[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"King Edward Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":457},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,49,73,98,119,148,170,191,222,252,282,301,325,350,376,409,435],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644547","comparison-of-gallbladder-extraction-via-subxiphoid-vs-infraumbilical-port-in-laparoscopic-cholecystectomy-100644547",false,"NCT07672145","Comparison of Gallbladder Extraction Via Subxiphoid vs Infraumbilical Port in Laparoscopic Cholecystectomy","Comparison of Gallbladder Extraction Via the Subxiphoid Port and the Infraumbilical Port During Laparoscopic Cholecystectomy: A Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged between 18 to 60 years.\n* Diagnosed with symptomatic gallstones on ultrasonography.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Scheduled for elective laparoscopic cholecystectomy.\n* Presence of acute or empyematous cholecystitis\n\nExclusion Criteria:\n\n* Intraoperative conversion to open cholecystectomy.\n* Diagnosed with Diabetes mellitus type 2.","ALL","18 Years","60 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","Laparoscopic cholecystectomy is the standard surgical treatment for symptomatic gallstone disease due to its advantages in reducing postoperative pain and recovery times. However, surgeons continue to debate the optimal port site for retrieving the gallbladder specimen from the abdominal cavity, as this choice can influence wound-related morbidity.\n\nTraditionally, the gallbladder is extracted through the infraumbilical port site. While effective, this route is associated with a potential risk of port-site infections due to bacterial colonization within the umbilicus and risk of contamination during specimen extraction. Retrieving the gallbladder through the subxiphoid port has been proposed as an alternative technique that may utilize a cleaner surgical site, potentially reducing patient pain scores and regional wound complications.\n\nThis prospective randomized clinical trial aims to directly compare the clinical outcomes of extracting the gallbladder through the subxiphoid port versus the traditional infraumbilical port. The study will evaluate and compare mean postoperative pain intensity within the first 24 hours, as well as the regional development of port-site infections, seromas, or hematomas within 7 days following elective laparoscopic surgery.",[27,28],"Cholelithiasis (Without Cholecystitis)","Cholecystitis, Acute",[30,31,32,33,34,35],"Laparoscopic Cholecystectomy","Gallbladder Extraction","Subxiphoid Port","Infraumbilical Port","Postoperative Pain","Port-Site Infection","RECRUITING","2026-06-23",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":40},"2026-05-20",{"date":44,"type":21},"2026-08-15",{"name":46,"class":47},"King Edward Medical University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100640952","comparison-of-the-efficacy-between-preoperative-calcium--vitamin-d3-versus-calcium-supplementation-alone-to-prevent-post-operative-symptomatic-hypocalcemia-after-total-thyroidectomy-in-euthyroid-patients-100640952","NCT07597096","COMPARISON OF THE EFFICACY BETWEEN PREOPERATIVE CALCIUM & VITAMIN D3 VERSUS CALCIUM SUPPLEMENTATION ALONE TO PREVENT POST OPERATIVE SYMPTOMATIC HYPOCALCEMIA AFTER TOTAL THYROIDECTOMY IN EUTHYROID PATIENTS","Inclusion Criteria:\n\n* A) Age between 18 to 60 years B) Both genders C) Multiple nodular goiter diagnosed on the basis of history and investigation like thyroid function test , USG neck for TIRADS scoring and USG guided FNAC to confirm the diagnosis .\n\nD) ASA grade 1 \\&2 E) With preserved one or two parathyroid gland\n\nExclusion Criteria:\n\n* A) Cardiovascular disease B) Deranged Renal parameters C) Pregnancy D) Concomitant endocrine pathology warranting the surgery","75 Years",{"count":57,"type":21},124,[24],"Total thyroidectomy is a commonly performed surgery for thyroid diseases such as multinodular goiter. One of the most frequent complications after this procedure is hypocalcemia (low blood calcium levels), which may cause symptoms such as tingling around the mouth, muscle cramps, and in severe cases, spasms or confusion. This condition usually occurs within the first 24-72 hours after surgery and may delay hospital discharge and increase patient discomfort.\n\nThis study aims to compare the effectiveness of preoperative calcium plus vitamin D3 supplementation versus calcium supplementation alone in preventing postoperative symptomatic hypocalcemia in patients undergoing total thyroidectomy. Patients diagnosed with multinodular goiter and planned for surgery will be randomly assigned into two groups. One group will receive calcium with vitamin D3 for seven days before surgery, while the other group will receive calcium alone for the same duration.\n\nAfter surgery, patients will be monitored for symptoms of hypocalcemia and their serum calcium levels will be checked at 6, 24, and 48 hours, as well as at a follow-up visit on day 14. The main outcome of the study is the occurrence of symptomatic hypocalcemia in both groups.