[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"King Abdulaziz University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":392},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,40,69,98,117,143,166,195,231,268,289,310,339,366],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100626469","color-change-and-desensitization-of-molar-incisor-hypomineralization-affected-enamel-using-biomimetic-nano-hydroxyapatite-toothpaste-100626469",false,"NCT07436039","Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste","Inclusion Criteria:\n\n\\- Children aged 6-12 years.\n\n* Diagnosed with Molar-Incisor Hypomineralization (MIH) in at least one first permanent molar or hypomineralization of a second primary molar (HSPM).\n* Presence of white, creamy, yellow, or brown demarcated opacities\n* Indexed teeth include permanent first molars and permanent maxillary incisors.\n\nExclusion Criteria:\n\n* • Decayed permanent molars.\n\n  * Diabetes, hypertension, sleeping disorders, or allergic reactions to medications.\n  * Children on medication\n  * Presence of other enamel defects (e.g., fluorosis, amelogenesis imperfecta, enamel hypoplasia, or white spot lesions).\n  * Previous treatment with liquid enamel or other remineralizing agents on affected teeth.","ALL","6 Years","12 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste. The main questions are:\n\n* Does Nano-HA toothpaste reduce caries incidence, improve tooth aesthetics, and decrease hypersensitivity?\n* How does Nano-HA compare to fluoridated toothpaste in terms of outcomes?\n\nParticipants will:\n\n* Use Nano-HA or fluoridated toothpaste daily for 12 months.\n* Visit the clinic for checkups and evaluations every 1 to 3 months.\n* Record symptoms, brushing compliance, and sensitivity.\n\nThe study will compare Nano-HA toothpaste to fluoridated toothpaste to determine its efficacy in managing MIH .",[26],"Molar-Incisor Hypomineralization (MIH)","RECRUITING","2026-02-21",{"date":30,"type":31},"2026-02-27","ACTUAL",{"date":33,"type":31},"2025-10-01",{"date":35,"type":20},"2027-07-01",{"name":37,"class":38},"King Abdulaziz University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":15,"minAge":47,"maxAge":17,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":58,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":39},"100621924","the-effect-of-virtual-reality-distraction-on-pain-and-discomfort-associated-with-bitewing-radiographs-in-pediatric-patients-100621924","NCT07376941","The Effect of Virtual Reality Distraction on Pain and Discomfort Associated With Bitewing Radiographs in Pediatric Patients","Inclusion Criteria:\n\n1. Healthy\n2. Cooperative children\n3. Aged 4 to 12 years\n4. Referred to the radiology department for two-bitewing radiographs.\n\nExclusion Criteria:\n\n1- Children with a history of epilepsy or anxiety disorder",true,"4 Years",{"count":49,"type":20},90,[23],"This study will be conducted at King Abdulaziz University Dental Hospital (KAUDH). Ethical approval was obtained from the Research Ethics Committee of the Faculty of Dentistry at King Abdulaziz University (32-03-25).\n\nInclusion criteria will include healthy and cooperative children aged 4 to 12 years who are referred to the radiology department for two-bitewing radiographs. Children with a history of epilepsy or anxiety disorder will be excluded. The study's purpose, risks, benefits, and limitations will be explained to the parents or guardians of eligible children by trained dental interns. Those who agree to participate will be asked to sign an Arabic consent form before their involvement. Additionally, an assent form will be obtained from children aged seven and older.\n\nSubjects' age, gender, previous dental experience, and behavior during previous dental visits, as assessed by Frankl's behavior rating scale , will be recorded, along with whether they own or have prior exposure to a virtual reality device. Only children with cooperative and definitely cooperative behavior will be included.\n\nA randomization sequence with an allocation ratio of 1:1 will be generated using computer software and kept with a radiology assistant who is not involved in the study to ensure allocation concealment. Due to the nature of the study, neither the subject nor the radiologist will be blinded to the group allocation. However, the statistician will be blinded to which group each subject will be allocated.\n\nBefore taking the radiographs, subjects will be asked to select a video from a list of popular cartoon shows or a video of their preference. In the test group, the subjects will wear virtual reality device goggles (LG 360 virtual reality \\[VR\\] headset, LG Electronics) connected to a mobile phone, and the chosen video will be played. In the control group, radiographs will be taken without the use of any distraction device. The sounds of the videos will be played on headphones. All bitewing radiographs will be taken by the same radiologist, following the As Low As Reasonably Achievable (ALARA) protocol and hospital guidelines. The procedure uses either size one or size two bitewing Photostimulable Phosphor digital sensors, along with a film holder and a rectangular collimator. While taking the radiographs, the Tell-Show-Do behavior management technique will be used with all participating children, and they will be recorded with a high-resolution camera.