[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kaohsiung Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":363},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,48,76,103,126,146,175,202,229,250,278,311,337],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100639039","ddk-acoustic-analysis-and-swallowing-indicators-100639039",false,"NCT07626749","DDK Acoustic Analysis and Swallowing Indicators","Acoustic Analysis of Performance in Diadochokinetic (DDK) Tasks and Swallowing Function Indicators Among Adults Across Different Age Groups","AAP-DDK","Inclusion Criteria:\n\n* 1.Community-dwelling adults aged 18 years or older, with no upper age limit.\n* 2.Ability to communicate in Mandarin or Taiwanese and understand the study procedures.\n* 3.Willingness to provide written informed consent.\n* 4 .Ability to complete the DDK tasks and RSST.\n\nExclusion Criteria:\n\n* 1.Presence of acute respiratory infection, upper respiratory inflammation, or other acute conditions that may significantly affect speech or swallowing.\n* 2.Impaired consciousness, significant cognitive deficits, or inability to understand the study procedures.\n* 3.Recent surgery or radiotherapy involving the oral cavity or pharynx that affects speech or swallowing.\n* 4.Severe hearing impairment that prevents understanding of instructions.\n* 5.Any other condition deemed unsuitable for participation by the investigators.",true,"ALL","18 Years",{"count":21,"type":22},720,"ESTIMATED","OBSERVATIONAL","This study examines whether simple speech tasks and a swallowing screening test can help identify swallowing risk in adults of different ages. Participants will complete basic questions, a swallowing self-assessment, a saliva swallowing test, and short voice recordings of rapid syllables. The study is non-invasive, takes about 75 minutes, and may help develop an easy, low-cost screening tool for early swallowing problems.",[26,27,28],"Swallowing Function","Swallowing Risk","Dysphagia",[28,26,30,31,32,33,34],"diadochokinetic","Acoustic Analysis","Repetitive Saliva Swallowing Test","EAT-10","Older Adults","NOT_YET_RECRUITING","2026-05-29",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":22},"2026-06-15",{"date":43,"type":22},"2030-04-09",{"name":45,"class":46},"Kaohsiung Medical University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100634012","blood-flow-restriction-parameters-and-lower-limb-function-in-older-adults-with-dynapenia-100634012","NCT07534150","Blood Flow Restriction Parameters and Lower Limb Function in Older Adults With Dynapenia","The Effects of Blood Flow Restriction Training Parameters on Lower Limb Muscle Function in Elderly Adults With Dynapenia: Mechanism and Intervention Outcomes","Inclusion Criteria\n\n* Aged 55 years and older.\n* No regular physical activity within the past three months, defined as exercising no more than twice per week.\n* No cognitive impairment and able to follow exercise and assessment instructions.\n\nExclusion Criteria\n\n* Have contraindications to exercise, such as severe musculoskeletal problems, osteoporosis, deep vein thrombosis, or coagulation disorders.\n* Have comorbid conditions that are severe or end-stage, such as stroke diagnosed by a neurologist, diabetes with severe complications (e.g., retinopathy), or cardiovascular disease including heart failure, coronary ischemia, or arrhythmia.\n* Have high-risk factors for exercise, such as uncontrolled hypertension (systolic blood pressure \\>160 mmHg or diastolic blood pressure \\>100 mmHg), angina or chest tightness during exercise, or deep vein thrombosis.\n* Have a history of hematologic disorders or are currently taking blood-related medications, such as hormones or anticoagulants.\n* Are expected to move out of the local community within three months.","55 Years","85 Years",{"count":21,"type":22},"INTERVENTIONAL",[60],"NA","The objective of the first year is to collect limb occlusion pressure (LOP) measurements in older adults with varying levels of muscle health, which will serve as foundational data for subsequent investigations on blood flow restriction (BFR) combined with resistance training in individuals with dynapenia. This phase aims to examine LOP values and their potential influencing factors, including demographic and physiological characteristics such as age, height, body weight, blood pressure, waist circumference, body fat percentage, medical history of chronic diseases, and habitual physical activity. Muscle-related assessments will include skeletal muscle mass, thigh and calf circumference, handgrip strength, and lower limb muscle strength. Functional performance will be evaluated using the five-times sit-to-stand test and the SARC-F questionnaire for sarcopenia risk screening. LOP of the lower limbs will be measured using a BFR cuff system combined with a laboratory-developed blood flow detection device. The study will further investigate whether LOP values are associated with the aforementioned factors.