\n\nThe results of this study may help determine whether adding vitamin D3 to preoperative calcium supplementation provides better protection against hypocalcemia after thyroid surgery, potentially improving patient outcomes and reducing hospital stay.",[61],"Postoperative Symptomatic Hypocalcemia Following Total Thyroidectomy",[63],"Total thyroidectomy Postoperative hypocalcemia Symptomatic hypocalcemia Calcium supplementation Vitamin D3 (cholecalciferol) Preoperative supplementation","NOT_YET_RECRUITING","2026-05-13",{"date":67,"type":40},"2026-05-19",{"date":69,"type":21},"2026-05-10",{"date":71,"type":21},"2026-06-30",{"name":46,"class":47},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100638833","phase-3-comparison-of-buffered-versus-non-buffered-local-anesthetic-in-patients-with-inflamed-tissues-for-pain-perception-onset-duration-and-adverse-effects-100638833","NCT07592143","\"Comparison of Buffered Versus Non-Buffered Local Anesthetic in Patients With Inflamed Tissues for Pain Perception, Onset, Duration and Adverse Effects\"","Inclusion Criteria:\n\n* Patient age between 18 and 60 and all gender.\n* Patients requiring surgical wound debridement under local anesthesia.\n\nExclusion Criteria:\n\n* Pregnant women (documented on medical record).\n* Patients taking the medications such as narcotics, antidepressants and sedatives from last 3 months that can influence the anesthetic assessment.\n* Patients with known allergy to local anesthetics or sulfites documented on previous medical record.",{"count":80,"type":21},68,[82],"PHASE3","This study aims to determine whether buffered or non-buffered local anesthetic (LA) is more effective and safer for managing pain in patients with inflamed tissues undergoing surgical procedures. Local anesthetics are widely used to reduce pain, but their effectiveness may vary, particularly in inflamed tissues where achieving adequate anesthesia can be challenging.\n\nIn this study, patients will be divided into two groups: one group will receive buffered local anesthetic, and the other will receive non-buffered local anesthetic. The study will compare the level of pain experienced during injection and the procedure, how quickly the anesthetic takes effect, and how long the numbness lasts. In addition, any side effects such as dizziness, nausea, vomiting, allergic reactions, or heart-related complications will be carefully monitored.\n\nThe study will also examine whether the presence of co-morbid conditions (such as diabetes, hypertension, or other chronic illnesses) affects the outcomes of both types of anesthetics.\n\nThe main question this study seeks to answer is whether buffered local anesthetic provides better pain relief, faster onset, longer duration, and fewer side effects compared to non-buffered local anesthetic, and how these outcomes differ in patients with and without co-morbid conditions. The findings may help improve pain management practices and guide healthcare providers in selecting the most appropriate anesthetic for different patient groups.",[85],"Comparison of Buffered Versus Non Buffered Local Anesthetic In Inflamed Tissues",[87,88,89,90],"Buffered","Non Buffered","Local anesthesia","Inflamed tissues",{"date":92,"type":40},"2026-05-18",{"date":94,"type":21},"2026-07-01",{"date":96,"type":21},"2026-12-31",{"name":46,"class":47},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":48},"100630469","phase-1-effect-of-liberal-and-restrictive-iv-fluids-on-recovery-after-gallbladder-surgery-100630469","NCT07488078","Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery","Effect of Liberal Versus Restrictive Intravenous Fluid Administration on Postoperative Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* All patients undergoing elective cholecystectomy\n* Age : 18-60 years\n* All genders\n* ASA class 1 and 2\n\nExclusion Criteria:\n\n* History of previous laparotomy\n* Perforated gall bladder\n* Duration of surgery more than 3 hours\n* More than 100ml intra operative blood loss",{"count":106,"type":21},380,[108],"PHASE1","The goal of this clinical trial is to learn whether giving less intravenous (IV) fluid (restrictive administration) after surgery is as effective as giving more IV fluid (liberal administration) in maintaining body stability (homeostasis) among adults undergoing laparoscopic gallbladder removal (cholecystectomy).\n\nThe main questions it aims to answer are:\n\nDoes restrictive IV fluid administration maintain stable blood pressure, heart rate, and urine output after laparoscopic cholecystectomy?\n\nAre there any differences in postoperative recovery or complications between restrictive and liberal fluid regimens?\n\nResearchers will compare patients receiving liberal IV fluid administration with those receiving restrictive IV fluid administration to see if both methods maintain similar postoperative homeostasis and recovery outcomes.\n\nParticipants will:\n\nBe adults aged 18-60 years (ASA class I-II) undergoing elective laparoscopic cholecystectomy.