[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"King Saud University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":514},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,55,88,112,147,182,215,244,266,298,323,357,385,411,440,467,492],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":37,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100643382","the-act-on-a-geriatric-5-ms-guided-physical-therapy-intervention-for-knee-osteo-arthritis-in-older-adults-100643382",false,"NCT07640529","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults: A Randomised Control Trial","5Ms\u002FPT\u002FKOA\u002FOA","Inclusion Criteria:\n\n* Prospective participants will be Saudi Nationals\n* aged 60 years or older\n* with a clinical diagnosis of knee osteoarthritis.\n* individuals must be capable of walking 10 meters independently or with an assistive device\n* self-report the ability to tolerate a one-hour assessment session.\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* knee surgery within the past 6 months.\n* diagnosis of rheumatoid arthritis\n* the presence of unstable comorbidities (e.g., uncontrolled hypertension, heart failure, arrhythmia, severe pulmonary disease requiring oxygen, or a cardiac event in the past 6 months).\n* severe joint instability or deformity.\n* unmanaged severe osteoporosis.\n* a recent intra-articular corticosteroid injection (\\\u003C3 months).\n* active cancer treatment within the past 6 months.\n* non-elective hospitalization for a major illness.\n* surgery within the past 6 months.",true,"ALL","55 Years","90 Years",{"count":22,"type":23},40,"ESTIMATED","INTERVENTIONAL",[26],"NA","The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis. The study will involve a in each group sample of 20 KOA patients, with a 12-month duration. The sample size was estimated using G\\*Power 3.1 software, and the initial power analysis indicated that 40 participants would be required to achieve 80.0% statistical power. The study's participants will be aged between 55 and 80 years, diagnosed with Knee osteoarthritis, without cognitive impairment, knee surgery in the past 6 months, or unstable comorbidities. The study will involve in-person 16 sessions, with the first two lasting approximately one hour and the remaining session 30-45 minutes. The main outcome measures that will be used in this study are Stay Independent Brochure, Iconographical Falls Efficacy Scale (icon-FES), Timed Up and Go, 2-Minute Walk Test, 5 Time Set to Stand Test AND Arthritis Self-Efficacy Scale 8 Item (ASES-8), Patient-Specific Functional Scale (PSFS), and Patient satisfaction level with Physical Therapy service MedRisk. Data will be taken from direct questions to patients, by filling out the questionnaire via Google Form, and through some tests and SPSS will be used for data analysis, with ANOVA Test intervention scores of the outcome measures.",[29,30,31,32,33,34,35,36],"Rehabilitation","Excercise","Geriatric","Physical Therapy","Rehabilitation Exercise","Rehabilitation Outcome","Knee Osteoarthristis","Knee Osteoarthritis",[38,39,40,41],"5Ms","PT","KOA","OA","NOT_YET_RECRUITING","2026-06-06",{"date":45,"type":46},"2026-06-10","ACTUAL",{"date":48,"type":23},"2026-05-15",{"date":50,"type":23},"2026-10-15",{"name":52,"class":53},"King Saud University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":17,"sex":18,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":24,"phases":67,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":54},"100635741","effect-of-chocolate-consumption-prior-to-prolonged-sitting-on-cardiovascular-health-in-adults-100635741","NCT07556627","Effect of Chocolate Consumption Prior to Prolonged Sitting on Cardiovascular Health in Adults","Effects of Dark, Milk, and White Chocolate Consumption Prior to Prolonged Sitting on Cardiovascular Health in Healthy Adults: A Randomized Crossover Trial","CHOC-SIT","Inclusion Criteria:\n\n* Adult males and females aged between 18 and 40 years.\n* Participants with blood pressure within the normal or elevated range (less than 130\u002F80 mmHg), according to the American Heart Association guidelines.\n\nExclusion Criteria:\n\n* Females with menopause will be excluded due to the physiological effects of menopause and to ensure hormonal stability.\n* Participants with nut allergies, due to the possibility that the chocolate used may contain traces of nuts resulting from manufacturing processes.\n* Participants with dairy allergies, due to the use of milk chocolate and white chocolate, and the possibility that dark chocolate may contain traces of milk resulting from manufacturing processes .\n* Participants with chronic diseases that may affect the study variables, such as cardiovascular diseases, respiratory diseases, diabetes, or any medical condition that affects circulation.\n* Participants using medications that may affect the targeted physiological measurements in the study, such as antihypertensive medications, antidiabetic medications, or drugs affecting the autonomic nervous system.\n* Participants with a body mass index (BMI) ≥ 30 kg\u002Fm², due to the association between obesity and vascular dysfunction, characterized by increased blood pressure and arterial stiffness, which may lead to variability in vascular responses.\n* Participants who are physically active (≥150 minutes per week of moderate-to-vigorous physical activity), to avoid the impact of high levels of training on vascular responses.\n* Smokers, due to the chronic effects of smoking on endothelial function and arterial stiffness.\n* Participants with back injuries that limit their ability to sit continuously for three hours.