\n\nThe camera will aim toward the face and the body. Later, two trained and calibrated evaluators will independently assess the participating children's behavioral pain using the face, legs, activity, cry, and consolability (FLACC) behavioral pain assessment scale. The FLACC scale ranges from 0 to 10, with 0 indicating no pain and 10 the worst possible pain. Additionally, the behavior during the BWS will also be recorded using Frankl's behavior rating scale classification. Training and calibration for the evaluators will involve watching videos of 20 randomly selected children during their dental treatment. A stopwatch will be used to measure the chair time required to take the radiographs. In the test group, the time needed to place the VR device will be included.\n\nImmediately after taking the BWS, the subjects will be shown the Arabic version of the Wong-Baker FACES pain rating scale. They will be asked to select the face that best describes their feelings during the procedure. Finally, the satisfaction with the use of VR during BWS taking will be assessed using a five-point Likert scale, where zero indicates 'not satisfied at all' and 10 means' very satisfied'. Subjects who require repeating any of the BWS will be excluded from the study",[53,54,55,56,57],"Objective Pain and Discomfort","Subjective Pain and Discomfort","Behavior","Satisfaction","Future Preferences",[59],"Satisfaction, Virtual Reality, Bitewings Radiographs","NOT_YET_RECRUITING","2026-01-26",{"date":63,"type":31},"2026-01-29",{"date":65,"type":20},"2026-02-01",{"date":67,"type":20},"2026-05-30",{"name":37,"class":38},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":46,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":76,"targetDuration":4,"studyType":21,"phases":78,"briefSummary":79,"conditions":80,"keywords":87,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":97,"locationsCount":39},"100622538","the-effect-of-vibration-devices-on-pain-and-discomfort-during-local-anesthesia-administration-in-children-100622538","NCT07384923","The Effect of Vibration Devices on Pain and Discomfort During Local Anesthesia Administration in Children","The Effect of Vibration Devices on Pain and Discomfort During Local Anesthesia Administration in Children: A Randmized Clinical Trial.","Inclusion Criteria:\n\n1. Healthy children\n2. Non-anxious\n3. cooperative\n4. Aged six to 12\n5. No previous dental history or experience.\n\n5- Who required non-urgent dental treatment involving at least one pair of contralateral maxillary molars needing buccal infiltration anesthesia\n\nExclusion Criteria:\n\n1. Children requiring urgent dental treatment\n2. Those with active infections at the injection site\n3. Non-Arabic speakers\n4. Children with high anxiety scores in the ACDAS\n5. Those who were uncooperative during the screening appointment",{"count":77,"type":20},20,[23],"This split-mouth randomized clinical trial will be conducted at the Department of Pediatric Dentistry, King Abdulaziz University Dental Hospital (KAAUDH). The inclusion criteria will include healthy, non-anxious, cooperative children aged six to 12 who require non-urgent dental treatment involving at least one pair of contralateral maxillary molars needing buccal infiltration anesthesia with no previous dental history or experience.\n\nThe children will be screened for eligibility, and a single trained dental intern will approach the parents or guardians of eligible children. Those who agree to be screened for participation in the study will be asked to sign an Arabic consent form. Before the scheduled screening appointment, children's anxiety levels will be assessed using a high score on the Abeer Children Dental Anxiety Scale (ACDAS) in the waiting area.\n\nDuring the appointment, a single trained dental intern will perform the dental examination and prophylaxis, while two trained and calibrated dental interns will assess children's behavior using the Frankl Behavior Rating Scale.\n\nChildren found to be non-anxious based on their ACDAS score and cooperative or definitely cooperative based on the Frankl Behavior Rating Scale will be considered eligible for the study. Two treatment appointments will be scheduled for them, and consent and assent forms for participation in the study will be obtained.\n\nComputer randomization will be performed to determine the treatment sequence (DentalVibe intraoral vibration device followed by Buzzy Bee® extraoral vibration device, or vice versa) and the site (right or left). Randomization will be performed before the first scheduled treatment appointment.