[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Konya City Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":543},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,48,74,94,123,151,180,206,232,254,279,302,331,351,373,392,419,447,471,495,521],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643067","easix-score-and-post-induction-hypotension-in-frail-patients-undergoing-non-cardiac-surgery-100643067",false,"NCT07642765","EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery","Evaluation of the Relationship Between Endothelial Activation and Stress Index (EASIX) and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery: A Prospective Observational Cohort Study","PIXEL","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective non-cardiac surgery under general anesthesia\n* Clinical Frailty Scale (CFS) score of 4 or above\n* Available routine preoperative laboratory values (LDH, creatinine, platelet count) within 24 hours before surgery\n\nExclusion Criteria:\n\n* Cardiac surgery\n* Emergency surgery\n* Preoperative vasopressor infusion\n* Severe hematological disease\n* Missing laboratory data required for EASIX calculation","ALL","18 Years",{"count":20,"type":21},160,"ESTIMATED","OBSERVATIONAL","Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction. Frail patients are particularly vulnerable due to impaired vascular reactivity and endothelial dysfunction. The Endothelial Activation and Stress Index (EASIX), calculated from routine laboratory parameters (LDH, creatinine, and platelet count), may serve as a preoperative biomarker to identify patients at risk for PIH.\n\nThis prospective observational cohort study aims to evaluate the association between preoperative EASIX score and the occurrence of post-induction hypotension in frail patients undergoing elective non-cardiac surgery under general anesthesia. A total of 160 patients with a Clinical Frailty Scale (CFS) score of 4 or above will be enrolled. Mean arterial pressure will be measured every 2 minutes for the first 15 minutes after induction. PIH is defined as MAP below 65 mmHg and\u002For a decrease of 20% or more from baseline.",[25,26,27],"Hypotension on Induction","Frailty","Anesthesia, General",[29,30,31,26,32,33,34],"Post-induction hypotension","EASIX","Endothelial Activation and Stress Index","Perioperative hemodynamics","Non-cardiac surgery","Clinical Frailty Scale","NOT_YET_RECRUITING","2026-06-08",{"date":38,"type":39},"2026-06-11","ACTUAL",{"date":41,"type":21},"2026-07-01",{"date":43,"type":21},"2027-03-01",{"name":45,"class":46},"Konya City Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100637765","machine-learning-for-diagnosis-of-occlusive-mi-in-lbbb-patients-100637765","NCT07620119","Machine Learning for Diagnosis of Occlusive MI in LBBB Patients","Development of a Machine Learning Model for the Diagnosis of Occlusive Myocardial Infarction in the Setting of Left Bundle Branch Block","AI-LBBB","Inclusion Criteria:\n\n* Patients aged 18 years and older who present to the emergency department. Patients presenting with acute ischemic chest pain or clinical ischemia-equivalent symptoms (such as acute dyspnea, unexplained diaphoresis, or syncope).\n\nPatients with a confirmed Left Bundle Branch Block (LBBB) on their initial 12-lead electrocardiogram (ECG), which can be either newly developed or known\u002Fchronic.\n\nPatients who undergo invasive coronary angiography during their index hospital admission.\n\nPatients or their legally authorized representatives who provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients under the age of 18. Pregnant or lactating women. Patients with poor-quality or uninterpretable digital ECG recordings due to severe artifact, missing leads, or technical errors.\n\nPatients who develop cardiopulmonary arrest before an initial diagnostic 12-lead ECG can be obtained in the emergency department.\n\nPatients transferred from another healthcare facility who have already undergone coronary angiography or revascularization.\n\nPatients who decline to participate or refuse to provide written informed consent.",{"count":57,"type":21},50,"This study investigates a new way to diagnose severe heart attacks in patients who have a specific electrical heart pattern called a Left Bundle Branch Block (LBBB). When patients present to the emergency department with chest pain, doctors routinely perform an electrocardiogram (ECG) to check for a heart attack. However, the presence of an LBBB can alter the heart's electrical signals on the ECG, effectively masking or hiding the typical signs of an ongoing acute coronary occlusion (a completely blocked artery). This making it highly challenging for emergency physicians to make an accurate and rapid diagnosis.\n\nThe primary purpose of this prospective and observational research is to develop and evaluate an artificial intelligence\u002Fmachine learning (ML) model that can analyze digital 12-lead ECG signals to accurately predict a true blocked coronary artery in patients with LBBB. The machine learning model will analyze raw digital ECG waveforms to detect subtle, microscopic patterns that might be missed by the human eye.\n\nTo confirm the accuracy of the model, its predictions will be compared directly with invasive coronary angiography results, which is the gold standard reference method used to visualize blocked vessels. Additionally, the study aims to evaluate if the model can differentiate between a true heart attack caused by a blocked artery (Type 1 MI) and other non-occlusive conditions that cause elevated heart enzymes (Type 2 MI). Ultimately, the investigators intend to determine whether integrating this machine learning tool into emergency care can safely reduce the rate of unnecessary emergency invasive procedures for patients who do not have a true coronary blockage.",[60,61,62,63,64],"Acute Myocardial Infarction (AMI)","Left Bundle Branch Block","Coronary Occlusion\u002FThrombosis","Chest Pain","Myocardial Infarction","RECRUITING","2026-05-22",{"date":68,"type":39},"2026-06-02",{"date":70,"type":21},"2026-06-01",{"date":72,"type":21},"2027-01-31",{"name":45,"class":46},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":91,"leadSponsor":93,"locationsCount":47},"100615636","effect-of-rebound-pain-on-postoperative-intensive-care-delirium-in-patients-undergoing-hip-surgery-with-peripheral-nerve-block-100615636","NCT07295184","Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block","Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 18-80\n* ASA I-III risk groups\n* Undergoing elective hip surgery\n\nExclusion Criteria:\n\n* Preoperative history of delirium, dementia, or major neurological disease\n* Present cognitive impairment or severe hearing or visual impairment that could affect pain assessment\n* Development of mechanical ventilation requirement in the intensive care unit; Need for bilateral hip surgery\n* Failure to provide meaningful analgesia after block application due to surgical pain outside the scope of the block\n* Patient's inability to complete the pain diary during postoperative follow-up;\n* Urgent hip surgery\n* Voluntary failure to give consent or request to withdraw from the study.","80 Years",{"count":83,"type":21},90,"Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising healthcare costs.