[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kathirvel Subramaniam\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100486309","precision-analgesia-for-cardiac-surgery-100486309",false,"NCT05612399","Precision Analgesia for Cardiac Surgery","Precision Perioperative Methadone Use in Adult Cardiac Surgical Patients to Reduce Opioid Use Adverse Effects While Improving Analgesia and Outcomes","Inclusion Criteria:\n\n* Elderly cardiac surgical patients over 60 years of age\n\nExclusion Criteria:\n\n* Methadone allergy\n* Morbid obesity (BMI \\>40kg\u002Fcm2)\n* Severe sleep apnea\n* Severe pulmonary disease requiring oxygen therapy\n* Preoperative mechanical circulatory support\n* Emergency surgery\n* Liver disease (liver enzymes more than two times normal)\n* End-stage renal disease requiring dialysis\n* Serum creatinine more than 2.0mg","ALL","60 Years","110 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone in elderly adults undergoing cardiac surgery.",[25,26],"Analgesia","Cardiac Surgery","NOT_YET_RECRUITING","2026-04-11",{"date":30,"type":31},"2026-04-15","ACTUAL",{"date":33,"type":21},"2026-05",{"date":35,"type":21},"2026-12-01",{"name":37,"class":38},"Kathirvel Subramaniam","OTHER",""]