under scrutiny, especially when new biomarkers are under investigation.\n\nProclarix is a CE-marked test based on two new biomarkers, Thrombospondin 1 (THBS1) and Cathepsin D (CTSD), combined with PSA values and the patient's age. A software algorithm returns a risk assessment that can be utilized to predict clinically significant PCa (ISUP group 2 or higher).",[24],"Prostate Cancer",[26],"Proclarix","RECRUITING","2024-10-09",{"date":30,"type":31},"2024-10-15","ACTUAL",{"date":33,"type":31},"2022-08-24",{"date":35,"type":20},"2026-12-30",{"name":37,"class":38},"Kantonsspital Aarau","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":47,"minAge":4,"maxAge":4,"enrollmentInfo":48,"targetDuration":50,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":39},"100424814","young-survivors-at-kantonsspital-aarau-switzerland-100424814","NCT04811794","Young Survivors at Kantonsspital Aarau, Switzerland","Young Survivors at Kantonsspital Aarau, Switzerland - A Standardized Assessment of Long-Term and Late-Onset Health Events in Survivors of Childhood and Adolescent Cancer","Inclusion Criteria:\n\nGroup A:\n\nChildren and adolescents who:\n\n* have been treated for cancer in the Division of Oncology-Hematology, Department of Pediatrics, at the Kantonsspital Aarau,\n* have been diagnosed at age 0-18 years,\n* are still in regular follow-up care at the Kantonsspital Aarau,\n* have finished cancer treatment and entered follow-up care, and\n* signed informed consent\n\nGroup B:\n\nAdolescents and adults who:\n\n* fulfill the same inclusion criteria as Group A\n* are not in regular follow-up care anymore\n\nExclusion Criteria:\n\nChildhood Cancer Survivors who:\n\n* are in a palliative situation or\n* have not given consent for further use of medical data","ALL",{"count":49,"type":20},300,"50 Years","The Young Survivors at Kantonsspital Aarau project assesses the prevalence and severity of late effects in survivors of childhood and adolescent cancer according to the modified CTCAE criteria prospectively. The clinical data are generated during regular follow-up care visits, the collection starts directly after completion of treatment and is longitudinally.",[53,54],"Childhood Cancer","Late Effects",[53,56,54,57],"Survivor","CTCAE","2022-08-16",{"date":60,"type":31},"2022-08-17",{"date":62,"type":31},"2021-03-15",{"date":64,"type":20},"2072-03-15",{"name":37,"class":38},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":47,"minAge":74,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":5},"100384323","aftercare-of-childhood-cancer-survivors-in-switzerland-100384323","NCT04284189","Aftercare of Childhood Cancer Survivors in Switzerland","Aftercare of Childhood Cancer Survivors in Switzerland - the ACCS Switzerland Project","ACCS","Inclusion Criteria:\n\n* 5-year survivor of childhood cancer\n* Diagnosis according to ICCC3 I-XII; Langerhans cell histiocytosis (LCH), Hemophagocytic lymphohistiocytosis (HLH)\n* Age at diagnosis \\\u003C18 years\n* Age at study ≥16 years\n* At study start in follow-up care at one of the three pediatric oncology centers (group before transition) or transitioned not before 2014 (group after transition).\n* Written informed consent\n\nExclusion Criteria:\n\n* Treatment only by means of surgery and without increased risk of late effects (e.g. teratoma)\n* \\\u003C5 years after therapy of a relapse or palliative situation\n* Severe cognitive impairment, which makes it impossible to complete the questionnaire independently\n* Insufficient knowledge of the German language\n* Informed consent form not signed","16 Years",{"count":76,"type":20},140,"The Aftercare of Childhood Cancer Survivors in Switzerland (ACCS) study is a multicenter cohort study designed to investigate transition of follow-up care from pediatric oncology to adult care in a prospective and longitudinal way. The investigators collect data on preferences and expectations for follow-up care and transition to adult care by questionnaires in adolescent and young adult survivors of childhood cancer.",[53,79,80],"Survivorship","Transition",[82,83],"Childhood Cancer Survivor","Transition of follow-up care",{"date":60,"type":31},{"date":86,"type":31},"2019-02-12",{"date":88,"type":20},"2030-08",{"name":37,"class":38},""]