[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ke Dong, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100637037","the-effect-of-tdcs-combined-with-tms-on-cognitive-impairment-and-motor-function-after-stroke-100637037",false,"NCT07573475","The Effect of tDCS Combined With TMS on Cognitive Impairment and Motor Function After Stroke","The Effect of Transcranial Electrical Stimulation Combined With Transcranial Magnetic Stimulation on Cognitive Impairment and Motor Function After Stroke","Inclusion Criteria:\n\n* Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;\n* Age ranging from 30 to 80 years old;\n* Native language is Mandarin or Cantonese;\n* Right-handed;\n* Diagnosed with post-stroke cognitive impairment(PSCI) by the MoCA scale;\n* Able to cooperate in completing the speech repetition test;\n* Normal hearing.\n\nExclusion Criteria:\n\n* Currently receiving non-invasive brain stimulation treatment;\n* Lesions involving the left DLPFC brain regions;\n* History of epilepsy, mental illness,or other neurological or mental disorders;\n* Any contraindications for transcranial electrical stimulation.","ALL","30 Years","80 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial aims to investigate whether transcranial electrical stimulation (tDCS) combined with transcranial magnetic stimulation(TMS) has an impact on the cognitive and motor functions of stroke patients, and to evaluate the safety of this protocol. The main objective is to answer the following question: Can electromagnetic combined stimulation of the left Dorsolateral prefrontal lobe(DLPFC) improve the performance of working memory, motor function and cognitively motor dual tasks in stroke patients? What is its mechanism of action? Participants will undergo a combined real or sham electromagnetic stimulation of 20 minutes of tDCS and 40 seconds of TMS once a day for 7 days. Researchers will compare the effects of real stimulation with sham stimulation to see if the real stimulation can bring better results to patients. Clinical evaluations (cognitive and motor scales) and functional Near-Infrared Spectroscopy(fNIRS) were conducted before and after stimulation to record relevant brain activities",[27,28],"Stroke","Cognition Disorders","NOT_YET_RECRUITING","2026-05-06",{"date":32,"type":33},"2026-05-11","ACTUAL",{"date":35,"type":21},"2026-05-01",{"date":37,"type":21},"2027-05-01",{"name":39,"class":40},"Ke Dong, MD","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":49,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":52,"startDateStruct":53,"completionDateStruct":54,"leadSponsor":55,"locationsCount":41},"100637039","dual-site-cross-frequency-coupled-transcranial-electrical-stimulation-modulates-working-memory-of-patients-with-post-stroke-cognitive-impairment-100637039","NCT07573501","Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment","Inclusion Criteria:\n\n* Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;\n* Age ranging from 30 to 80 years old;\n* Native language is Mandarin or Cantonese;\n* Right-handed;\n* Diagnosed with PSCI by the MoCA scale;\n* Able to cooperate in completing the speech repetition test;\n* Normal hearing.\n\nExclusion Criteria:\n\n* Currently receiving non-invasive brain stimulation treatment;\n* Lesions involving the left DLPFC brain regions;\n* History of epilepsy, mental illness,or other neurological or mental disorders;\n* Any contraindications for transcranial electrical stimulation.",{"count":20,"type":21},[24],"This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with cognitive impairment after stroke, and to evaluate the safety of this protocol. The main purpose is to answer the following question: Can dual-site cross-frequency coupled tACS in the frontal parietal region improve the performance of working memory and cognitive-motor dual tasks in stroke patients? What is its mechanism of action? Researchers will compare the effects of real cross-frequency coupled stimuli and sham stimuli to see if the real stimuli can bring better results to patients. Participants will receive 40 minutes of real or sham electrical stimulation once a day for 5 consecutive days. Clinical evaluations (cognitive scales) and fNIRS were conducted respectively before and after stimulation to record the relevant brain activities at rest and during cognitive tasks",[27,28],{"date":32,"type":33},{"date":35,"type":21},{"date":37,"type":21},{"name":39,"class":40},{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":41},"100636621","accelerated-temporal-interference-stimulation-on-bilateral-subthalamic-nucleus-for-parkinsons-disease-and-secondary-parkinsons-syndrome-100636621","NCT07568067","Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome","A Single-Center, Double-Blind Randomized Controlled Trial of Accelerated Temporal Interference Stimulation Applied to Bilateral Subthalamic Nucleus for Improving Motor and Vocal Functions in Patients With Parkinson's Disease Or Secondary Parkinson's Syndrome","Inclusion Criteria:\n\n1. Confirmed diagnosis of idiopathic Parkinson's disease or secondary parkinson's syndrome ; Hoehn-Yahr stage 1.5-3.