[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kit Wa Chan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100624029","effectiveness-of-exercise-alone-and-tdcsexercise-on-cognitive-function-improvement-in-patients-with-treatment-resistant-schizophrenia-100624029",false,"NCT07404319","Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia","Randomised Control Trial of Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia","TRACE","Inclusion Criteria:\n\n* DSM 5 schizophrenia-spectrum disorders\n* Treatment resistant schizophrenia: inadequate response to ≥2 antipsychotics of adequate dose\u002Fduration\n* Clinically stable ≥4 weeks\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Neurological disorder (e.g., epilepsy, stroke) or significant head injury\n* Implanted electronic devices \u002F contraindications to tDCS; scalp lesions at electrode sites\n* Medical contraindications to moderate aerobic exercise\n* Substance dependence within 3 months (except nicotine)\n* Pregnancy","ALL","18 Years","60 Years",{"count":21,"type":22},160,"ESTIMATED","INTERVENTIONAL",[25],"NA","Cognitive impairment is a major determinant of disability in schizophrenia. Aerobic exercise improves global cognition in schizophrenia, particularly working memory and attention\u002Fvigilance. Transcranial direct current stimulation (tDCS) targeting frontal regions has shown promise for cognitive deficits, including working memory improvements in some studies. This randomized 2×2 factorial trial will test the independent and combined effects of supervised aerobic exercise and prefrontal tDCS on cognition in treatment resistant schizophrenia, measured using the MATRICS Consensus Cognitive Battery (MCCB).",[28,29,30],"Schizophrenia","Treatment Resistant Schizophrenia","Cognitive Impairment",[32,33,34,35],"tDCS","aerobic exercise","cognitive function","treatment-resistant schizophrenia","NOT_YET_RECRUITING","2026-02-04",{"date":39,"type":40},"2026-02-11","ACTUAL",{"date":42,"type":22},"2026-02-23",{"date":44,"type":22},"2028-01-30",{"name":46,"class":47},"Kit Wa Chan","OTHER",""]