[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lady Reading Hospital, Pakistan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":101},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100614544","comparing-polyglactin-vs-polypropylene-sutures-for-rectus-sheath-closure-100614544",false,"NCT07280975","Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure","Comparative Outcomes of Polyglactin Versus Polypropylene Sutures for Rectus Sheath Closure: A Randomized Controlled Trial","PolySuture","Inclusion Criteria:\n\n1. Age: 18-70 years.\n2. Type of Surgery: Patients undergoing elective or emergency midline laparotomy.\n3. Wound Classification: Clean or clean-contaminated wounds (CDC Class I or II).\n4. Ability to Provide Informed Consent: Participants must be able to understand and sign the informed consent form.\n5. Availability for Follow-Up: Participants must be available for 6 months follow-up.\n\nExclusion Criteria:\n\n1. Contaminated or Dirty Wounds: Patients with CDC Class III or IV wounds.\n2. Immunocompromised Conditions: Patients on steroids, chemotherapy, or those with HIV.\n3. Previous Midline Laparotomy with Incisional Hernia: Patients who have a history of incisional hernia after midline laparotomy.\n4. Severe Malnutrition: Patients with BMI \\\u003C 16 kg\u002Fm² or albumin \\\u003C 2.5 g\u002FdL.\n5. Emergency Laparotomy with Hemodynamic Instability: Patients who are unstable or in a critical condition.\n6. Pregnancy: Pregnant women.\n7. Need for Temporary Abdominal Closure or Planned Reoperation: Patients requiring staged reoperation or temporary closure.","ALL","18 Years","70 Years",{"count":21,"type":22},156,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy. The study will evaluate the rates of incisional hernia, surgical site infection (SSI), wound dehiscence, chronic pain, and suture sinus formation. Participants aged 18-70 years, undergoing either elective or emergency laparotomy, will be randomly assigned to receive either Polyglactin or Polypropylene sutures. The primary outcome measure is the incidence of incisional hernia at 6 months, with secondary outcomes including SSI, wound complications, and chronic pain. The study is particularly important in the context of Pakistan, where such comparative data is limited, and aims to provide evidence-based recommendations for optimal suture material selection in general surgery.",[28,29,30,31,32,33],"Chronic Pain","Wound Dehiscence","Surgical Site Infection (SSI)","Incisional Hernia","Rectus Sheath Closure","Abdominal Surgery",[35,36,37,38,39],"Polyglactin Sutures","Polypropylene Sutures","Non-Absorbable Sutures","Postoperative Complications","Midline Laparotomy","NOT_YET_RECRUITING","2025-12-09",{"date":43,"type":44},"2025-12-15","ACTUAL",{"date":46,"type":22},"2026-04-01",{"date":48,"type":22},"2027-07-30",{"name":50,"class":51},"Lady Reading Hospital, Pakistan","OTHER_GOV",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":52},"100600916","comparison-of-frequency-of-wound-infection-between-open-and-laparoscopic-cholecystectomy-100600916","NCT07103707","Comparison of Frequency of Wound Infection Between Open and Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Both genders\n\n  * Patients aged 18 to 65 years\n  * Symptomatic cholelithiasis as per operational definition\n  * Undergoing cholecystectomy (open\u002Flaparoscopic)\n  * ASA score I\u002FII (Annexure-II)\n\nExclusion Criteria:\n\n* ● H\u002Fo diabetes mellitus\n\n  * H\u002Fo immunocompromised state (e.g. HIV, steroid use)\n  * H\u002Fo acute cholecystitis\n  * H\u002Fo empyema gallbladder\n  * H\u002Fo gallbladder perforation ● H\u002Fo choledocholithiasis\n  * H\u002Fo portal hypertension\n  * H\u002Fo abnormal blood clotting profiles (PTT \\>15 seconds, APTT \\>20 seconds)\n  * H\u002Fo pregnancy on HCG",true,"65 Years",{"count":62,"type":22},122,[25],"The goal of this clinical trial is to compare the frequency of wound infection between open and laparoscopic cholecystectomy in adult patient aged 18- 65 years with symptomatic cholelithiasis admitted through OPD the main question it aims to answer are\n\n* Does there is difference in the frequency of wound infection in patients with open cholecystectomy as compared to laparoscopic cholecystectomy Researcher will compare the frequency of wound infection in participant undergoing open and laparoscopic cholecystectomy to see there is difference in frequency of wound infection between open and laparoscopic cholecystectomy Participants will be asked\n* To Visit OPD after 1 week for follow up\n* Keep record of symptoms like erythema, pain, cloudy drainage from the incision site",[66],"Wound Infection, Surgical","RECRUITING","2025-08-01",{"date":70,"type":44},"2025-08-05",{"date":72,"type":22},"2025-08",{"date":74,"type":22},"2026-08",{"name":50,"class":51},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":52},"100566976","phase-2-role-of-dexmedetomidine-as-synergistic-agent-100566976","NCT06662175","Role of Dexmedetomidine as Synergistic Agent","Role of Dexmedetomidine as Synergistic Agent to Prolong a Subarachnoid Block Duration","Inclusion Criteria:\n\n1. Patients of either gender aged between 18 and 65 years.\n2. Patients scheduled for surgical procedures of lower limb requiring subarachnoid anesthesia.\n3. American Society of Anesthesiologists (ASA) physical status classification I or II.\n\nExclusion Criteria:\n\n1. Patients with contraindications to subarachnoid anesthesia, including severe coagulopathy, infection at the site of injection, or increased intracranial pressure.\n2. Patients with a history of significant cardiac, respiratory, hepatic, or renal disease.\n3. Pregnant or lactating women.\n4. Patients with a history of substance abuse or dependence.\n5. Patients on chronic opioid therapy or with opioid tolerance.\n6. Patients with neurological deficits affecting sensation or motor function in the lower extremities.\n7. Patients with psychiatric disorders affecting their ability to cooperate during the procedure or follow instructions.",{"count":84,"type":22},166,[86,87],"PHASE2","PHASE3","The aim of this clinical trial is to contribute valuable insights into the role of Dexmedetomidine as a synergistic agent in prolonging subarachnoid block duration, with the overarching goal of enhancing perioperative care and surgical success rates.",[90,91,92],"Dexmedetomidine","Hyperbaric Bupivacaine","Subarachnoid Anesthesia","2024-10-25",{"date":95,"type":44},"2024-10-28",{"date":97,"type":22},"2024-11",{"date":99,"type":22},"2025-09",{"name":50,"class":51},""]