\n\nThe subjects will be seated in the dental chair for five minutes to acclimate to the environment. To measure the physiological changes of the participating subjects, a pulse oximeter device (OxyWatch, ChoiceMMed, Hamburg, Germany) will be applied, and a trained dental intern will record the baseline heart rate (HR). During the treatment, HR will also be recorded.\n\nThe tip of the DentalVibe intraoral vibration device will be gently placed on the mucobuccal fold above the tooth to be anesthetized. In contrast, the Buzzy Bee® extraoral vibration device will be positioned externally above the buccal infiltration site.\n\nDuring maxillary buccal infiltration, all subjects will be videotaped using a high-resolution camera, focusing on the face and body. Later, two trained and calibrated evaluators will independently assess the child's behavior during the procedure using the Face, Legs, Activity, Cry, Consolability Scale (FLACC) Immediately after administering anesthesia, the subjects will be positioned upright, and the same trained dental intern will introduce the face version of the Visual Analogue Scale (VAS).\n\nFinally, after completing both procedures, the subjects will be asked about their future preference for the vibration device. Due to the study's design, both the investigator administering the maxillary buccal infiltration and the subjects will not be aware of which group they belong to.",[81,82,83,84,54,85,86],"Children's Anxiety Levels","Children's Behavior","Physiological Changes (Heart Rate)","Obejective Pain and Discomfort","Subjects' and Parents' Satisfaction","Subjects' and Parents' Future Preference",[88,89,90,91],"Pain and discomfort","future preferece","satisfaction","Vibration Device",{"date":93,"type":31},"2026-02-03",{"date":65,"type":20},{"date":96,"type":20},"2026-04-30",{"name":37,"class":38},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":46,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":104,"targetDuration":4,"studyType":21,"phases":106,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":114,"leadSponsor":116,"locationsCount":4},"100620272","the-effect-of-salvadora-persica-miswak-compared-to-fluoridated-toothpaste-on-childrens-teeth-diagnosed-with-molar-incisor-hypomineralization-mih-a-randomized-clinical-trial-100620272","NCT07355465","The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy children with age ranged between 6-12 years old\n\n  * Presence of at least one first permanent molar and incisor diagnosed with MIH.\n  * The MIH-affected teeth will have a clinical presentation of white, creamy, yellow, or brown demarcated opacities\n\nExclusion Criteria:\n\n* Medically compromised children.\n* Unwillingness to participate or be randomly assigned to the study groups.\n* Receiving treatment for controlling MIH other than fluoride application",{"count":105,"type":20},30,[23],"Molar-Incisor Hypo mineralization (MIH) was first described in 2001 as a developmental enamel defect . It is a condition in which the enamel of at least one first primary molar is affected with a qualitative defect causing abnormal translucency appearing as demarcated opacities; The permanent incisors and second primary molars can also be affected . MIH has adverse consequences on the oral health and child's quality of life. It increases the risk of caries, discomfort and teeth sensitivity .\n\nMIH management comprises a variety of treatment options ranging from total caries removal to the polar opposite treatment option of no caries removal and non-invasive methods used to prevent caries progression . Dental caries prediction and prevention are now more important than dental caries diagnosis and treatment. Recently, the reasons for repairing dental cavities have been narrowed, and caries prevention is being used to reduce caries . Salvadora persica, commonly known as Miswak was used as a toothbrush for many years among many countries . It was reported to have a significant effect on oral health and caries prevention .Other studies have found a consistent link between the use of Miswak and a reduction in oral bacteria. However, a comprehensive assessment of using Miswak in the treatment and control of MIH among young children has yet to be conducted.\n\nTherefore, the aim of this clinical trial is to assess the effect of SalvadoraPersica and fluoridated toothpaste on controlling hypersensitivity and preventing caries among children with MIH in primary schools. Additionally, this trial will evaluate the shade of the hypo-mineralized enamel before and after using SalvadoraPersica and fluoridated toothpaste",[109],"Molar Incisor Hypomineralisation","2026-01-20",{"date":112,"type":31},"2026-01-21",{"date":63,"type":20},{"date":115,"type":20},"2027-05-30",{"name":37,"class":38},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":46,"sex":15,"minAge":124,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":21,"phases":126,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":4},"100620999","effect-of-water-flossing-on-gingival-inflammation-around-single-implants-100620999","NCT07364916","Effect of Water Flossing on Gingival Inflammation Around Single Implants","Effect of Water Flossing on Gingival Inflammation Around Single Implants: Randomized Clinical Trial","Inclusion Criteria:\n\n* 18 years of age or older\n* Medically cleared\n* Have at least one implant-supported crown.