[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kintampo Health Research Centre, Ghana\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100442451","strengthening-the-evidence-for-policy-on-the-rtssas01-malaria-vaccine-100442451",false,"NCT05041556","Strengthening the Evidence for Policy on the RTS,S\u002FAS01 Malaria Vaccine","Strengthening the Evidence for Policy on the RTS,S\u002FAS01 Malaria Vaccine: Assessment of Safety and Effectiveness Using Case-control Studies Embedded in the Malaria Vaccine Pilot Evaluation","MVPE-CC","Inclusion Criteria:\n\n* Willingness to participate in study evidenced by written informed consent provided by an adult caregiver\n* Resident in an RTS,S\u002FAS01 implementation area within the catchment area of MVPE sentinel hospitals\n* Eligible, based on date of birth and age, to have received RTSS\u002FAS01\n* Meets the case or control definitions above.\n\nExclusion Criteria:\n\n* Caregiver not willing to provide consent","ALL","6 Months","59 Months",{"count":21,"type":22},9280,"ESTIMATED","OBSERVATIONAL","The ongoing Malaria Vaccine Pilot Evaluation (MVPE) is being conducted in Ghana, Malawi and Kenya through community and sentinel hospital surveillance systems and a series of household surveys (to measure vaccine coverage). The Malaria Vaccine Pilot Evaluation-Case Control (MVPE-CC) registered here as observational study is embedded within MVPE comprising case-control studies of clinical and mortality outcomes. Each case will require four controls, and caregiver informed consent will be required prior to study activities.\n\nThese observational case control studies will measure as complementary information to what is being collected through MVPE:\n\n1. Safety among children who received the malaria vaccine, with focus on cerebral malaria, meningitis and severe malaria\n2. The impact of the malaria vaccine on all-cause mortality for boys and girls, AND\n3. Promote use of case-control approaches by Expanded Programmes on Immunization (EPI) and malaria control programmes.",[26],"Malaria",[26,28,29,30,31],"Vaccines","Case-control","Safety","Mortality","RECRUITING","2025-02-25",{"date":35,"type":36},"2025-02-28","ACTUAL",{"date":38,"type":36},"2021-10-18",{"date":40,"type":22},"2025-04-30",{"name":42,"class":43},"Kintampo Health Research Centre, Ghana","OTHER",4,""]