\n\nThe incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.\n\nEffective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.",[86],"Rebound Pain Impact After Hip Surgery With Nerve Block","2026-05-12",{"date":89,"type":39},"2026-05-14",{"date":87,"type":39},{"date":92,"type":21},"2026-12-25",{"name":45,"class":46},{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":101,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":103,"conditions":104,"keywords":109,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":47},"100634556","the-impact-of-multiple-antihypertensive-therapy-on-post-induction-hypotension-burden-in-cardiac-surgery-patients-100634556","NCT07541222","The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients","The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Adult patients aged 40 years and older\n* Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy)\n* Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date\n* Voluntary participation and signed informed consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Preoperative shock or requirement for high-dose inotropic\u002Fvasopressor therapy\n* End-stage liver or kidney failure\n* Uncontrolled hypertension\n* Difficult intubation or prolonged induction process\n* Ejection fraction less than 35%","40 Years",{"count":20,"type":21},"This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.",[25,105,106,107,108],"Cardiac Surgery","Antihypertensive Agents","Anesthesia, Intravenous","Hemodynamics",[29,110,111,112,113,114],"Cardiac surgery","Antihypertensive drugs","Hypotension burden","Mean arterial pressure","Anesthesia induction","2026-05-05",{"date":117,"type":39},"2026-05-06",{"date":119,"type":39},"2026-05-01",{"date":121,"type":21},"2026-12-01",{"name":45,"class":46},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":47},"100636649","correlation-of-cardiac-index-measured-by-the-pram-method-with-nirs-and-lactate-levels-in-pediatric-aortic-coarctation-surgery-100636649","NCT07568431","Correlation of Cardiac Index Measured by the PRAM Method With NIRS and Lactate Levels in Pediatric Aortic Coarctation Surgery","Correlation of Cardiac Index Measured by the Pressure Recording Analytical Method (PRAM) With Near-Infrared Spectroscopy (NIRS) and Arterial Lactate Levels in Neonates and Infants Undergoing Surgical Repair of Aortic Coarctation: A Prospective Observational Study","MostCare-Ped","Inclusion Criteria:\n\n* Neonates and infants planned for surgical repair of aortic coarctation\n* Body weight between 2.5 and 3.5 kg\n* Postnatal age between 0 and 3 months\n* Considered hemodynamically stable for anesthesia and surgery\n* Written informed consent obtained from legal guardians\n\nExclusion Criteria:\n\n* Severe multiorgan dysfunction\n* Additional major congenital heart defect (e.g., Tetralogy of Fallot, Transposition of Great Arteries, Hypoplastic Left Heart Syndrome)\n* Surgery requiring cardiopulmonary bypass\n* Preoperative metabolic acidosis or sepsis\n* Inability to obtain informed consent from legal guardians","3 Months",{"count":133,"type":21},43,"This prospective observational study aims to evaluate the correlation between cardiac index measured by the MostCare™ system (Pressure Recording Analytical Method, PRAM) and cerebral\u002Frenal regional oxygen saturation measured by near-infrared spectroscopy (NIRS) and arterial lactate levels in neonates and infants (body weight 2.5-3.5 kg, age 0-3 months) undergoing surgical repair of aortic coarctation. Measurements will be recorded at four intraoperative time points: after anesthesia induction, before aortic cross-clamp, 3 minutes after cross-clamp release, and at end of surgery. No additional intervention beyond standard anesthesia and surgical care will be applied.",[136,137],"Aortic Coarctation","Cardiac Output, Low",[139,140,141,142,143,136],"PRAM","Near-Infrared Spectroscopy","Cardiac Index","Pediatric Cardiac Surgery","Lactate","2026-04-28",{"date":115,"type":39},{"date":147,"type":21},"2026-05",{"date":149,"type":21},"2027-03",{"name":45,"class":46},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":158,"minAge":18,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":162,"conditions":163,"keywords":167,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":177,"leadSponsor":179,"locationsCount":47},"100634449","effects-of-menstrual-cycle-on-optic-nerve-sheath-diameter-in-patients-undergoing-laparoscopic-gynecologic-surgery-100634449","NCT07539831","Effects of Menstrual Cycle on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery","The Effect of Menstrual Cycle Phase on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery","Inclusion Criteria:\n\n* Female patients aged 18 to 45 years\n* Scheduled for elective laparoscopic gynecologic surgery\n* Menstrual cycle in the follicular phase or luteal phase\n* American Society of Anesthesiologists (ASA) physical status I-II\n\nExclusion Criteria:\n\n* Irregular menstrual cycle (e.g., polycystic ovary syndrome, early menopause, hypothalamic amenorrhea)\n* Pregnancy or breastfeeding\n* Neurological disease associated with intracranial pressure changes\n* Glaucoma or another eye disease associated with high intraocular pressure\n* Previous brain surgery\n* Uncontrolled hypertension or severe cardiovascular disease","FEMALE","45 Years",{"count":161,"type":21},110,"This observational study aims to evaluate the effect of menstrual cycle phase on optic nerve sheath diameter (ONSD) in women undergoing elective laparoscopic gynecologic surgery. Patients will be grouped according to menstrual cycle phase as follicular or luteal. ONSD measurements will be performed