\n\nThe objective of the second year is to utilize high-density surface electromyography (dEMG) to analyze the electrophysiological characteristics of muscle contraction in individuals with sarcopenia under varying BFR pressures and resistance intensities. This includes examining motor unit recruitment patterns and recruitment thresholds, with the goal of identifying effective and appropriate BFR exercise parameters for this population.\n\nThe objective of the third year is to investigate the effects of lower limb BFR combined with resistance training on functional performance in individuals with dynapenia. Building upon the findings from the first year, this phase will implement BFR resistance training interventions and evaluate both short-term and long-term effects. Through an experimental design, the study will assess changes in body composition, muscle strength, and functional performance following a four-month intervention, along with a three-month follow-up period, to determine whether participants can improve to a healthy status and maintain these improvements over time.",[63],"Dynapenia",[65,66,63,67],"Blood Flow Restriction Training","Elderly","Occlusion Pressure","2026-04-15",{"date":70,"type":39},"2026-04-16",{"date":72,"type":22},"2026-04",{"date":74,"type":22},"2028-12",{"name":45,"class":46},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":58,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":47},"100619207","effectiveness-of-an-online-interactive-e-book-in-enhancing-home-care-nurses-knowledge-perceived-barriers-and-self-efficacy-in-home-pressure-injury-care-100619207","NCT07341620","Effectiveness of an Online Interactive E-book in Enhancing Home Care Nurses' Knowledge, Perceived Barriers, and Self-efficacy in Home Pressure Injury Care","Inclusion Criteria:\n\n* Registered nurses aged 18 years or older.\n* Currently employed full-time as a home care nurse in a hospital-affiliated home care agency, private home care agency, or public health center.\n* Have at least six months of clinical experience in home care nursing.\n* Willing to participate in this study and sign the informed consent form.\n\nExclusion Criteria:\n\n* Home care nurses who hold specialized certifications related to advanced wound care (due to their existing high level of expertise in pressure injury management).\n* Nurses practicing in community nursing homes or residential care facilities.",{"count":83,"type":22},132,[60],"The goal of this study is to learn if an interactive e-book helps home care nurses improve their skills in managing pressure injuries at home. It will also learn if digital learning can overcome the challenges of traditional training. The main questions it aims to answer are:\n\n1. Does the e-book increase home care nurses' knowledge about pressure injury prevention and treatment?\n2. Does it improve their confidence and reduce the barriers they face when providing wound care?\n3. How long do the learning benefits last after completing the program?\n\nResearchers will compare an interactive e-book to standard PDF training materials from the Ministry of Health and Welfare (MOHW) to see which is more effective for nursing education.