[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Knappschaft Kliniken GmbH\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":54},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":5},"100632230","symptoms-and-quality-of-life-in-patients-with-heterotopic-gastric-mucosa-hgm-100632230",false,"NCT07510984","Symptoms and Quality of Life in Patients With Heterotopic Gastric Mucosa (HGM)","Prevalence and Characterization of Dysphagia and Dyspepsia Symptoms and Assessment of Quality of Life in Heterotopic Gastric Mucosa (HGM)","SYM-HGM","Inclusion Criteria:\n\n* Planned upper gastrointestinal endoscopy (gastroscopy) for clinical reasons (any indication)\n* Age ≥ 18 years\n* Written informed consent\n* Ability to complete the study questionnaires prior to endoscopy\n\nExclusion Criteria:\n\n* Previously known heterotopic gastric mucosa (HGM)\n* Previously diagnosed dysphagia with prior therapeutic intervention (including pre-established diet modification, partial oral\u002Fenteral nutrition, steroid therapy, botulinum toxin injection, etc.)\n* Mechanical ventilation\n* Presence of a tracheostomy\n* Inadequate endoscopic assessability of the proximal esophagus, including:\n* General condition insufficient for careful endoscopic inspection (investigator's judgement)\n* Increased risk of aspiration\n* Inadequate visibility during the procedure (e.g., bleeding, food residue)\n* Complications preventing careful inspection of the proximal esophagus\n* History of surgery involving the pharynx or esophagus\n* Relevant severe neurological disorder (e.g., ALS, stroke)\n* Severe dementia\n* Severe depressive disorder\n* Lack of cooperation \u002F inability to comply with study procedures\n* Planned PEG placement\n* Emergency endoscopy","ALL","18 Years",{"count":20,"type":21},721,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether heterotopic gastric mucosa (HGM) in the upper esophagus is associated with swallowing difficulties (dysphagia) in adults undergoing a medically indicated gastroscopy. The main questions it aims to answer are:\n\n* Is the presence of HGM associated with dysphagia?\n* Is the presence of HGM associated with dyspepsia and reduced health-related quality of life? Among participants reporting dysphagia, what is the distribution of oropharyngeal versus esophageal dysphagia, and is this related to the presence of HGM? If there is a comparison group: Researchers will compare participants with endoscopically confirmed HGM to participants without HGM to determine whether dysphagia, dyspepsia symptoms, and quality-of-life measures differ between groups.\n\nParticipants will:\n\nComplete pseudonymised questionnaires about dysphagia, dyspepsia symptoms, and quality of life before the gastroscopy.\n\nUndergo the medically indicated gastroscopy as planned; the endoscopist will assess whether HGM is present based on the endoscopic appearance, and routine endoscopy findings will be documented.",[25,26,27,28],"Heterotopic Gastric Mucosa of the Proximal Esophagus","Gastric Inlet Patches","Dysphagia","Dyspepsia",[30,31,32,33,34,35,36,37,38,39,40,41],"Cervical Esophagus","Proximal Esophagus","Upper Endoscopy","Oropharyngeal Dysphagia","Eophageal Dysphagia","Sidney Swallowing Questionnaire","EAT-10","MDADI","GSRS","QOLRAD","Narrow Band Imaging","Quality of Life","RECRUITING","2026-04-09",{"date":45,"type":46},"2026-04-14","ACTUAL",{"date":48,"type":46},"2026-03-24",{"date":50,"type":21},"2027-07",{"name":52,"class":53},"Knappschaft Kliniken GmbH","OTHER",""]