[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Khyber Medical University Peshawar\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":353},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,45,74,100,129,155,180,218,246,273,302,328],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644271","effectiveness-of-neuroplasticity-targeted-supplements-on-neuroinflammatory-markers-adhd-symptom-severity-and-clinical-scores-in-children-100644271",false,"NCT07665658","Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children","Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* DSM-5 confirmed ADHD diagnosis\n* Age 6-12 years\n* Medication-free or on stable stimulant medication (≥1 month)\n\nExclusion Criteria:\n\n* Antibiotic use in last 4 weeks\n* Gastrointestinal disorders\n* Neurological comorbidities (e.g., epilepsy)\n* Severe food allergies","ALL","6 Years","12 Years",{"count":20,"type":21},68,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial will evaluate the effectiveness of neuroplasticity-targeted supplements on neuroinflammatory markers and ADHD symptoms in children aged 6 to 12 years diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Participants will be randomly assigned to one of four groups: gut-targeted supplements (prebiotics and probiotics), brain-targeted supplements (omega-3 fatty acids and vitamin B1), combined supplementation, or placebo. The intervention period will last 12 weeks. Primary outcomes include changes in ADHD symptom severity and clinical scores using validated rating scales. Secondary outcomes include changes in biomarkers of neuroinflammation and neuroplasticity, including IL-6, TNF-alpha, BDNF, short-chain fatty acids, and Claudin-5.",[27],"Attention Deficit Hyperactivity Disorder",[27,29,30,31],"Randomized Controlled Trial","Neuroinflammation","Neuroplasticity","RECRUITING","2026-06-22",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":36},"2026-03-01",{"date":40,"type":21},"2026-12-25",{"name":42,"class":43},"Khyber Medical University Peshawar","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100637010","efficacy-of-combining-mulligan-spinal-mobilization-with-leg-movement-and-mechanical-lumbar-traction-in-lumbar-radiculopathy-100637010","NCT07573124","Efficacy of Combining Mulligan Spinal Mobilization With Leg Movement and Mechanical Lumbar Traction in Lumbar Radiculopathy","Efficacy of Combining Mulligan's Spinal Mobilization With Leg Movement Technique and Mechanical Lumbar Traction Among Patients With Lumbar Radiculopathy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 20-50 years\n* Male and female participants\n* Unilateral radiculopathy due to L4-L5 or L5-S1 disc bulge, confirmed by clinical examination and MRI\n* Symptom duration of 4 weeks to 6 months\n* Positive Straight Leg Raise (SLR) test on the affected leg (\\\u003C70° of hip flexion)\n* Pain intensity \\\u003C7 on the Numeric Pain Rating Scale (NPRS; mild to moderate pain)\n\nExclusion Criteria:\n\n* Cognitive impairment, dementia, central cord signs\n* Inflammatory or degenerative spine conditions\n* Spine surgery within the last 6 months\n* Pregnant women in the later half of 2nd trimester or 3rd trimester\n* Muscular involvement (e.g., Deep Gluteal syndrome, Piriformis syndrome)\n* Currently receiving medications or other contemporaneous treatment","20 Years","50 Years",{"count":55,"type":21},32,[24],"Lumbar radiculopathy (LR), often caused by disc herniation, results in significant pain, disability, and reduced quality of life. Spinal Mobilization with Leg Movement (SMWLM) is a manual technique that has shown promise, while mechanical lumbar traction is used to reduce nerve compression, though its standalone effectiveness is debated. This randomized controlled trial aims to compare the combined effect of SMWLM plus mechanical lumbar traction against SMWLM alone, both administered with conventional physiotherapy. Outcomes will be assessed over 4 weeks to determine if the combined intervention offers superior pain relief, functional improvement, and range of motion in patients with unilateral L4-L5 or L5-S1 radiculopathy.",[59],"Lumbar Radiculopathy",[61,62,63,64,65],"Lumbar radiculopathy","Mulligan mobilization","Mechanical lumbar traction","Physical therapy","Randomized controlled