\n2. Ability to walk independently.\n3. Ability to follow instructions, with no cognitive impairment.\n4. Patient and their family agree to cooperate with treatment and provide written informed consent.\n\nExclusion Criteria:\n\n1. Claustrophobia or presence of metallic implants precluding MRI examination and evaluation.\n2. Severe dysfunction of vital organs including heart, lung, liver, kidney, etc.\n3. Complicated with other neurological diseases such as cerebral infarction.\n4. Presence of mental illness, severe depression, anxiety, etc., which may affect the accuracy of study results.\n5. History of deep brain stimulation (DBS) surgery.\n6. Patients unable or unwilling to cooperate with scale assessments.\n7. Aged over 80 years old.","85 Years",{"count":65,"type":21},60,[24],"This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease or secondary Parkinson's syndrome. Accelerated TIS will be delivered targeting the bilateral subthalamic nuclei of the brain. The primary objective is to assess whether accelerated TIS yields measurable improvements in motor performance and verbal speech function among enrolled subjects. Functional magnetic resonance imaging (fMRI) will be adopted as an auxiliary imaging modality to objectively characterize underlying cerebral functional alterations induced by accelerated TIS intervention. The core scientific research questions to be addressed in this trial are listed as follows:\n\n* Will accelerated TIS administered to the bilateral subthalamic nuclei produce significant improvements in motor function and speech performance among enrolled subjects with Parkinson-related disorders?\n* What quantitative and qualitative modifications in cerebral functional activity will be detected via fMRI after standardized accelerated TIS intervention administration?\n\nInvestigators will implement a four-arm parallel controlled comparative design for all enrolled eligible subjects. All confirmed Parkinson's disease patients will undergo standardized random grouping and be allocated into two independent research arms. Subjects in the experimental arm will receive continuous, standardized accelerated TIS intervention targeting bilateral subthalamic nuclei. Subjects in the control arm will receive matched sham stimulation intervention. Sham stimulation adopts identical operation procedures, equipment wearing mode and on-site operating environment as formal accelerated TIS, with no valid neuromodulation therapeutic effect generated. Identical random grouping, intervention arrangement and controlled research design will be fully implemented in eligible subjects diagnosed with secondary Parkinson's syndrome. Rigorous controlled grouping design will ensure objective, verifiable data support for verifying the actual intervention efficacy of accelerated TIS on motor dysfunction and speech impairment in Parkinson-related patients.\n\nAll enrolled subjects will complete the following standardized trial procedures in full compliance with the trial protocol:\n\n* Receive continuous targeted intervention of either formal accelerated TIS or matched sham stimulation on bilateral subthalamic nuclei, with consecutive 5-day fixed-course administration in strict accordance with trial operating specifications\n* Complete unified fMRI brain scanning examinations and standardized motor function as well as speech function quantitative evaluation assessments at two fixed time nodes, including the baseline time point before intervention initiation and the follow-up time point after all intervention courses are completed\n* Truthfully record all adverse reactions and abnormal physical discomfort symptoms that occur throughout the whole intervention and follow-up observation cycle in standardized adverse event registration forms",[69,70],"Parkinson Disease","Parkinson Disease, Secondary","RECRUITING","2026-04-29",{"date":74,"type":33},"2026-05-05",{"date":76,"type":33},"2026-01-05",{"date":78,"type":21},"2026-10-30",{"name":39,"class":40},""]