[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kiora Pharmaceuticals, Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100564420","phase-2-a-phase-ii-study-of-intravitreal-kio-301-in-patients-with-late-stage-retinitis-pigmentosa-100564420",false,"NCT06628947","A Phase II Study of Intravitreal KIO-301 in Patients With Late-stage Retinitis Pigmentosa","A Phase II, Randomised, Controlled, Double Masked, Multiple Dose Study of the Safety, Tolerability and Efficacy of Intravitreal KIO-301 in Patients With Late-stage Retinitis Pigmentosa","ABACUS-2","Inclusion Criteria:\n\n1. Be aged 18 years or older at the time of consent.\n2. Provide informed consent prior to any study procedures, as stipulated by local laws, Ethics Committee (EC) and Regulatory Authority (RA) guidelines.\n3. Be willing and able to follow all study instructions, attend all study visits, and complete all study assessments.\n4. Have a clinical diagnosis of non-syndromic RP, with the exception of Usher's Syndrome Type II (USH2) which is allowed.\n5. Have a visual acuity as per the Berkeley Rudimentary Vision Test (BRVT) at Screening of:\n\n   * NLP OU confirmed by inability to see pen torch light at 25 cm OD, OS, and OU (assigned logMAR of 4.0).\n   * LV OU limited to logMAR \\> 1.6 and \\\u003C 4.0.\n6. Other than intravitreal corticosteroids, participants must not receive intravitreal concomitant medications from Screening until end of study.\n7. For Low Vision (LV) OU participants only: must pass at least one multi-luminance functional vision (MLFV) test at two successive light levels (between 1 and 500 lux), or at 1400 lux. Additionally, they must fail the same test at 0.125 and 0.35 lux.\n8. Must agree to follow appropriate contraception requirements from Screening until 3 months after the last dose of IMP.\n\n   * Participants assigned female at birth who are of child-bearing potential (OCBP) must agree to a pregnancy test at Screening and use an acceptable method of birth control including oral, transdermal, injectable, or implantable hormonal contraception, intrauterine device, abstinence from intercourse with partner assigned male at birth, or surgical sterilisation of partner assigned male at birth. Participants assigned female at birth are not OCBP if they have had a hysterectomy, bilateral oophorectomy, bilateral tubal ligation, or are post-menopausal by at least 12 months.\n   * Participants assigned male at birth with a partner OCBP must be surgically sterile for at least 3 months prior to starting study drug, or ensure their partner uses contraception as outlined above, and must use a male condom. Participants assigned male at birth must not donate sperm from Screening until 3 months after the last dose of IMP.\n   * Participants who have practiced true abstinence for at least 1 year due to usual and preferred lifestyle choice are exempt from contraceptive requirements. If a participant who is abstinent becomes sexually active, they must agree to use appropriate contraception as described above.\n\nExclusion Criteria:\n\n1. Pregnant or breast-feeding, or plan to become pregnant during the study.\n2. Have, in the investigator's opinion, evidence of material\u002Fsubstantial optic nerve disease.\n3. Have a history of one or more retinal detachments.\n4. Other than RP related macular pathologies, have in the investigator's opinion, clinically significant ocular disease (e.g., corneal oedema, uveitis, severe keratoconjunctivitis sicca), or clinically significant opacities of the media which might interfere with the study assessments, or the ability of the participant to complete the study.\n5. Have a history of high myopia (\\> 6 diopters).\n6. Have uncontrolled severe glaucoma defined as intraocular pressure (IOP) of \\> 26 mmHg when on 2 or more IOP lowering medications and cup disc ratio of ≥ 0.8, as diagnosed by an ophthalmologist.\n7. Have had a previous intraocular surgery (with the exception of phacoemulsification cataract surgery and YAG capsulotomy more than 12 months prior to first study drug administration, which is allowed).\n8. Have aphakia or a subluxed intraocular lens, or have evidence of zonular weakness that in the opinion of the investigator would result in light obfuscation.\n9. Have a psychiatric condition that, in the investigator's opinion, precludes compliance with the protocol; past or present psychoses; past or present bipolar disorder; disorder requiring lithium; or within five years prior to screening, a history of suicide plan.\n10. Have any clinically significant abnormality at screening determined by medical history, vital signs, clinical biochemistry, haematology, urinalysis, or a 12-lead electrocardiogram (ECG), as assessed by the investigator, which might interfere with the study assessments or the ability of the participant to complete the study.