\n* Female participants who are pregnant, breastfeeding, due to the associated hormonal changes that may influence the physiological indicators measured in the study.","18 Years","40 Years",{"count":66,"type":23},22,[26],"This randomized controlled crossover trial investigates the acute effects of consuming dark, milk, and white chocolate before prolonged sitting on cardiovascular health in healthy adults. Each participant completes three separate study visits and receives all three chocolate conditions in a randomized order, with a 7-day washout period between visits. Blood pressure, heart rate, pulse wave velocity, blood glucose, appetite, pain, and calf circumference are measured before and during a 3-hour sitting perio",[70],"Cardiovascular Health During Prolonged Sitting",[72,73,74,75,76,77,78],"Dark Chocolate","Milk Chocolate","White Chocolate","Prolonged Sitting","Blood Pressure","Pulse Wave Velocity","Heart Rate Variability","RECRUITING","2026-04-22",{"date":82,"type":46},"2026-04-29",{"date":84,"type":46},"2026-04-04",{"date":86,"type":23},"2026-12",{"name":52,"class":53},{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":24,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100631424","tele-rehabilitation-in-adults-with-cystic-fibrosis-100631424","NCT07500493","Tele-Rehabilitation in Adults With Cystic Fibrosis","The Impact of an 8-Week Tele-Rehabilitation Program on Frailty, Sarcopenia, and Quality of Life in Adults With Cystic Fibrosis","CF-TR","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Confirmed diagnosis of cystic fibrosis\n* Clinically stable condition with no acute exacerbation at the time of enrollment\n* Ability to participate in an exercise program\n* Access to a device with internet connection for tele-rehabilitation sessions\n* Willingness to provide informed consent\n\nExclusion Criteria:\n\n* Acute pulmonary exacerbation within the past 4 weeks\n* Severe comorbidities that limit participation in exercise (e.g., unstable cardiovascular disease)\n* Musculoskeletal or neurological conditions preventing safe exercise performance\n* Cognitive impairment affecting ability to follow instructions\n* Participation in another structured rehabilitation or clinical trial during the study period\n* Pregnancy (if applicable based on your protocol)",{"count":97,"type":23},76,[26],"This study is a randomized controlled trial designed to evaluate the effectiveness of an 8-week tele-rehabilitation program in adults with cystic fibrosis. Cystic fibrosis is a chronic condition that affects the lungs and can lead to reduced muscle mass, physical weakness, frailty, and decreased quality of life.\n\nParticipants will be randomly assigned to either a tele-rehabilitation group or a usual care group. The tele-rehabilitation program includes supervised exercise sessions conducted remotely three times per week using video communication. The program combines aerobic and resistance training based on established rehabilitation guidelines.\n\nThe primary aim of the study is to assess the effect of the program",[101,102,103],"Cystic Fibrosis","Sarcopenia","Frailty","2026-03-25",{"date":106,"type":46},"2026-03-30",{"date":108,"type":23},"2026-04-17",{"date":110,"type":23},"2026-07-17",{"name":52,"class":53},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":24,"phases":121,"briefSummary":122,"conditions":123,"keywords":129,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":54},"100615113","investigating-the-feasibility-of-combining-virtual-reality-and-bilateral-transcranial-direct-stimulation-to-improve-upper-limb-recovery-in-patients-with-stroke-100615113","NCT07288385","Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Upper Limb Recovery in Patients With Stroke","bi-tDCS+VR","Inclusion Criteria: 1- Adult participants (over 18 years of age) (Elsner et al., 2020).\n\n2- Patients with a unilateral cerebral infarction or haemorrhage who are at least three months post-stroke (Muller et al., 2021).\n\n3- Adequate mental status confirmed by an MMSE (Arabic version) should be ≥24 (Kim, 2021). ensuring the ability to comprehend and follow instructions.\n\n4- Modified Ashworth scale score \\\u003C 3 (Ögün et al., 2019). 5- Fugl-Meyer assessment (FMA) scores between 29 and 58, indicating moderate impairments (Woytowicz et al., 2017).\n\n\\-\n\nExclusion Criteria: - Visual impairment and severe hemisensory neglect or inattention (Stahl et al., 2019; Fluet1 et al., 2015).\n\n2- Individuals who have aphasia find it difficult to follow instructions (Fluet et al., 2015).\n\n3- Presence of any medical condition that contraindicates the use of non-invasive brain stimulation (Stahl et al., 2019; Learmonth et al., 2021).\n\n4- History of neurological disorders unrelated to stroke or participation in another study.\n\n\\-",{"count":120,"type":23},100,[26],"Following a stroke, the function of the distal upper limb, especially hand and finger movements, is often severely compromised, significantly restricting the ability to carry out daily activities. It is estimated that 55-75% of stroke survivors suffer from motor dysfunction, with upper limb impairments affecting up to 85% of them (Tang et al., 2024). Current rehabilitation approaches, while beneficial, often produce limited gains in hand function, particularly in patients with chronic stroke. Virtual reality (VR) training has emerged as a promising tool in neurorehabilitation, providing repetitive, task-specific, and engaging practice environments that can promote motor learning (Cameirão et al., 2012). tDCS has also shown potential to enhance motor recovery when combined with motor practice (Kang et al., 2016). To date, no studies have directly compared the effectiveness of Bi-tDCS with VR for improving upper limb function after stroke.",[124,125,126,127,128],"Brain Diseases","Central Nervous