trial","2026-05-01",{"date":68,"type":36},"2026-05-07",{"date":70,"type":36},"2026-04-01",{"date":72,"type":21},"2026-11-15",{"name":42,"class":43},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100635546","comparison-of-radiological-outcome-of-conventional-vs-accelerated-ponseti-casting-technique-for-treatment-of-club-foot-100635546","NCT07554092","Comparison of Radiological Outcome of Conventional vs Accelerated Ponseti Casting Technique for Treatment of Club Foot","Comparison of Radiological Outcome of Conventional vs Accelerated Ponseti Casting Technique for Treatment of Club Foot: Randomized Controlled Trial","Inclusion Criteria:\n\n-Both gender with idiopathic club foot with age less than 6 months\n\nExclusion Criteria:\n\n* Syndromic club foot (e.g., associated with arthrogryposis, myelomeningocele, or other genetic syndromes)\n* Previous treatment for club foot (either serial casting or surgical intervention)\n* Any other significant congenital anomaly or medical condition that, in the opinion of the investigator, would interfere with treatment or follow-up","1 Day","5 Months",{"count":84,"type":21},144,[24],"Club foot (congenital talipes equinovarus) is a common birth deformity affecting 1-2 per 1,000 live births, with even higher rates in low-income countries. The standard treatment is the Ponseti method using weekly serial casts, but weekly visits for several weeks can be challenging for families in hot climates or with limited resources. This randomized controlled trial compares the standard once-weekly Ponseti casting with an accelerated twice-weekly casting technique. The primary outcome is radiological correction measured by the lateral talocalcaneal angle (target ≥35°) on standardized foot X-rays taken six weeks after brace fitting. Secondary outcomes include the talocalcaneal index (\\>40) and the tibio-calcaneal (dorsiflexion) angle (60-90°). Babies under six months of age with idiopathic club foot will be randomly assigned to either the standard or accelerated casting group. All other aspects of the Ponseti method (manipulation, number of casts, tenotomy when needed, final cast for three weeks, and foot abduction orthosis) remain identical. Adverse events such as skin problems, swelling, or cast complications will be recorded. The study aims to determine whether accelerated casting achieves better radiographic correction without increasing risks.",[88],"Club Foot",[88,90,65,91],"Ponseti Casting Technique","Congenital talipes equinovarus","2026-04-21",{"date":94,"type":36},"2026-04-28",{"date":96,"type":36},"2026-02-01",{"date":98,"type":21},"2026-11-25",{"name":42,"class":43},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":44},"100625639","impact-of-chewing-gum-on-postoperative-gut-motility-in-gastrointestinal-surgery-patients-100625639","NCT07425249","Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients","Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients: A Randomized Controlled Trial at Khyber Teaching Hospital, Peshawar, Pakistan","Inclusion Criteria:\n\n* Age between 17 and 85 years.\n* Patients of either gender.\n* Undergoing open gastrointestinal surgical procedures (elective or emergency).\n* Willing to participate and able to provide informed consent.\n\nExclusion Criteria:\n\n* Patients with metabolic or endocrine disorders (diabetes mellitus, hypothyroidism, or hyperthyroidism).\n* Patients with renal disease or electrolyte imbalance.\n* Patients with chronic constipation or neuromuscular disorders.\n* Patients with substance abuse or drug addiction.\n* Patients receiving medications affecting gut motility (calcium channel blockers or antiepileptic drugs).\n* Patients with dental prosthesis or undergoing laparoscopic gastrointestinal surgery.","17 Years","85 Years",{"count":110,"type":21},96,[24],"Postoperative ileus (POI) is a frequent complication after abdominal surgery, leading to delayed gastrointestinal motility, prolonged hospital stay, and increased patient discomfort. Chewing gum, as a form of sham feeding, has been proposed to stimulate gut motility through vagal stimulation and increased gastrointestinal secretions. This randomized controlled trial aims to assess the effect of chewing gum on early recovery of gastrointestinal motility in patients undergoing open gastrointestinal surgery.",[114,115,116],"Postoperative Ileus","Delayed Gastrointestinal Motility","Postoperative Gut Dysfunction",[114,118,119,120],"Gastrointestinal