\n\nBe randomly assigned to one of two groups:\n\nGroup A: Liberal IV fluid administration for 6 hours after surgery.\n\nGroup B: Restrictive IV fluid administration for 6 hours after surgery.\n\nHave their vital signs (pulse, blood pressure, mean arterial pressure) and urine output recorded at multiple time points after surgery (immediate, 3, 6, 12, and 24 hours).",[30],"2026-03-17",{"date":113,"type":40},"2026-03-23",{"date":115,"type":40},"2025-12-01",{"date":117,"type":21},"2026-07-28",{"name":46,"class":47},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":127,"maxAge":18,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":4},"100629882","comparison-of-pain-reduction-in-painful-chronic-wounds-with-and-without-fat-grafting-100629882","NCT07480447","Comparison of Pain Reduction in Painful Chronic Wounds With and Without Fat Grafting","Comparison of Pain Reduction in Chronic Wounds Treated With and Without Autologous Fat Grafting: A Randomized Controlled Trial","PAINFAT","Inclusion Criteria:\n\n* • 3 months old chronic wound (Venous arterial, traumatic, burn and diabetic) having mean VAS Pain score \\>3 at rest\n\n  * Wound area between 4 cm² to 10 cm²\n  * Aged 20-60 years.\n  * Both male and female\n\nExclusion Criteria:\n\n* • Active wound infection.\n\n  * Wounds due to malignancy or irradiation.\n  * Pregnant or lactating females\n  * Smokers","20 Years",{"count":129,"type":21},62,[24],"Chronic wounds, such as those caused by diabetes, burns, or poor blood circulation, often heal slowly and can cause significant pain, affecting daily life and quality of life. This study aims to evaluate whether autologous fat grafting-a procedure in which a patient's own fat tissue is injected into the wound-can reduce pain and improve healing in chronic wounds compared to standard care without fat grafting.\n\nWe will enroll 62 adult patients with chronic wounds lasting more than 3 months. Participants will be randomly assigned to two groups: one group will receive fat grafting along with standard wound care, and the other group will receive standard wound care alone. Pain will be measured using a Visual Analog Scale (VAS) over 21 days after treatment. Wound healing and any complications will also be monitored.\n\nThe results of this study will help determine if autologous fat grafting is an effective and safe method to reduce pain and improve recovery in patients with chronic wounds.",[133,134],"Wound and Injuries","Pain",[136,137,138,139],"Chronic Wounds","Pain Reduction","Nanofat Grafting","Autologous fat grafting","2026-03-14",{"date":142,"type":40},"2026-03-18",{"date":144,"type":21},"2026-05-01",{"date":146,"type":21},"2026-11-01",{"name":46,"class":47},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":48},"100626365","comparison-of-extended-totally-extra-peritoneal-repair-etep-and-subcutaneous-on-lay-endoscopic-approach-scola-for-para-umbilical-hernia-puh-100626365","NCT07434687","Comparison of Extended Totally Extra-peritoneal Repair (ETEP) and Subcutaneous On-lay Endoscopic Approach (SCOLA) for Para-umbilical Hernia (PUH).","Comparison of Extended Totally Extra Peritoneal Repair (ETEP) and Subcutaneous Onlay Endoscopic Approach (SCOLA) for the Treatment of Para Umbilical Hernias (PUH) in Terms of Intraoperative Factors(Operative Time, Hernial Contents, Divarication of Recti, Conversion to Any Other Technique) and Postoperative Complications( Surgical Site Infection, Seroma Formation, Postoperative Pain, Rescue Analgesia, Drain Output)","Inclusion Criteria:\n\n* Adults of the age group from 18 to 65 years\n* Patients of both genders admittes with the diagnosis of para-umbilical Hernias through the outdoor department, documented on clinical examination by a consultant general surgeon.\n\nExclusion Criteria:\n\n* Patients with a hernial defect more than 5cm, documented in the perioperative findings\n* Patients with complicated hernias, including irreducible and obstructed varieties, documented on clinical findings.\n* Patients who require abdominoplasty, opinion given by the operative surgeon.\n* Patients with intermediate to high risk of MACE during the surgery, documented on the fitness form filled by the cardiology team.\n* Patients with previous midline incision or laparotomy, documented on clinical examination.","65 Years",{"count":157,"type":21},86,[24],"The goal of this clinical trial is to learn if one of two surgical techniques works better for treating paraumbilical hernias in adult men and women between 18 and 65 years old.\n\nThe main questions it aims to answer are:\n\nDoes one technique lead to fewer complications after surgery, such as infection or fluid buildup (seroma)?\n\nDoes one technique result in less pain or a shorter operating time?\n\nResearchers will compare the ETEP repair group to the SCOLA repair group to see if one method leads to better outcomes for patients.\n\nParticipants will:\n\nBe randomly assigned to receive either the ETEP or SCOLA surgical repair.\n\nHave their surgery and recovery tracked by the research team.