\n\nExclusion Criteria:\n\n1. Smoking\n2. Any systemic or localized illness that would interfere with dental implant therapy\n3. On medications\n4. Pregnancy\n5. History of periodontitis\u002F or peri-implant disease\n6. Poor oral hygiene\n7. Probing depth is \\>5","18 Years",{"count":77,"type":20},[23],"This study aims to evaluate the effect of water floss in reversing peri- implant mucositis around dental implants",[129],"Peri Implant Mucositis",[131,132,133,134],"Peri- implant","Mucositis","Water irrigation","Water flosser","2026-01-18",{"date":137,"type":31},"2026-01-23",{"date":139,"type":20},"2026-01-01",{"date":141,"type":20},"2026-09-30",{"name":37,"class":38},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":15,"minAge":124,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":21,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":39},"100620997","platelet-derived-growth-factors-to-enhance-healing-and-reduce-post-extraction-complications-in-smokers-100620997","NCT07364890","Platelet-Derived Growth Factors to Enhance Healing and Reduce Post-Extraction Complications in Smokers","Inclusion Criteria:\n\n* Smokers\n* Aged 18 years or older\n* Actively smoking at least 10 cigarettes per day\n* Requiring bilateral extractions.\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* Diabetes mellitus\n* Hypertension\n* Bleeding disorders\n* Pregnant or lactating women\n* Individuals who used tobacco products other than conventional cigarettes (such as e-cigarettes or waterpipes) were excluded.",{"count":150,"type":20},12,[23],"This study is a randomized controlled clinical trial with a split-mouth design to evaluate the effect of Advanced Platelet-Rich Fibrin (A-PRF) application on socket healing following dental extractions in smokers. In the split-mouth design, each participant serves as their own control, minimizing inter-subject variability and controlling for potential confounders such as smoking habits, oral hygiene, and systemic health conditions.\n\nBilateral tooth extractions will be performed for each participant, with one extraction site randomly assigned to receive socket preservation using an A-PRF plug, while the contralateral site will be left to heal naturally without intervention.\n\nThe study will be conducted at the Faculty of Dentistry and the University Dental Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. Recruitment began in December 2025 and will continue until the targeted sample size is achieved.",[154],"Smoke Exposure",[156,157,158,159],"Smokers","A- PRF","Extraction","Socket",{"date":137,"type":31},{"date":162,"type":20},"2026-01-31",{"date":164,"type":20},"2026-06-30",{"name":37,"class":38},{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":46,"sex":15,"minAge":16,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":21,"phases":176,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":39},"100616518","effect-of-vibrasthetic-device-on-pain-reduction-during-local-anesthesia-in-pediatric-patients-100616518","NCT07306650","Effect of Vibrasthetic Device on Pain Reduction During Local Anesthesia in Pediatric Patients","Effect of Vibrasthetic Vibration Device on Pain Reduction During Local Anesthesia in Pediatric Patients: A Randomized Clinical Study","Inclusion Criteria:\n\n* Children aged 6-14 years\n* who have previously received local anesthesia\n* and whose behavior, according to the Frankl scale, was positive or definitely positive\n* and the absence of systemic diseases or known allergies to local anesthetic agents\n\nExclusion Criteria:\n\n* Uncooperative children\n* Children with special healthcare needs\n* Children with conditions affecting pain perception","14 Years",{"count":175,"type":20},22,[23],"The goal of this clinical trial is to test if children aged between 6 and 14 years who are receiving a dental injection will feel less pain by using a vibration device applied to the injection site during the injection compared to vibrating the lip using only the researcher's hands without using the vibration device. It will also test if this device makes them feel less anxious during the injection. The main question it aims to answer is:\n\nDoes using the Vibrasthetic device make dental injections more comfortable for children? Researchers will compare the effect of using this vibration device versus using their hands for manual vibration of the lip in the same child.\n\nParticipants will:\n\n* Experience one method of vibration during their visit to the dentist (either the vibration device or manual vibration).\n* then after 2 weeks they will go to the same dentist again and experience the other method of vibration.