[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kartal Kosuyolu High Speciality Training and Research Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100625292","effects-of-extracorporeal-circulation-techniques-on-cerebral-perfusion-in-cabg-surgery-100625292",false,"NCT07420738","Effects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG Surgery","The Effects of Different Extracorporeal Circulation Techniques on Cerebral Perfusion Markers and Postoperative Awakening in Coronary Artery Bypass Graft Surgery","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for elective coronary artery bypass graft (CABG) surgery\n* American Society of Anesthesiologists (ASA) physical status II-III\n* Planned use of extracorporeal circulation during surgery\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* ASA physical status other than II-III\n* Emergency surgery\n* Pregnancy\n* History of neurological disease affecting consciousness or decision-making capacity\n* History of psychiatric disease affecting decision-making capacity\n* History of head trauma within the previous 24 hours\n* Presence of carotid artery stenosis or significant carotid artery disease\n* Coagulation disorders (INR \\> 1.25, aPTT \\> 35 s, or platelet count \\\u003C 100,000\u002FμL)\n* Reoperation (redo cardiac surgery)\n* Congestive heart failure\n* Chronic kidney failure\n* Sepsis\n* Hypoxia\n* Ocular trauma\n* Optic nerve pathology","ALL","18 Years","75 Years",{"count":20,"type":21},70,"ESTIMATED","OBSERVATIONAL","This prospective study aims to compare the effects of minimal invasive extracorporeal circulation (MiECC) and conventional reservoir-based extracorporeal circulation techniques on cerebral perfusion in patients undergoing elective coronary artery bypass graft (CABG) surgery. Although the adverse effects of cardiopulmonary bypass on cerebral perfusion and oxygenation are well recognized, the relationship between these effects and changes in intracranial pressure has not been fully elucidated. In this context, ultrasonographic measurement of optic nerve sheath diameter (ONSD), a non-invasive surrogate marker of intracranial pressure, will be used in combination with near-infrared spectroscopy (NIRS) to enable a comprehensive assessment of cerebral perfusion and oxygenation.\n\nBetween February 2026 and February 2027, a total of 70 ASA II-III patients scheduled for elective CABG surgery will be prospectively enrolled and allocated according to the extracorporeal circulation technique used. Perioperative ONSD measurements will be performed by a single anesthesiologist blinded to the perfusion technique. The primary endpoint is the comparison of perioperative changes in ONSD between the two techniques. Secondary endpoints include the correlation between ONSD and NIRS values, incidence of cerebrovascular events, extubation time, duration of intensive care unit and hospital stay, perioperative hemodynamic parameters, and postoperative complications. This study is expected to provide clinically relevant data on the cerebral effects of different extracorporeal circulation strategies and contribute to perioperative neuromonitoring practices in cardiac surgery.",[25],"Intracranial Hypertension",[27,28],"İntracranial pressure","optic nerve sheath diameter","NOT_YET_RECRUITING","2026-02-11",{"date":32,"type":33},"2026-02-19","ACTUAL",{"date":35,"type":21},"2026-05-01",{"date":37,"type":21},"2027-05-01",{"name":39,"class":40},"Kartal Kosuyolu High Speciality Training and Research Hospital","OTHER_GOV",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100624660","serratus-posterior-superior-intercostal-plane-block-for-analgesia-in-off-pump-minimally-invasive-cabg-100624660","NCT07412522","Serratus Posterior Superior Intercostal Plane Block for Analgesia in Off-Pump Minimally Invasive CABG","Off-pump Minimal Invaziv Koroner Arter Bypass Cerrahisi geçiren Hastalarda Serratus Posterior Superior Interkostal Plan Blokunun Analjezik etkinliği: Randomize kontrollü çalışma","CABG","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* ASA physical status II-III\n* Scheduled for elective off-pump minimally invasive coronary artery bypass grafting (CABG) surgery\n* Ability to understand and use the Numerical Rating Scale (NRS)\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy or contraindication to local anesthetics\n* Coagulation disorders or ongoing anticoagulant therapy incompatible with regional anesthesia\n* Infection at the block injection site\n* Severe hepatic or renal dysfunction\n* Chronic opioid use or opioid dependence\n* History of chronic pain syndromes\n* Severe pulmonary disease (e.g., advanced COPD)\n* Neurological or psychiatric disorders that may interfere with pain assessment\n* Emergency surgery\n* Conversion to on-pump CABG or sternotomy during surgery",true,{"count":52,"type":21},60,"INTERVENTIONAL",[55],"NA","Postoperative pain after cardiac surgery is commonly moderate to severe due to sternotomy, thoracotomy, internal mammary artery harvesting, and chest tube placement, and may contribute to adverse systemic and pulmonary outcomes if inadequately managed. Enhanced Recovery After Surgery (ERAS) protocols emphasize opioid-sparing strategies to reduce opioid-related side effects and complications. Ultrasound-guided fascial plane blocks have increasingly been incorporated into perioperative analgesia protocols for cardiac surgery. The serratus posterior superior intercostal plane block (SPSIPB), a recently described technique, provides wide dermatomal sensory coverage and may offer effective analgesia in thoracic and cardiac surgical procedures.