System Diseases","Nervous System Diseases","Stroke","Paresis",[130,131,132,133,134,135,136,137,138,127],"ischemic stroke","Hemorrhagic stroke","bi-tDCS","Hemiparesis","Neural activation","Primary motor cortex","NIBS","Non-invasive brain stimulation","Transcranial direct current stimulation","2025-12-29",{"date":141,"type":46},"2025-12-30",{"date":143,"type":46},"2025-12-28",{"date":145,"type":23},"2027-01-30",{"name":52,"class":53},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":17,"sex":18,"minAge":63,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":24,"phases":158,"briefSummary":159,"conditions":160,"keywords":167,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":54},"100617855","chrono-align-a-chronotype-based-chrono-nutrition-intervention-in-post-bariatric-patients-100617855","NCT07324044","Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients","Chrono-ALIGN Trial: The Impact of Chronotype-Based Chrono-Nutrition on Metabolic Health, Gut Microbiota, Appetite, and Circadian Alignment in Post-Bariatric Surgery Patients: A Randomized Controlled Trial","Chrono-ALIGN","Inclusion Criteria:\n\n* Adults aged 18-50 years who underwent Sleeve Gastrectomy (SG) 6 Months prior to enrollment.\n* Have achieved ≥50% of excess weight loss post-surgery (to ensure initial success).\n* Current BMI between 25-40 kg\u002Fm².\n* No major postoperative complications and cleared for a regular diet by their healthcare provider.\n* Participants must be able to align their eating schedule within a daytime window (morning to evening), ensuring that the first meal is consumed in the early part of the day and the last meal is completed before late evening, in accordance with chrono-nutrition guidelines.\n\nExclusion Criteria:\n\n* • Pregnancy or planned pregnancy during the study period, and post menopaused females\n\n  * Current diagnosis of severe psychiatric illness that may interfere with adherence (e.g., untreated major depression, psychosis, severe eating disorders).\n  * Active malignancy or serious chronic disease unrelated to obesity that may confound outcomes (e.g., advanced renal failure, uncontrolled liver disease).\n  * Use of medications known to significantly alter circadian rhythm or metabolism (e.g., corticosteroids, melatonin therapy) within the last 3 months.\n  * Inability to comply with study requirements (dietary interventions, sample collection, or follow-up visits).Participants who have previously undergone revision bariatric surgery.\n  * Individuals following intermittent fasting regimens prior to the study.","50 Years",{"count":157,"type":23},246,[26],"This randomized controlled trial will evaluate the impact of chrono-nutrition, a dietary approach that aligns meal timing with the body's circadian rhythms, on weight change, metabolic outcomes, appetite, and gut microbiota in post-bariatric surgery patients. A total of 246 adults who underwent sleeve gastrectomy at least six months earlier will be enrolled at King Saud Medical City. Participants will be randomized to receive either standard post-bariatric nutritional care or personalized chrono-nutrition based on individual chronotype. Outcomes include weight change, metabolic biomarkers, dietary behaviors, sleep patterns, and gut microbiota composition. The study aims to determine whether integrating chrono-nutrition into post-bariatric follow-up can enhance metabolic health and improve long-term health.",[161,162,163,164,165,166],"Obesity (Disorder)","Morbid Obesity","Bariatric Sleeve Gastrectomy","Meal Time","Chronotype","Circadian Rhythm",[168,169,170,171,172,173],"chrononutrition","Bariatric Surgery","Gastric Sleeve","Gut Microbiota","Appetite","Meal Timing","2025-12-23",{"date":176,"type":46},"2026-01-07",{"date":178,"type":23},"2026-01-01",{"date":180,"type":23},"2028-12-01",{"name":52,"class":53},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":24,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":54},"100611648","evaluating-functional-outcomes-of-3d-printed-splints-in-post-stroke-upper-limb-recovery-100611648","NCT07243314","Evaluating Functional Outcomes of 3D-Printed Splints in Post-Stroke Upper Limb Recovery","3D-splint","Inclusion Criteria:\n\n1. Over 18 years old.\n2. Chronic stroke\n3. Upper limb hemiparalysis\n4. Ability to understand and follow orders and able to provide informed consent (Mini-Mental State Exam (MMSE) \\> 24)\n5. Upper-limb mild to moderate spasticity (Modified Ashworth Scale 1+ to 3 at the wrist).\n6. Not participating in other clinical or research studies at the same time\n\nExclusion Criteria:\n\n1. Had deficits in language or cognitive impairments that were likely to interfere with their cooperation in the study\n2. Deformity or presented with severe upper-limb contractures\n3. Inability to commit to the time requirement of the protocol.\n4. Unilateral neglect",{"count":120,"type":23},[26],"This study aims to evaluate the upper limb motor recovery using a 3D-printed dynamic orthosis compared to a conventional one as part of a rehabilitation program in individuals with chronic stroke.\n\nThe main question it seeks to answer:\n\nWhich type of dynamic splint (3D-printed or traditional), combined with the task-oriented therapy program, leads to greater improvement in affected upper-limb function, patient satisfaction, and usability in stroke patients? Researchers will compare these two types of dynamic splints.\n\nParticipants will:\n\nReceive 20 sessions of task-oriented therapy combined with either a 3D-printed dynamic splint or a traditional dynamic splint.