\n11. Have any other medical condition or significant co-morbidities, or any finding during screening, which in the view of the Investigator is likely to interfere with the study or put the Participant at risk, confound study data, or interfere significantly with study participation.\n12. Have clinical signs of active ocular or systemic infection and\u002For a temperature greater than 38.0°C at the time of screening. Study entry must be deferred at least 14 days from resolution.\n13. Have participated in any investigational study within 30 days prior to screening, prior exposure to an investigational product within 5 elimination half-lives, or planned used of an investigational product or device during the study.\n14. Have known or suspected hypersensitivity to any of the study drug excipients.\n15. Are taking any medications that are known to be toxic to the retina or optic nerve.","ALL","18 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of the study is to investigate the safety, tolerability and efficacy of up to 3 doses of KIO-301 administered by intravitreal (IVT) injection bilaterally every 6 weeks in patients with late-stage retinitis pigmentosa (RP).\n\nLate-stage RP patients will include those patients with No Light Perception (NLP), or Low Vision (LV).",[27],"Retinitis Pigmentosa",[29,30],"Late-stage RP with No Light Perception","Late-stage RP with Low Vision","RECRUITING","2026-06-16",{"date":34,"type":35},"2026-06-18","ACTUAL",{"date":37,"type":35},"2025-08-29",{"date":39,"type":21},"2027-08",{"name":41,"class":42},"Kiora Pharmaceuticals, Inc.","INDUSTRY",5,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},"100579546","phase-2-safety-tolerability-and-efficacy-of-intravitreal-kio-104-in-patients-with-macular-edema-100579546","NCT06825702","Safety, Tolerability and Efficacy of Intravitreal KIO-104 in Patients With Macular Edema","A Phase 2, Open-label, Multiple Dose Study of the Safety, Tolerability and Efficacy of Intravitreal KIO-104 in Patients With Macular Edema (KLARITY-1)","KLARITY-1","Inclusion Criteria:\n\nParticipants must meet all the following criteria:\n\n1. Be aged 18 to 85 years inclusive at the time of consent.\n2. Provide informed consent prior to any study procedures, as stipulated by local laws, Ethics Committee (EC) and Regulatory Authority (RA) guidelines.\n3. Be willing and able to follow all study instructions, attend all study visits, and complete all study assessments.\n4. Have a clinical diagnosis of ME in the study eye secondary to non-infectious uveitis, retinal vein occlusion, diabetic retinopathy or cataract surgery.\n5. If currently receiving systemic corticosteroid therapy or immunosuppressive therapy (or any combination thereof), be on a stable dose of therapy for at least 3 months prior to Screening and during the study.\n6. Have a Central Subfield Thickness (CST) of ≥ 350 μm.\n7. Have a Best Corrected Visual Acuity (BCVA) in the study eye of:\n\n   1. ≤ 20\u002F32 (6\u002F9.5); logMAR ≥ 0.2; ≤ 75 ETDRS letters\n   2. ≥ 20\u002F800 (6\u002F240); logMAR ≤ 1.6; ≥ 5 ETDRS letters\n8. Have media clarity and pupillary dilation sufficient for adequate visualization and assessment of the study eye.\n9. Be willing to avoid disallowed medications and treatments for the duration of the study.\n10. Agree to follow appropriate contraception requirements from screening until 3 months after the last dose of the study drug.\n\n    1. Participants assigned female at birth who are of child-bearing potential (OCBP) must agree to a pregnancy test at Screening and prior to each dose of investigational medicinal product (IMP) and use an acceptable method of birth control including oral, transdermal, injectable, or implantable hormonal contraception, intrauterine device, abstinence from intercourse with partner assigned male at birth, or surgical sterilisation of partner assigned male at birth.\n    2. Participants assigned female at birth are not OCBP if they have had a hysterectomy, bilateral oophorectomy, bilateral tubal ligation, or are post-menopausal by at least 12 months. Post-menopausal status of amenorrheic female participants should be confirmed at Screening through testing of follicle-stimulating hormone (FSH) as per analysing laboratory threshold.\n    3. Participants assigned male at birth with a partner OCBP must be surgically sterile for at least 3 months prior to starting study drug, or ensure their partner uses contraception as outlined above, and must use a male condom. Participants assigned male at birth must not donate sperm from Screening until 3 months after the last dose of IMP.\n    4. Participants who have practiced true abstinence for at least 1 year due to usual and preferred lifestyle choice are exempt from contraceptive requirements. If a participant who is abstinent becomes sexually active, they must agree to use appropriate contraception as described above.