[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kessler Foundation\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":613},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,43,0,25,[9,60,94,118,143,165,189,215,237,257,277,304,324,350,370,391,411,432,456,474,497,520,539,570,590],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100580737","cardiovascular-function-and-response-to-stimulation-within-the-first-year-after-spinal-cord-injury-100580737",false,"NCT06841198","Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury","Assessing Cardiovascular Effects: Is There a Time Too Early for Spinal Stimulation in Acute SCI? A Year-Long Evaluation of Autonomic Function Following Injury","For the main study:\n\nInclusion Criteria:\n\n* Individuals with a spinal cord injury undergoing inpatient rehabilitation at the Kessler Institute for Rehabilitation\n* Between 18-75 years old\n* 7-50 days after injury\n* Injury level ≥ T6 (a cervical or a high-level chest injury)\n* Individuals experiencing low blood pressure after the injury\n* American Spinal Injury Association Impairment Scale (AIS) A or B\n\nExclusion Criteria:\n\n* A ventilator is needed for breathing.\n* Devices such as brain\u002Fspine\u002Fnerve stimulators, a cardiac pacemaker\u002Fdefibrillator, or intra-cardiac lines are present in the body.\n* There is a significant disease affecting the blood vessels or signals in the heart, or a recent heart attack (myocardial infarction) has occurred.\n* A new medication has been prescribed to treat blood pressure or a heart problem within the last five days (excluding midodrine).\n* There is a known infection in the body (e.g., urinary tract infection) or a current illness (e.g., recent diagnosis of deep vein thrombosis (DVT) or other blood clotting issues, and\u002For a pressure injury that might interfere with the study).\n* There is a history of seizures.\n* Pregnancy.\n\nFor the spin-off study ice-water vs ice-wrap test (see description in study arms):\n\n\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\\_\n\nInclusion:\n\nAge 18-75.\n\nInclusion for individuals with SCI:\n\n* Injury sustained more than 6 months ago\n* Injury level ≥ T6 (a cervical or a high-level chest injury)\n* American spinal injury association impairment scale (AIS) A - D\n\nExclusion:\n\nFoot lesions, uses a ventilator, devices such as brain\u002Fspine\u002Fnerve stimulators, significant or recent cardiovascular disease, known infection in the body",true,"ALL","18 Years","75 Years",{"count":22,"type":23},15,"ESTIMATED","INTERVENTIONAL",[26],"NA","The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect blood pressure.\n\nThe main questions are:\n\nHow does stimulation affect blood pressure over the year? What is the level of cardiovascular activation throughout the year?\n\nThe study will start during the inpatient stay at the Kessler Institute for Rehabilitation and continue after discharge as an outpatient, totaling about 20-29 sessions over the year.",[29,30,31,32],"Spinal Cord Injuries (SCI)","Orthostatic Hypotension, Dysautonomic","Cardiovascular","Transcutaneous Spinal Stimulation",[34,35,36,37,38,39,40,41,42,43,44,45,46],"Transcutaneous Spinal Cord Stimulation","spinal cord stimulation","orthostatic hypotension","blood pressure","cardiovascular","neuromodulation","acute spinal cord injury","chronic spinal cord injury","inpatient rehabilitation","tilt testing","cold pressor test","ambulatory blood pressure monitoring","autonomic dysfunction following spinal cord injury","RECRUITING","2026-06-26",{"date":50,"type":51},"2026-07-01","ACTUAL",{"date":53,"type":51},"2025-04-01",{"date":55,"type":23},"2026-11",{"name":57,"class":58},"Kessler Foundation","OTHER",1,{"id":61,"slug":62,"hasResults":12,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":68,"targetDuration":4,"studyType":24,"phases":70,"briefSummary":71,"conditions":72,"keywords":82,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":59},"100644654","impact-of-transcutaneous-spinal-stimulation-on-blood-pressure-and-orthostasis-in-spinal-cord-injury-100644654","NCT07674511","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury: Short and Long-Term Effects","(SCI)","Inclusion Criteria:\n\n* Individuals with a SCI ≥ 1 year after injury\n* Injury level ≥ T6 (thoracic level)\n* AIS grade A-C\n* Cardiovascular dysfunction characterized by one or more of the following:\n\n  1. Persistent hypotension (SBP \\\u003C 90mmHg)\n  2. Orthostatic hypotension (OH, a drop of 20\u002F10 mmHg in SBP\u002FDBP within 5 minutes of standing\u002Fupright positioning).\n\nAdditionally, experiencing orthostatic symptoms in daily life and\u002For requiring medication to manage OH.\n\nExclusion Criteria:\n\n* Current illness (e.g., infection, a pressure injury that might interfere with the intervention)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* History of seizures\n* pregnancy\n* Insufficient mental capacity to understand and independently provide consent\n* Deemed unsuitable by the study physician",{"count":69,"type":23},10,[26],"The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.\n\nThe main questions this study attempts to solve:\n\n1. What are the immediate effects of spinal cord transcutaneous stimulation on BP?\n2. Does stimulation produce lasting improvements in BP regulation and subsequently, daily function?",[73,74,75,76,77,78,79,80,81],"Spinal Cord Injuries","Hypotension","Orthostatic Hypotension","Spinal Cord Diseases","Cardiovascular Diseases","Trauma, Nervous System","Central Nervous System Disease","Nervous System Diseases","Blood Pressure",[83,84,36,37,39],"transcutaneous spinal cord stimulation","spinal stimulations","NOT_YET_RECRUITING","2026-06-24",{"date":88,"type":51},"2026-06-29",{"date":90,"type":23},"2026-09",{"date":92,"type":23},"2028-12",{"name":57,"class":58},{"id":95,"slug":96,"hasResults":12,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":24,"phases":105,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":59},"100429735","neurofeedback-intervention-for-reading-deficits-in-subacute-stroke-100429735","NCT04875936","Neurofeedback Intervention for Reading Deficits in Subacute Stroke","Rehabilitation of Reading Deficits in Subacute Stroke Using Functional Magnetic Resonance Imaging (fMRI) Neurofeedback and Motor Imagery","ReadingNFB","Inclusion Criteria:\n\n* First-ever left-hemisphere stroke \\\u003C 3 months prior to study recruitment or healthy volunteer\n* Age: 18 - 80 years old\n* Fluent and literate in English prior to stroke\n* Reading deficits, defined as \\>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct.\n\nExclusion Criteria:\n\n* Inability to consent or complete study tasks\n* Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia)\n* A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)","80 Years",{"count":104,"type":23},28,[26],"The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.",[108,109],"Stroke","Dyslexia, Acquired","2026-05-04",{"date":112,"type":51},"2026-05-08",{"date":114,"type":51},"2023-04-03",{"date":116,"type":23},"2027-06-30",{"name":57,"class":58},{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":102,"enrollmentInfo":125,"targetDuration":4,"studyType":24,"phases":126,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":4},"100631333","the-safety-and-effectiveness-of-q-therapeutic-system-frequency-tuned-electromagnetic-field-treatment-in-facilitating-the-recovery-of-patients-with-chronic-stroke-100631333","NCT07499310","The Safety and Effectiveness of Q Therapeutic System, Frequency-tuned Electromagnetic Field Treatment in Facilitating the Recovery of Patients With Chronic Stroke.","RESPARK","Inclusion Criteria:\n\n* Be between ages 18-80\n* Have an score between 22-50 (inclusive) of impaired limb on the Fugl-Meyer Assessment for the Upper Extremity (FMA-UE), as determined by study staff\n* Have upper extremity function that is not changing much over time (as determined by study staff based on assessments I complete at screening and before treatment starts)\n* Have stroke due to ischemia or to intracerebral hemorrhage • Be \\>6 months to 5 years from stroke onset\n* Have a Box \\& Block Test score with affected arm is ≥1 block in 60 seconds at Baseline Visit\n* Be able to sit with the investigational System for 40 consecutive minutes\n* Be able to follow a 3-step command in English, such as \"take the paper, fold it in half, and return it to me\", or a non-verbal equivalent\n* Have the willingness to participate in physical exercises during study intervention sessions.\n* Be sure of the availability of a relative, friend, or other non-hired caregiver to be able to assist during program sessions and study visits, as needed\n\nExclusion Criteria:\n\n* Be younger than 18 years old or older than 80\n* Have implanted MR-incompatible devices or MR-incompatible retained objects (like shrapnel) or an implanted life-sustaining MR-compatible devices (such as a pacemaker or internal cardiac defibrillator)\n* Have conditions other than stroke, such as:\n\nA. Severe neglect impairment interfering with assessments or treatments. B. Severe depression, defined as GDS Score \\>10\u002F15 C. Active epilepsy or currently taking anti-epileptic medication (indicated for the treatment of a seizure disorder), or any epileptic seizure in the last 5 years.\n\nD. Severe upper extremity spasticity, defined as presence of upper extremity contracture or modified Ashworth Scale score ≥3 in either biceps or chest muscles.