\n\nVisit the clinic five times a week for a period of four weeks. Undergo assessments before and after the 4-week program.",[127,193,194],"Stroke Rehabilitation","Hemiparesis of the Upper Limb Following Stroke",[196,197,198,133,199,200,201,202,203,204,205,206],"stroke","Ischemic Stroke","Hemorrhagic Stroke","Splint","Dynamic Splint","Three-Dimensional Printing","3D-Printed Splint","Orthosis","Task-Oriented","Traditional Dynamic Splint","Motor Function","2025-11-17",{"date":209,"type":46},"2025-11-21",{"date":211,"type":23},"2025-11",{"date":213,"type":23},"2027-09-30",{"name":52,"class":53},{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":17,"sex":18,"minAge":63,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":24,"phases":224,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":54},"100605179","effects-of-coffee-versus-hibiscus-tea-consumption-during-prolonged-sitting-on-blood-pressure-and-heart-rate-100605179","NCT07159152","Effects of Coffee Versus Hibiscus Tea Consumption During Prolonged Sitting on Blood Pressure and Heart Rate","Inclusion Criteria:\n\n* Age between 18 and 35 years.\n* Normal to elevated blood pressure (systolic \\\u003C130 mmHg and diastolic \\\u003C80 mmHg) and normal resting heart rate (60-100 bpm), ensuring selection of healthy adults and minimizing confounding factors.\n* Generally healthy, without chronic or acute medical conditions, to reduce external influences on study outcomes.\n* Physically inactive, not meeting current physical activity guidelines, as the study targets sedentary individuals.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to hibiscus or coffee, as participants will consume these beverages during the study.\n* Current use of medications that could influence blood pressure, heart rate, or heart rate variability, including antihypertensive, chronotropic, or vasoactive drugs.\n* Any medical condition or health issue that may interfere with safe participation or affect study measurements.","35 Years",{"count":223,"type":23},30,[26],"Modern lifestyles often involve long periods of sitting, which can increase the risk of heart problems, obesity, and other health issues. Diet also plays a key role in heart health. Coffee and hibiscus tea are two common beverages, but their effects during prolonged sitting are not well understood.\n\nThis study will examine how drinking coffee versus hibiscus tea affects blood pressure, heart rate, and heart rate variability in men and women during extended periods of sitting.\n\nParticipants (30 in total: 15 women and 15 men) will take part in a randomized crossover study, meaning each person will try both beverages at different times. Data will be collected using questionnaires, body measurements, and devices to measure heart rate, blood pressure, and heart rate variability.\n\nThe goal is to better understand how these drinks influence heart health during sedentary behavior.",[227],"Hypertension",[229,230,231,232,233,234,235],"hibiscus drink","coffee","prolonged sitting","sedentary behavior","cardiovascular health","vascular function","cardiovascular regulation","2025-08-28",{"date":238,"type":46},"2025-09-08",{"date":240,"type":23},"2025-09-01",{"date":242,"type":23},"2026-03-01",{"name":52,"class":53},{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":24,"phases":254,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":54},"100603873","improving-cervical-spine-alignment-and-intervertebral-foramen-expansion-using-a-novel-distally-expanding-cervical-facet-implant-for-cervical-degenerative-disease-100603873","NCT07142174","Improving Cervical Spine Alignment and Intervertebral Foramen Expansion Using a Novel Distally Expanding Cervical Facet Implant for Cervical Degenerative Disease","Improving Cervical Spine Alignment and Intervertebral Foramen Expansion Using a Novel Distally Expanding Cervical Facet Implant (CeLFI) for Cervical Degenerative Disease","CeLFI","Inclusion Criteria:\n\n* Age \\> 18\n* Signed Informed Consent\n* Patients undergoing posterior cervical Spine surgery for CDD (for radiculopathy or myelopathy)\n\nExclusion Criteria:\n\n* Non-degenerative cervical spine pathologies, including infection, tumor, or trauma.",{"count":253,"type":23},20,[26],"Cervical degenerative disease (CDD) resulting in myelopathy represents the commonest disease affecting the spinal cord in adults. Cervical radiculopathy can be associated with myelopathy or occurs alone. The treatment frequently requires surgical intervention; which could be done through anterior or posterior cervical spine approach, or a combination. In this study, we aim to evaluate the value of the innovative device (CeLFI; Cervical expanding facet implant), inserted from posterior approach, in widening the neural intervertebral foramina by providing an anterior distraction of the cervical facet joint space (FJS). Therefore, achieving indirect nerve decompression while maintaining cervical alignment and stability.\n\nA prospective clinical study of a biomechanically and cadaver-validated device, following the pathway of similarly approved devices. Informed consent will be taken before the participation of every patient. 