\n\nThis prospective, randomized controlled study aims to evaluate the analgesic efficacy of SPSIPB in adult patients undergoing off-pump minimally invasive coronary artery bypass grafting (CABG). A total of 60 ASA III patients aged 18 years or older will be randomized into two groups: SPSIPB group and control group. The SPSIPB will be performed preoperatively under ultrasound guidance using 0.25% bupivacaine, while the control group will receive standard general anesthesia without any plane block. All patients will receive standardized general anesthesia and postoperative patient-controlled analgesia with tramadol.\n\nThe primary outcome of the study is postoperative recovery quality assessed using the Quality of Recovery-15 (QoR-15) questionnaire. Secondary outcomes include intraoperative remifentanil consumption, postoperative opioid requirements, time to first rescue analgesia, numerical rating scale (NRS) pain scores at rest and during coughing, extubation time, intensive care unit and hospital length of stay, and postoperative complications such as nausea, vomiting, and atelectasis. This study aims to determine whether SPSIPB can improve postoperative recovery quality and reduce opioid consumption in patients undergoing off-pump minimally invasive CABG.",[58,59],"Postoperative Pain","Postoperative Analgesia",[61,62],"Serratus posterior superior intercostal plane block","Postoperative pain","RECRUITING",{"date":65,"type":33},"2026-02-17",{"date":67,"type":33},"2025-09-01",{"date":69,"type":21},"2026-09-01",{"name":39,"class":40},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":78,"targetDuration":4,"studyType":53,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":41},"100625290","serratus-posterior-superior-plane-block-in-minimally-invasive-cardiac-surgery-100625290","NCT07420712","Serratus Posterior Superior Plane Block in Minimally Invasive Cardiac Surgery","Multimodal Analgesia in Minimally Invasive Cardiac Surgery: A Randomized Controlled Study on the Effectiveness of the Serratus Posterior Superior Intercostal Plane Block","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* American Society of Anesthesiologists (ASA) physical status III\n* Scheduled for elective minimally invasive coronary artery bypass surgery\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years\n* ASA physical status other than III\n* Pregnancy\n* Emergency surgery\n* History of trauma within the previous 24 hours\n* Neurological disorders affecting consciousness or decision-making capacity\n* Psychiatric disorders affecting decision-making capacity or cooperation\n* Known allergy to local anesthetic agents\n* Infection or skin disease at the block injection site\n* Body mass index greater than 35 kg\u002Fm²\n* Body weight less than 42 kg\n* Coagulation disorders (international normalized ratio \\>1.25, activated partial thromboplastin time \\>35 seconds, or platelet count \\\u003C100,000\u002FµL)",{"count":52,"type":21},[55],"This prospective randomized controlled trial aims to evaluate the effectiveness of the serratus posterior superior intercostal plane block (SPSIPB) as part of a multimodal analgesia strategy in patients undergoing minimally invasive cardiac surgery. Sixty adult ASA III patients scheduled for minimally invasive coronary artery bypass surgery will be randomly assigned to either an SPSIPB group or a control group receiving standard analgesic management without a plane block. The primary outcome is postoperative opioid (tramadol) consumption, while secondary outcomes include intraoperative remifentanil consumption, pain scores at rest and during coughing, time to first rescue analgesia, time to extubation, and lengths of intensive care unit and hospital stay.\n\nAll patients will receive standardized general anesthesia and postoperative patient-controlled analgesia. Pain intensity will be assessed using the Numeric Rating Scale at predefined postoperative intervals. Postoperative complications such as nausea, vomiting, and atelectasis will be recorded. This study aims to determine whether SPSIPB provides effective opioid-sparing analgesia and improves postoperative recovery parameters in minimally invasive cardiac surgery.",[82],"Analgesia",[61,62],{"date":32,"type":33},{"date":86,"type":33},"2025-07-01",{"date":88,"type":21},"2026-07-01",{"name":39,"class":40},""]