\n* Receive the dental treatment they need in both visits. Participants will be asked to rate the pain they felt after the injection. This will be done by the participants choosing one of 6 pictures we will show them. Each picture explains the level of the pain they felt, and each picture has a score. We will score the pain the participants felt by looking at which picture they chose to describe their pain from the injection.",[179,180],"Healthy","Behavior Management",[182,183,184,185,186],"Vibrasthetic","Vibration","child behavior management","local anesthesia","pediatric dentistry","2025-12-28",{"date":189,"type":31},"2026-01-02",{"date":191,"type":20},"2025-12-26",{"date":193,"type":20},"2026-06",{"name":37,"class":38},{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":15,"minAge":124,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":21,"phases":203,"briefSummary":204,"conditions":205,"keywords":210,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":230},"100598201","impact-of-3d-printed-anatomical-model-on-patient-understanding-in-orthognathic-surgery-100598201","NCT07068412","Impact of 3D-Printed Anatomical Model on Patient Understanding in Orthognathic Surgery","Impact of 3D-Printed Anatomical Models on Patient Understanding, Anxiety, Patient-Doctor Relationship, and Overall Satisfaction During the Informed Consent Process in Orthognathic Surgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients (aged 18 and above)\n* Scheduled for orthognathic surgery (specifically double-jaw or triple-jaw procedures)\n\nExclusion Criteria:\n\n* Pediatric patients (under 18 years old)\n* Patients undergoing re-do\u002Frevision surgery\n* Patients with psychiatric disorders\n* Patients receiving only orthodontic treatment\n* Patients undergoing single-jaw surgery",{"count":19,"type":20},[23],"The goal of this clinical trial is to learn whether using three dimensional (3D)-printed anatomical models improves the informed consent process for participants undergoing orthognathic surgery. The trial also explores how these models affect participants understanding, anxiety, satisfaction, and communication with the surgeon.\n\nThe main questions it aims to answer are:\n\n* Do 3D-printed anatomical models improve participants understanding of their jaw condition and the surgical procedure?\n* Do they reduce participants anxiety before surgery?\n* Do they enhance overall participants satisfaction and the physician-patient relationship?\n\nResearchers compares participants who received standard two dimensional (2D) imaging and verbal explanations with those who received the same information plus 3D-printed jaw models.\n\nParticipants:\n\n* Scheduled for double- or triple-jaw orthognathic surgery\n* Randomly assigned to receive either traditional 2D education or the 3D-printed model intervention\n* Complete a validated questionnaires assessing understanding, anxiety, satisfaction, and doctor-patient communication",[206,207,208,209],"Skeletal Deformities","Orthognathic Surgical Procedures","Anxiety","Patient Education",[211,212,213,214,215,216,217,218,219,220,221],"Skeletal deformities","Skeletal class II","Skeletal class III","Orthognathic surgery","Patient understanding","Patients' satisfaction","Patient-doctor relationship","Anxiety level","anatomical models","3D printed models","Patient education","2025-07-06",{"date":224,"type":31},"2025-07-16",{"date":226,"type":31},"2025-06-01",{"date":228,"type":20},"2025-08-30",{"name":37,"class":38},2,{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":46,"sex":15,"minAge":124,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":21,"phases":240,"briefSummary":242,"conditions":243,"keywords":250,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":39},"100594388","phase-3-art-based-pain-assessment-tool-in-patients-with-temporomandibular-joint-disorders-100594388","NCT07018791","Art-Based Pain Assessment Tool in Patients With Temporomandibular Joint Disorders","Assessment of the Impact of Art-Based Pain Assessment Tool on Pain Communication, Joint Function, and Anxiety in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosed with Temporomandibular Disorders (TMD) requiring conservative management only and classified as Wilkes' stage I or II\n* Able to understand and sign the informed consent form\n\nExclusion Criteria:\n\n* Patients requiring surgical intervention for TMD\n* Presence of severe mental illness, such as psychotic disorders or bipolar affective disorders\n* Regular use of narcotic (opioid) pain medications",{"count":239,"type":20},70,[241],"PHASE3","Title of Study:\n\nAssessment of the Impact of Art-Based Pain Assessment Tool on Pain Communication, Joint Function, and Anxiety in Patients with Temporomandibular Disorders (TMD): A Randomized Controlled Trial\n\nLocation:\n\nKing Abdulaziz University Dental Hospital (KAUFD), Jeddah, Saudi Arabia What Is This Study About?\n\nThis study examines how an art-based tool can help improve communication and understanding of pain among patients with jaw joint disorders (TMD). It compares two groups:\n\n* Standard care: Routine diagnostic and therapeutic procedures\n* Intervention: Standard care plus a guided art-based tool using paintings to express and discuss the TMD experiences What Is the Art-Based Tool?