20 adult patients undergoing posterior surgery for CDD (for radiculopathy or myelopathy); from C2-6, will be included. Clinical evaluation will include pre- and post-operative standard outcome measures including visual analogue score (VAS), Neck disability index (NDI), and Modified Japanese Orthopedic Association score (mJOA). Standard radiologic evaluation will be performed before and after surgery including X-ray, computer tomography scan (CT), and Magnetic resonance imaging (MRI). Interim detailed safety analysis will be conducted after the first 5 cases are performed.",[257],"Cervical Degenerative Disease","2025-08-19",{"date":260,"type":46},"2025-08-26",{"date":262,"type":46},"2024-12-01",{"date":264,"type":23},"2027-06",{"name":52,"class":53},{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":272,"eligibilityCriteria":273,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":274,"targetDuration":4,"studyType":24,"phases":276,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":54},"100576492","neurophysiological-and-behavioral-effects-of-combining-transcranial-direct-current-stimulation-tdcs-and-modified-constraint-induced-movement-therapy-mcimt-100576492","NCT06786000","Neurophysiological and Behavioral Effects of Combining Transcranial Direct Current Stimulation (tDCS) and Modified-Constraint Induced Movement Therapy (mCIMT)","Neurophysiological and Behavioral Effects of Combining Transcranial Direct Current Stimulation (tDCS) and Modified-Constraint Induced Movement Therapy (mCIMT) on Upper Limb Function Recovery in Patients with Stroke","tDCS and mCIMT","Inclusion Criteria:\n\n1. Adult participants clinically diagnosed and confirmed by imaging of ischemic or hemorrhagic cerebrovascular accident (Dahl et al., 2008; Jin et al., 2019).\n2. Participant's age older than 18 years (Baltar et al., 2020).\n3. Stroke onset more than 3 months with unilateral motor deficits (Lin et al., 2010).\n4. Adequate cognitive function is required to follow instructions. The Arabic version of the Mini Mental State Examination (MMSE) should be ≥24 (Kim, 2021).\n5. 10° of active extension to the metacarpophalangeal and interphalangeal joints and 20° at wrist will be assessed by manual goniometer (Dahl et al., 2008).\n6. Fugl-Meyer assessment (FMA) scores between 19 and 58, indicating moderate to mild impairments.\n7. Not participating in other clinical, or research studies at the same time.\n\nExclusion Criteria:\n\n1. Severe muscle spasticity at the affected limb at all joints (the Modified Ashworth Scale scores \\> 3) (Baltar et al., 2020).\n2. Contraindications to NIBS (Bornheim et al., 2019).\n3. Unilateral neglect (Dahl et al., 2008)\n4. Other neurologic or orthopedic conditions that may affect hand function.\n5. Unstable medical conditions.",{"count":275,"type":23},300,[26],"This clinical trial aims to evaluate the effect of different types of tDCS modulation with mCIMT in improving affected upper-limb motor function for stroke patients. The main question it seeks to answer:\n\nWhich type of tDCS (bi-hemispheric, anodal, or cathodal) combined with the mCIMT program leads to greater improvement in affected upper-limb function in patients with stroke? Researchers will compare these three types of tDCS to a sham tDCS. To see which kind of tDCS protocol combined with the mCIMT program will be more effective in improving affected upper-limb function for stroke patients.\n\nParticipants will:\n\n1. Participants will receive 12 sessions of mCIMT combined with tDCS or mCIMT alone.\n2. Visit the clinic three times a week for four weeks.\n3. Participants will do fMRI and TMS before and after the program and three times of assessment before and after two weeks after the program.",[127,194,279],"Stroke Rehabilitatiom",[196,130,281,282,283,284,285,286,136,287,288,289],"hemorrhagic stroke","tDCS","mCIMT","hemiparesis","neural activation","primary motor cortex","non invasive brain stimulation","trans direct current stimulation","modified constraint induced movement therapy","2025-01-14",{"date":292,"type":46},"2025-01-22",{"date":294,"type":46},"2023-04-11",{"date":296,"type":23},"2025-04-11",{"name":52,"class":53},{"id":299,"slug":300,"hasResults":11,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":282,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":24,"phases":306,"briefSummary":308,"conditions":309,"keywords":311,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":322},"100574862","phase-3-investigating-the-efficacy-of-combining-virtual-reality-based-mirror-therapy-vrmt-and-transcranial-direct-current-stimulation-tdcs-to-improve-upper-limb-recovery-in-patients-with-stroke-100574862","NCT06764797","Investigating the Efficacy of Combining Virtual Reality-Based Mirror Therapy (VRMT) and Transcranial Direct Current Stimulation (tDCS) to Improve Upper Limb Recovery in Patients with Stroke","Investigating the Efficacy of Combining Virtual Reality-Based Mirror Therapy and Transcranial Direct Current Stimulation to Improve Upper Limb Recovery in Patients with Stroke","Inclusion Criteria:\n\n* At least 18 years old.\n* Stroke patients with unilateral cerebral infarction or hemorrhage, more than three months following the stroke.\n* Adequate cognitive ability to follow instructions (The Arabic version of the Mini-Mental State Examination scores \\> 24).\n* Modified Ashworth scale score \\\u003C 3.\n* Fugl-Meyer Assessment (FMA) score of 10-58 indicating moderate-to-severe arm impairment.\n\nExclusion Criteria:\n\n* visual impairment and field defect or hemi-sensory inattention and unilateral neglect.\n* Wernicke's aphasia, or global aphasia, leads to difficulty following instructions.\n* Any contraindication to NIBS.\n* Other neurological conditions or participation in another study.",{"count":275,"type":23},[307],"PHASE3","This study will investigate whether combining virtual reality-based mirror therapy (VRMT) and transcranial direct current stimulation (tDCS) alongside conventional physical therapy (CPT) will significantly improve hand function for patients with stroke compared to using VRMT or tDCS alone.",[310,127],"Stroke Rehabilitaion",[312,313],"Virtual reality, Mirror therapy, non invasive brain stimulation, tDCS, stroke","transcranial direct current stimulation","2025-01-02",{"date":316,"type":46},"2025-01-08",{"date":318,"type":46},"2023-09-19",{"date":320,"type":23},"2025-07-21",{"name":52,"class":53},2,{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":4,"enrollmentInfo":331,"targetDuration":333,"studyType":334,"phases":4,"briefSummary":335,"conditions":336,"keywords":345,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":54},"100567034","arabic-pro-measures-for-head-and-neck-cancer-radiotherapy-100567034","NCT06662929","Arabic PRO Measures for Head and Neck Cancer Radiotherapy.","Arabic Patient-reported Outcome Measures During Radiotherapy for Head and Neck Cancer: a Validation Study","PROMs","Inclusion Criteria:\n\n* Adults aged 18 or above and who is planned for receiving and who is currently receiving and who had already received radiotherapy for the HNC at King Saud University Medical City.