perioperatively, and postoperative nausea and vomiting as well as postoperative cognitive function will also be assessed. The study is designed to investigate whether hormonal variations during the menstrual cycle are associated with differences in intracranial pressure reflected by ONSD measurements and postoperative outcomes",[164,165,166],"Menstrual Cycle","Optic Nerve Sheath Diameter","Postoperative Nausea and Vomiting",[165,168,169,170,171,172],"Laparoscopic Gynecologic Surgery","Mini-Mental State Examination","Verbal Descriptive Scale","Follicular Phase","Luteal Phase","2026-04-20",{"date":175,"type":39},"2026-04-21",{"date":173,"type":39},{"date":178,"type":21},"2027-04-05",{"name":45,"class":46},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":17,"minAge":187,"maxAge":188,"enrollmentInfo":189,"targetDuration":191,"studyType":22,"phases":4,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":203,"leadSponsor":205,"locationsCount":47},"100633321","early-prediction-of-bronchopulmonary-dysplasia-in-preterm-infants-using-clinical-data-100633321","NCT07525167","Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data","Early Prediction of Bronchopulmonary Dysplasia Using Clinical Data From the First Three Postnatal Weeks in Preterm Infants: A Retrospective Study With Large Language Models","Inclusion Criteria:\n\n* Preterm infants born before 32 weeks of gestation or with birth weight \\\u003C1,500 grams\n* Admitted and followed in the Neonatal Intensive Care Unit (NICU) of Konya City Hospital\n* Availability of complete clinical data in hospital records\n* Documented bronchopulmonary dysplasia (BPD) outcome status\n\nExclusion Criteria:\n\n* Presence of major congenital anomalies\n* Incomplete or missing clinical data\n* Death shortly after birth with insufficient follow-up data to determine BPD status","0 Days","28 Days",{"count":190,"type":21},108,"3 Weeks","Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data from the First Three Postnatal Weeks with Large Language Models: A Retrospective Study This retrospective, observational study aims to evaluate the early prediction of bronchopulmonary dysplasia (BPD) in preterm infants using clinical data from the first, second, and third postnatal weeks. The study includes infants born before 32 weeks of gestation or weighing less than 1,500 grams, followed at the Neonatal Intensive Care Unit of Konya City Hospital.\n\nThe study will compare the performance of different large language models (LLMs), including ChatGPT, Gemini, and Claude, in predicting BPD development. Clinical variables such as gestational age, birth weight, respiratory support, oxygen requirement, mechanical ventilation duration, and infection status will be used.\n\nPrimary outcome: Accuracy of BPD risk prediction by each AI model compared to actual clinical outcomes. Secondary outcomes: Sensitivity and specificity of predictions, weekly prediction performance, and comparative performance among AI models.\n\nThe results will provide insight into the potential clinical utility of AI-based approaches for early BPD risk assessment in preterm infants.",[194],"Bronchopulmonary Dysplasia",[194,196,197,198],"Machine Learning","Artificial Intelligence","preterm infant","2026-04-12",{"date":201,"type":39},"2026-04-15",{"date":119,"type":21},{"date":204,"type":21},"2026-12-31",{"name":45,"class":46},{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":214,"phases":215,"briefSummary":217,"conditions":218,"keywords":222,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":229,"leadSponsor":231,"locationsCount":47},"100631747","comparison-of-intertransverse-process-and-erector-spinae-plane-blocks-in-acute-postoperative-analgesia-management-for-laparoscopic-cholecystectomy-patients-100631747","NCT07504705","Comparison of Intertransverse Process and Erector Spinae Plane Blocks in Acute Postoperative Analgesia Management for Laparoscopic Cholecystectomy Patients","Comparison of Intertransverse Process and Erector Spinae Plane Blocks in Acute Postoperative Analgesia Management for Laparoscopic Cholecystectomy Patients: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Undergoing elective laparoscopic cholecystectomy\n* Body mass index (BMI) between 18 and 35 kg\u002Fm²\n* American Society of Anesthesiologists (ASA) physical status score of I-III\n* Ability to provide written and verbal informed consent\n\nExclusion Criteria:\n\n* Coagulopathy or use of anticoagulant medications\n* Infection at the injection site\n* Allergy to local anesthetics\n* Pregnancy or breastfeeding\n* Chronic opioid use or analgesic dependence\n* Severe cardiopulmonary disease or psychiatric disorders\n* Previous regional block performed within the last 24 hours\n* Patients requiring emergency surgery\n* Cases converted from laparoscopic surgery to open surgery",{"count":161,"type":21},"INTERVENTIONAL",[216],"NA","Laparoscopic cholecystectomy is considered the gold standard for the surgical treatment of benign gallbladder diseases; however, despite its minimally invasive nature, a significant proportion of patients experience substantial early postoperative pain, which impacts patient comfort and the duration of hospital stay. The current PROSPECT review and previous studies emphasize that this pain is multifactorial-comprising somatic, visceral, and phrenic nerve-mediated shoulder-tip components-and therefore advocate for an opioid-sparing multimodal analgesic approach. Within this framework, first-line recommendations include paracetamol, NSAIDs\u002FCOX-2 inhibitors, dexamethasone, and local anesthetic infiltration of the surgical site and\u002For intraperitoneal cavity, alongside appropriate regional blocks; opioids should be reserved solely for rescue analgesia.\n\nUltrasound-guided regional anesthesia blocks are increasingly utilized for acute visceral pain conditions, such as renal colic. The Erector Spinae Plane Block (ESPB) is an interfacial block performed in the thoracic paraspinal region, and it is hypothesized that its extensive spread may influence somatic and, to some extent, visceral pain pathways. Nevertheless, anatomical and clinical studies report inconsistent effects of ESPB on visceral pain, noting that local anesthetics may not consistently reach the paravertebral space, thereby leading to variable block efficacy.