\n\nThis novel method, called the Artistic Pain Exploration (APE), uses paintings to help patients describe their pain that relates to TMD and its effect on their quality of life:\n\n1. Participants will be shown three paintings (e.g., The Scream by Edvard Munch)\n2. Participants will choose the one that best resonates with them\n3. A guided discussion follows, exploring how the image relates to their physical and emotional pain as well as the effect of pain on their daily activities\n\nResearch Questions:\n\n1. Does using the APE method help participants better communicate and understand their pain?\n2. Does it improve jaw function and reduce anxiety more than standard assessment? Who Can Participate?\n\nParticipants may be eligible if they:\n\n* Are 18 years or older\n* Have early-stage TMD (not needing surgery)\n* Can give informed consent\n\nParticipants cannot participate if they:\n\n* Require jaw surgery\n* Have severe mental illness (e.g., psychosis or bipolar disorder)\n* Take narcotic pain medications regularly What Will Happen During the Study?\n* Participants are randomly assigned to one of the two groups.\n* Each participant will complete a standardized questionnaire before and after two weeks to assess the level of anxiety.\n* All participants will be screened for depression via a standardized questionnaire before the first visit.\n* All will undergo a clinical exam to assess the TMJ pain and function and receive appropriate medications and lifestyle instructions.\n* Some participants (intervention group) will also discuss their pain using the artwork.\n* All participants will be seen for a follow up in 2 weeks to assess the TMJ function and pain.\n\nPotential Risks and Discomforts\n\nParticipants may experience:\n\n* Emotional discomfort while discussing pain\n* Mild anxiety during interviews or questionnaires If needed, a psychiatrist on the research team will provide support or referrals.\n\nPotential Benefits\n\n* A better understanding of pain\n* Improved communication with care provider\n* Possible improvement in pain and jaw function\n\nCosts There are no costs to participate. All treatments are provided free of charge.\n\nCompensation \u002F Treatment for Injury\n\n* If participants experience harm from this study, necessary medical care will be provided by the research team.\n* No financial compensation will be provided by King Abdulaziz University.\n\nConfidentiality Participants' identity and medical records will remain confidential. Only approved researchers and auditors will have access to data, in accordance with applicable laws. Any results published will not include participants' name or identifying details.",[244,245,246,247,248,249],"Temporomandibular Disorders (TMD)","Wilkes 1 and 2","TMJ Pain","TMJ - Oral &Amp;Maxillofacial Surgery","Art Therapy","TMD Art Pain Study",[251,252,253,254,255,256,257,258,259],"Temporomandibular joint disorders","Artistic Pain Exploration (APE)","Visual Pain Expression","Art-Based Assessment","Multisensory Pain Assessment","Randomized Controlled Trial","Pain Communication","Patient-Reported Outcomes","TMJ Function","2025-06-11",{"date":262,"type":31},"2025-06-15",{"date":264,"type":31},"2025-04-25",{"date":266,"type":20},"2025-10-30",{"name":37,"class":38},{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":11,"sex":15,"minAge":275,"maxAge":276,"enrollmentInfo":277,"targetDuration":4,"studyType":21,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":288,"locationsCount":39},"100589577","the-effect-of-hybrid-tele-rehabilitation-versus-in-person-rehabilitation-on-pain-and-function-in-patients-with-knee-osteoarthritis-100589577","NCT06956222","The Effect of Hybrid Tele-rehabilitation Versus In Person Rehabilitation on Pain and Function in Patients With Knee Osteoarthritis","The Effect of Hybrid Tele-rehabilitation Versus Standard Rehabilitation in Patients With Knee Osteoarthritis: A Single-blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Mild to moderate knee osteoarthritis.\n* Age 40 to 80 years old.\n* Body Mass Index \\\u003C 34 kg\u002Fm2.\n* Numeric pain rating scale \\> 4 out of 10.\n* Pain for more than 3 months.\n* Morning stiffness lasting \\\u003C 30 minutes (standard clinical criteria of knee osteoarthritis)\n* Pain and crepitus with active motion (e.g., walking, sit to stand, stair climbing) (standard clinical criteria of knee osteoarthritis)\n* Access to the device with an internet connection.\n* Ability to use electronic devices or smart phones.\n\nExclusion Criteria:\n\n* Severe knee osteoarthritis and limited mobility or bonded to a wheelchair.\n* Body Mass Index \\> 34 kg\u002Fm2\n* On a waiting list for hip or knee surgery.\n* Undergoing other forms of rehabilitation.\n* Previous knee arthroplasty.\n* Recent knee surgery within 6 months.\n* Received cortisone injection within the previous 30 days.