\n\nE. Pre-existing neurological condition (such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, traumatic brain injury, spinal cord injury) or physical limitation that would interfere significantly with my participation in the study and\u002For confound neurological or functional evaluation F. Unstable serious illness\u002Fcondition (such as active cancer, severe heart failure, active major psychiatric condition) or life expectancy of less than 12 months. significant visual disturbances, pre-existing or resulting from the index stroke, that cannot be corrected and that would interfere significantly with my participation in the study and\u002For confoundneurological or functional evaluation\n\n* Have alcohol abuse and\u002For drug abuse in the past 6 months, which is likely to influence ability to fully participate in the trial\n* Had active participation in an arm rehabilitation program with a therapist in the 4 weeks prior to the screening visit\n* Plan to have an arm rehabilitation program with a therapist between the screening visit and the assessment visit at 3-months\n* Be an employee of Kessler Foundation\n* Be a prisoner\n* Be pregnant or breastfeeding or planning pregnancy during the study period.\n* Have other conditions or circumstances that, in the opinion of the investigators, would affect the safety or effectiveness of the training in which I would participate",{"count":7,"type":23},[26],"This trial will test a promising new intervention to promote post-stroke neural reorganization and functional recovery. The overall aim is to identify a systematic, methodological approach to system fitting, training protocols, and optimization of collecting outcome measures.\n\nAim 1: Assess the safety of using the Q Therapeutic (BQ 3.0) System, including in-clinic and at- extremity rehabilitation training for individuals with chronic stroke, as determined by the number of adverse events. Device deficiencies will also be recorded to detect operational reliability.\n\nAim 2: Evaluate the effectiveness of the Q Therapeutic (BQ 3.0) System for individuals with chronic stroke in improving upper extremity function as determined by change in functional outcome measures after 3-month treatment, including in-clinic and at-home sessions.",[108,129],"Chronic Stroke Patients",[131,132,133,134],"BrainQ Electromagnetic Stimulation","upper extremity","rehabilitation","exercise mobility","2026-03-27",{"date":137,"type":51},"2026-03-30",{"date":139,"type":23},"2026-02",{"date":141,"type":23},"2026-12-31",{"name":57,"class":58},{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":24,"phases":152,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":164,"locationsCount":59},"100631495","phase-1-shockwave-for-elbow-and-wrist-spasticity-in-people-with-spinal-cord-injury-100631495","NCT07501429","Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury","Pilot Trial of a Novel, Non-invasive Treatment for Upper-limb Spasticity in People With Spinal Cord Injury","Inclusion Criteria:\n\n1. 18 years of age or older.\n2. Have chronic, non-progressive SCI of all levels and severities that occurred greater than 1 year prior to their enrollment.\n3. MAS score of between 1+ and 3 in elbow and wrist flexors of the treated upper limb.\n4. Can be treated with shockwaves. Contraindications include current or recent (within the past 3 months) infection at the site of treatment and severe coagulopathies (e.g. hemophilia).129\n5. No change in antispasmodic medications within the past three months or intended changes over the course of the trial.\n6. Participant is able and willing to comply with the protocol.\n\nExclusion Criteria:\n\n1. History of surgical procedures in the upper extremity\n2. Severe, inflammatory arthritic diseases\n3. Thrombosis\n4. Anticoagulant medication;\n5. Pregnancy\n6. Cancer\n7. Recent history of local injection of botulinum toxin within 6 months, or phenol\u002Falcohol within the 12 months",{"count":151,"type":23},12,[153],"PHASE1","Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands. One of the consequences of SCI is spasticity - involuntary activation of muscles that can hinder bodily functions and negatively affect participation in various aspects of life. Spasticity can lead to loss of functional independence and activity limitations, cause pain, and lead to mood disorders like depression. It can even interfere with rehabilitation and lead to hospitalization. In people with tetraplegia, spasticity of the arms and hands can have a tremendous impact on independence and quality of life, and thus regaining function in these areas remains a top priority. Unfortunately, spasticity is difficult to treat. Common treatments include physical therapy, including exercise or stretching; medications such as Baclofen; and injections with agents like botulinum toxin (also known as Botox). Botox injections are often implemented alongside other modalities like therapy, yet they are invasive, tend to last for only a few months, and carry potential side effects. One potential non-invasive treatment for upper limb spasticity is focused extracorporeal shockwave therapy (f-ESWT), which involves an external application of high-pressure sound waves, similar to ultrasound. An applicator\u002Fhandpiece is placed on the skin over the spastic muscle and the focused sound waves are applied. f-ESWT carries no long-term side effects with minimal discomfort during application. However, there has been limited research on this treatment option in people with SCI who have arm and hand dysfunction caused by spasticity. The purpose of this study is to fill in that knowledge gap. This will be accomplished by measuring different aspects of spasticity from the perspective of both the clinician and the person with SCI. These will include clinical measures, such as elbow and wrist range of motion, as well as how the treatment impacts the person's functional independence and quality of life. Ultrasound methods will be used to look at the person's muscles to see if any beneficial changes occur in their structure and stiffness. People with SCI who meet eligibility criteria will be invited to the laboratory to receive f-ESWT, which will occur once per week for three consecutive weeks. Treatment will entail application of f-ESWT to the elbow and wrist flexor muscles. Participants will be invited back to the laboratory to have their spasticity measured by a clinician, be asked questions about how their spasticity has impacted their lives, and have their muscles imaged with ultrasound. Findings from this study are expected to generate insight on whether f-ESWT could be a viable treatment option for spasticity of the arms and hands in people with SCI, and if a larger clinical trial is warranted.",[156,157,158],"Spinal Cord Injury","Spasticity","Shockwave Therapy","2026-03-26",{"date":137,"type":51},{"date":162,"type":23},"2026-04",{"date":92,"type":23},{"name":57,"class":58},{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":18,"minAge":172,"maxAge":102,"enrollmentInfo":173,"targetDuration":4,"studyType":24,"phases":174,"briefSummary":175,"conditions":176,"keywords":180,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":188},"100485094","focused-extracorporeal-shockwave-therapy-for-knee-arthritis-100485094","NCT05596591","Focused Extracorporeal Shockwave Therapy for Knee Arthritis","Focused Extracorporeal Shockwave Therapy for Subchondral Bone Marrow Lesions in People With Knee Osteoarthritis: A Pilot Study","Inclusion Criteria:\n\n1. Males and females 30-80 years old, inclusive.\n2. Kellgren-Lawrence (KL) score grade 2-4 as diagnosed on X-Ray.\n3. Presence of BML(s) on MRI in a weight-bearing region of the knee (medial\u002Flateral femoral condyle or tibial plateau).\n4. Knee pain for more than 2 months.\n5. Knee pain intensity during the week leading up to the screening visit is at least 4 out of 10 on an 11-point numerical rating scale (NRS; 0, no pain; 10, maximum pain imaginable).\n6. Patient pain confined to the same compartment as the BML(s).\n7. Subjects would have failed a minimum of 4 weeks of conservative treatment including rest, analgesics, limited weight-bearing with or without an assistive device.\n\nExclusion Criteria:\n\n1. Traumatic BMLs.\n2. Primary cause of patient pain and loss of function is due to pathology other than BML(s), according to patient history and clinical evaluation.\n3. Presence of bilateral BML(s).\n4. Systemic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis.\n5. Participants receiving glucocorticoids due to any other underlying disease.\n6. Prior treatment for BMLs including:\n\n   1. Subchondroplasty in the involved knee.\n   2. Intraosseous and\u002For intra-articular injection of orthobiologics in the past 6 months, such as platelet rich plasma (PRP), bone marrow aspirate concentrates, micro-fragmented adipose tissue (MFAT) or stromal vascular fraction.\n7. Prior use of bisphosphonates, except according to the washout schedule:\n\n   1. 2 years (if use \\> 48 weeks).\n   2. 1 year (if used \\> 8 weeks but \\\u003C 48 weeks)\n   3. 6 months (if used \\> 2 weeks but \\\u003C 8 weeks)\n   4. 2 months (if used \\\u003C 2 weeks)\n   5. Any intravenous bisphosphonate within the prior 2 years.\n8. Intra-articular steroid injection in the prior 3 months.\n9. Previous knee surgery in the past 6 months.\n10. Tumors\n11. Infection or fracture on ipsilateral lower limb.\n12. Pregnancy.\n13. Contraindications to f-ESWT, such as severe coagulopathy, malignant tumor in the treatment area.\n14. Contraindications to MRI scanning including:\n\n    * Presence of metal implants such as implanted pacemaker, metal sutures, metallic protheses (including metal pins and rods, heart valves), presence of shrapnel or iron filings in the eye, magnetic dental implants, cochlear implants, cerebral aneurysm clip, and deep brain stimulator.\n    * Claustrophobia.