\n\nParticipants will:\n\n1. Use an online interactive e-book covering 11 units of wound care for 1 month\n2. Use standard PDF training materials from the MOHW Long-term Care section\n3. Complete surveys about their knowledge and skills before the study, immediately after the program, and 1 month later\n\nExpected Outcomes and Contributions:\n\nThis study aims to solve the problem of nursing shortages and training difficulties in rural areas. The researchers expect that home care nurses will become more competent in wound management, leading to better patient health and fewer hospital readmissions. These results will support Taiwan's \"Long-term Care 3.0\" policy by driving innovation in digital education.",[87],"Pressure Injuries",[89,90,91,92,93],"Home care nursing","home health nurses","pressure injuries","home health care","digital education","RECRUITING","2026-03-13",{"date":97,"type":39},"2026-03-17",{"date":99,"type":39},"2026-02-01",{"date":101,"type":22},"2027-07-31",{"name":45,"class":46},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":58,"phases":112,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":47},"100620477","efficacies-of-bismuth-amoxicillin-vonoprazan-triple-therapy-and-bismuth-quadruple-therapy-100620477","NCT07358130","Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy and Bismuth Quadruple Therapy","Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy and Bismuth Quadruple Therapy in the First-line Anti-Helicobacter Pylori Treatment","Inclusion Criteria:\n\n* Subjects with Helicobacter pylori infection\n\nExclusion Criteria:\n\n1. Subjects with known hypersensitivity to the study drug.\n2. Subjects with a history of gastric surgery.\n3. Subjects with severe liver cirrhosis or uremia.\n4. Subjects with a history of malignancy within the past five years.\n5. Pregnant or breastfeeding women.\n6. Subjects currently receiving treatment with atazanavir sulfate or rilpivirine hydrochloride.",{"count":111,"type":22},552,[60],"(1) To compare the efficacy and safety of a 14-day bismuth-amoxicillin-vonoprazan triple therapy versus a 14-day bismuth-based quadruple therapy as first-line treatments for H. pylori infection, and (2) To investigate the influence of H. pylori antibiotic resistance, along with host CYP3A4, CYP2C19, and IL-1B -511 genotypes, on the eradication efficacy of H. pylori therapies.",[115],"Helicobacter Pylori Infection",[117],"Helicobacter pylori eradication","2026-01-13",{"date":120,"type":39},"2026-01-22",{"date":122,"type":39},"2025-10-21",{"date":124,"type":22},"2027-12-31",{"name":45,"class":46},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":58,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":47},"100542947","efficacies-of-bismuth-amoxicillin-vonoprazan-triple-therapy-vonoprazan-amoxicillin-dual-therapy-and-proton-pump-inhibitor-based-standard-triple-therapy-for-hp-eradication-100542947","NCT06349486","Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy, Vonoprazan-amoxicillin Dual Therapy and Proton Pump Inhibitor-based Standard Triple Therapy for Hp Eradication","Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy, Vonoprazan-amoxicillin Dual Therapy and Proton Pump Inhibitor-based Standard Triple Therapy in the First-line Anti-H. Pylori Treatment","Inclusion Criteria:\n\n(1) At least 18 years old. (2) Subjects infected with Helicobacter pylori.\n\nExclusion Criteria:\n\n1. Those who have ever received Helicobacter pylori sterilization treatment.\n2. Those who are allergic to the drugs used in this research.\n3. Those who have had stomach surgery.\n4. Those with severe liver cirrhosis or uremia or malignant tumors.\n5. Women who are pregnant or breastfeeding.",{"count":134,"type":22},390,[60],"1. Compare the efficacies and safety of 14-day bismuth-amoxicillin-vonoprazan tiple therapy, 14-day vonoprazan dual therapy and 14-day rabeprazole triple therapy in the first-line treatment of H. pylori infection.\n2. To investigate the impacts of antibiotic resistance of H. pylori as well as CYP3A4, CYP2C19 and IL-1B -511 genotypes of host on the eradication efficacies of anti-H. pylori treatments.",[138],"Helicobacter Pylori Eradication",{"date":140,"type":39},"2026-01-15",{"date":142,"type":39},"2023-11-28",{"date":144,"type":22},"2026-12-31",{"name":45,"class":46},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":58,"phases":155,"briefSummary":156,"conditions":157,"keywords":161,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":47},"100618867","the-effectiveness-of-three-good-things-on-gratitude-and-psychological-well-being-among-nursing-students-100618867","NCT07337200","The Effectiveness of Three Good Things on Gratitude and Psychological Well-being Among Nursing Students","The Effectiveness of Daily Three Good Thing Intervention on Gratitude and Psychological Well-being Among Indonesian Nursing Students: Solomon Four-Group Design","Inclusion Criteria:\n\n* Active first- and second-year students in the D-III Nursing Program at Subang State Polytechnic.\n* Willing to participate in the study by signing an informed consent form.