\n* Rheumatoid arthritis, bilateral knee morning stiffness \\> 30 minutes.\n* Unstable medical conditions.","40 Years","80 Years",{"count":19,"type":20},[23],"People with knee osteoarthritis often need regular physiotherapy sessions to reduce pain and improve movement. Attendance of in-person sessions can be difficult because of travel and time. This study aims to learn if combining in-person and video sessions using Zoom works for people with knee osteoarthritis. The main questions it aims to answer are :\n\n* Does combining in-person and video sessions improve pain and physical function in people with knee osteoarthritis?\n* Does combining in-person and video sessions improve adherence to the exercise program?\n* Are people satisfied with video sessions using Zoom?\n\nThe researchers will compare the use of one in-person session and one video session per week to the standard care of two in-person sessions per week.\n\nParticipants will :\n\n* Attend either (one in-person and one video session per week) or (two in-person sessions per week) for 8 weeks.\n* Perform exercise program that suits their needs during in-person and video sessions.\n* Record the number of attended sessions over 8 weeks.\n* Complete questionnaires about pain, physical function at the start and the end of the study.\n* Complete questionnaire about usability and satisfaction at the end of the study.",[281],"Knee Osteoarthritis","2025-04-30",{"date":284,"type":31},"2025-05-04",{"date":286,"type":31},"2025-04-01",{"date":193,"type":20},{"name":37,"class":38},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":15,"minAge":124,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":21,"phases":298,"briefSummary":299,"conditions":300,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":4},"100589481","smartphone-application-home-based-exercises-in-obstructive-sleep-apnea-in-jeddah-100589481","NCT06954974","SMARTPHONE APPLICATION HOME-BASED EXERCISES IN OBSTRUCTIVE SLEEP APNEA IN JEDDAH","THE EFFECT OF SMARTPHONE APPLICATION HOME-BASED EXERCISES ON SLEEP QUALITY, FATIGUE, FUNCTIONAL CAPACITY, AND QUALITY OF LIFE IN OBSTRUCTIVE SLEEP APNEA IN JEDDAH","Inclusion Criteria:\n\n* Male and female patients with confirmed mild or moderate OSA\n* aged between 18 and 65 years\n* BMI ≤ 40 kg\u002Fm2\n* agreed to participatein the study were recruited.\n\nExclusion Criteria:\n\n* Pregnant patients\n* individuals younger than 18 or older than 65\n* those who refused to participate in the study\n* those with severe cardiopulmonary conditions such as chronic obstructive pulmonary disease or heart failure\n* those with head and neck anomalies\n* those with a BMI \\>40 kg\u002Fm² were excluded from the study.","65 Years",{"count":19,"type":20},[23],"The study aim is to explore the effects of a home-based exercise training smartphone application on sleep quality, fatigue, functional capacity, and quality of life among obstructive sleep apnea (OSA) patients in Jeddah city, Saudi Arabia.",[301],"OSA - Obstructive Sleep Apnea","2025-04-28",{"date":304,"type":31},"2025-05-02",{"date":306,"type":20},"2025-05-25",{"date":308,"type":20},"2025-12-25",{"name":37,"class":38},{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":15,"minAge":124,"maxAge":296,"enrollmentInfo":317,"targetDuration":4,"studyType":21,"phases":319,"briefSummary":321,"conditions":322,"keywords":325,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":39},"100589363","phase-4-the-effect-of-dexamethasone-submucosal-injection-after-surgical-extraction-of-lower-impacted-third-molars-on-trismus-and-edema-100589363","NCT06953440","The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Third Molars on Trismus and Edema","The Effect of Dexamethasone Submucosal Injection After Third Molar Surgery on Trismus and Edema","Inclusion Criteria:\n\n* Patients with impacted lower third molars requiring surgical extraction.\n* Adults over the age of 18 years old.\n* American Society of Anaesthesiologists (ASA) 1, and ASA 2\n\nExclusion Criteria:\n\n* Patients with preoperative intraoral or extraoral swelling.\n* Patients requiring simple extraction (Class I group A according to Pell and ---Gregory classification).\n* Patients with uncontrolled systemic disease such as uncontrolled diabetic - patients.\n* Patients who are allergic to corticosteroids.\n* Patients who are contraindicated to use corticosteroids such as uncontrolled diabetic patients, and osteoporotic patients.\n* Patients who require extraction of additional teeth at the same visit.",{"count":318,"type":20},66,[320],"PHASE4","This clinical trial aims to investigate whether dexamethasone decreases edema and trismus in adults undergoing lower third molar surgical extraction.\n\nThe main question it aims to answer is:\n\nDoes dexamethasone submucosal injection have a positive impact on trismus and edema after third molar surgery compared to conventional postoperative prescription?\n\nParticipants will:\n\n* Be administered with dexamethasone submucosal injection or a placebo after the surgery.