\n\nConsequently, the Intertransverse Process Block (ITPB), which targets a plane anatomically closer to the paravertebral space, has been described in recent years as an alternative technique. ITPB is performed by injecting local anesthetic into the interfacial space adjacent to the retro-superior costotransverse ligament; it is reported to carry a low risk of complications as it does not require direct orientation toward the pleura or neuraxial structures. Clinical trials indicate that ITPB provides analgesic efficacy comparable to paravertebral blocks in both thoracic and abdominal surgeries and reduces opioid consumption. Furthermore, anatomical studies suggest that the probability of local anesthetic spread into the paravertebral space is higher with ITPB than with ESPB.\n\nHowever, a randomized controlled trial comparing ESPB and ITPB in patients undergoing laparoscopic cholecystectomy is currently lacking in the literature. Therefore, the present study was designed to address this gap.",[219,220,221],"Acut Postoperative Pain","Erector Spinae Plane Block","Intertransverse Process Block",[223,220,221,224],"Laparoscopic Cholecystectomy","Postoperative Pain","2026-04-08",{"date":227,"type":39},"2026-04-13",{"date":119,"type":21},{"date":230,"type":21},"2027-05-25",{"name":45,"class":46},{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":214,"phases":242,"briefSummary":243,"conditions":244,"keywords":247,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":252,"leadSponsor":253,"locationsCount":47},"100618717","intertransverse-process-block-for-postoperative-analgesia-after-thoracotomy-and-lobectomy-100618717","NCT07335250","Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy","Postoperative Pain Control With Intertransverse Process Block in Patients Undergoing Thoracotomy With Lobectomy","Inclusion Criteria:\n\n* Provision of written informed consent\n\nAge between 18 and 85 years\n\nASA Physical Status classification I-III\n\nElective thoracotomy with planned unilateral lobectomy\n\nAnticipated hospital stay of at least one night\n\nExpected requirement for parenteral opioid analgesia for at least 24 hours postoperatively\n\nAbility to operate an intravenous patient-controlled analgesia (PCA) device\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n\nPresence of infection or open wound at the injection site\n\nCoagulopathy\n\nHepatic or renal failure\n\nPatients undergoing reoperation\n\nPatients with missing or incomplete data\n\nPregnancy or lactation\n\nTracheal malformation or tracheostomy\n\nChronic opioid use (≥30 days within the last 3 months, ≥15 mg\u002Fday morphine equivalent)\n\nPatients exceeding the maximum safe local anesthetic dose based on weight (2.5 mg\u002Fkg, max 150 mg)\n\nPatients who refuse data privacy consent will be excluded from the study","85 Years",{"count":241,"type":21},66,[216],"This prospective, randomized, triple-blind, placebo-controlled clinical trial will investigate the effectiveness of the intertransverse process block (ITPB) for postoperative analgesia in patients undergoing elective thoracotomy with unilateral lobectomy. The study will be conducted at a single tertiary center in accordance with the principles of the Declaration of Helsinki, and written informed consent will be obtained from all participants.\n\nPatients will be randomized in a 1:1 ratio to receive either ultrasound-guided ITPB with 0.5% bupivacaine or placebo (normal saline) prepared in identical syringes to ensure allocation concealment. The block will be performed by an experienced anesthesiologist immediately after surgery and before emergence from anesthesia. Both groups will receive standardized general anesthesia, multimodal perioperative analgesia, and postoperative intravenous morphine patient-controlled analgesia (PCA).\n\nThe trial aims to evaluate the analgesic efficacy and opioid-sparing effect of ITPB while maintaining safety and adherence to routine clinical practice. Outcomes will include postoperative pain scores, opioid consumption, rescue analgesia requirement, and adverse events.",[245,246,221],"Acute Postoperative Pain","Thoracotomy Surgery",[221,248,245],"Thoracotomy Lobectomy",{"date":250,"type":39},"2026-04-09",{"date":225,"type":39},{"date":43,"type":21},{"name":45,"class":46},{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":263,"conditions":264,"keywords":268,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":4},"100632307","effect-of-rebound-pain-on-chronic-postsurgical-pain-after-total-knee-arthroplasty-100632307","NCT07511985","Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty","Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18 years or older\n* ASA physical status I to III\n* Scheduled for unilateral elective total knee arthroplasty\n* Planned to undergo spinal anesthesia\n* Planned to receive a peripheral nerve block as part of routine multimodal analgesia\n* Able to provide informed consent and complete study assessments\n\nExclusion Criteria:\n\n* Chronic opioid use (60 mg oral morphine equivalent per day or more, or use for 3 months or longer)\n* Significant neuropathy or radiculopathy\n* Bilateral or two-stage total knee arthroplasty during the same hospitalization\n* Contralateral total knee arthroplasty within the previous 6 months\n* Severe cognitive impairment or major psychiatric disorder\n* Chronic analgesic dependence",{"count":262,"type":21},220,"This prospective observational study aims to evaluate whether rebound pain after peripheral nerve block is associated with the development of chronic postsurgical pain following elective total knee arthroplasty. Adult patients undergoing unilateral total knee arthroplasty under spinal anesthesia and receiving a peripheral nerve block as part of routine multimodal analgesia will be included. No additional intervention, drug administration, or biological sampling will be performed beyond standard clinical care.