[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Kufa University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":97},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100641094","micro-osteoperforation-versus-photobiomodulation-therapy-for-accelerating-maxillary-canine-retraction-100641094",false,"NCT07658235","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction: A Three-Arm Parallel Randomized Controlled Clinical Trial.","MOP-PBMT","Inclusion Criteria:\n\n* Age 18 to 40 years at the time of enrollment\n* Systemically healthy with no chronic medical conditions affecting bone metabolism or wound healing\n* Requiring bilateral maxillary first premolar extraction as part of a comprehensive fixed orthodontic treatment plan\n* Class I or mild Class II malocclusion requiring maximum anchorage canine retraction\n* Fully erupted maxillary permanent dentition with no missing teeth other than planned extraction teeth\n* Good oral hygiene (Plaque Index ≤ 1) and healthy periodontal status (probing depth ≤ 3 mm, no bleeding on probing)\n* No previous orthodontic treatment\n* Willing to attend all scheduled appointments and comply with study protocol\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Systemic diseases affecting bone metabolism including osteoporosis, osteopenia, diabetes mellitus, thyroid disorders, or autoimmune conditions\n* Current use of medications affecting bone remodeling including corticosteroids, bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), or vitamin D supplements\n* Current or recent smokers (within the past 6 months)\n* Pregnant or breastfeeding women\n* History of head and neck radiation therapy\n* Periodontal disease or active dental infection at the time of enrollment\n* Skeletal Class III malocclusion or severe Class II requiring surgical intervention\n* Previous orthodontic treatment or orthognathic surgery\n* Craniofacial syndromes or cleft lip and palate\n* Photosensitivity disorders or use of photosensitizing medications (relevant to LLLT group)\n* Coagulation disorders or anticoagulant therapy (relevant to MOP group)\n* Uncooperative patients or those unable to maintain adequate oral hygiene throughout treatment\n* Parafunctional habits such as severe bruxism or tongue thrusting'",true,"ALL","18 Years","40 Years",{"count":22,"type":23},75,"ESTIMATED","INTERVENTIONAL",[26],"NA","Orthodontic treatment often requires moving the upper canine teeth (the pointed teeth) into the spaces left after removing premolar teeth. This process is usually slow and can take many months, making the total treatment time longer.This study will compare two techniques that may speed up this tooth movement:\n\nMicro-osteoperforation (MOP): A minimally invasive procedure in which a small device is used to create tiny holes in the jawbone near the canine tooth under local anesthesia. These micro-perforations stimulate the bone to remodel faster, which allows the tooth to move more quickly.\n\nPhotobiomodulation therapy (PBMT) \u002F Low-Level Laser Therapy (LLLT): A painless, non-invasive technique that uses a low-power laser light applied to the gum tissue near the canine tooth. The laser energy stimulates cells in the bone and supporting tissues to accelerate tooth movement without any cutting or drilling.\n\nThis trial will randomly assign eligible patients into one of three groups: MOP, LLLT, or a control group receiving standard orthodontic treatment only. Each group will contain 25 participants (75 total). The main goal is to measure and compare how fast the upper canine tooth moves in each group over the first month and until the space is fully closed. The study will also measure the effect of age and sex on the results. The findings will help orthodontists choose the best, fastest, and most comfortable method for each patient to shorten overall treatment time",[29,30,31],"Malocclusion","Orthodontic Tooth Movement","Maxillary Canine Retraction",[33,34,35,36],"Micro-osteoperforation","Photobiomodulation therapy","low-level laser therapy","acceleration of tooth movement","NOT_YET_RECRUITING","2026-06-16",{"date":40,"type":41},"2026-06-18","ACTUAL",{"date":43,"type":23},"2026-07-01",{"date":45,"type":23},"2027-05-28",{"name":47,"class":48},"Kufa University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":49},"100625295","investigate-the-effectiveness-of-3d-printed-shape-memory-aligners-in-the-treatment-of-anterior-open-bite-100625295","NCT07420777","Investigate the Effectiveness of 3D-printed Shape Memory Aligners in the Treatment of Anterior Open Bite","Evaluating the Effectiveness of 3D Directly Printed Shape Memory Aligners in the Management of Anterior Open Bite","Inclusion Criteria:\n\n1. Age 18-35 years,\n2. Both genders.