\n    * The patient has been informed by his\u002Fher doctor that it is medically unsafe to receive regular MRI as part of his\u002Fher medical care.","30 Years",{"count":22,"type":23},[26],"Subchondral bone marrow lesions (BMLs) in knee osteoarthritis (OA) are strongly associated with presence and severity of knee pain, structural deterioration, disease progression with an increased risk of total knee arthroplasty. OA-related BMLs may regress or resolve within 30 months which could be associated with long lasting disability. It has been reported that BMLs persist in the majority of knee OA patients. Different treatment strategies have been proposed including rest and protected weight-bearing, bisphosphonates, subchondroplasty and intraosseous orthobiologic injection. However, conservative treatment response takes a long time and other interventions may be considered invasive procedures that show varying results with several side effects. Focused extracorporeal shockwave therapy (f-ESWT) has been established as a safe non-invasive treatment with positive results in different bone disorders that share the same pathological features of BMLs. This is an exploratory, randomized-controlled, pilot study to determine the efficacy and safety of f-ESWT compared to the standard-of-care (analgesics and protected weight bearing) for the treatment of BMLs in patients with knee OA. Thirty subjects with knee OA who have history of knee pain at rest and during walking with the confirmed diagnosis of subchondral BML(s) on magnetic resonance imaging (MRI) despite at least 4 weeks of conservative treatment will be enrolled into this study. Subjects will receive a total of 4 sessions (at high energy level) over 4 consecutive weeks. Participants will be evaluated for adverse events and changes in pain intensity and knee function, using an 11-point numerical rating scale (NRS; 0-10, with anchors \"no pain\" and \"pain as bad as you can imagine\") and; the Knee injury and Osteoarthritis Outcome Score, respectively. Subjects will be assessed with these outcome measures at baseline, 1 month, 2 months, 3 months, and 6 months after the treatment. MRI of the involved knee will be performed prior to treatment (baseline) and 3 months and 6 months after treatment.",[177,178,179],"Bone Marrow Edema","Knee Osteoarthritis","Knee Pain Chronic",[158],"2026-03-23",{"date":135,"type":51},{"date":184,"type":51},"2022-10-13",{"date":186,"type":23},"2027-12",{"name":57,"class":58},2,{"id":190,"slug":191,"hasResults":12,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":24,"phases":198,"briefSummary":199,"conditions":200,"keywords":203,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":59},"100293157","exoskeleton-and-spinal-cord-stimulation-for-sci-100293157","NCT03096197","Exoskeleton and Spinal Cord Stimulation for SCI","Inclusion Criteria:\n\nIn order to be eligible to participate in this study a participant must:\n\n* be a non-walker with an SCI greater than 6 years post injury;\n* have a lower extremity motor score greater or equal to 16 as measured by the International Standards for Neurological Classification of SCI exam;\n* be between the ages of 18-65 years old;\n* have a spinal cord injury at a neurological level of injury as determined by study staff between C5-T-10;\n* be wheelchair reliant 100% of the time;\n* have knee bone mineral density great than .5755gm\u002Fcm2 as determined by study staff;\n\nExclusion Criteria:\n\n* have a history of broken or fractured bones.\n* have a history of bone trauma or bone disease.","65 Years",{"count":197,"type":23},24,[26],"The overall aim of this project is to assess the effect of combining transcutaneous lumbosacral stimulation (TLS) during Exoskeleton Assisted Walking (EAW) compared to EAW alone without stimulation on walking recovery.",[156,201,202],"Ambulation Difficulty","Muscle Spasticity",[204,205,206],"Spinal Cord injury (SCI)","Transcutaneous lumbosacral stimulation (TLS)","Exoskeleton-Assisted Walking (EAW)","2026-01-12",{"date":209,"type":51},"2026-01-14",{"date":211,"type":51},"2017-03-30",{"date":213,"type":23},"2029-09",{"name":57,"class":58},{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":102,"enrollmentInfo":221,"targetDuration":4,"studyType":24,"phases":223,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":59},"100542943","the-utilization-effects-of-powered-wearable-orthotics-in-improving-upper-extremity-function-and-adl-in-persons-with-sci-100542943","NCT06349434","The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI","Inclusion Criteria:\n\n* Be between ages 18-80\n* Be able to activate certain muscles in my arm and forearm on my own a sufficient amount as measured by EMG amplitude. This will be determined by the study OT\u002FPT.\n* Be diagnosed with spinal cord injury (SCI) with level C1-C8 and ASIA Impairment Scale (AIS) C or D, as determined by study staff. If I have not had an exam to determine my injury level and impairment scale recently, I may participate in an examination of my sensation and strength in my arms, legs, trunk and rectum as was done in the hospital soon after my injury.\n* Be at least 1-year post injury\n* Have sufficient ability to move my shoulder (active shoulder flexion of 30 degrees and active shoulder abduction 20 degrees), as determined by study staff\n* Be medically stable\n* Have sufficient learning and memory abilities and abilities to communicate in English to be able to participate and follow directions during my rehabilitation\n* Continue to take all prescribed medication (e.g., oral or via pump baclofen) without any dosing changes\n* Be able to tolerate functional tasks for 60 minutes with periodic rests without excessive fatigue\n* Have minimal strength in the muscles that bend and straighten my elbow, as determined by study staff\n* Have full range of motion in my elbow when it is moved by the study therapist\n\nExclusion Criteria:\n\n* Be younger than 18 years old or older than 80\n* Have excessive pain in my arm, wrist, or hand that limits providing rehabilitation\n* Have excessive spasticity in my elbow or wrist, as determined by study staff\n* Be participating in any experimental rehabilitation or drug studies\n* Have history of nervous system disorder other than SCI\n* Have difficulty following multiple step directions\n* Have severe cognitive or psychiatric problems might be contraindications to start training.\n* Have skin issues or severe sensory deficits that would prevent wearing the Myo-Pro device safely\n* Be pregnant\n* Have other conditions or circumstances that, in the opinion of the investigators, would affect the safety or effectiveness of the training in which I would participate",{"count":222,"type":23},60,[26],"To evaluate the usefulness of an upper extremity assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury. The Department of Defense is supporting this study.",[226,227,228],"SCI - Spinal Cord Injury","Upper Extremity Dysfunction","Upper Extremity Problem","2025-11-19",{"date":231,"type":51},"2025-11-24",{"date":233,"type":51},"2023-10-15",{"date":235,"type":23},"2028-10-01",{"name":57,"class":58},{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":243,"targetDuration":4,"studyType":24,"phases":244,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":251,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":59},"100428191","investigating-the-effects-of-wearable-robotic-exoskeleton-for-improving-mobility-and-cognition-in-persons-with-ms-100428191","NCT04855825","Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS","Inclusion Criteria:\n\n* Be diagnosed with multiple sclerosis.\n* Be determined by the study staff to have moderate to severe difficulty walking but still be able to walk while using the robotic exoskeleton.\n* Have some difficulty thinking and problem solving as determined by my performance on a special test that I will take during the screening visit.\n* Be between the ages of 18 and 75.\n* Be free from flair ups of my MS Symptoms for at least one month prior to testing.\n* Discuss with study staff how to maintain a constant level of my spasticity medication (for example baclofen) throughout the study.\n* Be able to walk (with the use of one or more assistive device if needed).\n* Have English as my primary language.\n* Be able to physically fit into the exoskeleton device: height between 60 and 76\", weight under 220 lbs.\n* Be able to tolerate upright standing for 30 minutes with assistance if needed.\n* Have normal joint range of motion for walking as determined by study staff.\n* Have sufficient strength to use the hemiwalker, bilateral canes or walker while wearing the RE.\n* Have stable blood pressure.\n* Be willing and able to give informed consent.\n* Be able and willing to comply with study procedures and follow directions and commands, verbal instructions, and follow-up requirements.\n\nExclusion Criteria:\n\n* Have a history of head injury, stroke, seizures, or any other significant neurological history other than MS.\n* Have a high degree of difficulty in thinking and problem solving that prevents me from participating in the study as determined by my performance on a special test taken during the screening visit.\n* Be currently taking steroids, benzodiazepines, antipsychotics, and\u002For neuroleptics as determined by study staff review of my medications.\n* Be pregnant.\n* Be completely reliant on a wheelchair.\n* Have joint contracture or spasticity of any limb that limits normal range of motion during walking with assistive devices as determined by study staff.\n* Have skin issues that would prevent wearing the RE.\n* Have pressure sore stage 2 or higher located in an area that would negatively affect weight bearing, harness fit, or therapist assistance.\n* Have orthopedic issues or history that will interfere with walking or limit the range of motion of the lower limbs (e.g., knee replacement, inflammation)\n* Have been hospitalized for heart attack, heart surgery or acute heart failure within 3 months of enrollment in study.