\n\nRebound pain will be assessed during the early postoperative period using pain diaries, numeric rating scale pain scores, and analgesic consumption records. Chronic postsurgical pain and related outcomes will be evaluated at postoperative 3 and 6 months using validated instruments assessing pain severity, neuropathic pain features, psychological status, functional outcomes, and health-related quality of life. The primary outcome is the presence of chronic postsurgical pain at 3 months after surgery. Secondary outcomes include chronic pain at 6 months, pain intensity, neuropathic pain characteristics, opioid consumption, rescue analgesic requirements, sleep disturbance, and quality-of-life measures. The study also aims to explore demographic and clinical factors associated with rebound pain and chronic postsurgical pain.",[265,266,267],"Acute Pain, Postoperative","Chronic Pain","Arthroplasty, Replacement, Knee",[269,270,271],"rebound pain","chronic postsurgical pain","total knee arthroplasty","2026-04-05",{"date":250,"type":39},{"date":275,"type":21},"2026-04-07",{"date":277,"type":21},"2026-12-12",{"name":45,"class":46},{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":286,"enrollmentInfo":287,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":47},"100622862","heart-rate-variability-and-anxiety-as-predictors-of-emergence-agitation-after-septorhinoplasty-100622862","NCT07389135","Heart Rate Variability and Anxiety as Predictors of Emergence Agitation After Septorhinoplasty","The Role of Heart Rate Variability and Anxiety in Predicting Emergence Agitation in Patients Undergoing Septorhinoplasty : A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18 to 65 years\n* ASA physical status I-II\n* Scheduled for elective septorhinoplasty under general anesthesia\n* Able to provide informed consent and complete questionnaires\n\nExclusion Criteria:\n\n* ASA physical status III or higher\n* Pregnancy or breastfeeding\n* Known dysrhythmia\u002Farrhythmia or autonomic dysfunction, or use of medications that may affect autonomic function\u002FHRV\n* Diagnosed anxiety disorder\n* Use of preoperative anxiolytic medication\n* Inability to understand\u002Fcomplete the anxiety scales\u002Fquestionnaires\n* Emergency surgery","65 Years",{"count":288,"type":21},100,"This prospective observational study aims to evaluate whether preoperative heart rate variability (HRV) and anxiety are associated with, and can help predict, emergence agitation in adult patients undergoing elective septorhinoplasty under general anesthesia. Preoperative anxiety will be assessed using a visual analog scale (VAS) and the State-Trait Anxiety Inventory (STAI-1). Resting HRV will be recorded preoperatively using a chest-strap heart rate monitor and HRV metrics (e.g., SDNN, RMSSD, LF\u002FHF) will be derived. Emergence agitation will be assessed in the post-anesthesia care unit (PACU) using the Richmond Agitation-Sedation Scale (RASS) during the early recovery period. Secondary observations will include early postoperative events such as postoperative nausea and vomiting (PONV) and laryngospasm. The study is planned to enroll approximately 100 participants.",[291,292,293],"Emergence Agitation","Heart Rate Variability (HRV)","Septorhinoplasty","2026-03-30",{"date":296,"type":39},"2026-03-31",{"date":298,"type":39},"2026-02-01",{"date":300,"type":21},"2026-08-01",{"name":45,"class":46},{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":309,"sex":17,"minAge":310,"maxAge":311,"enrollmentInfo":312,"targetDuration":4,"studyType":214,"phases":314,"briefSummary":315,"conditions":316,"keywords":319,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":47},"100584610","blood-phoenixin-14-levels-and-echocardiographic-findings-in-infants-of-diabetic-mothers-100584610","NCT06891586","Blood Phoenixin-14 Levels and Echocardiographic Findings in Infants of Diabetic Mothers","Investigation of the Relationship Between Phoenixin-14 Levels and Echocardiographic Findings in Infants of Diabetic Mothers","Inclusion Criteria:\n\n* Infants of diabetic mothers\n* Healthy term infants\n\nExclusion Criteria:\n\n* Infants whose families did not provide consent\n* Infants with a syndromic appearance or congenital heart disease",true,"1 Day","5 Days",{"count":313,"type":21},84,[216],"In this study, the investigators hypothesize that echocardiographic pathologies observed in infants of diabetic mothers are associated with elevated serum phoenixin-14 levels.",[317,318],"Newborn Morbidity","Newborn Complication",[320,321,322],"NEWBORN","phoenixin-14","Infants of Diabetic Mothers","2026-03-26",{"date":325,"type":39},"2026-03-27",{"date":327,"type":39},"2024-09-01",{"date":329,"type":21},"2026-10-01",{"name":45,"class":46},{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":17,"minAge":310,"maxAge":311,"enrollmentInfo":337,"targetDuration":4,"studyType":214,"phases":339,"briefSummary":340,"conditions":341,"keywords":343,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":346,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":350,"locationsCount":47},"100583722","evaluation-of-serial-lung-ultrasound-data-after-surfactant-treatments-applied-with-different-methods-in-preterm-babies-100583722","NCT06880016","Evaluation of Serial Lung Ultrasound Data After Surfactant Treatments Applied With Different Methods in Preterm Babies","Inclusion Criteria:\n\n* Infants of families who agree to participate in the study\n* Preterm infants born before 32 weeks of gestation requiring surfactant therapy due to an RDS diagnosis.\n\nExclusion Criteria:\n\n* Infants whose families did not provide consent\n* Infants with a syndromic appearance or congenital heart disease\n* Preterm infants born after 32 weeks of gestation",{"count":338,"type":21},68,[216],"This study aims to investigate the relationship between the method of surfactant administration and improvements in serial lung ultrasound findings in preterm infants requiring surfactant therapy.",[318,342],"Respiratory Distress Syndrome, Newborn",[320,344,345],"Respiratory Distress Syndrome","surfactant",{"date":296,"type":39},{"date":348,"type":39},"2024-07-01",{"date":329,"type":21},{"name":45,"class":46},{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":357,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":286,"enrollmentInfo":359,"targetDuration":4,"studyType":214,"phases":361,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":47},"100615634","effect-of-sevoflurane-vs-desflurane-on-mechanical-power-in-laparoscopic-cholecystectomy-100615634","NCT07295158","Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy","Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial","VAPOR","Inclusion Criteria:\n\n* Adults aged 18-65 years\n\nASA Physical Status I-II\n\nScheduled for elective laparoscopic cholecystectomy\n\nAble to provide written informed consent\n\nExclusion Criteria:\n\nKnown hypersensitivity or contraindication to study medications (sevoflurane or desflurane)\n\nSevere chronic obstructive pulmonary disease (COPD)\n\nUncontrolled bronchial asthma\n\nDecompensated heart failure (NYHA Class III-IV)\n\nHistory of prior lung surgery\n\nMorbid obesity (BMI \\> 35 