\n\nAttend follow-up visits for up to six months to check for any complications.",[161],"Paraumbilical Hernia","2026-02-20",{"date":164,"type":40},"2026-02-25",{"date":166,"type":40},"2023-11-01",{"date":168,"type":21},"2026-09-01",{"name":46,"class":47},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":176,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":48},"100625871","comparison-of-wound-healing-for-diabetic-carbuncle-treated-with-incision-and-drainage-technique-using-cruciate-incision-vs-saucerization-technique-both-followed-by-vacuum-assisted-closure-100625871","NCT07428265","Comparison of Wound Healing for Diabetic Carbuncle Treated With Incision and Drainage Technique Using Cruciate Incision vs Saucerization Technique Both Followed by Vacuum Assisted Closure.","Inclusion Criteria:\n\n* All patients of either gender aged 25-70 years with ASA class 2-3 presenting to the emergency department with carbuncle requiring surgical drainage\n\nExclusion Criteria:\n\n* Failure to tolerate VAC\n* Patient with co-morbidities like: CKD, CLD, CVA\n* Patients not giving consent\n* Close to the anal opening\n* Wound near the joint","25 Years","70 Years",{"count":57,"type":21},[24],"The goal of this clinical trial is to compare the effectiveness of two surgical techniques for wound healing in diabetic patients aged 25-70 years with a carbuncle requiring surgical drainage. The main questions it aims to answer are:\n\nIs there a difference in blood loss during surgery between the two techniques?\n\nIs there a difference in the duration required for wound healing between the two techniques?\n\nResearchers will compare the Incision \\& Drainage group to the Saucerization group (both followed by Vacuum Assisted Closure) to see which technique results in better outcomes.\n\nParticipants will:\n\nBe randomly assigned to one of the two surgical groups.\n\nReceive their assigned surgical procedure (either cruciate incision \\& drainage or saucerization).\n\nReceive post-operative Vacuum Assisted Closure (VAC) therapy.\n\nHave their wounds assessed during follow-up visits every 14 days until healed.",[182],"Carbuncle","2026-02-17",{"date":185,"type":40},"2026-02-23",{"date":187,"type":40},"2026-01-02",{"date":189,"type":21},"2026-03-01",{"name":46,"class":47},{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":16,"minAge":198,"maxAge":18,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":205,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":48},"100621270","effect-of-feedback-based-balance-training-on-balance-and-gait-in-cancer-patients-with-chemotherapy-induced-peripheral-neuropathy-100621270","NCT07368439","Effect of Feedback-Based Balance Training on Balance and Gait in Cancer Patients With Chemotherapy-Induced Peripheral Neuropathy","Effects of Feedback-Based Balance Training on Balance and Gait Performance in Cancer Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Randomized Controlled Trial","Inclusion Criteria:\n\nAdults aged 30 to 60 years\n\nDiagnosed with breast, rectal, or stomach cancer\n\nHistory of treatment with neurotoxic chemotherapy\n\nPresence of chemotherapy-induced peripheral neuropathy as indicated by an EORTC CIPN20 total score of 24 or higher\n\nAbility to walk independently for at least 6 meters, with or without an assistive device\n\nMedically stable and able to participate in physiotherapy\n\nExclusion Criteria:\n\n* Peripheral neuropathy due to causes other than chemotherapy (e.g., diabetes mellitus)\n\nHistory of neurological disorders affecting balance or gait (e.g., stroke, Parkinson's disease)\n\nSevere musculoskeletal conditions affecting balance or lower limb function\n\nActive foot ulcers, infections, or soft tissue injuries\n\nSevere visual impairment affecting balance\n\nAny medical condition that, in the investigator's judgment, would interfere with safe participation","30 Years",{"count":200,"type":21},70,[24],"Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication of cancer treatment that can cause numbness, tingling, pain, balance problems, and difficulty walking. These symptoms may increase the risk of falls and reduce independence and quality of life in cancer survivors.\n\nThe purpose of this study is to determine whether adding feedback-based balance training to conventional physiotherapy improves balance and walking ability in cancer patients with CIPN. Participants will be randomly assigned to one of two groups. One group will receive conventional physiotherapy along with feedback-based balance and gait training, while the other group will receive conventional physiotherapy alone.