[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ke Dou\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100597992","microscopic-varicocele-bypass-versus-ligation-100597992",false,"NCT07065695","Microscopic Varicocele Bypass Versus Ligation","A Prospective Randomized Controlled Study on the Safety and Effectiveness of Microscopic Varicocele Bypass Surgery Compared With Simple Ligation","Inclusion Criteria:\n\n* Patients with varicocele and meet the surgical indications\n* Male patients aged between 18 and 60 years old\n* Patients have the willingness to receive treatment, voluntarily participate in this study and sign the informed consent form\n* Semen analysis reveals abnormalities associated with varicocele\n* The patient has no severe dysfunction of vital organs and can tolerate surgery\n* The patient has received no relevant treatment affecting varicocele or semen quality in the past three months\n\nExclusion Criteria:\n\n* Secondary varicocele\n* Complicated with other severe reproductive system diseases\n* Suffering from severe systemic diseases, which may affect the surgical effect or prognosis\n* Presence of coagulation dysfunction or taking medications that affect coagulation function\n* Having a history of allergy to the drugs used in the surgery\n* Having mental illness or cognitive impairment and being unable to cooperate to complete this study\n* Having already participated in other relevant clinical trials.","MALE","18 Years","60 Years",{"count":20,"type":21},284,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study, titled \"A Prospective Randomized Controlled Study on the Safety and Efficacy of Microscopic Varicocele Transposition Surgery Compared with Simple Ligation,\" is conducted by the Urology and Andrology Department of Sichuan Provincial People's Hospital, with Dou Ke serving as the principal investigator. The research period spans from May 2025 to December 2027. It aims to compare the outcomes of microscopic varicocele transposition surgery and simple ligation in treating left varicocele through a prospective randomized controlled trial, focusing on postoperative recovery, complications, semen quality, and other aspects to provide evidence for clinical surgical selection.\n\nA total of 284 male patients will be enrolled, meeting criteria including clinical diagnosis of varicocele with surgical indications, aged 18-60 years, willing to participate and signing informed consent, abnormal semen analysis related to varicocele, no severe organ dysfunction, and no relevant treatments affecting the condition in the past three months. Exclusions include secondary varicocele, severe genitourinary or systemic diseases, coagulation disorders, drug allergies, mental\u002Fcognitive impairments, and participation in other related clinical trials. The experimental group will receive microscopic varicocele transposition surgery, while the control group will undergo microscopic simple ligation. Primary evaluation indicators include changes in spermatic vein diameter, reflux velocity, and duration assessed by color Doppler ultrasound at 1, 3, and 6 months post-surgery (with additional measurements of anastomotic vessel diameter and flow velocity in the experimental group), as well as pre- and post-surgery (3 and 6 months) semen routine parameters. Secondary indicators surgical success rate, postoperative complication rate, changes in reproductive hormone levels, pain relief evaluated by VAS scale, and quality of life improvements via specific assessment tools. Complying with the Declaration of Helsinki and approved by the ethics committee, informed consent will be obtained from all participants. Study results will be disseminated through academic papers, conference presentations, clinical research reports, and patient-focused summaries to advance new treatment directions for varicocele and optimize clinical protocols.",[27],"Varicocele",[27,29,30],"microscopic simple ligation","transposition surgery","NOT_YET_RECRUITING","2025-07-03",{"date":34,"type":35},"2025-07-15","ACTUAL",{"date":37,"type":21},"2025-07-22",{"date":39,"type":21},"2027-12-31",{"name":41,"class":42},"Ke Dou","OTHER",""]