Motility","Enhanced Recovery After Surgery (ERAS)","Postoperative Recovery","2026-02-16",{"date":123,"type":36},"2026-02-20",{"date":125,"type":36},"2026-01-01",{"date":127,"type":21},"2026-10-29",{"name":42,"class":43},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":145,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":152,"leadSponsor":154,"locationsCount":44},"100625641","integrated-oral-care-intervention-for-xerostomia-in-diabetes-patients-100625641","NCT07425275","Integrated Oral Care Intervention for Xerostomia in Diabetes Patients","The Impact of Integrated Oral Care Intervention Provided by Endocrinologists on Oral Health and Well-being in Diabetes Patients","IOCID","Inclusion Criteria:\n\n* Presence of a single stone in the renal pelvis.\n* Age less than 18 years.\n* No congenital or acquired urinary tract abnormalities.\n* No pre-existing chest diseases (e.g., chronic lung disease, pleural effusion).\n\nExclusion Criteria:\n\n* Patients with multiple kidney stones.\n* Calyceal stones (stones located specifically in a calyx).\n* Pelviureteric junction obstruction (PUJO).\n* Pelvic kidney (renal ectopia).","18 Years",{"count":139,"type":21},80,[24],"Diabetes patients commonly experience dry mouth also known as xerostomia which can affect eating speaking oral health and overall quality of life. This study evaluates whether simple oral care actions delivered by endocrinologists during routine diabetes clinic visits can improve dry mouth symptoms and oral health related quality of life. Endocrinologists will be trained to screen for dry mouth provide brief counseling prescribe saliva substitutes and refer patients to dental services when needed. Adult patients with diabetes and symptoms of dry mouth will be followed before and after the intervention to assess changes in xerostomia severity and oral health outcomes. The study will also explore barriers and facilitators to integrating oral health care into routine diabetes management in Pakistan.",[143,144],"Diabetes Mellitus","Diabetic Neuropathies",[146,147,148,149],"Diabetes mellitus","Oral health quality of life","Non communicable diseases","Integrated oral care",{"date":123,"type":36},{"date":96,"type":36},{"date":153,"type":21},"2026-07-30",{"name":42,"class":43},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":137,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":168,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":177,"leadSponsor":179,"locationsCount":44},"100619569","comparative-study-of-functional-outcomes-between-peroneus-longus-and-hamstring-tendon-autografts-in-arthroscopic-acl-reconstruction-100619569","NCT07346326","Comparative Study of Functional Outcomes Between Peroneus Longus and Hamstring Tendon Autografts in Arthroscopic ACL Reconstruction","Comparative Study of Functional Outcomes Between Peroneus Longus and Hamstring Tendon Autografts in Arthroscopic ACL Reconstruction: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Isolated, primary Anterior Cruciate Ligament (ACL) injury confirmed by clinical assessment and Magnetic Resonance Imaging (MRI).\n* Provides written informed consent for the surgical procedure and study participation, including follow-up assessments.\n\nExclusion Criteria:\n\n* Multiligament knee injuries (e.g., concomitant PCL, MCL, or LCL injuries).\n* Previous surgery or history of fracture in the involved lower limb.\n* Radiographic evidence of osteoarthritis in the affected knee.\n* Presence of any neuromuscular disease.",{"count":163,"type":21},64,[24],"This is a prospective, single-blinded, randomized controlled trial. Sixty patients (≥18 years) with an isolated ACL injury will be randomly assigned to receive an ACL reconstruction using either a Peroneus Longus Tendon (PLT) autograft or a Hamstring Tendon (HST) autograft. The primary objective is to compare early functional outcomes between the two groups at 6 weeks and 3 months post-surgery, using the Lysholm Knee Score. The study aims to demonstrate the non-inferiority of the PLT graft. All surgeries will be performed arthroscopically at Khyber Teaching Hospital, Peshawar, followed by a standardized rehabilitation protocol.",[167],"Anterior Cruciate Ligament Injuries",[169,170,171,172],"ACL reconstruction","Hamstring tendon autograft","Functional