\n\nThe intervention will be provided twice per week for four weeks. Balance, gait performance, neuropathy symptoms, and fear of falling will be assessed before and after the intervention using standardized clinical outcome measures. The findings of this study may help identify effective rehabilitation strategies to improve balance and mobility in cancer patients affected by chemotherapy-induced peripheral neuropathy.",[204],"Chemotherapy Induced Peripheral Neuropathy (CIPN)",[206,207,208,209,210,211,212,213],"Chemotherapy-Induced Peripheral Neuropathy","Balance Training","Feedback-Based Training","Gait Training","Physiotherapy","Cancer Rehabilitation","Fall Prevention","Postural Control","2026-01-18",{"date":216,"type":40},"2026-01-26",{"date":218,"type":21},"2025-12-29",{"date":220,"type":21},"2026-04-29",{"name":46,"class":47},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":228,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":232,"conditions":233,"keywords":235,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":48},"100613489","phase-2-evaluating-the-efficacy-of-vonoprazan-in-preventing-post-endoscopic-variceal-band-ligation-ulcers-a-randomized-controlled-trial-100613489","NCT07267260","Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 75 years (male or female)\n* Diagnosis of liver cirrhosis confirmed by clinical, biochemical, or imaging findings.\n* Presence of documented esophageal varices requiring endoscopic variceal band ligation (EVBL).\n* Able and willing to provide written informed consent in English or Urdu.\n* Willing to comply with study procedures, including taking study medication and attending follow-up endoscopy.\n\nExclusion Criteria:\n\n* History of gastric or esophageal surgery\n* Allergy or contraindication to vonoprazan or study drug components\n* Pregnant or lactating women\n* Individuals who are non-cooperative or unable to understand local languages\n* Critically ill patients, including:\n\nICU admission Requirement for mechanical ventilation GCS \\\u003C 10\n\n* Active gastrointestinal bleeding at the time of enrollment\n* Malignancy of the upper gastrointestinal tract",{"count":229,"type":21},154,[231],"PHASE2","The goal of this clinical trial is to learn if the medicine vonoprazan can help prevent ulcers that may develop after endoscopic variceal band ligation (EVBL) in adults with liver cirrhosis. These ulcers sometimes cause pain or delayed bleeding after the procedure.\n\nThe study will also look at how well vonoprazan is tolerated and if it improves comfort after the procedure.\n\nThe main questions this study will answer are:\n\nDoes vonoprazan lower the number and severity of ulcers found on endoscopy after EVBL?\n\nDoes vonoprazan reduce swallowing pain or chest discomfort compared with placebo?\n\nIs vonoprazan safe and well tolerated in people with liver cirrhosis?\n\nResearchers will compare vonoprazan 20 mg once daily with a placebo (a look-alike tablet that contains no active medicine) to see if vonoprazan works better to prevent these ulcers.\n\nParticipants will:\n\nTake vonoprazan or placebo by mouth once daily for 14 days after EVBL.\n\nReturn for a follow-up endoscopy about two weeks later to check for ulcers.\n\nReport any symptoms such as pain, nausea, or swallowing difficulty during the study.\n\nAdults aged 18 to 75 years with liver cirrhosis who undergo EVBL will be invited to join. Participants will be randomly assigned to one of two groups, and neither they nor the study doctors will know which treatment they receive (double-blind design).\n\nThe study will take place at Mayo Hospital, Lahore, Pakistan, over about six months.\n\nBy comparing vonoprazan to placebo, researchers hope to find a better way to protect the esophagus and stomach after EVBL, reduce post-procedure pain, and support faster recovery in people with liver cirrhosis.",[234],"Cirrhoses, Liver",[236,237,238,239,240,241,242,243],"Vonoprazan","Potassium-competitive acid blocker","Endoscopic variceal band ligation","Esophageal varices","Post-procedure ulcer","Cirrhosis","Portal hypertension","Double-blind randomized controlled trial","2025-12-24",{"date":246,"type":40},"2025-12-26",{"date":248,"type":21},"2025-12-16",{"date":250,"type":21},"2026-03-05",{"name":46,"class":47},{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":259,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":22,"phases":261,"briefSummary":262,"conditions":263,"keywords":266,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":4},"100615980","outcome-of-active-aspiration-versus-simple-compression-to-remove-residual-gas-from-abdominal-cavity-in-reducing-pain-after-laparoscopic-cholecystectomy-100615980","NCT07299656","Outcome of Active Aspiration Versus Simple Compression to Remove Residual Gas From Abdominal Cavity in Reducing Pain After Laparoscopic Cholecystectomy","Lap Chole","Inclusion criteria:\n\n* Patients of both genders.\n* Patients of age ≥ 18 years.\n* All patients presenting for elective laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients suffering from obstructive jaundice anamnesis.\n* Patients who had received a diagnosis of gallbladder cancer.\n* Patients whose procedures were converted to open cholecystectomy during the surgery.\n* Patients who had additional pathologies such as bronchial asthma, chronic obstructive pulmonary disease.