\n* Visit the clinic three times the week after the extraction for follow-up.",[323,324],"Swelling\u002F Edema","Trismus",[158,326,327,328,329,330],"third molar","wisdom teeth","dexamethasone","steroids","submucosal","2025-04-23",{"date":333,"type":31},"2025-05-01",{"date":335,"type":31},"2024-02-01",{"date":337,"type":20},"2025-06-30",{"name":37,"class":38},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":17,"enrollmentInfo":346,"targetDuration":4,"studyType":21,"phases":348,"briefSummary":349,"conditions":350,"keywords":352,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":365,"locationsCount":39},"100569819","phase-4-effect-of-silver-diamine-fluoride-application-on-oral-microbiome-of-healthy-pediatric-patient-100569819","NCT06699199","Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient","Effect of Silver Diamine Fluoride Application on Oral Microbiome of Saudi Children: Randomized Clinical Trial in Jeddah City","Inclusion criteria\n\n* Healthy patients.\n* Patients within 4-10 years of age.\n* The presence of at least one deciduous tooth with a caries lesion that is directly accessible (cavitates)\n\nExclusion Criteria:\n\n* Presentation of irreversible pulpititis or necrosis• The extensive lesion was restored.\n* The surface of the lesion was hard and smooth.\n* Children with inherited or systemic conditions.\n* Children with a substantial medication history or those who have taken antibiotics within the previous three months.\n* Children who have undergone topical fluoride treatment within the previous 2 weeks.",{"count":347,"type":20},50,[320],"This clinical trial aims to learn more about the working mechanism of an antimicrobial agent used to manage dental caries, especially in young, uncooperative children. It will also provide a deeper insight into different products of the same agent and its effectiveness in Arresting dental caries.\n\nThe main questions it aims to answer are:\n\nWhat is the clinical impact of silver diamine fluoride application in caries-active children? What is the antimicrobial effect of silver diamine fluoride in oral microbial inhabitants? Researchers will compare silver diamine fluoride (SDF)only and silver diamine fluoride+ potassium iodide(SDF+KI) to see which materials substantially affect on dental caries and oral microbial inhabitants\n\nParticipants\u002FParent will:\n\nThe parent will fill out a comprehensive data sheet for the child (childhood and current dental and medical history) Visit the dental clinic to Receive one of 2 (SDF or SDF+KI) treatment applications once Visit the clinic a 2nd time for a 2-4 week Treatment Follow-up Go through the sample collection process twice( pre- and 2-4 weeks post- Treatment) Sample collection including (Saliva- Biofilm and caries tissue sample)",[351],"Dental Caries",[353,354,355,356,357,358],"Dental Management","Oral Microbiome","Caries Arrest","SDF","Silver diamine fluoride 38%","Potassium iodide","2025-03-03",{"date":361,"type":31},"2025-03-06",{"date":363,"type":31},"2023-11-01",{"date":337,"type":20},{"name":37,"class":38},{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":15,"minAge":124,"maxAge":4,"enrollmentInfo":374,"targetDuration":4,"studyType":376,"phases":4,"briefSummary":377,"conditions":378,"keywords":380,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":39},"100470973","neurologic-function-post-intubation-100470973","NCT05412823","Neurologic Function Post Intubation","Post Intubation Neurologic Outcomes in Critically Ill Adults","NeuroHypoxia","Inclusion Criteria:\n\n* Good baseline neurologic function (Modified Rankin Scale: 1-3)\n* Emergency departments\n* Critical care units\n* In-patient floors\n* Patients undergoing emergent intubations as determined by the treating physician\n* Age\\> 17 years old\n* Good baseline modified rankin scale (mRs 1-3)\n\nExclusion Criteria:\n\n* Pediatric patients (17 years of age of less)\n* Pregnant patients\n* Intubations occurring in the operating room\n* Prisoners\n* Trauma\n* Status epilepticus\n* Primary intracranial pathology\n* Cardiopulmonary arrest\n* Poor baseline neurologic function (Modified Rankin Scale: 4-5)\n* Pre-Hospital Intubation",{"count":375,"type":20},1000,"OBSERVATIONAL","The frequency of oxygen desaturation during emergency intubation is not uncommon. However, the significance and clinical sequalae of hypoxia during emergency intubation in critically ill, non-trauma patients is not known. Therefore, the aim of this study is to evaluate neurologic function post-intubation of critically ill, non-trauma patients. Providing knowledge on whether the degree of hypoxia during emergency intubation is associated with worse neurologic outcomes, will guide clinical practice to ameliorate that level of hypoxia",[379],"Intubation Complication",[381,382,383],"Emergency Intubation","Hypoxia","Neurologic Function","2022-08-15",{"date":386,"type":31},"2022-08-16",{"date":388,"type":31},"2022-07-22",{"date":390,"type":20},"2027-08-01",{"name":37,"class":38},""]