\n* Have any other medical conditions that my doctor or physical therapist feels would affect my ability to use the robotic device.\n* Have a pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids \\[cochlear implants\\]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments.\n* Have dental implants- I should discuss any dental implants with the investigators.\n* Have been told by my doctor that it is unsafe for me to have a regular MRI as part of my medical care.",{"count":69,"type":23},[26],"The purpose of this research study is to evaluate the usefulness of a wearable robotic exoskeleton device (Ekso-GT), to improve learning and memory, and gait therapy in persons with walking disability due to Multiple Sclerosis. The study will evaluate the mobility, learning and memory, and walking abilities of individuals with multiple sclerosis who went through the traditional as compared to others who used the robotic exoskeleton as part of their therapy.",[247,248,249,250],"Multiple Sclerosis","Gait Disorders, Neurologic","Motility Disorder","Cognitive Impairment",{"date":231,"type":51},{"date":253,"type":51},"2017-10-05",{"date":255,"type":23},"2027-12-30",{"name":57,"class":58},{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":195,"enrollmentInfo":263,"targetDuration":4,"studyType":24,"phases":265,"briefSummary":266,"conditions":267,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":59},"100605931","evaluation-and-refinement-of-kf-stride-into-the-interview-100605931","NCT07168941","Evaluation and Refinement of KF-STRIDE Into the Interview!","Inclusion Criteria:\n\n* You live in the United States of America\n* You speak English Fluently and at a 4th grade reading level\n\nExclusion Criteria:\n\n* You have a history of significant psychiatric illness (like bipolar disorder, schizophrenia, or psychosis)\n* You have a history of substance abuse",{"count":264,"type":23},30,[26],"Examine the acceptability, usability, feasibility, and initial efficacy of KF-STRIDE 3.0, the data from which will serve as a basis for a future fully powered RCT",[268],"Autism Spectrum Disorder","2025-09-04",{"date":271,"type":51},"2025-09-11",{"date":273,"type":23},"2025-10-01",{"date":275,"type":23},"2026-10-01",{"name":57,"class":58},{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":283,"eligibilityCriteria":284,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":285,"targetDuration":4,"studyType":24,"phases":286,"briefSummary":287,"conditions":288,"keywords":291,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":59},"100495499","spinal-cord-transcutaneous-stimulation-effect-on-blood-pressure-in-acute-spinal-cord-injury-sci-100495499","NCT05731986","Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)","Neuromodulation of Blood Pressure Using Transcutaneous Spinal Stimulation in Individuals With an Acute Spinal Cord Injury - A Safety, Feasibility and Efficacy Study","SCI","Inclusion Criteria:\n\n* 7-30 days after injury\n* Injury level ≥T2 (thoracic level)\n* American Spinal Injury Association Impairment Scale (AIS) A-C\n* Exhibits at least one of the following hypotensive symptoms:\n\n  1. Baseline hypotension - resting supine or seated SBP \\\u003C 90mmHg;\n  2. SBP drop ≥ 20 mmHg within 5 minutes of assuming seated position;\n  3. Symptoms of orthostasis with a drop of SBP (\\\u003C90mmHg) from supine to sitting.\n\nExclusion Criteria:\n\n* Current illness (e.g., a recent diagnosis of a deep vein thrombosis (DVT) or pulmonary embolism (PE), a pressure injury that might interfere with the intervention, etc.) or infection\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* Initiated on new cardiac medications within the past 5 days\n* Insufficient mental capacity to understand and independently provide consent\n* Pregnancy\n* Cancer\n* Deemed unsuitable by study physician",{"count":151,"type":23},[26],"The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury). Blood pressure instability, specifically orthostatic hypotension (a drop in blood pressure when moving lying flat on your back to an upright position), appears early after the injury and often significantly interferes with participation in the critical rehabilitation time period.\n\nThe main questions it aims to answer are:\n\n1. Can optimal spinal stimulation increase blood pressure and resolve orthostatic symptoms (such as dizziness and nausea) when individuals undergo an orthostatic provocation (a sit-up test)? Optimal stimulation and sham stimulation (which is similar to a placebo treatment) will be compared.\n2. What are the various spinal sites and stimulation parameters that can be used to increase and stabilize blood pressure to the normal range of 110-120 mmHg?\n\nParticipants will undergo orthostatic tests (lying on a bed that starts out flat and then moved into an upright seated position by raising the head of bed by 90° and dropping the base of the bed by 90° from the knee) with optimal and sham stimulation, and their blood pressure measurements will be evaluated and compared.",[73,76,78,80,289,74,75,77,290,81],"Central Nervous System Diseases","Acute Spinal Cord Injury",[34,292,75,81,293,294,74,295],"Spinal stimulation","Neuromodulation","Acute spinal cord injury","Acute inpatient rehabilitation","2025-08-29",{"date":298,"type":51},"2025-09-02",{"date":300,"type":51},"2023-12-01",{"date":302,"type":23},"2026-08",{"name":57,"class":58},{"id":305,"slug":306,"hasResults":12,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":283,"eligibilityCriteria":310,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":311,"targetDuration":4,"studyType":24,"phases":313,"briefSummary":314,"conditions":315,"keywords":316,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":318,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":59},"100495001","the-effect-of-transcutaneous-stimulation-on-blood-pressure-in-spinal-cord-injury-sci-100495001","NCT05725499","The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)","Neuromodulation of Blood Pressure Using Transcutaneous Spinal Stimulation in Chronic Spinal Cord Injury","Inclusion Criteria:\n\n* Spinal cord injury for greater than or equal to 6 months\n* Injury level ≥ T6 (thoracic level)\n* American Spinal Injury Association (ASIA) Impairment Scale (AIS) A-D\n* Exhibits at least one of the following hypotensive symptoms:\n\n  1. Baseline hypotension - resting supine or seated systolic blood pressure(SBP) \\\u003C 90mmHg;\n  2. SBP drop ≥ 20 mmHg within 5 minutes of assuming seated position;\n  3. Symptoms of orthostasis with a drop of SBP (\\\u003C90mmHg) from supine to sitting\n\nExclusion Criteria:\n\n* Current illness (infection, a pressure injury that might interfere with the intervention, a recent diagnosis of DVT\u002FPE, etc.)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* Insufficient mental capacity to understand and independently provide consent\n* Pregnancy\n* Cancer\n* Deemed unsuitable by study physician",{"count":312,"type":23},5,[26],"This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back to an upright position).\n\nThe main questions it aims to answer are:\n\n1. What are the various spinal sites and stimulation parameters that normalize and stabilize blood pressure during an orthostatic provocation (70 degrees tilt)?\n2. Does training, i.e., exposure to repeated stimulation sessions, have an effect on blood pressure stability?\n\nParticipants will undergo orthostatic tests (lying on a table that starts out flat, then tilts upward up to 70 degrees), with and without stimulation, and changes in their blood pressure will be evaluated.",[73,74,75,76,77,78,289,80,81],[34,317,75,81,293],"Spinal Stimulation",{"date":298,"type":51},{"date":320,"type":51},"2023-02-01",{"date":322,"type":23},"2026-08-01",{"name":57,"class":58},{"id":325,"slug":326,"hasResults":12,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":4,"eligibilityCriteria":330,"healthyVolunteers":17,"sex":18,"minAge":331,"maxAge":102,"enrollmentInfo":332,"targetDuration":4,"studyType":24,"phases":334,"briefSummary":336,"conditions":337,"keywords":339,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":59},"100605175","early-phase-1-tdcs-for-cancer-related-fatigue-and-weakness-100605175","NCT07159100","tDCS for Cancer-Related Fatigue and Weakness","Neuromodulation as a Therapeutic Intervention to Improve Cancer Related Fatigue and Weakness","General Inclusion - All participants\n\n1. Aged 40-80\n2. Right Handed, as determined by the Edinburgh Inventory 21\n3. Proficient in English\n4. Must be available for the familiarization, and testing sessions\n\nGeneral Inclusion - Cancer Patients only\n\n1. Cancer (\\>6 months post therapy)\n2. Suffers from a subjective feeling of cancer related fatigue and weakness as assessed by the following question: \"Do you suffer from symptoms of fatigue and weakness related to your cancer or cancer treatment?\"\n3. Have had cancer diagnosis and treatment in the past\n4. Must have a stable physical\u002Fhealth condition for the past 3 months with no expected changes for the duration of the study\n\nGeneral Exclusion - All participants\n\n1. Neurological, psychiatric, musculoskeletal or other types of disorder not caused by cancer and\u002For cancer treatment, which may affect participants sensorimotor function and cognitive abilities\n2. No consciousness to understand and sign informed consent voluntarily\n3. History of alcohol, and illicit drug use\n4. History of smoking within the last 5 years.\n\nGeneral Exclusion - Cancer Patients 1. Radiation, surgery, chemo, or other cancer treatment therapies in the past 6 months prior to enrollment. Hormonal maintenance treatment is allowed.