\n* Patients refused to give consent.",true,{"count":129,"type":21},[24],"The aim of this study is to compare outcome of active aspiration versus simple compression to remove residual gas from abdominal cavity in reducing pain after laparoscopic cholecystectomy.",[264,265],"Shoulder Pain","Abdominal Pain (AP)",[267,268,269,270,271,272,273],"abdominal pain","shoulder pain","laparoscopic procedure","cholecystectomy","pneumoperitonium","lap chole","laparoscopic cholecystectomy","2025-12-10",{"date":276,"type":40},"2025-12-23",{"date":278,"type":21},"2025-12-11",{"date":280,"type":21},"2027-01-30",{"name":46,"class":47},{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":259,"sex":16,"minAge":17,"maxAge":155,"enrollmentInfo":288,"targetDuration":4,"studyType":290,"phases":4,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":298,"leadSponsor":300,"locationsCount":4},"100609120","comparative-study-on-the-post-operative-pain-and-other-outcomes-of-mesh-fixation-with-prolene-vs-vicryl-vs-skin-staples-in-lichtenstein-inguinal-hernia-repair-100609120","NCT07210424","Comparative Study on the Post-operative Pain and Other Outcomes of Mesh Fixation With Prolene vs Vicryl vs Skin Staples in Lichtenstein Inguinal Hernia Repair.","Inclusion Criteria:\n\n* Patients undergoing inguinal hernia repair\n* 18-65 years\n* Both genders\n\nExclusion Criteria:\n\n* COPD\n* Immunocompromised\n* Obstructive Uropathy\n* Chronic constipation",{"count":289,"type":21},132,"OBSERVATIONAL","We are going to see the outcome measures for patient and compare them across two groups, those who are undergoing mesh fixation for inguinal hernia by sutures, and those who are fixated by skin staples.",[293],"Inguinal Hernia","2025-12-09",{"date":296,"type":40},"2025-12-17",{"date":218,"type":21},{"date":299,"type":21},"2026-02-28",{"name":46,"class":47},{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":11,"sex":16,"minAge":307,"maxAge":18,"enrollmentInfo":308,"targetDuration":4,"studyType":22,"phases":310,"briefSummary":311,"conditions":312,"keywords":314,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":324,"locationsCount":48},"100608454","the-efficacy-of-intralesional-bleomycin-as-compared-to-5-flourouracil-5-fu-and-triamcinolone-acetonide-tac-for-the-treatment-of-keloids-a-randomized-control-trial-100608454","NCT07201766","The Efficacy of Intralesional Bleomycin as Compared to 5-Flourouracil (5-FU) and Triamcinolone Acetonide (TAC) for the Treatment of Keloids: A Randomized Control Trial.","Inclusion Criteria:\n\n* All, patients aged 13-60 years of age, either gender enrolled for Keloid treatment under local anaesthesia.\n\nExclusion Criteria:\n\n* Allergic to bleomycin, 5-FU DIABETICS VASCULAR INSUFFICIENCY AT THE AFFECTED SITE","13 Years",{"count":309,"type":21},104,[24],"The goal of this clinical trial is to learn if drug bleomycin intralesionally is beneficial than intralesional 5FU and Triamcinolone Acetonide in treating Keloids. The main questions it aims to answer are:\n\nDoes drug Bleomycin injected intrasleisonally lower the time duration to effectively treat the keloids in participants as compared to intralesional Triamcinolone Acetonide and 5-Flourouracil? Researchers will compare drug Bleomycin and 5FU plus Triamcinolone Acetonide and determine if bleomycin is better.\n\nParticipants will:\n\nTreatment will be given in two groups by a researcher blinded of the treatment being given in each group. POSAS patient and observer scar scale will be used to assess the keloids at 0, 2, 4, 6, 8, 10, and 12 weeks and during follow ups afterwards, assessments will be carried out by another researcher who will assess the improvement on the scale of 0-no improvement, to excellent-75-100% improvement in terms of POSAS variables. Effectiveness will be indicated by 50% reduction in POSAS score from the baseline.",[313],"Keloids Scars",[315,316,317],"intralesional injection","bleomycin","keloid scars","2025-11-23",{"date":320,"type":40},"2025-11-25",{"date":322,"type":21},"2025-12-02",{"date":299,"type":21},{"name":46,"class":47},{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":333,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":336,"conditions":337,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":48},"100597366","aloe-vera-vs-paraffin-tulle-dressings-for-pain-management-in-split-thickness-skin-graft-donor-sites-100597366","NCT07057557","Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites","Comparison of Postoperative Pain After Application of Aloe Vera Gel Dressings With Conventional Paraffin-Based Tulle Dressings at Split-Thickness Skin Graft Donor Site","AloePaTu","Inclusion Criteria:\n\n* • Patients aged 18-60 years of age of either gender needing Split thickness skin graft\n\nExclusion Criteria:\n\n* • Patients known to have exaggerated\u002Fdiminished pain response due to certain medical conditions (e.g. diabetes, neuropathy, chemotherapy, opioids etc.)\n\n  * Patients allergic to either dressings",{"count":334,"type":21},72,[24],"The goal of this clinical trial is to learn if Aloe Vera gel dressing helps reduce pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adult patients aged 18 to 60. The main questions it aims to answer are:\n\nDoes Aloe Vera gel dressing reduce postoperative pain more effectively than paraffin-based tulle dressing on the 7th day after surgery?