outcomes","Arthroscopy","2026-01-08",{"date":175,"type":36},"2026-01-16",{"date":125,"type":36},{"date":178,"type":21},"2026-09-15",{"name":42,"class":43},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":188,"sex":16,"minAge":81,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":192,"phases":4,"briefSummary":193,"conditions":194,"keywords":202,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":44},"100517522","impact-of-diet-and-nutrition-on-growth-and-development-in-young-children-100517522","NCT06018636","Impact of Diet and Nutrition on Growth and Development in Young Children","Dietary Intake\u002FPatterns, Nutritional Status and Their Association With Growth and Development of Children From Remote, Agropastoral Communities of District Swat, Pakistan","DIGEST","Inclusion Criteria:\n\n* Households living in the area from the last two 2 years.\n* Households having infants or young children ≤ years.\n* Households planning to reside in the same area for the next 1 year.\n\nExclusion Criteria:\n\n* Children with any co-existent systemic diseases, confirmed from medical records.\n* Children on continuous medications for any medical issue.\n* Physically or mentally handicapped children",true,"24 Months",{"count":191,"type":21},832,"OBSERVATIONAL","The association between nutrition in early life and its long-term health consequences has long been known. However, there is a scarcity of scientific evidence on how nutritional status affects child growth and development in remote, rural agro-pastoral communities with distinct dietary intake habits, geographical location, socio-economic status, and cultures.",[195,196,197,198,199,200,201],"Nutrition","Growth","Development","Stunting","Wasting","Obesity","Child Development",[203,204,196,205,206,207,208,209,210],"Nutritional status","Malnutrition","Cognitive Development","Anthropometry","Agropastoral","remote","rural","Urban","2026-01-06",{"date":173,"type":36},{"date":214,"type":36},"2023-06-28",{"date":216,"type":21},"2028-09-30",{"name":42,"class":43},{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":16,"minAge":137,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":229,"conditions":230,"keywords":232,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":245},"100618845","effect-of-conventional-vs-intensive-management-on-gestational-diabetes-and-maternal-fetal-outcomes-100618845","NCT07336914","Effect of Conventional vs Intensive Management on Gestational Diabetes and Maternal Fetal Outcomes","Effect of Conventional vs Intensive Management on Gestational Diabetes and Maternal Fetal Outcomes: Randomized Controlled Trial.","Inclusion Criteria:\n\n* Maternal age between 18-45 years\n* Gestational age at enrollment 24 - 28 weeks\n* Patients having Hba1c levels less then 6%\n\nExclusion Criteria:\n\n* Patients having twin pregnancies\n* Patients having PCOS\n* Diabetes diagnosed prior to pregnancy\n* Patients having severe hypertension\n* Patients having renal diseases\n* Patients using glucose altering medications","45 Years",{"count":227,"type":21},60,[24],"This study involved two management protocols to manage diabetes in pregnancy. Sixty patients having GDM will be recruited on the basis of the OGTT and randomly allocated to two management groups. One group of patients will receive counselling and the conventional method of management. while the other group will receive a tailored diet plan and physical activity with low caloric and moderate intense exercises. Both groups will receive a dietary plan based on their sugar levels weekly basis and physical activity with pharmacotherapy to adjust their sugar levels, while the intensive group will have rigorous monitoring on a monthly basis and frequent visits with repeated lab checks. This will help us to reduce short and long-term complications with improved maternal and neonatal outcomes.",[231],"Gestational Diabetes",[233,234,235,236,237],"Gestational Diabetes Mellitus (GDM)","Intensive Management","Randomized Controlled Trial (RCT)","Glycemic Control","Maternal Health",{"date":239,"type":36},"2026-01-13",{"date":241,"type":36},"2025-10-01",{"date":243,"type":21},"2026-04-25",{"name":42,"class":43},2,{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":16,"minAge":137,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":22,"phases":256,"briefSummary":257,"conditions":258,"keywords":261,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":270,"leadSponsor":272,"locationsCount":245},"100615619","impact-of-lifestyle-interventions-on-cognitive-decline-in-non-alcoholic-fatty-liver-disease-100615619","NCT07294963","Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease","Impact of Lifestyle Interventions on Cognitive Decline in NAFLD: A Randomized Controlled Trial of Liver Fibrosis, Hormonal Imbalance, and Inflammatory Markers","Inclusion Criteria:\n\n* Age 18 to 42 years.