\n* Able to use Google Forms online for the intervention.\n\nExclusion Criteria:\n\n* Students who are on academic leave.\n* Students who did not complete the daily intervention until the end in groups 1 and 3.",{"count":154,"type":22},277,[60],"The goal of this clinical trial is to learn if the daily Three Good Thing intervention can prevent negative mental health outcomes like stress and burnou, and promote Gratitude and Psychological Wellbeing in undergraduate Nursing Students.\n\nThe main questions it aims to answer are:\n\nDoes the daily Three Good Things intervention effective in promoting gratitude and psychological wellbeing among nursing students?\n\nResearchers will compare four different arms from Solomon Four Group Design to see if the increase in Gratitude and Psychological Wellbeing scores is significantly greater in the groups that received the 3GT intervention.\n\nParticipants will be randomly assigned to one of the four groups, and those in the intervention groups will:\n\n1. Complete a pre-test questionnaire (for some groups) on their current level of Gratitude and Psychological Wellbeing.\n2. Perform the Three Good Things (3GT) intervention by writing down three positive things that happened each day for 7 consecutive days.\n3. Complete a post-test questionnaire to measure the final level of Gratitude and Psychological Wellbeing.",[158,159,160],"Nursing Student","Gratitude","Psychological Well-being",[162,159,163,164,165,166,167],"Three Good Things","Psychological well-being","Daily intervention","Nursing students","Solomon Four Group Design","Positive psychology","2026-01-06",{"date":118,"type":39},{"date":171,"type":22},"2025-12-23",{"date":173,"type":22},"2026-03-25",{"name":45,"class":46},{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":183,"enrollmentInfo":184,"targetDuration":186,"studyType":23,"phases":4,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":47},"100615815","application-of-multiple-vertical-jump-tests-in-return-to-play-assessment-for-anterior-cruciate-ligament-reconstruction-athletes-100615815","NCT07297511","Application of Multiple Vertical Jump Tests in Return-to-Play Assessment for Anterior Cruciate Ligament Reconstruction Athletes","The Application of Vertical Jump Performance in Return-to-Play Assessment for Anterior Cruciate Ligament Reconstruction Athletes","RTP-VJ","Inclusion Criteria:\n\n* 1.Age 18-35 years\n\n  2.Unilateral anterior cruciate ligament (ACL) rupture confirmed by magnetic resonance imaging (MRI)\n\n  3.Positive Lachman test grade ≥2 pre-operatively\n\n  4.Anterior cruciate ligament reconstruction (ACLR) using hamstring or gracilis autograft\n\n  5.Post-operative time ≥6 months\n\n  6.Completed rehabilitation program with clearance from orthopedic surgeon or physical therapist\n\n  7.Quadriceps strength symmetry index ≥90%\n\n  .Elite athlete status (prior participation in national-level competitions)\n\nExclusion Criteria:\n\n1. Other lower extremity injuries or pathologies (including other knee ligament injuries)\n2. Contralateral lower limb injury within the past 3 months\n3. Quadriceps strength symmetry index \\\u003C90%\n4. Non-elite athlete status (no prior national-level competition participation)\n5. Incomplete rehabilitation or lack of medical clearance","35 Years",{"count":185,"type":22},36,"1 Day","Anterior cruciate ligament (ACL) injury is a common sports-related injury, particularly in sports that require extensive jumping and cutting movements. Although anterior cruciate ligament reconstruction (ACLR) surgery can restore knee stability, many athletes still face the risk of re-injury after returning to competition.Current return-to-play assessment relies primarily on single-plane horizontal hop tests and symmetry indices (LSI ≥ 90%); however, an increasing body of research suggests that these tests may not comprehensively reflect functional deficits in the vertical plane, repeated hopping, or high-intensity sport-specific activities.This study hypothesizes that incorporating multiple vertical jump tests-including single-leg vertical jumps and 10-second repeated vertical jumps-combined with advanced force plate analytics (such as Reactive Strength Index \\[RSI\\] and Time to Stabilization \\[TTS\\])-can more sensitively reveal residual neuromuscular control deficits following surgery. This approach would provide evidence-based guidance for return-to-play decision-making, thereby