\n\nExclusion Criteria:\n\nParticipants must not meet any of the following criteria:\n\n1. Have media opacities (cornea, anterior or posterior synechia, cataract, vitreous haze and others) of either eye that preclude investigation and documentation of the posterior pole and intravenous fluorescein angiography, or optical coherence tomography evaluation in the study eye.\n2. Receive local or systemic biologicals (i.e. tumour necrosis factor \\[TNF\\]-blockers, B-cell blockers, cytokines, cytokine-blockers, receptor antagonists) 90 days prior to Day 1 or planned during the study.\n3. Receive treatment with cyclophosphamide or chlorambucil during the study.\n4. Receive intravitreal injections (including but not limited to anti-vascular endothelial growth factors) 90 days prior to Day 1 or planned during the study.\n5. Receive a posterior subtenon's or orbital floor injection of steroids 90 days prior to Day 1 or planned during the study.\n6. Have any implantable corticosteroid-eluting device (Ozurdex, Iluvien, Retisert, triamcinolone intravitreal implant, fluocinolone intravitreal implant) in the study eye, with the following exceptions:\n\n   1. If the device had been removed more than 90 days prior to Day 1 of the study.\n   2. If Ozurdex® had been implanted at least 6 months before Day 1 of the study.\n   3. If Iluvien® or Retisert® had been implanted at least 3 years before Day 1 of the study.\n   4. Use of topical steroids are permissible provided the participant is receiving a stable dose for at least 3 months prior to Screening and during the study.\n7. Have ocular surgery (including cataract extraction, laser surgery such as pan retinal photocoagulation, vitreoretinal or scleral buckling surgery) in the study eye, within 90 days prior to Day 1, or planned during the study.\n8. Have a capsulotomy in the study eye, within 30 days prior to Day 1, and during the study.\n9. Have Intraocular pressure (IOP) ≥ 25 mmHg in the study eye (glaucoma patients maintained on no more than one topical medication with IOP \\\u003C 25 mmHg are allowed to participate).\n10. Have ocular hypotony (IOP \\\u003C 6 mmHg) in the study eye.\n11. Have aphakia or anterior chamber lens in the study eye.\n12. Have visible scleral thinning, scleral ectasia or keratoconus in the study eye.\n13. Have presence of any ocular malignancy in either eye.\n14. Have evidence of any other clinically significant ocular disease that might interfere with the study assessments.\n15. Have ocular or periocular (either eye) or systemic infection and\u002For a temperature greater than 38.0°C, or the use of systemic or topical ocular antibiotics within 14 days of Day 1.\n16. Have a psychiatric condition that, in the Investigator's opinion, precludes compliance with the protocol; past or present psychoses; past or present bipolar disorder; disorder requiring lithium; or within five years prior to screening, a history of suicide plan.\n17. Have any clinically significant abnormality at screening determined by medical and ophthalmic history, vital signs, clinical biochemistry, hematology, urinalysis, or a 12-lead electrocardiogram (ECG), as assessed by the Investigator, which might interfere with the study assessments or the ability of the participant to complete the study.\n18. Have any other medical condition or significant co-morbidities, or any finding during screening, which in the view of the Investigator is likely to interfere with the study or put the participant at risk, confound study data, or interfere significantly with study participation.\n19. Have participated in any other investigational drug or device clinical trial within 90 days prior to Day 1 or planning to participate in other investigational drug or device clinical trials during the study and within 120 days following Day 1. This includes both ocular and non-ocular clinical trials.\n20. Have any clinically significant clotting abnormality as assessed by the Investigator, which might interfere with the collection of blood samples required by the study.\n21. Have a known allergy or hypersensitivity to the study medication, any component of the delivery vehicle, any corticosteroids, any diagnostic agents used during the study (e.g., fluorescein, dilation drops), or any other standard of care medications likely to be used during the study (e.g., antibiotic drops, povidone, rescue medications).\n22. Be pregnant or breast-feeding, or plan to become pregnant during the study.","85 Years",{"count":54,"type":21},28,[24],"This is a multi-center, open label study to assess the safety, tolerability, and efficacy of KIO-104 administered by IVT injection to the study eye of eligible participants with macular edema.",[58],"Macular Edema",[58],"2026-06-14",{"date":32,"type":35},{"date":63,"type":35},"2025-05-01",{"date":65,"type":21},"2026-12",{"name":41,"class":42},6,""]