[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kaplan Medical Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":102},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100630761","use-of-nitrous-oxide-for-pain-and-anxiety-management-during-cervical-cerclage-removal-100630761",false,"NCT07491874","Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal","Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal- A Multicenter Randomized Controlled Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Women at ≥34 weeks of gestation\n* Singleton or twin pregnancy\n* Ability to understand, sign informed consent, and complete questionnaires\n\nExclusion Criteria:\n\n* Triplet or higher-order pregnancy\n* Contraindications to nitrous oxide use\n* Fetal monitoring category 2 or higher\n* Maternal body temperature \\>38°C\n* Significant vaginal bleeding\n* Severe preeclampsia\n* Cerclage removal under general anesthesia\n* Language or cognitive barrier\n* Baseline pain \\>3 on VAS scale, prior to the procedure","FEMALE","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to determine whether inhaled nitrous oxide can reduce pain and anxiety during cervical cerclage removal compared with standard care. Cervical cerclage removal is commonly performed in the outpatient setting during the third trimester of pregnancy and may be associated with discomfort and anxiety despite being a brief procedure.\n\nThe study will include pregnant women aged 18 years or older undergoing elective cervical cerclage removal at 36 weeks of gestation or later.\n\nThe main questions the study aims to answer are:\n\n* Does inhaled nitrous oxide reduce pain during cervical cerclage removal?\n* Does inhaled nitrous oxide reduce anxiety during the procedure?\n* Does the use of nitrous oxide improve overall patient satisfaction during cerclage removal?\n\nResearchers will compare women receiving inhaled nitrous oxide to those receiving standard care without analgesia, as routinely practiced in the participating institutions, in order to determine whether nitrous oxide improves pain control and patient experience during the procedure.\n\nParticipants will:\n\n* Be randomly assigned to receive either inhaled nitrous oxide (50% nitrous oxide \u002F 50% oxygen) or standard care without analgesic treatment during cervical cerclage removal.\n* Undergo the procedure according to routine clinical practice in the participating centers.\n* Complete questionnaires assessing pain and anxiety, including a visual analog scale (VAS) for pain and the State-Trait Anxiety Inventory (STAI).\n* Have routine clinical data recorded from their medical records, including maternal vital signs and any procedure-related side effects.",[26,27,28],"Preterm Delivery","Cervical Cerclage","Cervical Insufficiency","NOT_YET_RECRUITING","2026-04-02",{"date":32,"type":33},"2026-04-08","ACTUAL",{"date":35,"type":20},"2026-05-01",{"date":37,"type":20},"2028-05-01",{"name":39,"class":40},"Kaplan Medical Center","OTHER",4,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100585918","prevalence-of-ethnic-neutropenia-and-duffy-null-phenotype-in-neonates-100585918","NCT06908616","Prevalence of Ethnic Neutropenia and Duffy Null Phenotype in Neonates","The Prevalence of Ethnic Neutropenia in Neonates","Inclusion Criteria:\n\n* Neonates born at Kaplan Medical Center between 1.9.2024 and 31.12.2025\n* Parental informed consent obtained\n* Umbilical cord blood available for routine testing\n\nExclusion Criteria:\n\n* None","ALL","1 Minute","1 Day",{"count":53,"type":20},1000,"OBSERVATIONAL","This is a prospective observational study designed to assess the prevalence of the Duffy null phenotype (associated with ethnic neutropenia) in neonates born at Kaplan Medical Center. Blood samples will be collected from umbilical cords (non-invasively) to evaluate Duffy antigen expression. Data on ethnicity, perinatal factors, and routine blood counts at 9-12 months (when available) will also be collected to correlate phenotype with absolute neutrophil count (ANC).",[57],"Neutropenia (Low White Blood Cell Count)",[59,60,61],"Neonates","Neutropenia","Duffy null associated count","RECRUITING","2025-04-03",{"date":65,"type":33},"2025-04-06",{"date":67,"type":33},"2024-10-08",{"date":69,"type":20},"2027-12-31",{"name":39,"class":40},1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":49,"minAge":79,"maxAge":17,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},"100586896","iron-deficiency-in-pediatric-celiac-disease-diet-vs-iron-supplementation-trial-100586896","NCT06921343","Iron Deficiency in Pediatric Celiac Disease: Diet vs. Iron Supplementation Trial","Iron Deficiency Without Anemia in Children With Newly Diagnosed Celiac Disease: A Randomized, Open-Label, Controlled Trial.","Inclusion Criteria:\n\n* Children aged 18 months to 18 years\n* Newly diagnosed with celiac disease (based on ESPGHAN guidelines)\n* Ferritin levels below 15 ng\u002FdL\n* Normal hemoglobin, MCV, and MCH levels for age and sex\n\nExclusion Criteria:\n\n* IgA deficiency preventing TTG antibody monitoring\n* Potential celiac disease (positive serology with normal intestinal histology)\n* Underlying diseases that may cause anemia (e.g., Inflammatory bowel disease, eosinophilic gastrointestinal disease, certain gastritis types)\n* Diseases affecting iron absorption (e.g., Cystic Fibrosis)\n* Congenital anemia (e.g., Thalassemia, hereditary spherocytosis)\n* Prior iron supplementation (\\>14 days oral iron within 2 months or IV iron within 6 months before diagnosis)","18 Months",{"count":81,"type":20},150,[23],"This study aims to understand how to best manage iron deficiency in children newly diagnosed with celiac disease. Many children with celiac disease have low iron levels, even if they do not have anemia. While some doctors recommend iron supplements, others believe that simply following a gluten-free diet may be enough to restore iron levels naturally.\n\nIn this study, children with newly diagnosed celiac disease and low iron levels (but normal hemoglobin) will be randomly assigned to one of two groups:\n\nGluten-Free Diet Only - No additional iron supplements Gluten-Free Diet + Iron Supplementation Researchers will compare iron store levels over one year to see if iron supplements provide any additional benefit beyond the gluten-free diet alone. The study will also track possible side effects of iron supplements, such as stomach discomfort.\n\nThis study will help doctors determine the best approach to managing iron deficiency in children with celiac disease, ensuring they receive the safest and most effective treatment.",[85,86],"Celiac Disease in Children","Iron Deficiency",[88,89,90,91,92,93],"Celiac disease","Pediatric celiac disease","Iron deficiency","Ferritin levels","Gluten-free diet","Iron supplementation",{"date":95,"type":33},"2025-04-10",{"date":97,"type":20},"2025-04",{"date":99,"type":20},"2028-12",{"name":39,"class":40},5,""]