\n\nExclusion Criteria:\n\n* Individuals who are less than 18 years, presence of debilitating disease (e.g. heart failure) or who lack the capacity to read, understand and sign the informed consent and those.",{"count":332,"type":23},125,"2 Weeks","OBSERVATIONAL","The goal of Arabic patient-reported outcome measures during radiotherapy for head and neck cancer is to test the patient-reported outcome measure (PROM) tools. PROM tools are not validated cross-culturally in Arabic-speaking patient populations, which limits their use in our clinical setting. Validation of these PROM tools will allow clinicians to identify the concerns related to our patient population and measure the outcome of our interventions. Main objectives are:\n\n* To further validate (cross-culture) the PROM instruments related to head and neck cancer (HNC) in Arabic patients.\n* To investigate the prevalence and severity of the patient-reported concerns and their relevance with demographics and clinical characteristics.\n\nThe participants will be given tasks to complete 6 tools survey before, during, and after radiotherapy.",[337,338,339,340,341,342,343,344],"Head and Neck Cancer","Head and Neck Neoplasms","Head and Neck Squamous Cell Carcinoma","Oropharynx Cancer","Nasopharyngeal Cancer","Oral Cancer","Tongue Cancer","Oral Neoplasm",[329,337,346,347,348],"Radiotherapy","COSMIN","Cancer","2024-10-26",{"date":351,"type":46},"2024-10-29",{"date":353,"type":46},"2023-05-01",{"date":355,"type":23},"2025-10-01",{"name":52,"class":53},{"id":358,"slug":359,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":17,"sex":18,"minAge":63,"maxAge":364,"enrollmentInfo":365,"targetDuration":4,"studyType":24,"phases":367,"briefSummary":368,"conditions":369,"keywords":372,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":54},"100556889","the-effectiveness-of-a-tailored-nutritional-education-program-on-profound-hearing-impairment-adults-100556889","NCT06530979","The Effectiveness of a Tailored Nutritional Education Program on Profound Hearing Impairment Adults","The Effectiveness of a Tailored Nutritional Education Program Utilizing Saudi-Sign Language on Adults With Profound Hearing Impairment","Inclusion Criteria:\n\n1. Saudi adults\n2. Aged between 18-65 years\n3. Both males and females\n4. Known case of profound hearing impairment \u002Fdisability\n5. knowledgeable in Saudi Sign Language.\n\nExclusion Criteria:\n\n1. Aged \\\u003C18 years\n2. Not knowing the Saudi Sign Language\n3. Other disabilities such as mental or physical disability\n4. Have nutritional knowledge such as attended course\u002Fs related nutrition or studied in nutrition field\n5. Illiterate\n6. Pregnant or planning a pregnancy, or on breastfeeding","65 Years",{"count":366,"type":23},61,[26],"Literature suggests that profound hearing-impaired people have poor access to health care directly related to communication difficulties. A lack of knowledge regarding health and healthy dietary patterns has been documented. Several associations between chronic diseases such as obesity, CVD, hyperlipidemia etc., and hearing impairments have been established. There is a gap in the literature for studies that use Saudi-sign language-tailored programs in patient health and nutrition education.\n\nThis project aims to create a Saudi-sign language general nutritional education program and then test its effectiveness in enhancing the nutritional status and knowledge of Saudis with profound hearing impairments.",[370,371],"Profound Hearing Impairment","Nutrition, Healthy",[373,374,375,376],"Profound hearing impairment","Nutrition knowledge","Nutrition status","Intervention nutrition education","2024-07-29",{"date":379,"type":46},"2024-07-31",{"date":381,"type":46},"2023-06-01",{"date":383,"type":23},"2025-03-02",{"name":52,"class":53},{"id":386,"slug":387,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":4,"eligibilityCriteria":391,"healthyVolunteers":11,"sex":18,"minAge":392,"maxAge":63,"enrollmentInfo":393,"targetDuration":395,"studyType":334,"phases":4,"briefSummary":396,"conditions":397,"keywords":399,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":54},"100555527","screening-program-for-type-1-diabetes-in-a-high-risk-population-100555527","NCT06513247","Screening Program for Type 1 Diabetes in a High-Risk Population","Feasibility of a Pilot Screening Program for Type 1 Diabetes in a High-Risk Population","Inclusion Criteria:\n\n* T1D diagnosis in a first-degree relative:\n\nDiabetes is defined based on the American diabetes association (ADA) definition: Classic symptoms of diabetes or hyperglycemic crisis, with plasma glucose concentration ≥11.1 mmol\u002FL (200 mg\u002FdL), or Fasting plasma glucose ≥7.0 mmol\u002FL (≥126 mg\u002FdL). Fasting is defined as no caloric intake for at least 8 h, or Two-hour post load glucose ≥11.1 mmol\u002FL (≥200 mg\u002FdL) during an OGTT, or HbA1c \\>6.5%.\n\nExclusion Criteria:\n\n* first-degree relative case with Maturity-Onset Diabetes of the Young (MODY) or Type 2 Diabetes Mellitus (T2DM).\n* Non-Saudi children.