improving athletes' long-term athletic performance and safety.",[189],"ACL Reconstruction",[191,192,193],"ACL reconstruction","vertical jump test","return to play","2025-12-09",{"date":196,"type":39},"2025-12-22",{"date":198,"type":22},"2025-12-29",{"date":200,"type":22},"2026-01-30",{"name":45,"class":46},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":213,"conditions":214,"keywords":218,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":4},"100613952","adh1b-and-aldh-gene-variants-and-lung-cancer-risk-100613952","NCT07273279","ADH1B and ALDH Gene Variants and Lung Cancer Risk","Associations of ADH1B and ALDH Family Gene Polymorphisms With Lung Cancer Risk and Its Subtypes: Results From the Oncoarray Project of the International Lung Cancer Consortium","ALDH","Inclusion Criteria:\n\n* Incident lung cancer cases confirmed by pathology and healthy adult over age of 18 years.\n\nExclusion Criteria:\n\n* Individuals with incomplete data will not be included as study participants.","99 Years",{"count":212,"type":22},100000,"Lung cancer in never-smokers is increasingly recognized as a disease influenced by genetic susceptibility. Aldehyde-metabolizing enzymes, including the ALDH gene family and ADH1B, play key roles in detoxifying reactive aldehydes that can damage DNA and promote oxidative stress. In this study, we will examine whether ten selected genetic variants, nine single nucleotide polymorphisms (SNPs) across five ALDH family genes and one variant in ADH1B are associated with the risk of lung cancer and its major subtypes. Limited epidemiological evidence is currently available on the association between these aldehyde-metabolizing gene variants and lung cancer. This research aims to clarify their potential contribution to the development of lung cancer, particularly among never-smokers.",[215,216,217],"Condition\u002FDisease","Lung Cancer (Diagnosis)","Lung Adenocarcinoma",[219,220,221],"ALDH2","ADH1B","Lung cancer","2025-11-26",{"date":194,"type":39},{"date":225,"type":22},"2026-01",{"date":227,"type":22},"2027-12",{"name":45,"class":46},{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":58,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":47},"100599826","acute-effects-of-progressive-muscle-relaxation-on-brain-waves-100599826","NCT07089537","Acute Effects of Progressive Muscle Relaxation on Brain Waves","Acute Effects of Progressive Muscle Relaxation on Brain Waves, Heart Rate Variability, Muscle Tone, and Mental Stress","Inclusion Criteria:\n\n* Healthy adults\n* Age: 18 years and above\n* Body Mass Index (BMI) between 18 and 24\n* Able to remain in a semi-recumbent position for 2 hours\n\nExclusion Criteria:\n\n* Individuals with communication impairments or difficulty understanding instructions\n* Color vision deficiency\n* Open wounds or injuries on the scalp\n* Currently taking medications that affect cardiovascular or autonomic nervous system regulation\n* Muscle strain or pain",{"count":237,"type":22},32,[60],"In modern environments, stress is present regardless of age or social role. Stress does not always have negative effects; in fact, it is a necessary response for survival, known as the stress response. This response includes increased heart rate, blood pressure, blood glucose levels, and decreased alpha brainwave activity. These physiological changes are primarily regulated by the sympathetic and parasympathetic branches of the autonomic nervous system, enabling us to cope with environmental threats. However, when the stress response system becomes overwhelmed or imbalanced-whether due to accumulated chronic stress or acute stress-it may result in adverse effects on both physical and mental health.\n\nRelaxation techniques are non-pharmacological methods that promote parasympathetic nervous system activity. The goal is to reduce excessive arousal, alleviate anxiety, slow down thought processes, and relieve stress, thereby achieving relaxation in a natural way. These methods help lower blood pressure, improve circulation, relax muscles, and enhance concentration. Previous studies have demonstrated a correlation between relaxation and attention, suggesting that relaxation can improve attentional efficiency. Moreover, it is well-documented that executive function tends to decline under stress. Relaxation techniques are commonly incorporated into psychological therapies, yet they are more accessible, easier to practice, and can be conveniently performed at home.