[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Korea University Ansan Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":79},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100627748","fistula-rfa-trial-radiofrequency-ablation-for-perianal-fistula-100627748",false,"NCT07452666","FISTULA-RFA Trial: Radiofrequency Ablation for Perianal Fistula","FISTULA-RFA Trial (Fistula Inactivation by Segmental Thermal Uniform Lesion Ablation-Radiofrequency Ablation): A Prospective, Multicenter, Single-Arm Pilot Study in Patients With Perianal Fistula","FISTULA-RFA","Inclusion Criteria:\n\n* Adults aged 20 to 74 years\n* Able and willing to provide written informed consent after receiving explanation of the study purpose, procedures, potential benefits, and risks\n* Diagnosed with one or more of the following perianal fistula types:\n\n  1. High trans-sphincteric fistula\n  2. Low trans-sphincteric fistula with high risk of fecal incontinence (sphincter injury risk)\n  3. Fistula with seton placement (seton in situ or previously placed per protocol)\n  4. Crohn's disease-associated perianal fistula\n  5. Complex fistula, including cases with a history of perineal or gynecologic surgery and\u002For recurrent fistula\n\nExclusion Criteria:\n\n* Superficial fistula that is expected to be curable with simple fistulotomy with minimal risk of sphincter injury\n* Fistula related to malignancy\n* Any contraindication to RFA, including: History of stapled hemorrhoidopexy, Presence of endoscopic clips (or similar metallic clips) within the anal canal, Fecal diversion with stoma (diverting stoma in place), Pregnancy","ALL","20 Years","74 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this pilot clinical study is to learn whether radiofrequency ablation (RFA) can safely and effectively treat perianal fistulas in adults. It will also evaluate procedure-related safety and changes in symptoms over time. The main questions it aims to answer are:\n\n* How many participants achieve fistula closure by 6 months after RFA treatment?\n* How often do fistulas recur during follow-up?\n* What medical problems or adverse events occur after the RFA procedure (for example, pain, bleeding, infection, urinary retention, or changes in continence)?\n* How do patient-reported outcomes (such as pain and quality of life) change after treatment? This is a prospective, multicenter, single-arm pilot study. All participants will receive RFA treatment; there is no comparison (control) group.\n\nParticipants will:\n\n* Be screened and enrolled at one of the participating hospitals\n* Undergo a standardized RFA procedure for the perianal fistula\n* Attend follow-up visits with clinical assessments at regular time points up to 6 months (including key assessments around 3 and 6 months)\n* Report symptoms and any adverse events during the follow-up period",[28],"Rectal Fistulas",[30,31,32,33],"Rectal Fistula","RFA","Minimal Invasive Surgery","Radiofrequency Ablation","NOT_YET_RECRUITING","2026-03-01",{"date":37,"type":38},"2026-03-05","ACTUAL",{"date":40,"type":22},"2026-04-01",{"date":42,"type":22},"2027-08-30",{"name":44,"class":45},"Korea University Ansan Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100472917","stabilization-of-atheroma-by-lipid-reducing-effect-of-drug-coated-balloon-stable-dcb-100472917","NCT05438121","STabilization of Atheroma by Lipid-reducing Effect of Drug-Coated Balloon (STABLE-DCB)","Drug-Coated Balloon Angioplasty Facilitates Rapid Reduction in Plaque Lipid Burden in Patients with Multivessel Coronary Artery Disease: a Serial NIRS-IVUS Imaging Study","STABLE-DCB","Inclusion Criteria:\n\n* Patients with significant multivessel coronary artery disease requiring revascularization\n* Any De novo lesions (reference vessel diameter of 2.25mm\\~4.0mm) suitable for DCB angioplasty\n* Lesion suitable for intravascular imagings\n* Written informed consent\n\nExclusion Criteria:\n\n* Hemodynamically unstable or cardiogenic shock\n* Left main stenotic lesion or graft vessel lesion\n* Visible angiographic thrombus, not resolved by balloon angioplasty\n* Pregnancy or breastfeeding\n* Comorbidities with life expectancy \\\u003C 12 months\n* Severe coronary calcification or tortuosity, hindering timely DCB delivery","18 Years","85 Years",{"count":57,"type":22},65,"OBSERVATIONAL","This study aims to investigate whether DCB angioplasty, compared to statin-based medical treatment alone, will lead to more reduction in plaque lipid burden as assessed by near infrared spectroscopy (NIRS) at 6-9 months following the index procedure.",[61,62,63],"Coronary Artery Disease","Atherosclerotic Plaque","De Novo Stenosis",[65,66,67,68],"drug coated balloon","Near infrared spectroscopy","NIRS-IVUS","De novo coronary lesion","RECRUITING","2024-10-09",{"date":72,"type":38},"2024-10-15",{"date":74,"type":38},"2022-10-13",{"date":76,"type":22},"2026-12-31",{"name":44,"class":45},1,""]