\n* Diagnosed with fatty liver (NAFLD) via imaging (e.g., ultrasound).\n* Liver fibrosis assessed and staged via FibroScan and the FIB-4 index.\n* Literate (to consent and complete cognitive assessments\u002Fquestionnaires).\n\nExclusion Criteria:\n\n* History of alcohol intake \\>20g\u002Fday.\n* Chronic viral hepatitis B or C.\n* Major neuropsychiatric illnesses.\n* Pregnancy or breastfeeding.\n* Chronic illnesses including Diabetes Mellitus and thyroid dysfunction.","42 Years",{"count":255,"type":21},45,[24],"This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.",[259,260],"Non-Alcoholic Fatty Liver Disease","Neurocognitive Disorders",[262,263,264,265,259],"Hepatocerebral Syndrome","Metabolic dysfunction-Associated SteatoHepatitis","Cognitive Decline","Liver Fibrosis","2025-12-08",{"date":268,"type":36},"2025-12-19",{"date":241,"type":36},{"date":271,"type":21},"2026-06-15",{"name":42,"class":43},{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":188,"sex":16,"minAge":279,"maxAge":280,"enrollmentInfo":281,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":287,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":44},"100602156","comparison-of-clinical-effects-of-listerine-and-chlorhexidine-mouth-wash-in-patients-undergoing-fixed-orthodontic-treatment-100602156","NCT07119840","Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic Treatment","Inclusion Criteria:\n\n* Aged 13-40 years\n* Permanent dentition (including first molars)\n* Willing to undergo orthodontic treatment and follow instructions\n\nExclusion Criteria:\n\n* Systemic illness (e.g., diabetes, heart disease, hepatitis)\n* Pregnant\u002Flactating females\n* Tobacco use\n* History of allergies to mouthwash\u002Ftoothpaste\n* Use of mouthwash in past 3 months\n* Abnormal oral morphology or parafunctional habits","13 Years","40 Years",{"count":227,"type":21},[24],"This randomized clinical trial aims to compare the effectiveness of Listerine and Chlorhexidine mouthwashes in improving periodontal health in patients undergoing fixed orthodontic treatment. Gingival Index and Plaque Index will be assessed at baseline, 2 weeks, and 4 weeks.",[285,286],"Gingivitis","Dental Plaque",[288,289,290,291,292,293],"Listerine","Chlorhexidine","Gingival Index","Plaque Index","Oral Hygiene","Orthodontic Appliances","2025-11-20",{"date":296,"type":36},"2025-11-26",{"date":298,"type":36},"2025-08-01",{"date":300,"type":21},"2025-12-30",{"name":42,"class":43},{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":316,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":325,"leadSponsor":327,"locationsCount":44},"100611594","bone-turnover-markers-and-treatment-efficacy-in-postmenopausal-osteoporosis-100611594","NCT07242612","Bone Turnover Markers and Treatment Efficacy in Postmenopausal Osteoporosis","Determination of Selective Bone Turnover Markers and Their Association With Treatment Efficacy in Primary Postmenopausal Osteoporotic Women: A Randomized Control Trial","Inclusion Criteria:\n\n* Postmenopausal women (at least one year since last menstrual cycle).\n* Age greater than 50 years.\n* Diagnosis of primary osteoporosis.\n* Currently not on any anti-osteoporosis medications.\n* Not taking Calcium or Vitamin D supplements.\n* Volunteer to participate and provide informed consent.\n\nExclusion Criteria:\n\n* Women with multiple vertebral fractures or severe lumbar degenerative changes.\n* Use of hormone\u002Festrogen therapy, calcitonin, oral bisphosphonates, IV ibandronate, IV Zoledronic acid, denosumab, or teriparatide within the past 18 months.\n* Use of corticosteroids (short or long-term).\n* History of hyperthyroidism, hypothyroidism, liver disease, kidney disease, or tumors.