\n\nTherefore, the aim of this study is to investigate whether PMR can produce immediate relaxation effects as measured by EEG (cortical excitability), heart rate variability, and muscle tone, and whether it can improve performance under psychological stress. The goal is to further explore the potential application of PMR in healthy populations facing acute stress conditions.",[241],"Progressive Muscle Relaxation","2025-07-21",{"date":244,"type":39},"2025-07-28",{"date":246,"type":39},"2025-02-24",{"date":248,"type":22},"2025-12-31",{"name":45,"class":46},{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":58,"phases":259,"briefSummary":260,"conditions":261,"keywords":266,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":47},"100583930","the-immediate-effect-of-applying-transcutaneous-electrical-nerve-stimulation-tens-on-sympathetic-ganglion-and-gastrocnemius-for-popliteal-blood-flow-100583930","NCT06882733","The Immediate Effect of Applying Transcutaneous Electrical Nerve Stimulation (TENS) on Sympathetic Ganglion and Gastrocnemius for Popliteal Blood Flow","TENS","Inclusion Criteria:\n\n1. Healthy people\n2. Age: 18 years and above (inclusive)\n3. Body mass index (BMI) between 18.5 and 24\n\nExclusion Criteria:\n\n1. Unable to complete two interventions within a week\n2. Have contraindications to electrotherapy (for example: metal implants in the body, open wounds, pregnancy, sensory loss)\n3. Obvious varicose veins 4. Unable to lie down for about 1 to 2 hours 5. Taking drugs or nutritional supplements that affect autonomic nervous activity or vasodilation (for example: Ginkgo biloba) 6. Smoking 7. Ankle and Ankle Index (ABI) less than 0.9 or greater than 1.3",{"count":258,"type":22},43,[60],"This study aims to evaluate the immediate hemodynamic effects of transcutaneous electrical nerve stimulation (TENS) on the popliteal artery and vein. Vascular issues like PAOD and DVT are common in patients with diabetes, obesity, or immobility due to increased resistance and reduced blood flow. Traditional treatments (medication or surgery) are not always feasible, prompting interest in TENS as an alternative. Although primarily used for pain relief, TENS may enhance blood flow. This research compares different stimulation frequencies (80 Hz vs. 4 Hz) and sites (gastrocnemius muscle vs. thoracolumbar sympathetic ganglia) to identify the most effective configuration.",[262,263,264,265],"Transcutaneous Electrical Nerve Stimulation (TENS)","Popliteal","Blood Flow","Sympathetic Ganglia",[267,268,269],"transcutaneous electrical nerve stimulation (TENS)","blood flow","sympathetic ganglia","2025-07-16",{"date":272,"type":39},"2025-07-18",{"date":274,"type":39},"2024-12-03",{"date":276,"type":22},"2025-12-01",{"name":45,"class":46},{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":11,"sex":18,"minAge":285,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":58,"phases":288,"briefSummary":289,"conditions":290,"keywords":298,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":47},"100585459","geriatric-trauma-care-program-for-living-alone-older-adults-with-injuries-100585459","NCT06902636","Geriatric Trauma Care Program for Living Alone Older Adults With Injuries","Patient Experience of Older Adults Living Alone With Injuries and Long-Term Effects of Geriatric Trauma Care Program for Living Alone Older Adults With Injuries","Inclusion Criteria:\n\n1. willing to join this study for three months\n2. with limb injuries\n3. living alone in a household\n4. aged 65 years old or older\n5. independent before a traumatic injury\n6. having a smartphone.\n\nExclusion Criteria:\n\n1. with an ISS greater than 16 (severe injuries)\n2. having cognitive impairments\n3. diagnosed with psychiatric illness","65 Years",{"count":287,"type":22},90,[60],"To examine the long-term effects of the Geriatric Trauma Care Program (GTCP) regarding pain, functional disability, depression, loneliness, and health-related quality of life among older adults with traumatic injuries who live alone.",[291,34,292,293,294,295,296,297],"Limb Injury","Geriatric","Pain","Geriatric Depression","Barthel Index","Quality of Life","Loneliness",[299,300,301,302],"Limb injury","geriatric trauma","older