\n* first-degree relative not following at our centre.","2 Years",{"count":394,"type":23},1300,"5 Years","Type 1 diabetes mellitus (T1D) is a growing public health concern in Saudi Arabia, ranking ninth globally in T1D incidence and tenth in T1D prevalence in children, and the rates are expected to rise and incur greater healthcare costs. Genetic and immunological factors are believed to play a significant role in disease development, and recent clinical trials have shown promise in delaying or preventing T1D onset in high-risk individuals. Early screening for immunological or genetic markers in children is crucial to identify high-risk individuals and provide early intervention. Last year, the American diabetes association's recommended clinicians to screen first degree relatives of individual with T1D. Unfortunately, Saudi Arabia and other Arab countries lack established T1D screening programs, making early identification and intervention challenging. The benefits of screening include education for symptom awareness, monitoring to track progression to clinical T1D, a five-fold reduction in diabetic ketoacidosis (DKA) at onset, and improved glucose control for the first years following diagnosis. To address this issue, exploring effective and efficient screening methods in identifying high-risk children and the cultural acceptability, feasibility, and barriers to a broader implementation of such screening programs among Saudi families is crucial. Therefore, the investigators aim to conduct a prospective cohort study among young children and adolescents with a family history of T1D (i.e., T1D first-degree relatives). Children 2-18 years old will be screened using a 5 spots filter-dried blood sample for the following:\n\n1. Islet autoantibodies: IAA, GADA, IA-2A, Zn-transporter autoantibodies using the antibody detection by agglutination PCR (ADAP) assay.\n2. HLA phenotyping\n3. Genetic risk score after the cross-sectional assessment those who are determined to be in stage I, or II of T1D will be offered prospective follow-up for 5 years.",[398],"Type 1 Diabetes",[400,401,402],"screening","early detection","ADAP","2024-07-17",{"date":405,"type":46},"2024-07-22",{"date":407,"type":46},"2024-05-26",{"date":409,"type":23},"2029-05",{"name":52,"class":53},{"id":412,"slug":413,"hasResults":11,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":11,"sex":18,"minAge":418,"maxAge":419,"enrollmentInfo":420,"targetDuration":4,"studyType":24,"phases":422,"briefSummary":423,"conditions":424,"keywords":427,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":4},"100549947","effects-of-lifestyle-intervention-in-the-biological-aging-in-prediabetes-100549947","NCT06440681","Effects of Lifestyle Intervention in the Biological Aging in Prediabetes","Effects of a 6-month Lifestyle Intervention Program in the DNAm PhenoAge, SOST, and GDF15 Markers of Biological Aging in Adults With Prediabetes","Inclusion Criteria:\n\n1. Clinical diagnosis of pre-diabetes for all Saudis aged 30 years and above, males and females\n2. They must be able to exercise and be able to follow a diet\n\nExclusion Criteria\n\n1. Insulin-dependent diabetes and non-diabetic patients\n2. People with diseases that prevent them from participating and doing exercises","30 Years","80 Years",{"count":421,"type":23},500,[26],"Lifestyle modifications, including dietary changes and increased physical activity, play a crucial role in controlling complications to reduce or eliminate them. As well as controlling disturbances in biochemical markers such as DNAm PhenoAge, and signs of aging such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15). This study seeks to address this dilemma by focusing on specific groups of elderly Saudis with prediabetes . Lifestyle changes in elderly Saudis with prediabetes show promise in reducing or eliminating complications. The potential insights derived from this research extend beyond academia, offering tangible benefits for clinical practice and public health\n\nThe proposed study will be implemented to achieve the following objective:\n\n1. To determine changes in DNAm PhenoAge of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program.\n2. To determine changes in other candidate senescence markers such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15) of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program.",[425,426],"PreDiabetes","Marker; Structural",[428,429,430,431],"DNAm PhenoAge","Lifestyle modification","SOST","DGF-15","2024-06-08",{"date":434,"type":46},"2024-06-11",{"date":436,"type":23},"2024-08-01",{"date":438,"type":23},"2025-11-01",{"name":52,"class":53},{"id":441,"slug":442,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":444,"acronym":445,"eligibilityCriteria":446,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":447,"enrollmentInfo":448,"targetDuration":450,"studyType":334,"phases":4,"briefSummary":451,"conditions":452,"keywords":455,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":54},"100492887","non-alcoholic-fatty-liver-disease-in-a-saudi-cohort-with-type-2-diabetes-mellitus-100492887","NCT05697991","Non-Alcoholic Fatty Liver Disease in a Saudi Cohort With Type 2 Diabetes Mellitus","CORDIAL","Inclusion Criteria:\n\n* Subject has provided informed consent prior to screening\n* Men and women aged 18 to 60 years\n* T2DM\n\nExclusion Criteria:\n\n* Evidence of hepatic decompensation (ascites, clinical jaundice-bilirubin ≥ 40 µmol\u002FL, encephalopathy)\n* Preexisting hepatocellular carcinoma\n* Other preexisting hepatic or extrahepatic malignancy\n* Previous overt ischemic heart disease (myocardial infarction or acute coronary syndrome) or cerebrovascular disease (stroke or transient ischemic attack)\n* Previous coronary artery bypass grafting, angioplasty, or stenting\n* Any other issues that, in