kg\u002Fm²)\n\nPregnancy\n\nRefusal to participate or inability to provide informed consent\n\n\\-",{"count":360,"type":21},138,[216],"This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).",[364],"Perioperative Respiratory Mechanics","2026-03-12",{"date":367,"type":39},"2026-03-13",{"date":369,"type":39},"2026-03-09",{"date":371,"type":21},"2026-05-30",{"name":45,"class":46},{"id":374,"slug":375,"hasResults":11,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":4,"eligibilityCriteria":379,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":286,"enrollmentInfo":380,"targetDuration":4,"studyType":214,"phases":382,"briefSummary":383,"conditions":384,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":391,"locationsCount":47},"100582384","qipb-in-inguinal-hernia-100582384","NCT06862609","QIPB in Inguinal Hernia","Effect of the Quadro-Iliac Plane Block on Quality of Recovery Following Laparoscopic Inguinal Hernia Surgery: A Prospective, Randomized, Controlled, Double-Blind, Multicenter Study","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* Undergoing elective,\n* unilateral laparoscopic inguinal hernia repair\n* Receiving general anesthesia\n\nExclusion Criteria:\n\n* Patients who refuse to provide consent\n* Patients with contraindications to regional anesthesia\n* Patients with impaired consciousness\n* Patients with coagulopathy\n* Patients with infections at the block site\n* Emergency cases",{"count":381,"type":21},70,[216],"Inguinal hernia repair is one of the most commonly performed surgical procedures. It is generally performed under regional anesthesia techniques, such as local anesthesia, peripheral nerve blocks, or neuraxial anesthesia (spinal or epidural anesthesia), or under general anesthesia. Despite various available analgesic regimens, numerous studies have demonstrated that postoperative pain control remains inadequate. Opioids, nonsteroidal anti-inflammatory drugs, and analgesics are frequently used for postoperative pain management. However, these medications are associated with uncertain efficacy and undesirable side effects. Pain is a critical factor in the postoperative period, contributing to delayed ambulation and paralytic ileus, ultimately hindering early discharge.",[224],"2026-03-08",{"date":387,"type":39},"2026-03-11",{"date":389,"type":39},"2025-03-23",{"date":70,"type":21},{"name":45,"class":46},{"id":393,"slug":394,"hasResults":11,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":286,"enrollmentInfo":399,"targetDuration":4,"studyType":214,"phases":401,"briefSummary":402,"conditions":403,"keywords":405,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":414,"completionDateStruct":416,"leadSponsor":418,"locationsCount":47},"100613286","4-point-tap-block-vs-combined-rsb-ostap-block-for-recovery-after-laparoscopic-cholecystectomy-100613286","NCT07264608","4-Point TAP Block vs. Combined RSB-OSTAP Block for Recovery After Laparoscopic Cholecystectomy","Comparison of 4-Point Transversus Abdominis Plane Block and Combined Bilateral Rectus Sheath-Oblique Subcostal TAP Block on Quality of Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\nAdults aged 18-65 years\n\nASA physical status I-II\n\nScheduled for elective laparoscopic cholecystectomy\n\nAbility to understand the study and provide written informed consent\n\nExclusion Criteria:\n\nAllergy or hypersensitivity to local anesthetics or study medications\n\nCoagulopathy, anticoagulant therapy, or local infection at block site\n\nSevere pulmonary disease (severe COPD, uncontrolled asthma, respiratory failure)\n\nNYHA class III-IV heart failure\n\nHistory of thoracic or abdominal surgery affecting block area\n\nChronic pain syndrome or regular opioid\u002Fanalgesic use\n\nMorbid obesity (BMI \\> 35 kg\u002Fm²)\n\nPregnancy or breastfeeding\n\nCognitive impairment preventing cooperation\n\nConversion to open cholecystectomy\n\n\\-",{"count":400,"type":21},76,[216],"Laparoscopic cholecystectomy is a common keyhole surgery to remove the gallbladder. Although the cuts are small, patients can still have significant pain and nausea after the operation, which may delay recovery and discharge. To improve comfort, doctors often use ultrasound-guided abdominal nerve blocks as part of multimodal pain management.\n\nIn this single-center, randomized controlled trial, adult patients scheduled for elective laparoscopic cholecystectomy will receive standard general anesthesia and be randomly assigned to one of two routinely used block techniques at the end of surgery: (1) a 4-point transversus abdominis plane (TAP) block, or (2) a combined bilateral rectus sheath block plus oblique subcostal TAP block. Both techniques are performed under ultrasound guidance while the patient is still asleep.\n\nThe main aim of the study is to compare the quality of recovery on the first day after surgery between the two groups, using a short questionnaire (QoR-15). Secondary aims are to compare pain scores, the need for additional pain medicine, and the frequency of postoperative nausea and vomiting between the groups during the first 24 hours. All other aspects of anesthesia and surgical care will follow standard hospital practice. Participation is not expected to add significant risk beyond that of routine anesthesia and surgery, as both block techniques are already commonly used in clinical practice.",[224,404],"Quality of Recovery",[406,407,408,409,410],"Quality of recovery","TAP block","Rectus sheath block","OSTAP block","Laparoscopic cholecystectomy","2025-12-03",{"date":413,"type":39},"2025-12-10",{"date":415,"type":21},"2025-12-30",{"date":417,"type":21},"2026-04-30",{"name":45,"class":46},{"id":420,"slug":421,"hasResults":11,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":309,"sex":17,"minAge":18,"maxAge":286,"enrollmentInfo":426,"targetDuration":4,"studyType":214,"phases":428,"briefSummary":429,"conditions":430,"keywords":434,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":446,"locationsCount":47},"100607321","methylprednisolone-vs-dexamethasone-effects-on-sugammadex-reversal-pain-and-nausea-in-adults-100607321","NCT07187037","Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults","Comparison of the Effects of the Interaction of Methylprednisolone and Dexamethasone With Sugammadex on Rocuronium Reversal Time, Postoperative Pain, and Nausea in Adult Patients","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective septoplasty or rhinoplasty under general anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* ASA physical status ≥ III\n* Emergency surgery\n* Known allergy or contraindication to rocuronium, sugammadex, or corticosteroids\n* Chronic or recent (within 3 months) systemic corticosteroid therapy\n* Concomitant use of drugs that may interact with sugammadex (e.g., toremifene, flucloxacillin, fusidic acid)\n* Neuromuscular disorders (e.g., myasthenia gravis, muscular dystrophy)\n\n  * Significant hepatic, renal, respiratory, or cardiac dysfunction\n* Anticipated difficult airway or history of difficult intubation\n* Nasopharyngeal or oropharyngeal anomalies interfering with airway management\n* Developmental or cognitive impairment interfering with informed consent or cooperation",{"count":427,"type":21},130,[216],"This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty. The primary outcome is the time from sugammadex administration to recovery of a train-of-four (TOF) ratio of 0.9. Secondary outcomes include extubation time, postoperative nausea and vomiting (PONV), pain scores, complications in the post-anesthesia care unit (PACU), and intraoperative hemodynamic parameters. The study will provide new evidence on whether perioperative corticosteroid choice modifies the efficacy of sugammadex and influences postoperative recovery.",[431,432,433],"Neuromuscular Block, Residual","Pain","Postoperative Nausea",[435,436,437,438,439],"sugammadex","dexamethasone","methylprednisolone","postoperative nausea","postoperative pain","2025-09-18",{"date":442,"type":39},"2025-09-22",{"date":444,"type":21},"2025-10-01",{"date":417,"type":21},{"name":45,"class":46},{"id":448,"slug":449,"hasResults":11,"nctId":450,"briefTitle":451,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":286,"enrollmentInfo":454,"targetDuration":4,"studyType":214,"phases":456,"briefSummary":457,"conditions":458,"keywords":460,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":465,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":470,"locationsCount":47},"100606941","fentanyl-vs-remifentanil-in-laparoscopic-cholecystectomy-effects-on-bowel-function-and-pain-100606941","NCT07182097","Fentanyl vs. Remifentanil in Laparoscopic Cholecystectomy: Effects on Bowel Function and Pain","Effects of Intraoperative Fentanyl vs. Remifentanil on Postoperative Bowel Function and Pain Outcomes in Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-65 years\n* American Society of Anesthesiologists (ASA) physical status I or II\n* Scheduled for elective laparoscopic cholecystectomy\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Opioid use preoperatively\n* Previous abdominal surgery\n* History of ileus or gastrointestinal disease\n* Preoperative electrolyte imbalance\n* Liver or renal failure\n* Neuromuscular or psychiatric disorders\n* Known allergy to study medications\n* Emergency surgery\n* Surgical duration exceeding 90 minutes",{"count":455,"type":21},106,[216],"Background: Postoperative ileus (POI) is a common complication after abdominal surgery, leading to delayed gastrointestinal recovery, prolonged hospitalization, and increased healthcare costs. Opioids, while essential for intraoperative analgesia, are known to impair bowel motility through their μ-receptor effects. Among opioids, fentanyl and remifentanil are widely used but differ in their pharmacokinetic and pharmacodynamic profiles. Remifentanil undergoes rapid metabolism, resulting in a shorter context-sensitive half-life, while fentanyl accumulates with longer infusions. Although remifentanil may theoretically have less impact on bowel recovery, its potential to induce opioid-induced hyperalgesia (OIH) and increased analgesic requirements might prolong gastrointestinal dysfunction and worsen postoperative pain outcomes.\n\nObjective: This randomized controlled trial aims to compare the effects of intraoperative fentanyl versus remifentanil on the recovery of postoperative bowel function and pain outcomes in patients undergoing elective laparoscopic cholecystectomy.\n\nMethods: A total of 106 patients, aged 18-65 years and classified as ASA I-II, will be randomized into two groups: Group F (fentanyl) and Group R (remifentanil). Standardized anesthesia with propofol, rocuronium, and sevoflurane will be applied. The primary endpoint is time to first flatus. Secondary endpoints include time to first defecation, tolerance of oral diet, incidence of prolonged POI, postoperative pain scores, analgesic consumption, PONV incidence, PACU and hospital length of stay, and patient satisfaction.\n\nSignificance: The findings of this study will provide clinical evidence on whether fentanyl or remifentanil is more advantageous in terms of gastrointestinal recovery and pain management following laparoscopic cholecystectomy.",[459,224],"Postoperative Bowel Function",[439,461,462,463,464],"postoperative ileus","postoperative bowel function","fentanyl","remifentanil",{"date":466,"type":39},"2025-09-23",{"date":468,"type":39},"2025-09-19",{"date":417,"type":21},{"name":45,"class":46},{"id":472,"slug":473,"hasResults":11,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":477,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":478,"targetDuration":4,"studyType":214,"phases":480,"briefSummary":481,"conditions":482,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":47},"100602514","regional-anesthesia-in-tka-impact-on-postoperative-joint-motion-and-patient-satisfaction-100602514","NCT07124494","Regional Anesthesia in TKA: Impact on Postoperative Joint Motion and Patient Satisfaction","Evaluation of the Effects of Regional Anesthesia Methods Applied in Total Knee Arthroplasty on Joint Range of Motion in the Postoperative Period and Patient Satisfaction","* Minimum Age: 18 Years\n* Maximum Age: None\n* Sex: All\n* Gender Based: No\n* Accepts Healthy Volunteers: No\n* Inclusion Criteria:\n\n  * Scheduled for primary total knee arthroplasty\n  * Age ≥ 18 years\n  * American Society of Anesthesiologists (ASA) physical status I-III\n  * Accepting neuraxial anesthesia\n* Exclusion Criteria:\n\n  * Skin infection at the planned injection site\n  * Sepsis\n  * Coagulopathy\n  * Refusal of neuraxial anesthesia\n  * Severe hypovolemia\n  * Demyelinating central nervous system disease\n  * Age under 18 years\n  * Illiterate in Turkish\n  * Non-cooperative patients\n  * Known allergy or hypersensitivity to bupivacaine",{"count":479,"type":21},30,[216],"This is a single-center, prospective, randomized controlled trial aiming to evaluate the effects