\n* Presence of secondary causes of osteoporosis (e.g., eating disorders, celiac disease, diabetes, hematologic disorders).",{"count":310,"type":21},40,[24],"This study investigates the use of blood tests known as Bone Turnover Markers (BTMs) to quickly monitor the effectiveness of osteoporosis treatment in postmenopausal women. Osteoporosis, which weakens bones and increases fracture risk, is typically monitored using a DEXA scan to measure bone density (BMD), but this method changes slowly. BTMs may show a response to medication within just 3 to 6 months. In this randomized controlled trial, 40 postmenopausal women with osteoporosis will be assigned to receive either antiresorptive drugs (which slow bone loss) or anabolic drugs (which build new bone), along with calcium and vitamin D. The study will compare how these treatments affect BTMs and BMD over six months to determine if BTMs can serve as an early and reliable indicator of treatment success, which could be particularly useful in regions like Pakistan where access to repeated DEXA scans is limited.",[314,315],"Osteoporosis","Osteoporosis, Postmenopausal",[317,318,319,320],"Bone Turnover Markers","Bone Density","Postmenopausal Osteoporosis","DEXA Scan","2025-11-17",{"date":323,"type":36},"2025-11-21",{"date":241,"type":36},{"date":326,"type":21},"2026-04-15",{"name":42,"class":43},{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":188,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":335,"targetDuration":4,"studyType":22,"phases":337,"briefSummary":338,"conditions":339,"keywords":342,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":44},"100559207","engagement-of-community-through-participatory-learning-and-action-for-control-and-prevention-of-type-ii-diabetes-and-its-risk-factors-empower-d-100559207","NCT06561126","Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]","Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]: Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals aged 20 years and above.\n* Participants residing in the rural areas of Peshawar and Swabi, Pakistan.\n* Individuals willing to participate in the study and provide consent.\n* Both individuals with normoglycemia, intermediate hyperglycemia, and diabetes are encouraged to participate.\n* Participants who can attend the scheduled meetings and interventions as per the study protocol.\n\nExclusion Criteria:\n\n* Individuals below the age of 20 years.\n* Individuals unwilling to provide consent for participation.\n* Participants with severe health conditions that may hinder their active involvement in the study.\n* Individuals with a history of non-compliance with medical interventions or research protocols",{"count":336,"type":21},12744,[24],"This project aims to adapt, implement, and evaluate Participatory Learning and Action (PLA) based intervention in rural areas of KPK, Pakistan which includes Peshawar and Swabi for TIIDM prevention and control. The pivotal components of this approach include adapting, implementing, and evaluating the PLA-based intervention for the prevention and control of Type II diabetes. These components will be tailored to meet the specific needs of two different settings in Peshawar and Swabi, Pakistan.\n\nType II Diabetes Mellitus (TIIDM) is considered the fastest-growing health emergency, affecting 537 million adults worldwide. Global projections for the year 2045 suggest that a 12.2% rise in TIIDM is anticipated with an additional 11.4% rise for intermediate hyperglycemia (IHG) \\[1\\]. Around 80% of people with TIIDM reside in low-and middle-income countries (LMICs), exhausting the already burdened healthcare system \\[2\\]. The intervention \"Community groups or mobile phone messaging to prevent and control type 2 diabetes and intermediate hyperglycemia in Bangladesh (DMagic)\" has been tested and found effective in the rural context of Bangladesh \\[1-3\\]. A full trial will be conducted in the rural areas of Peshawar and Swabi, Pakistan.\n\nIt is anticipated that with the use of evidence-based approaches, best practices, and meaningful community participation, PLA is expected to enhance social and behavioural determinants of health and subsequent outcomes. This will further pave the way for the control of other NCDs through a similar focused approach.",[340,341],"Type II Diabetes Mellitus","Intermediate Hyperglycemia (IHG)",[343,143,340,344],"Community-Based Participatory","Intermediate hyperglycemia","2025-08-29",{"date":347,"type":36},"2025-09-02",{"date":349,"type":36},"2025-05-01",{"date":351,"type":21},"2026-08-31",{"name":42,"class":43},""]