\n3. The patient is well fitted with no systemic disease.\n4. Mild-moderate dental anterior open bite.\n5. Well-aligned or mildly crowded dentition.\n\nExclusion Criteria:\n\n1. Patient with a history of trauma to the molars or incisors.\n2. Patient with a history of endodontic treatment to the maxillary first molar or incisors.\n3. Patient with a systemic disease related to bone metabolism.\n4. Patient taking immunosuppressive drugs or drugs inhibiting or accelerating tooth movement; and\n5. Patient with neuromuscular deficiencies.","35 Years",{"count":59,"type":23},51,[26],"The goal of this randomised clinical trial study is to investigate 3D-printed shape memory aligners in the treatment of anterior dental open bite adult patients. The main questions it aims to answer are:\n\n1. Do 3D-direct-printed shape memory aligners demonstrate potentiality in the management of AOB?\n2. What is the effect of 3D-direct printed shape memory aligners on molar intrusion?\n3. Can the 3D-direct printed shape memory aligners extrude anterior teeth without the use of attachments?\n4. Do 3D-direct printed shape memory aligners generate greater\u002Fhigher stress distribution and initial teeth displacement compared to conventional clear aligners? Researchers will compare three groups: Group I: Patients treated with conventional clear aligners with attachments; Group II: Patients treated with 3D direct-printed shape-memory aligner without attachment; Group III: Patients treated with 3D direct-printed shape memory clear aligners with attachments and see its effect on anterior open bite treatment.\n\nParticipants will wear a clear aligner for about 6-8 months. Then",[63],"Open Bite",[65,66,67,68],"open bite","clear aligner","memory shape","3D direct printed","RECRUITING","2026-05-08",{"date":72,"type":41},"2026-05-11",{"date":74,"type":41},"2026-05-01",{"date":76,"type":23},"2027-03-27",{"name":47,"class":48},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":24,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":96,"locationsCount":4},"100630446","efficacy-of-structured-progressive-training-exercise-on-muscle-strength-of-patients-with-rheumatoid-arthritis-100630446","NCT07487779","Efficacy of Structured Progressive Training Exercise on Muscle Strength of Patients With Rheumatoid Arthritis","RA","Inclusion Criteria:\n\n* Diagnosed with Rheumatoid Arthritis according to American College of Rheumatology criteria\n* Age 18-65 years\n* Both genders eligible\n* Disease duration of at least 6 months\n* Stable medication regimen for at least 3 months before study\n* Mild to moderate disease activity\n* Able to walk independently with or without assistive devices\n* Willing and able to provide informed consent\n* Agree to participate in the exercise program for 6 weeks\n* Attending AL-Najaf Teaching Hospital for RA management\n\nExclusion Criteria:\n\n* Severe cardiovascular disease (unstable angina, recent MI, severe heart failure)\n* Other inflammatory arthritis (psoriatic arthritis, ankylosing spondylitis, lupus)-\n* Recent joint surgery or fracture within the past 6 months\n* Severe osteoporosis with fracture risk\n* Pregnancy\n* Severe cognitive impairment preventing participation\n* Uncontrolled hypertension (BP \\>180\u002F110 mmHg)\n* Active infection or fever at baseline\n* Severe joint damage preventing exercise participation\n* Participation in another exercise program during the study period\n* Neuromuscular disorders affecting muscle function",{"count":86,"type":23},118,[26],"This study aims to find out if a specific exercise program helps patients with Rheumatoid Arthritis (RA). RA is a chronic autoimmune disease that causes pain, weakness, and reduced function in the joints and muscles. While medication is common, exercise is also important for management.\n\nThe study will test a program called \"Progressive Resistance Training.\" About 118 adult patients with RA at AL-Najaf Teaching Hospital will participate. They will be divided into two groups. One group will perform specific resistance exercises for six weeks, while the other group will continue their usual care without this specific training.\n\nThe researchers will measure muscle strength, cardiovascular function, and energy levels before and after the six-week program. The goal is to determine if this exercise improves muscle strength and helps patients perform daily activities more efficiently. The study hopes to show that resistance training is a safe and effective way to improve quality of life for people with RA.",[90],"Rheumatoid Arthritis (RA)","2026-03-26",{"date":93,"type":41},"2026-04-01",{"date":93,"type":23},{"date":43,"type":23},{"name":47,"class":48},""]