\n\nGeneral Exclusion - Healthy Participants\n\n1\\. History of cancer or cancer treatment\n\nExclusion criteria related to tDCS and TMS safety - All participants\n\n1. History of epilepsy or unprovoked seizures\n2. Family history of epilepsy (father, mother, children, siblings with diagnosis of epilepsy)\n3. Active migraine headaches\n4. Past or current history of treated tinnitus or severe hearing problems\n5. Implanted medical devices (pacemakers, defibrillators, medical pump, implanted brain stimulator, aneurysm clip, carotid or cerebral stents, central venous catheter, non-removable hearing aids)\n6. Damage to the skin on the scalp\n7. History of mental illness (schizophrenia, anxiety, major depression, manic disorders)\n8. Tattoo with metal based ink in the head or neck\n9. Currently taking or withdrawing from any central nervous system active medication (stimulants, anticonvulsants, antidepressants, psychotropic medications).\n10. Pregnant as determined by a Pregnancy test for non-menopausal (no menstruation for at least 1 year) women younger than 55 years (for TMS and fMRI only).\n\nExclusion criteria related to MRI safety - All participants\n\nWe will be using the Kessler Foundation RONIC MRI center screening form to screen participants for the MRI scan. Exclusion criteria includes:\n\n1. Suffer from claustrophobia (fear of confined spaces)\n2. Prior injury to the eye involving a metallic object or fragment (e.g., metallic slivers, shavings, foreign body, etc.)?\n3. Presence or prior injury by a metallic object, or foreign body or metallic fragment (e.g., BB, bullet, shrapnel, etc.)\n4. Currently or former metal worker (welder, machinist, etc.)\n5. Implanted electrical devices (e.g. pacemakers, defibrillators or ICD)\n6. Implanted stimulators or internal electrodes or wires (neurostimulator, brain stimulator, spinal cord, bone growth\u002Fbone fusion)\n7. Aneurysm clips (metal clips on the wall of a large artery), metallic stent, shunt (spinal)\n8. Metallic prostheses or implants (including metal pins and rods, plate, screw, surgical staples, clips or metallic sutures, joint replacement (hip, knee), cochlear or other otologic implant, eye, penile, heart valves, eyelid spring or wires, prosthetic limbs)\n9. Dental implants, dentures or partial plates (regular filling, amalgam and crown are OK)\n10. Insulin, medication or other infusion pumps\n11. Radiation seeds or implants\n12. Transdermal medication patch (Nitroglycerine, Nicotine)\n13. IUD, diaphragm or pessary\n14. Tissue expander (e.g. breast)\n15. Body tattoos or permanent makeup (eyeliner, lip) if deemed unsafe in the MRI\n16. Body piercing","40 Years",{"count":333,"type":23},75,[335],"EARLY_PHASE1","This pilot study investigates the effectiveness of non-invasive brain stimulation (tDCS) in alleviating cancer-related fatigue (CRF) and muscle weakness. Using a randomized, double-blind crossover design, participants perform fatiguing muscle tasks with and without tDCS, and outcomes include task endurance, maximal voluntary contraction force, and neuromuscular markers. Neural mechanisms will be assessed via EEG, TMS, and MRI.",[338,293],"Cancer-related Fatigue",[340,341,39],"tDCS","Cancer-related fatigue","2025-08-28",{"date":344,"type":51},"2025-09-08",{"date":346,"type":23},"2025-09-10",{"date":348,"type":23},"2027-12-31",{"name":57,"class":58},{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":195,"enrollmentInfo":358,"targetDuration":4,"studyType":24,"phases":359,"briefSummary":360,"conditions":361,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":59},"100494274","phase-1-combinatory-rehabilitation-used-for-substantially-helping-individuals-with-traumatic-brain-injury-100494274","NCT05716048","Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury","Randomized Controlled Trial of Combined Cognitive Rehabilitation and Exercise Training for Learning and Memory in Persons With Moderate to Severe Traumatic Brain Injury","CRUSH-IT","Inclusion Criteria:\n\n* Age between 18-65 to control for age related brain changes\n* Diagnosis of moderate-to-severe TBI based on TBIMS criteria at least one year prior to enrollment\n* Having no to low substance use \u002F involvement (drug\u002Falcohol) as documented via ASSIST\n* Being insufficiently physically active based on a Godin Leisure-Time Exercise Questionnaire Health Contribution Score of \\\u003C14\n* Having a proficiency in the English language\n* Being right handed to control for brain organization\n* Having chronic medical conditions (e.g. diabetes) in addition to TBI will require approval to participate from a physician, consistent with PAR-Q+.\n* Having an in-tact ability to follow directions based on the Telephone Interview for Cognitive Status (TICS-M) (i.e., TICS-M scores of ≥18)\n* Demonstrating new learning and memory impairment based on Open-Trial Selective Reminding Task (OT-SRT) scores at least 1.5 standard deviations below healthy controls (8+ trials to reach criterion)\n\nExclusion Criteria:\n\n* Regularly taking steroids \\& benzodiazapines to control for medications effects\n* Having a history of neurological disorders beyond TBI\n* Having a history of severe mental illness (e.g., schizophrenia, bipolar, severe major depression)\n* Having metal in the body, claustrophobia, and other risk factors that would make MRI scanning unsafe.\n* Having moderate or high risk for exercise training contraindications (e.g. diabetes), defined as ≥1 YES on pages 2-3 of the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+)\n* Having significantly impaired vision by scotomas (corrected vision in worse eye worse than 20\u002F60), diplopia, or nystagmus.",{"count":222,"type":23},[153],"New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g. story) as well as beneficial changes in default-mode network (DMN) activation during list-learning19 following treatment with the Kessler Foundation modified Story Memory Technique® (KF-mSMT®). Benefits, however, were moderate and did not yield downstream improvements in daily life. It is thus critical to examine other approaches to complement the KF-mSMT® for robustly managing NLMI in TBI. The proposed RCT will be the first to include aerobic exercise training (AET) as a highly-promising complement to the KF-mSMT® for robustly managing NLMI, examining impact on NLM, its neural correlates, and daily life in NLM impaired persons with moderate-to-severe TBI. We thus propose a two-arm, parallel group, double-blind RCT comparing the effects of the KF-mSMT+AET with the KF-mSMT+S\u002FT (active control condition) on NLM (Aim 1), hippocampal MRI (Aim 2), and daily life outcomes (Aim 3). 60 NLM impaired persons with moderate-to-severe TBI will be randomized to one of 2 conditions (30 per condition). Each condition will take place 3 days per week for 12 weeks and will be supervised by KF personnel. Participants will be blinded as to the intent of the conditions. We will further explore baseline predictors of clinically meaningful changes in NLM for those completing the KF-mSMT + AET condition (Exploratory Aim 4). If successful, this trial will position combinatory KF-mSMT and AET within the clinician's arsenal for robustly managing NLMI in persons with TBI. By augmenting the effects of KF-mSMT with AET, this treatment aims to exert a powerful countermeasure to TBI-related NLMI, and ultimately help those with TBI-related NLMI return to the workforce, independently manage their everyday lives, and maintain optimal quality of life. Additionally, while rigorously designed to answer the scientific question of the relative benefit of AET with the KF-mSMT, the proposed study is will likely provide some level of benefit to all study participants.\n\nIf successful, this trial will provide Class I evidence of combined KF-mSMT and AET for rehabilitating NLMI in TBI, based on standards published for therapeutic trials by the American Academy of Neurology, thus positioning such an approach within the clinician's arsenal for robustly managing NLMI. By augmenting the effects of KF-mSMT with AET, we anticipate this treatment will ultimately help those with TBI-related NLMI return to the workforce, independently manage their everyday lives, and maintain optimal quality of life.",[362],"Traumatic Brain Injury","2025-08-27",{"date":269,"type":51},{"date":366,"type":51},"2023-04-21",{"date":368,"type":23},"2028-02-28",{"name":57,"class":58},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":376,"eligibilityCriteria":377,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":195,"enrollmentInfo":378,"targetDuration":4,"studyType":24,"phases":379,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":188},"100584193","spinal-stimulation-and-gait-training-to-improve-mobility-in-tbi-100584193","NCT06886152","Spinal Stimulation and Gait Training to Improve Mobility in TBI","Transcutaneous Spinal Stimulation and Gait Training to Improve Mobility and Motor Control in Individuals With Traumatic Brain Injury","DOD SS","Inclusion Criteria:\n\n* Have weakness on at least one side of my body.\n* No injury to my unaffected side in 6 months.\n* Be cleared by a physician to participate in this study.\n* Have had a non-penetrating TBI at least 2 years ago. A non-penetrating injury is an injury where my skull remained closed and no object entered it.\n* Have enough strength to use a hemiwalker or walker.\n* Be between 18-65 years of age.\n* Be medically stable for at least 6 months before enrolling. This means that I have not had an emergency room visit, hospitalization, or medical procedure (such as a surgery) during this period of time.\n* Able to walk 10 yards with minimal assistance without an ankle-foot orthosis (brace)\n* Able to respond to and tolerate surface stimulation, as determined by study staff\n* Have the ability to communicate in English.\n* Have stable blood pressure.\n* Be willing and able to give informed consent.