[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lahey Clinic\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":88},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100123330","evaluation-of-non-invasive-assays-for-the-detection-of-urothelial-cancer-100123330",false,"NCT00872495","Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer","Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer of the Bladder and Kidney","Inclusion Criteria:\n\n* Patients scheduled to have a nephroureterectomy, cystectomy, cytoscopy (newly diagnosed bladder cancer and those with recurrent disease in follow up)\n* Control Group: No known evidence of bladder cancer-one urine sample\n* \\> than 18 years of age\n\nExclusion Criteria:\n\n* \\\u003C than 18 years of age",true,"ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine if analysis of DNA and protein material found in urine will be useful in the detection of urothelial cancer of the bladder and kidney. This analysis may be helpful to determine if how a particular cancer will act regarding remission and recurrence",[25,26,27,28],"Urothelial Cancer","Cancer","Bladder Neoplasms","Urinary Bladder Cancer",[25,26,27,28],"RECRUITING","2025-12-01",{"date":33,"type":34},"2025-12-08","ACTUAL",{"date":36,"type":4},"2002-09",{"date":38,"type":21},"2028-11",{"name":40,"class":41},"Lahey Clinic","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":42},"100339184","phase-4-randomized-controlled-trial-for-ankle-fracture-pain-control-100339184","NCT03696199","Randomized Controlled Trial for Ankle Fracture Pain Control","A Prospective, Randomized Trial Evaluating Regional Anesthesia, Long-Acting Local Anesthesia, and Traditional Care for Pain Control of Operatively Treated Ankle Fractures","Inclusion Criteria:\n\n* Sustained a bimalleolar ankle fracture (OTA\u002FAO type 44 A2, B2, C1, and C2 fracture) with surgery indicated and an approach with medial and lateral incisions planned Syndesmotic injuries will be included, due to the practical difficulty of reliably determining the presence of a syndesmotic injury preoperatively Trimalleolar ankle fractures where fixation of the posterior malleolus is not planned will also be included\n* Isolated Injury\n\nExclusion Criteria:\n\n* Unifocal malleolar fractures\n* Bimalleolar fractures where fixation of only one malleolus is planned\n* Posterior malleolus fractures requiring fixation\n* Patients ineligible for a peripheral nerve block (e.g. concern for compartment syndrome)\n* Open injury\n* Patients treated with external fixation\n* Neurologic condition that would confound results (e.g. peripheral neuropathy)\n* Inability to consent\n* Chronic opioid use\n* History of opiate abuse\n* Polytrauma as defined as additional boney injury, visceral injury or moderate soft tissue injury (requiring suture repair or other invasive procedure)\n* Prisoners (unlikely to be accessible for follow-up)\n* Pregnant patients\n* Non-English-speaking subjects (post-operative data collection procedure involves conversations via phone calls. As we do not have access to translators for this research project, we will work exclusively with English-speaking subjects).\n* Subjects unable to take the standard post-operative pain regimen that consists of gabapentin, oxycodone, acetaminophen, and ibuprofen.","89 Years",{"count":52,"type":21},70,"INTERVENTIONAL",[55],"PHASE4","This project is a multicenter, three armed, prospective randomized control trial studying the effectiveness of a long-acting local anesthetic \"cocktail\" in patients undergoing operative fixation of ankle fractures.",[58],"Ankle Fractures","2025-11-03",{"date":61,"type":34},"2025-11-06",{"date":63,"type":34},"2020-09-01",{"date":65,"type":21},"2027-09-01",{"name":40,"class":41},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":53,"phases":75,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":42},"100607323","using-urine-tumor-dna-to-de-intensify-surveillance-in-non-muscle-invasive-bladder-cancer-100607323","NCT07187063","Using Urine Tumor DNA to De-Intensify Surveillance in Non-Muscle Invasive Bladder Cancer","Inclusion Criteria:\n\n* AUA high-risk bladder cancer1\n* Received induction BCG or gemcitabine\u002Fdocetaxel\n* Negative initial post-induction therapy assessment (negative cytology and cystoscopy +\u002F- biopsy)\n\nExclusion Criteria:\n\n* High-risk NMIBC within 3 years\n* Prior induction intravesical therapy\n* Variant histology\n* Concurrent upper tract disease",{"count":74,"type":21},56,[76],"NA","The goal of this clinical trial is to use urine tumor DNA (utDNA) as an indicator for non-muscle invasive bladder cancer to identify patients suitable for less frequent cystoscopy surveillance.",[79],"Non-muscle Invasive Bladder Cancer (NMIBC)","2025-09-18",{"date":82,"type":34},"2025-09-22",{"date":84,"type":34},"2025-01-01",{"date":86,"type":21},"2029-01-01",{"name":40,"class":41},""]