of different regional anesthesia\u002Fanalgesia techniques on postoperative knee range of motion (ROM) and patient satisfaction following total knee arthroplasty (TKA). Ninety patients undergoing elective TKA under spinal anesthesia will be randomly assigned to one of three groups: 1) spinal anesthesia with epidural catheter, 2) spinal anesthesia followed by adductor canal catheterization, and 3) spinal anesthesia with multimodal intravenous analgesia. The primary outcome is postoperative knee joint ROM measured on postoperative days 1, 2, and 3. Secondary outcomes include patient satisfaction, Oxford Knee Score, postoperative opioid consumption, and VAS scores. The study is conducted at Konya City Hospital and will be completed over a 6-month period.",[483,224,484,485,486],"Total Knee Arthroplasty","Regional Anesthesia","Knee Range of Motion","Patient Satisfaction","2025-08-21",{"date":489,"type":39},"2025-08-28",{"date":491,"type":39},"2025-08-05",{"date":493,"type":21},"2026-02-19",{"name":45,"class":46},{"id":496,"slug":497,"hasResults":11,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":4,"eligibilityCriteria":501,"healthyVolunteers":309,"sex":17,"minAge":502,"maxAge":503,"enrollmentInfo":504,"targetDuration":4,"studyType":214,"phases":505,"briefSummary":506,"conditions":507,"keywords":509,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":47},"100580881","comparison-of-the-effects-of-sacral-erector-spinae-plane-block-and-dorsal-penile-block-on-postoperative-pain-in-circumcision-procedures-100580881","NCT06843070","Comparison of the Effects of Sacral Erector Spinae Plane Block and Dorsal Penile Block on Postoperative Pain in Circumcision Procedures","Comparison of the Effects of Sacral Erector Spinae Plane Block and Dorsal Penile Block on Postoperative Pain in Circumcision Operations","Inclusion Criteria:\n\n* Inclusion criteria of the patients: Age between 7-12 years, ASA Physical Status 1 and 2, circumcision surgery, general anesthesia, planned hospital stay of at least 24 hours.\n\nExclusion Criteria:\n\n* Exclusion criteria were defined as patients whose family or personal consent could not be obtained for the study, Asa 3 and above cases, patients in the study age group who will undergo emergency surgery, patients with serious hematopoietic system, cardiovascular, liver or kidney disease, patients receiving anticoagulation therapy, patients with sensitivity to regional anesthetic agents and patients who have previously undergone penile surgery.","7 Years","12 Years",{"count":57,"type":21},[216],"Egypt performed circumcision in 2300 BC, although its origin is unknown. Some societies use circumcision for health, whereas others do it for religious and cultural reasons . Our competent pediatric surgeons perform circumcisions without ultrasonography using midazolam (0.1 mg\u002Fkg) premedication and penile block. In addition to penile block, general anesthesia is given using sevoflurane, ketamine, fentanyl, and propofol, depending on age and weight, for intraoperative anesthesia and analgesia. Penis procedures are frequently simple (phimosis, circumcision), but the pain is significant and long-lasting, affecting young patients' postoperative recovery. The topic of analgesia remains relevant and important in anesthesia practice. Early patient mobilization and discharge are crucial. Pediatric opioid use is questioned due to adverse effects include somnolence, vomiting, and respiratory depression. The advent of ultrasound-guided nerve blocks has revolutionized regional anesthesia in pediatrics. Many upper and lower abdominal operations use truncal blocks with good success and patient safety. Since its applicability, ease of anatomical approach, distance to the medulla spinalis and surgical site, and minimal risk of infection, sacral ESP block has become a popular method for youngsters. Postoperative pain trials demonstrate it works well.",[508],"Postoperative Analgesia",[510,511,512],"Pediatric Regional Anesthesia","Sacral Erector Spinae Plane Block","Postoperative Analgesia in Circumcision","2025-08-08",{"date":515,"type":39},"2025-08-11",{"date":517,"type":39},"2025-02-25",{"date":519,"type":21},"2025-12-25",{"name":45,"class":46},{"id":522,"slug":523,"hasResults":11,"nctId":524,"briefTitle":525,"officialTitle":526,"acronym":4,"eligibilityCriteria":527,"healthyVolunteers":11,"sex":158,"minAge":18,"maxAge":528,"enrollmentInfo":529,"targetDuration":4,"studyType":214,"phases":531,"briefSummary":532,"conditions":533,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":47},"100533093","sacral-erector-spinae-plane-block-in-normal-birth-100533093","NCT06221332","Sacral Erector Spinae Plane Block in Normal Birth","The Effect of Sacral Erector Spinae Plane Block on the Quality of Recovery After Vaginal Birth: A Double-blind Prospective Randomized Controlled Study.","Inclusion Criteria:\n\n* 36-42. Pregnant women who are their gestational age and request epidural anesthesia\n* Pregnant women aged 18-42 with ASA II\n* Pregnant women who will stay in the hospital for at least 24 hours\n* Primiparous pregnant women who will have a planned normal birth\n* Singleton births with vertex presentation\n\nExclusion Criteria:\n\n* Pregnant women who do not want to give consent\n* Regional anesthesia is contraindicated\n* Pregnant women who use anticoagulants and have an abnormal bleeding profile\n* Pregnant women with infection in the area to be treated\n* Emergency cases and pregnant women who had a birth with instruments (forceps and vacuum)","42 Years",{"count":530,"type":21},40,[216],"Pregnant women feel severe pain during normal birth and in the postpartum period. Preventing pain during and after birth is very important for both the mother and the baby. Rapid recovery in the postoperative period in pregnant women is very important for both mother and baby. To evaluate this recovery, the quality of recovery-10 scores developed by Shalev et al. are used in pregnant women. Our study will be the first in the literature to use sacral erectör spinae plane block (S-ESPB) in normal birth. Our primary aim in this study is to evaluate the effects of S-ESPB on the quality of recovery and recovery at the 24th hour in pregnant women who will undergo vaginal birth with epidural analgesia, using the Quality of Recovery-10T scores.",[534],"Analgesia","2024-10-07",{"date":537,"type":39},"2024-10-08",{"date":539,"type":39},"2024-01-24",{"date":541,"type":21},"2025-11-15",{"name":45,"class":46},""]