\n* Be able and willing to comply with study procedures, verbal instructions, and follow-up requirements.\n\nExclusion Criteria:\n\n* Have must have not had physical or occupational therapy or treatment for a balance disorder within 30 days prior to study enrollment. I must not participate in physical or occupation therapy throughout the duration of the study to avoid affecting the study results.\n* Have any medical issues that affect my unaffected side (such arthritis, fracture, etc.).\n* Have skin issues that would prevent me from being able to use the surface stimulation (such as a open wound or rash).\n* Have a pre-existing condition that may make it difficult for me to participate in exercise. (uncontrolled hypertension as described by a physician, heart disease, abnormal heart rate or rhythm, or congestive heart failure).\n* Have been hospitalized for heart attack, heart surgery or acute heart failure within 3 months of enrollment in study.\n* Have an implanted medical or metallic device.\n* Reduced sensation in my lower limbs and stimulation locations.\n* Have Botox injections in my legs up to 3 months prior to enrolling.\n* Have physical therapy for walking.\n* Have uncontrolled seizure disorder (such as epilepsy)\n* Have nervous system-related issues (for example Parkinson's disease, multiple sclerosis).\n* Major changes to my medications throughout the study\n* Have bone or muscle issues unrelated to traumatic brain injury that interfere with my walking or limit my range of motion in my legs.\n* Be currently pregnant. Because of potential risk to the fetus, women of child bearing potential will be required to have a pregnancy test before they can enroll in this study. If I am female, and have a positive pregnancy test, I will not be enrolled.\n* Have any other medical conditions that my doctor or physical therapist feels would affect my ability to use the stimulation or participate in walking training TMS Specific - Exclusion (those with these exclusions can still participate in other parts of the study)\n* I have a history of seizure disorder or have a close family member (parent, brother, sister, or child) who has a seizure disorder.\n* I have had unexplained fainting spells.\n* I have had an active migraine headaches.\n* I have a past or current history of ringing in the ears (tinnitus) or severe hearing problems.\n* I am currently taking or withdrawing from any medication that would increase my risk of seizure (determination made in consultation with study physician).\n* I have a history of alcohol or drug abuse in the prior 3 years.\n* I have nerve damage outside of my brain or spinal cord (such as in an arm or leg).\n* I am unwilling to participate in TMS.",{"count":264,"type":23},[26],"The purpose of this research study is to assess the effects of receiving transcutaneous spinal stimulation while performing walking exercises compared to completing walking exercises without spinal stimulation for individuals with hemiplegic TBI.",[362,382,383],"Traumatic Brain Injury (TBI)","Hemiplegia and Hemiparesis","2025-08-25",{"date":298,"type":51},{"date":387,"type":23},"2025-09-01",{"date":389,"type":23},"2028-09-01",{"name":57,"class":58},{"id":392,"slug":393,"hasResults":12,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":102,"enrollmentInfo":398,"targetDuration":4,"studyType":24,"phases":400,"briefSummary":401,"conditions":402,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":59},"100587046","improving-walking-after-a-lower-limb-injury-using-a-custom-motorized-orthosis-100587046","NCT06923293","Improving Walking After a Lower Limb Injury Using a Custom Motorized Orthosis","Individualizing Powered Orthotic Intervention for Improved Gait Outcomes Using ML-enabled Methods","Inclusion Criteria:\n\n* Have a lower limb injury greater than a year ago.\n* Be 18-80 years old.\n* Be able to stand for 30 minutes.\n* Have enough range of motion in my ankle to comfortably wear the AFO.\n* Be able to follow directions and commands.\n* Be willing and able to give informed consent.\n* Be able and willing to comply with study procedures, verbal instructions, and follow-up requirements.\n\nExclusion Criteria:\n\n* Have any joint or muscle tightness that would limit my movement while walking with the AFO.\n* Have any medical issue that prevents me from supporting my weight and walking (e.g. orthopedic injuries, pain, severe spasticity).\n* Have any medical issues that affect my unaffected side.\n* Have skin issues that would prevent wearing the device.\n* Have a pre-existing condition that caused exercise intolerance. (Documented uncontrolled hypertension, coronary artery disease, abnormal heart rate or rhythm, or congestive heart failure).\n* Have been hospitalized for heart attack, heart surgery or acute heart failure within 3 months of enrollment in study.\n* Have nervous system issues that affect my movement (for example Parkinson's disease, multiple sclerosis).\n* Have additional orthopedic issues that interfere with my walking or limit my range of motion in my legs.\n* Have any other medical conditions that my doctor or physical therapist feels would affect my ability to use the device.",{"count":399,"type":23},19,[26],"The purpose of this research study is to assess the ease, convenience, and efficacy of walking when using a motor powered ankle foot orthosis (AFO) brace, in adults who have had a lower limb injury.",[403],"Lower Limb Injury",{"date":405,"type":51},"2025-08-26",{"date":407,"type":51},"2025-06-01",{"date":409,"type":23},"2027-06-01",{"name":57,"class":58},{"id":412,"slug":413,"hasResults":12,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":417,"eligibilityCriteria":418,"healthyVolunteers":12,"sex":18,"minAge":419,"maxAge":102,"enrollmentInfo":420,"targetDuration":4,"studyType":24,"phases":422,"briefSummary":423,"conditions":424,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":426,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":59},"100572661","post-stroke-ambulation-recovery-using-robotic-exoskeletons-100572661","NCT06736171","Post Stroke Ambulation Recovery Using Robotic Exoskeletons","Prescription of Robotic Exoskeletons for Ambulation Recovery Post Stroke","RERC","Inclusion Criteria:\n\n* Stroke survivors 3 - 8 months from a recent stroke.\n* Age: 50 - 80 years\n* Unilateral hemiparesis\n* Medical clearance by the Medical Director\n* Be able to physically fit into the exoskeleton device: Height between 60\\" and 76\\" and weight below 220 lbs\n* Patient cognitive status and ability to communicate in English must be at a level consistent with that required to participate in standard motor rehabilitation (e.g. can follow directions).\n* Adequate cognitive function to give informed consent, understand the training, instructions, use investigational devices and give adequate feedback.\n* Have a joint range of motion within normal functional limits for ambulation.\n* Have sufficient strength to use the hemiwalker, cane or walker (etc. assistive device) while wearing the RE.\n* No history of injury or pathology to the unaffected limb.\n* Have an appropriate walking speed as determined by the study staff.\n\nExclusion Criteria:\n\n* Any medical issue that precludes full weight-bearing and ambulation (e.g. orthopedic injuries, pain, severe spasticity).\n* Skin issues that would prevent wearing the device.\n* Pre-existing condition that caused exercise intolerance (documented uncontrolled hypertension, coronary artery disease, cardiac arrhythmia, or congestive heart failure).\n* Hospitalization for heart attack, heart surgery, or acute heart failure within 3 months of enrollment in the study.\n* Uncontrolled seizure disorder, spasticity, or joint contracture that would interfere with walking.\n* Neuromuscular, neurological, or orthopedic pathologies that interfere with neuromuscular function, ambulation, or limit the range of motion of the lower limbs.","50 Years",{"count":421,"type":23},96,[26],"The purpose of this research study is to evaluate and compare different robotic exoskeletons (RE) and identify which is most appropriate for gait training for each patient based off their specific needs. This will help guide clinicians in prescribing the appropriate RE for rehabilitation.",[425],"Hemiparesis After Stroke",{"date":298,"type":51},{"date":428,"type":51},"2025-05-15",{"date":430,"type":23},"2030-06",{"name":57,"class":58},{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":436,"acronym":437,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":439,"enrollmentInfo":440,"targetDuration":4,"studyType":24,"phases":442,"briefSummary":443,"conditions":444,"keywords":445,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":450,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":59},"100531275","a-novel-combinatory-approach-to-maximize-functional-recovery-of-learning-and-memory-in-multiple-sclerosis-100531275","NCT06197685","A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis","COMBINE","Inclusion Criteria:\n\n* Be within the ages of 18 and 70 years of age\n* Speak English as their primary language\n* Confirmed MS diagnosis by a neurologist\n* Be relapse and steroid-free for at least 30 days\n* Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS)\n* Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ)\n* Right handedness\n\nExclusion Criteria:\n\n* History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)\n* Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)\n* Currently use medications that may impact cognition (ex: steroids, benzodiazepines)\n* Currently pregnant\n* Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe)\n* Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)","70 Years",{"count":441,"type":23},78,[26],"The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.",[247],[247,446,447,448,449],"Aerobic