\n\nIs there a difference in the need for additional pain medication between the two groups?\n\nResearchers will compare Aloe Vera gel dressing to paraffin-based tulle dressing to see if Aloe Vera leads to better pain control.\n\nParticipants will:\n\nUndergo split-thickness skin graft surgery\n\nReceive either Aloe Vera gel dressing or paraffin-based tulle dressing at the donor site\n\nHave pain measured using a visual analogue scale (VAS) on the 7th day after surgery\n\nBe given pain medication if their pain score is 4 or higher, and the amount used will be recorded",[338,339,340,341],"Skin Graft Wounds","Donor Site Complication","Pain, Postoperative","Skin Transplantation","2025-09-21",{"date":344,"type":40},"2025-09-25",{"date":346,"type":40},"2025-08-05",{"date":348,"type":21},"2026-04-14",{"name":46,"class":47},{"id":351,"slug":352,"hasResults":11,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":357,"targetDuration":4,"studyType":22,"phases":359,"briefSummary":360,"conditions":361,"keywords":363,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":48},"100605193","lignocaine-vs-gtn-ointment-for-postoperative-pain-after-hemorrhoidectomy-100605193","NCT07159334","\"Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy\")","Role of Topical Application of Lignocaine Versus 0.2% Glyceryl Trinitrate (GTN) Ointment as a Postoperative Local Analgesic in Hemorrhoidectomy in Terms of Pain Score,Wound Healing Time and Patient Satisfaction Level","Inclusion Criteria:\n\n* Age between 18 - 60 years\n* Both genders\n* Grade III and IV hemorrhoids diagnosed on the basis of history and clinical examination by consultant Surgeon.(Grade III Hemorrhoid manually reduced by patient with finger and Grade IV is prolapsed)\n* ASA (American society of Anesthesia) grades I, and II\n\nExclusion Criteria:\n\n* Previously reported allergy or reaction to lignocaine and GTN\n* Pregnancy or lactation\n* Concomitant perianal pathology warranting surgery\n* Cardiovascular disease\n* Patient taking Nitrates or Calcium channel blocker",{"count":358,"type":21},64,[24],"This study is being conducted at the Department of General Surgery, King Edward Medical University, Lahore, Pakistan. The purpose of the trial is to compare the effectiveness of topical Lignocaine ointment versus topical Glyceryl Trinitrate (GTN) ointment in reducing postoperative pain following hemorrhoidectomy.\n\nPatients undergoing hemorrhoidectomy will be randomly assigned to receive either Lignocaine ointment or GTN ointment applied locally after surgery. Pain relief will be assessed using a visual analog scale (VAS) at regular intervals during the postoperative period. The study aims to determine which ointment provides better pain control and improves patient comfort during recovery.",[362,34],"Hemorrhoid",[364,365,366,367],"Hemorrhoidectomy","Lignocaine ointment","Glyceryl Trinitrate ointment","Anal pain","2025-09-03",{"date":370,"type":40},"2025-09-08",{"date":372,"type":40},"2025-08-02",{"date":374,"type":21},"2025-12",{"name":46,"class":47},{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":16,"minAge":384,"maxAge":385,"enrollmentInfo":386,"targetDuration":4,"studyType":22,"phases":388,"briefSummary":390,"conditions":391,"keywords":397,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":4},"100592084","phase-4-comparison-of-g-csf--antibiotics-versus-antibiotics-alone-in-resolution-of-febrile-neutropenia-100592084","NCT06988826","Comparison of G-CSF & Antibiotics Versus Antibiotics Alone in Resolution of Febrile Neutropenia","Comparison of Antibiotics With and Without Granulocyte Colony-Stimulating Factor in Children With Chemotherapy Induced Febrile Neutropenia","AGF-FN","Inclusion Criteria:\n\n* Age 1-16 years\n* any Gender\n* Febrile neutropenia\n* diagnosed case of solid or hematological malignancy\n* taking chemotherapy\n\nExclusion Criteria:\n\n* Non-neutropenic fever\n* already received G-CSF or antibiotics before presenting to hospital\n* any other cause of neutropenia","1 Year","16 Years",{"count":387,"type":21},150,[389],"PHASE4","This study aim to find the best option for children having cancer who develop low immunity state due to chemotherapy",[392,393,394,395,396],"Febrile Neutropenia","Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy","Febrile Neutropenia, Drug-Induced","G-CSF","Antibiotic Therapy",[398,399,400,395],"febrile neutropenia","chemotherapy-induced febrile neutropenia","Antibiotics","2025-05-23",{"date":403,"type":40},"2025-05-25",{"date":405,"type":21},"2025-06-01",{"date":407,"type":21},"2026-12",{"name":46,"class":47},{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":155,"enrollmentInfo":415,"targetDuration":4,"studyType":22,"phases":417,"briefSummary":418,"conditions":419,"keywords":421,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":48},"100574898","phase-4-impact-of-atorvastatin-versus-rosuvastatin-on-25-hydroxy-vitamin-d-levels-in-patients-with-acute-coronary-syndrome-100574898","NCT06765265","Impact of Atorvastatin Versus Rosuvastatin on 25 Hydroxy Vitamin