the opinion of the investigators, may preclude satisfactory completion of the study protocol","60 Years",{"count":449,"type":23},1000,"15 Years","The global rise in the prevalence of obesity paved the way for the increased prevalence of yet another obesity-related complication significant enough to be considered within the roster of major public health threats: non-alcoholic fatty liver disease (NAFLD). In this follow-up study, the investigators will attempt to decipher the natural history of hepatic steatosis among patients with type 2 diabetes mellitus (T2DM) using state-of-the-art methods in a well-characterized Saudi cohort. The investigators aim also to validate existing biomarkers of disease severity and explore the pathogenesis of progressive disease using metabolic profiling technologies. A total of 1000 adult Saudi patients (males and females) with T2DM will be recruited. Those with co-morbidities, including hepatic decompensation, will be excluded. Participants will be followed three times for a total of 10 years\u002Fpatient (Year 2, Year 5, and Year 10), and measures such as dietary evaluations, anthropometrics, and urine, stool, and blood examinations will be performed. Patients who develop NAFLD will be noted, and patterns\u002Fchanges in the metabolic profile will be examined. For this specific grant (the first 2 years of the whole project), the investigators will be able to recruit the study cohort, do the baseline anthropometric, imaging, and biochemical measurements, and report the prevalence of NAFLD among patients with T2DM. This information will be the basis of subsequent follow-up and allow for validating potential diagnostic and prognostic biomarkers. This project will be of high importance at the national level since it will create awareness in the local medical community of the current severity status of NAFLD in the kingdom and will be used as a tool to promote public health awareness in the community.",[453,454],"Nonalcoholic Fatty Liver Disease","Type 2 Diabetes Mellitus",[456,457,458],"T2DM","Fatty Liver Disease","NAFLD","2023-10-03",{"date":461,"type":46},"2023-10-05",{"date":463,"type":46},"2015-03-23",{"date":465,"type":23},"2030-12-31",{"name":52,"class":53},{"id":468,"slug":469,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":18,"minAge":473,"maxAge":4,"enrollmentInfo":474,"targetDuration":4,"studyType":334,"phases":4,"briefSummary":475,"conditions":476,"keywords":478,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":54},"100408939","national-systemic-lupus-erythematosus-prospective-cohort-saudi-arabia-100408939","NCT04604990","National Systemic Lupus Erythematosus Prospective Cohort, Saudi Arabia","Inclusion Criteria:\n\n1. Adult patients defined as age greater than 18 years old.\n2. Patients should fulfil one of the following classification criteria for SLE (ACR, SLICC or ACR\u002FEULAR criteria).\n3. No restriction on time of diagnosis.\n\nExclusion Criteria:\n\n* Patients who don't fulfil classification criteria mentioned above.","19 Years",{"count":449,"type":23},"SLE disease in Saudi Arabia is yet not well defined especially in a population with high consanguinity and high inbreeding coefficient . Up until now, there has been no prospective cohort study for SLE patients in Saudi Arabia. As a result, current published literature is focused on retrospective chart reviews which are subjected to many forms of bias. so the investigator proposed this prospective registry which will follow open cohort study design aiming to provide better understanding of disease presentation, course and outcomes especially if complemented by detailed immunological, molecular, genetic and microbiome data.",[477],"SLE (Systemic Lupus)",[479,480,481,482,483],"SLE","Lupus erythematosus","Outcomes","Phenotypes","Observational","2021-08-31",{"date":486,"type":46},"2021-09-01",{"date":488,"type":46},"2020-12-20",{"date":490,"type":23},"2050-11-01",{"name":52,"class":53},{"id":493,"slug":494,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":11,"sex":499,"minAge":63,"maxAge":500,"enrollmentInfo":501,"targetDuration":4,"studyType":24,"phases":502,"briefSummary":504,"conditions":505,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":513,"locationsCount":54},"100378835","phase-2-prostate-sabr-with-intra-prostatic-sabr-boost-100378835","NCT04212715","Prostate SABR With Intra-Prostatic SABR Boost","Prostate SABR With Intra-Prostatic SABR Boost: A Phase II Study","Inclusion Criteria:\n\n* Histologically confirmed prostate adenocarcinoma\n* High-risk prostate cancer, defined as at least one of: T3, Gleason 8-10, OR PSA \\> 20 ng\u002FmL\n* Willing to give informed consent to participate in this clinical trial\n\nExclusion Criteria:\n\n* Prior pelvic radiotherapy\n* Contraindication to radical prostate radiotherapy e.g. connective tissue disease or inflammatory bowel disease\n* Contraindication to prostate MRI\n* No evidence of castrate resistance (defined as PSA \\\u003C 3 ng\u002Fml while testosterone is \\\u003C 0.7nmol\u002Fl. Patients could have been on combined androgen blockade but are excluded if this was started due to PSA progression.\n* Definitive extrapelvic nodal or distant metastatic disease on staging investigations.","MALE","99 Years",{"count":223,"type":23},[503],"PHASE2","Stereotactic Ablative Radiation (SABR\u002FSBRT) will be prescribed to a dose of 35 Gy in 5 fractions, once weekly to prostate with a simultaneous intra-prostatic boost to the MR detected nodule up to 50Gy. The pelvic lymph nodes and seminal vesicles will also receive 25 Gy in 5 weekly fractions.",[506],"Prostate Cancer","2019-12-27",{"date":509,"type":46},"2020-01-02",{"date":511,"type":46},"2019-12-26",{"date":86,"type":23},{"name":52,"class":53},""]