exercise","Virtual Reality","Leg cycling","Mobility disability",{"date":298,"type":51},{"date":452,"type":51},"2024-02-12",{"date":454,"type":23},"2026-06-30",{"name":57,"class":58},{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":419,"enrollmentInfo":462,"targetDuration":4,"studyType":463,"phases":4,"briefSummary":464,"conditions":465,"keywords":466,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":470,"completionDateStruct":471,"leadSponsor":473,"locationsCount":4},"100598578","using-muscle-functional-mri-to-study-spatial-muscle-activation-patterns-in-people-with-sci-100598578","NCT07073313","Using Muscle Functional MRI to Study Spatial Muscle Activation Patterns in People With SCI","Inclusion Criteria:\n\nSCI group Inclusion criteria\n\n* Age: 18-50 yrs\n* BMI \\\u003C35 kg\u002Fm2\n* Chronic injury (at least 1 year post injury)\n* Neurological injury status: Incomplete motor and sensory SCI classified with ASIA Impairment Scale C or D\n* Ambulatory status: Participants must be nonambulatory. Individuals who can stand or walk even a few steps with or without assistance will not be eligible to participate\n* Ability to flex and extend at least one knee joint under volitional control:\n\n  * without stimulation or assistance\n  * full range of motion not required\n  * ability to move against gravity not required Able bodied group Inclusion criteria\n* Age: 18-50 yrs\n* BMI \\\u003C35 kg\u002Fm2\n\nExclusion Criteria:\n\n\\-",{"count":69,"type":23},"OBSERVATIONAL","Several types of treatment and therapy have been shown to promote improvements in movement and other health gains in people with spinal cord injury (SCI). Researchers use many different methods to measure these gains- for instance they measure their ability to stand and walk and use scanning technologies to measure bone loss and recovery. They also often use a technique known as electromyography (EMG), which detects electrical signals coming from muscles, to measure how well the muscles are being activated. While EMG has many advantages, it also has some important limitations. For instance, it is difficult to gather information from muscles below the surface, and the results can change significantly if the sensing electrodes are moved only slightly, making it harder to measure differences across different testing sessions. In this project, the investigators will use another technique to study muscle activations in people with SCI. This technique, known as muscle functional MRI (mfMRI), uses MRI scanning to measure the activation of muscles. One of the signals that MRI imaging uses has been found to change with exercise; this change is understood to be related to a buildup of chemicals in the water inside the muscle. MRI scanning has many variable settings, or parameters, that can be changed to pick up specific signals, and our team has developed a set of settings (also known as an MRI sequence) that is specially adapted to measure the mfMRI signal. Although other groups have used mfMRI to study muscle activation in other groups of people and other activities, the investigators do not believe there have been any previous studies in people with SCI. Participants in our study will lie on their back with their knee raised on a bolster and raise the lower part of their leg to straighten the knee, for several repetitions. They will do this in a room outside the MRI scanner, on a table that can be attached to the scanner for imaging. After they finish exercising, they will be moved into the MRI scan room for mfMRI scanning of the muscles of the thigh. The four muscles of the quadriceps that straighten the knee will be studied, with specialized data processing used to measure the overall activation of each of the muscles. The investigators will compare mfMRI values between people with SCI and a control group of able bodied people. These people will have motor incomplete SCI, meaning that they still have some ability to move their body in regions below the injury. By completing this study the investigators will provide new information on spatial muscle activation patterns, and they expect that this will lead the way to more widespread application of the technique in the future.",[156],[156,467],"muscle functional MRI","2025-08-19",{"date":405,"type":51},{"date":387,"type":23},{"date":472,"type":23},"2026-09-01",{"name":57,"class":58},{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":12,"sex":18,"minAge":480,"maxAge":4,"enrollmentInfo":481,"targetDuration":4,"studyType":24,"phases":482,"briefSummary":483,"conditions":484,"keywords":486,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":59},"100602734","treating-new-learning-and-memory-deficits-following-stroke-100602734","NCT07127367","Treating New Learning and Memory Deficits Following Stroke","Inclusion Criteria:\n\n* Stroke over 1 year ago\n* Memory challenges\n\nExclusion Criteria:\n\n* Aphasia\n* non English speaking","60 Years",{"count":264,"type":23},[26],"The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons following stroke",[485],"Stoke",[487,488,108],"Memory","Learning","2025-08-11",{"date":491,"type":51},"2025-08-17",{"date":493,"type":23},"2025-09",{"date":495,"type":23},"2026-10",{"name":57,"class":58},{"id":498,"slug":499,"hasResults":12,"nctId":500,"briefTitle":501,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":504,"targetDuration":4,"studyType":24,"phases":506,"briefSummary":507,"conditions":508,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":517,"leadSponsor":519,"locationsCount":59},"100601634","neuromodulation-enhanced-use-of-robotic-balance-training-to-improve-balance-function-in-individuals-with-stroke-100601634","NCT07113041","Neuromodulation-Enhanced Use of RObotic BALANCE Training to Improve Balance Function in Individuals With Stroke","NEUROBALANCE","Inclusion Criteria:\n\n1. Aged between 18-75 years\n2. Diagnosed with a cortical\u002Fsubcortical ischemic stroke at least 6 months before the screening, as confirmed by the neurological exam or an MRI.\n3. Have complaints of impaired balance and poor postural control determined by a BBS score of ≤50.\n4. Ability to stand upright with or without support for at least 20 seconds\n5. Ability to walk with or without a walking aid for at least ten meters\n6. Not planning to change medication in the next four months\n7. Minimum Cognitive Ability to understand the verbal instructions and comply with the study procedures, as determined by the University of California, San Diego, Brief Assessment of Capacity to Consent Instrument (UBACC).\n\nExclusion Criteria:\n\n1. Currently undergoing any regular physical therapy program or research studies focusing on balance functions.\n2. Having a brainstem stroke.\n3. Contraindication for MRI scan (presence of metal implants, claustrophobia)\n4. Affected by the peripheral nerve injury, neuromuscular conditions, or orthopedic issues of lower limbs before stroke, or have any persistent pain or difficulty maintaining blood pressure while upright.\n5. Have a scalp or skin condition (e.g., psoriasis or eczema) \\* on the scalp near the stimulation site\n6. Having severe visual impairment (e.g., spatial neglect) or hearing problems that may affect study compliance\n7. Any other neurological injury or psychiatric conditions (e.g., severe anxiety or schizophrenia etc.)\n8. Contraindications to MRI, including the presence of non-titanium metallic implants, claustrophobia, etc.\n9. Not be pregnant or thinking of becoming pregnant\n10. Diagnosed with alcohol or substance abuse in the last 3 years\n11. Contraindications to TMS, including the presence of metallic implants in the head and a history of seizures or medication-resistant epilepsy or ongoing use of anti-seizure\u002Fseizure threshold-lowering medications.",{"count":505,"type":23},45,[26],"Our proposed study, \"NEUROBALANCE Stroke,\"; aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance function and postural control in individuals with chronic stroke. The study will recruit 45 participants who have had a stroke at least 6 months before enrolment and experience persistent balance and gait deficits. Participants will be randomized into three groups: (1) robotic balance training with active brain stimulation, (2) robotic balance training with sham brain stimulation, and (3) standard-of-care rehabilitation.\n\nThe study will involve 15 training sessions over 5 weeks, with assessments conducted at baseline, post-training, and two months post-training to evaluate balance recovery and retention. The primary focus is understanding how this intervention affects brain and muscle activity during balance tasks and how these changes translate into functional improvements in clinical outcome measures of balance function. Additionally, participant feedback on brain stimulation and exercise engagement will be collected to inform future studies.\n\nThe findings may guide the development of personalized training protocols and contribute to broader rehabilitation strategies.",[108,509,510,511,512],"Stroke (CVA) or Transient Ischemic Attack","Stroke Ischemic","Stroke Gait Rehabilitation","Balance Deficits","2025-08-01",{"date":515,"type":51},"2025-08-08",{"date":407,"type":51},{"date":518,"type":23},"2029-08-31",{"name":57,"class":58},{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":4,"eligibilityCriteria":526,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":527,"targetDuration":4,"studyType":24,"phases":528,"briefSummary":529,"conditions":530,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":537,"leadSponsor":538,"locationsCount":59},"100561010","neurobalance-training-to-improve-postural-control-in-individuals-with-traumatic-brain-injury-100561010","NCT06584591","NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury","Neuromodulation-Enhanced Use of RObotic Balance Training to Improve Postural Control in Individuals With Traumatic Brain Injury","Inclusion Criteria:\n\n1. Aged between 18-75 years\n2. Diagnosed with a non-penetrating TBI at least six months before the screening.