adults","loneliness","2025-05-13",{"date":305,"type":39},"2025-05-16",{"date":307,"type":39},"2025-03-27",{"date":309,"type":22},"2026-07-31",{"name":45,"class":46},{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":17,"sex":18,"minAge":285,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":58,"phases":319,"briefSummary":320,"conditions":321,"keywords":323,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":336},"100502725","the-effects-of-healthy-beat-acupunch-on-physical-fitness-of-thai-older-adults-in-residential-homes-100502725","NCT05825989","The Effects of Healthy Beat Acupunch on Physical Fitness of Thai Older Adults in Residential Homes","Inclusion Criteria:\n\n* Mild to moderate dependence or complete independence as defined by an Activity Daily Living assessment using the Barthel Index (BI Thai version) with a score of 61 or higher\n* No cognitive impairment defined by a Short Portable Mental Status Questionnaire (SPMSQ Thai version) a score of ≥ 8\n* No experience with the HBA regimen\n* Able to communicate in Thai\n\nExclusion Criteria:\n\n* Older adults whom physicians have advised not to exercise because of medical conditions, severe disease, such as severe cardiopulmonary disease (CVD, COPD), or severe musculoskeletal diseases, and have sensory impairments such as visual and auditory impairments.",{"count":318,"type":22},92,[60],"The purpose of this study is to test the effects of the first three months of instructor-led HBA regimen on physical fitness (aerobic endurance, lung capacity, upper body flexibility, lower body flexibility, handgrip strength, upper body strength, and lower body strength) between the HBA intervention and control groups, to test the effects of another three months of DVD-led HBA regimen followed by the three months of instructor-led on physical fitness between the HBA intervention and control groups and to test the changes at three and six months of the HBA regimen in comparison to the baseline of the physical fitness in the HBA intervention group.",[322],"Aging",[324,301,325,326,327],"acupunch exercise","physical fitness","residential homes","cluster-randomized controlled trial","2025-02-04",{"date":330,"type":39},"2025-02-06",{"date":332,"type":39},"2023-06-07",{"date":334,"type":22},"2025-06-30",{"name":45,"class":46},2,{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":11,"sex":344,"minAge":345,"maxAge":285,"enrollmentInfo":346,"targetDuration":4,"studyType":58,"phases":348,"briefSummary":350,"conditions":351,"keywords":353,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":4},"100565327","phase-4-investigating-the-optimal-remifentanil-and-dexmedetomidine-concentration-for-uterine-fibroid-ablation-100565327","NCT06640738","Investigating the Optimal Remifentanil and Dexmedetomidine Concentration for Uterine Fibroid Ablation","Remifentanil and Dexmedetomidine in Uterine Fibroid Ablation: a Comparative Study","Inclusion Criteria:\n\n* Aged between 20 and 65 years old\n* American Society of Anesthesiology classification I\\~III\n* Female patients diagnosed with uterine fibroids by obstetricians and gynecologists\n\nExclusion Criteria:\n\n1. Patients with heart disease (such as arrhythmia or severe ventricular dysfunction)\n2. Patients with chronic kidney disease in stage III or above or dialysis patients\n3. Long-term alcohol addiction or drug abuse\n4. Patients with abnormal liver index or chronic hepatitis\n5. Those who are allergic Remifentanil\n6. Those who refuse to participate in the experiment","FEMALE","20 Years",{"count":347,"type":22},60,[349],"PHASE4","This clinical trial aims to find a better drug concentration of Remifentanil in Uterine Fibroid Ablation. The main question it seeks to answer is:\n\n\\[primary hypothesis 1\\] Remifentanil concentration of 2.0 ng\u002FmL provides better pain control in Uterine Fibroid Ablation.\n\nThere is a comparison group in this study: Researchers will compare Remifentanil concentration of 1.0 ng\u002FmL to see if provides similar pain control with fewer side effects.\n\nParticipants will be separated into two groups, one group with a Remifentanil concentration of 2.0 ng\u002FmL and the other 1.0 ng\u002FmL. During uterine fibroid ablation, the patient\\'s pain index will be recorded (using a Visual Analogue Scale (VAS) of 0\\~10 points). We will also record vital signs during the procedure.",[352],"Uterine Fibroids (UF)",[352,354],"Remifentanil","2024-10-11",{"date":357,"type":39},"2024-10-15",{"date":359,"type":22},"2024-10-01",{"date":361,"type":22},"2026-10-31",{"name":45,"class":46},""]