D Levels in Patients With Acute Coronary Syndrome","Inclusion Criteria:\n\nAcute Coronary Syndrome\n\n25 OH-Vitamin D levels between 30-70ng\u002Fml\n\nExclusion Criteria:\n\nHypercalcemia\n\nhypocalcemia\n\npregnancy\n\nlactation\n\nhypersensitivity to statins\n\nhypothyroidism\n\nDeranged LFTs \\& RFTs\n\nUse of following within last 3 months (Vitamin D Supplements, lipid lowering drugs, anti-obesity drugs, corticosteroids)",{"count":416,"type":21},152,[389],"there will be 2 groups of patients with acute coronary syndrome. The patients will receive one of the 2 study drugs and impact on raising Vitamin D level will be seen after 6 months",[420],"Acute Coronary Syndromes",[422,423,424,425,426],"atorvastatin","rosuvastatin","Vitamin D","Triglyceride","Lipid Profile","2025-03-07",{"date":429,"type":40},"2025-03-11",{"date":431,"type":40},"2025-01-05",{"date":433,"type":21},"2026-01-01",{"name":46,"class":47},{"id":436,"slug":437,"hasResults":11,"nctId":438,"briefTitle":439,"officialTitle":439,"acronym":440,"eligibilityCriteria":441,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":442,"targetDuration":4,"studyType":22,"phases":444,"briefSummary":445,"conditions":446,"keywords":448,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":48},"100569655","the-comparison-of-interrupted-modified-smead-jones-versus-conventional-continuous-suturing-technique-for-closure-of-rectus-sheath-in-patients-undergoing-laparotomy-for-hollow-viscus-perforation-100569655","NCT06697067","The Comparison of Interrupted Modified Smead-Jones Versus Conventional Continuous Suturing Technique for Closure of Rectus Sheath in Patients Undergoing Laparotomy for Hollow Viscus Perforation.","Farrukh 24","Inclusion Criteria:All patients of both genders with age greater than 18 to 60 years, undergoing emergency laparotomy through midline incision for hollow viscus perforation.\n\nASA grade III -\n\nExclusion Criteria:Patients who had undergone a previous laparotomy for any condition or had an incisional hernia or burst abdomen at presentation.\n\nPatients undergoing laparotomy with anterior abdominal wall injury in the form of muscle, hematoma, disruption or abdominal wall laceration.\n\n\\-",{"count":443,"type":21},108,[24],"After taking approval from Board of Studies, IRB \\& ASRB of KEMU, 108 patients fulfilling inclusion criteria will be admitted in Department of General Surgery, East Surgical Ward, Mayo Hospital Lahore through Emergency Department. Firstly patients will be seen in emergency department, history and clinical examination will be done and laboratory investigations and imaging will be done. All the patients aged greater than 18 years undergoing emergency laparotomy for hollow viscus perforation will be included in the study. Informed consent will be obtained. Demographic data including name, age, sex will be recorded.\n\nEmergency laparotomy will be done with midline incision and intra-operative findings will be recorded. Thorough peritoneal lavage will be done and necessary procedures will be carried out for the pathology identified, and abdominal drains will be placed. The patients then will be randomly divided into 2 groups; group A (Experimental Group) undergoing Modified Smead-Jones interrupted suture technique and group B (Reference Group) undergoing conventional continuous suture closure of rectus sheath. In Modified Smead-jones suture technique describe as a far bite starting at 2 cm on the edge of linea from outside-in and then taking a near bite of 0.5 cm on the other side inside-out- a near bite on the same side outside-in and then a far bite on the other side inside-out. The suture was next converted to a horizontal mattress by taking a far bite 1 cm above or below the previous bite on the other side- near bite on the same side, near bite on the other side, and finally a far bite on the same side. The two ends of the suture were tied to approximate the edges of the linea alba9. In conventional continuous closure suture technique I will use number 1 polypropylene suture, care being taken to place each bite 1-1.5 cm from the cut edge of linea alba and successive bites being taken 1cm away from each other The edges of linea alba were gently approximated without strangulation with an attempt to keep a suture to wound length ratio of 4:110.Rectus sheath will be closed by the suture material No.1 polypropylene in both groups.\n\nThe midline laparotomy wound will be managed with daily antiseptic dressing and intravenous antibiotics. All patients will be examined daily till discharge then weekly till 2 weeks and on each visit, a slandered physical examination of abdomen of wound will be done and presence of burst abdomen will be noted. When there are no signs of burst abdomen (after 14 postoperative days) the laparotomy wound will be considered normal. All the data will be collected in accordance to patient's proforma.",[447],"Wound Dehiscence, Surgical",[440],"2024-11-17",{"date":451,"type":40},"2024-11-20",{"date":453,"type":40},"2024-06-06",{"date":455,"type":21},"2025-06-21",{"name":46,"class":47},""]