\n3. Have complaints of impaired balance and poor postural control determined by a BBS score of ≤50.\n4. Ability to stand upright with or without support for at least 20 seconds\n5. Ability to walk with or without a walking aid for at least ten meters\n6. Not planning to change medication in the next four months\n7. Minimum Cognitive Ability to understand the verbal instructions and comply with the study procedures, as determined by the University of California, San Diego, Brief Assessment of Capacity to Consent Instrument (UBACC).\n\nExclusion Criteria:\n\n1. Currently undergoing any regular physical therapy program or research studies focusing on balance functions.\n2. Having a stroke or a penetrating TBI.\n3. Affected by the peripheral nerve injury, neuromuscular conditions, or orthopedic issues of lower limbs before TBI, or have any persistent pain or difficulty maintaining blood pressure while upright.\n4. Have a scalp or skin condition (e.g., psoriasis or eczema) on the scalp near the stimulation site.\n5. Severe visual impairment (e.g., spatial neglect) or hearing problems may affect study compliance.\n6. Any other neurological injury or psychiatric conditions (e.g., severe anxiety or schizophrenia, etc.)\n7. Not being pregnant or thinking of becoming pregnant during the study period.\n8. Diagnosed with alcohol or substance abuse in the last three years.\n9. Contraindications to TMS, including the presence of metallic implants in the head and history of seizures or medication-resistant epilepsy.",{"count":505,"type":23},[26],"Our proposed study, \\"NEUROBALANCE,\\" aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance functions in individuals with chronic traumatic brain injury (TBI). The study will recruit 45 participants who have had a TBI for over six months and experience persistent balance deficits. Participants will be randomized into three groups: (1) robotic balance training with active brain stimulation, (2) robotic balance training with sham brain stimulation, and (3) standard-of-care rehabilitation.\n\nThe study will involve 12 training sessions over four weeks, with assessments conducted at baseline, post-training, and two months post-training to evaluate balance recovery and retention. The primary focus is understanding how this intervention affects brain and muscle activity during balance tasks and how these changes translate into functional improvements in clinical outcome measures of balance function. Additionally, participant feedback on brain stimulation and exercise engagement will be collected to inform future studies.\n\nThis research is particularly relevant to military service members, as TBI and balance impairments are common among this population. The findings may guide the development of personalized training protocols and contribute to broader rehabilitation strategies.",[362,531,532,533],"TBI","Diffuse Axonal Brain Injury","Brain Injuries, Traumatic",{"date":535,"type":51},"2025-08-06",{"date":513,"type":51},{"date":186,"type":23},{"name":57,"class":58},{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":4,"eligibilityCriteria":545,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":546,"enrollmentInfo":547,"targetDuration":4,"studyType":24,"phases":549,"briefSummary":550,"conditions":551,"keywords":554,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":59},"100532474","combined-exercise-and-targeted-therapy-for-post-stroke-reading-deficits-100532474","NCT06213272","Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits","Improving Reading Competence in Aphasia With Combined Aerobic Exercise and Phono-Motor Treatment","Inclusion Criteria:\n\n* fluent and literate in English prior to stroke\n* 1st ever stroke\n* more than 3 months post-stroke\n* post-stroke reading deficits, defined as reading aloud accuracy \\\u003C83% for single words or \\\u003C65% for readable nonwords\n* living within a 50-mile radius from Kessler Foundation.\n\nExclusion Criteria:\n\n* contraindication to MRI\n* prior neurological disease\n* developmental learning or reading disability (i.e., developmental dyslexia)\n* contraindication to exercise\n* concurrent speech and language therapy","85 Years",{"count":548,"type":23},70,[26],"The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment. This approach is expected to increase cerebral circulation and help to rebuild and strengthen the damaged phonological neural networks. Through this combinatory approach, the study aims to enhance the reading and language improvements seen with existing treatments.",[108,552,553],"Aphasia","Reading Disorder",[555,556,557,558,559,560,561],"exercise","stroke","aphasia","reading therapy","phono-motor therapy","aerobic exercise treatment","MRI","2025-05-16",{"date":564,"type":51},"2025-05-21",{"date":566,"type":51},"2024-04-18",{"date":568,"type":23},"2029-03-01",{"name":57,"class":58},{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":17,"sex":18,"minAge":480,"maxAge":4,"enrollmentInfo":577,"targetDuration":4,"studyType":24,"phases":579,"briefSummary":580,"conditions":581,"keywords":583,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":587,"completionDateStruct":588,"leadSponsor":589,"locationsCount":59},"100536831","theory-driven-manualized-approach-to-improving-new-learning-and-memory-in-healthy-aging-and-mci-100536831","NCT06269939","Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI","Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and Mild Cognitive Impairment","Inclusion Criteria:\n\n* Inclusion Criteria:\n\n  * read and speak English fluently\n\nExclusion Criteria:\n\n* prior stroke or neurological injury\u002Fdisease (i.e. traumatic brain injury, Multiple Sclerosis, or Stroke).\n* history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis).\n* significant alcohol or drug abuse history (inpatient treatment).\n* Benzodiazepines and steroid use\n* Diagnosis of dementia",{"count":578,"type":23},40,[26],"The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.",[582],"Aging",[584],"memory","2025-05-13",{"date":562,"type":51},{"date":407,"type":23},{"date":137,"type":23},{"name":57,"class":58},{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":12,"sex":18,"minAge":480,"maxAge":4,"enrollmentInfo":597,"targetDuration":4,"studyType":24,"phases":599,"briefSummary":600,"conditions":601,"keywords":603,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":607,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":612,"locationsCount":188},"100469702","improve-new-learning-and-memory-in-individuals-with-mild-cognitive-impairment-100469702","NCT05396248","Improve New Learning and Memory in Individuals With Mild Cognitive Impairment","Use of a Memory Technique to Improve New Learning and Memory in Individuals With Mild Cognitive Impairment","Inclusion Criteria:\n\n* 60 or older.\n* read and speak English fluently.\n* Research based diagnosis of Amnestic Mild Cognitive Impairment\n\nExclusion Criteria:\n\n* prior stroke or neurological injury\u002Fdisease (i.e. traumatic brain injury, Multiple Sclerosis, or Stroke).\n* history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis).\n* significant alcohol or drug abuse history (inpatient treatment).\n* Benzodiazepines and steroid use",{"count":598,"type":23},120,[26],"The current study is a double-blind, placebo-control randomized clinical trial examining the efficacy of memory retraining in individuals with Mild Cognitive Impairment (MCI). Impairment in higher level cognitive processing, such as new learning and memory, is one of the most common deficits in individuals with MCI and such deficits have been shown to exert significant negative impact on multiple aspects of everyday life, including occupational and social functioning. Despite these findings, few studies have attempted to treat these cognitive deficits in order to improve the everyday functioning of individuals with MCI. Through a small randomized clinical trial, the investigators found that individuals with MCI with documented cognitive impairment show a significant improvement in their memory performance following a treatment protocol designed to facilitate learning. The current proposal will replicate this finding and further evaluate (a) the impact of the treatment on everyday functioning, (b) the long term efficacy of the treatment and (c) the utility of booster sessions in facilitating long-term treatment effects. We will randomly assign older individuals who meet criteria for a diagnosis of amnestic MCI to a memory retraining group or a placebo control group. Both groups will undergo baseline, immediate and long-term follow-up assessment consisting of: (1) a traditional neuropsychological battery, (2) an assessment of global functioning examining the impact of the treatment on daily activities, and (3) functional neuroimaging. This design will allow the investigators to evaluate the efficacy of this particular memory retraining technique in an aMCI population through the assessment of cognitive function via a standard evaluation. In addition, the investigators will be able to draw conclusions regarding the impact of this particular memory remediation program on everyday life from questionnaires completed by the participant and a significant other. Optional enrollment in pre- post neuroimaging will also allow the investigators to look at changes in the brain.",[602],"Mild Cognitive Impairment",[487,604,133,605,606],"learning","aging","cognition",{"date":562,"type":51},{"date":609,"type":51},"2023-06-28",{"date":611,"type":23},"2027-03",{"name":57,"class":58},""]