[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lahore University of Biological and Applied Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":677},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,44,0,25,[9,46,75,95,123,150,173,198,224,247,278,307,332,359,382,406,431,458,485,511,540,570,603,628,655],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100645161","effects-of-clinical-based-versus-synchronized-telerehabilitation-on-pain-exercise-adherence-and-functional-disability-among-patients-with-grade-ii-cervical-spondylosis-100645161",false,"NCT07679373","Effects of Clinical Based Versus Synchronized Telerehabilitation on Pain, Exercise Adherence, and Functional Disability Among Patients With Grade-II Cervical Spondylosis.","Inclusion Criteria:\n\n* Middle age adults (45-64) years\n* Both gender ( male and female )\n* Clinical daignosis of cervical spondylosis grade 2\n* Mild to moderate pain on NPRS\n* Sub acute stage ( 2-6 weeks) of grade 2 cervical spondylosis\n* Able to follow instructions and give informed consent (cognitively able) Neurologically stable\n\nExclusion Criteria:\n\n* Prior cervical spine surgery within the last 1 months or cervical instability.\n* Inflammtory or systemic rheumatologic disease affecting the cervical spine (e.g., active rheumatoid arthritis ) or infection, tumor, fracture.\n* Severe cardiopulmonary or other medical comorbidity that contraindicates exercise (unstable angina, uncontriolled hypertension, recent MI)\n* Severe hearing or visual impairment\n* No smoking and daibetic history","ALL","45 Years","64 Years",{"count":20,"type":21},52,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to compare the effects of clinical-based rehabilitation and synchronized telerehabilitation on pain, exercise adherence, and functional disability in patients with Grade-II cervical spondylosis. A total of 52 participants will be randomly allocated into two parallel groups. Both groups will receive a standardized 6-week rehabilitation program, including cervical mobility exercises, strengthening, isometric exercises, stretching, and Mulligan self-mobilization techniques. The clinical group will receive in-person physiotherapy, while the telerehabilitation group will undergo real-time supervised sessions via video conferencing. Outcome measures will include pain (Numeric Pain Rating Scale), functional disability (Neck Disability Index), and exercise adherence (Exercise Adherence Rating Scale), assessed at baseline and post-intervention. The study aims to determine whether synchronized telerehabilitation is as effective as clinical-based rehabilitation and may provide a more accessible alternative for delivering physiotherapy care.",[27],"Grade-II Cervical Spondylosis",[29,30,31,32,33],"Telerehabilitation","Pain","Excercise Adherence","Functional Disability","Cervical Spondylosis","NOT_YET_RECRUITING","2026-06-25",{"date":37,"type":38},"2026-07-01","ACTUAL",{"date":37,"type":21},{"date":41,"type":21},"2026-11-30",{"name":43,"class":44},"Lahore University of Biological and Applied Sciences","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100644340","effects-of-blood-flow-restriction-training-and-instrument-assisted-soft-tissue-mobilization-for-pain-strength-range-of-motion-and-kinesiophobia-among-acl-reconstruction-patients-100644340","NCT07662850","Effects of Blood Flow Restriction Training and Instrument-Assisted Soft Tissue Mobilization for Pain, Strength, Range of Motion, and Kinesiophobia Among ACL Reconstruction Patients.","Inclusion Criteria:\n\n* Age between 18 and 40 years.\n* Both genders.\n* Undergoing Primary Unilateral ACLR (using autologous tendon graft).\n* Medically cleared for low load rehabilitation (Wound healed, stable graft per surgeon).\n* Active knee flexion of ≥100° on the operative limb.\n* 8-16 weeks after reconstructive surgery.\n* Willing to comply with all rehabilitation sessions and follow up assessments; give informed consent\n\nExclusion Criteria:\n\n* Significant meniscectomy requiring protected weight-bearing\n* Active DVT, vascular disease, uncontrolled hypertension or other BFR contraindications\n* Patients exhibiting extension lag (inability to achieve full active knee extension) on the operated limb.\n* Neuromuscular disorders\n* Skin lesions preventing IASTM\n* Pregnancy\n* Contraindications to exercise","18 Years","40 Years",{"count":55,"type":21},46,[24],"This randomized clinical trial aims to compare the effects of Blood Flow Restriction Training (BFR) and Instrument-Assisted Soft Tissue Mobilization (IASTM) on pain, quadriceps muscle strength, knee range of motion (ROM), and kinesiophobia in patients following anterior cruciate ligament reconstruction (ACLR). ACLR patients commonly experience persistent muscle weakness, limited ROM, pain, and fear of movement, which can delay functional recovery and return to activity. A total of 46 participants (8-16 weeks post-ACLR) will be randomly allocated into two groups: a BFR group and an IASTM group. Both groups will receive interventions twice weekly for 8 weeks alongside standard physiotherapy. The BFR group will perform low-load resistance exercises under controlled vascular occlusion, while the IASTM group will receive soft tissue mobilization using specialized instruments combined with conventional rehabilitation. Outcome measures will include quadriceps strength (handheld dynamometer), pain (Numeric Pain Rating Scale), knee ROM (goniometer), and kinesiophobia (Tampa Scale of Kinesiophobia), assessed at baseline and post-intervention. The study aims to determine which intervention provides superior improvements in physical and psychological outcomes during early rehabilitation after ACL reconstruction.",[59],"ACL Reconstruction",[61,62,63,64,65,30,66],"Anterior Cruciate Ligament Reconstruction","Blood Flow Restriction Training","Instrument-Assisted Soft Tissue Mobilization","Quadriceps Strength","Range Of Motion","Kinesiophobia","RECRUITING",{"date":69,"type":38},"2026-06-29",{"date":71,"type":21},"2026-06-12",{"date":73,"type":21},"2026-11-20",{"name":43,"class":44},{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":94,"locationsCount":45},"100643666","effects-of-telerehabilitation-and-supervised-clinic-based-rehab-with-pain-neuroscience-education-for-painkinesiophobia-and-functional-disability-among-chronic-non-specific-neck-pain-patients-100643666","NCT07617623","Effects of Telerehabilitation and Supervised Clinic Based Rehab With Pain Neuroscience Education for Pain,Kinesiophobia and Functional Disability Among Chronic Non-Specific Neck Pain Patients","Inclusion Criteria:\n\n1. Age between 18-40 years of both male and female gender.\n2. Currently suffering from neck pain \\& bilateral neck pain for at least three months.\n3. Moderate pain intensity (30mm to 70mm) on Visual Analogue Scale .\n4. Access \\& knowledge of mobile phone and internet use .\n\nExclusion Criteria:\n\n1. Any previous neck surgery or cervical trauma .\n2. Fibromyalgia \\& Myelopathy .\n3. Spinal deformities like thoracic hyper kyphosis or scoliosis .\n4. Cervical radiculopathy ,vertigo, cancer \\& vertebral fractures.\n5. Infection or inflammatory arthritis in cervical spine .\n6. History of the whiplash injury .\n7. Physiotherapeutic treatment in the last six months .\n8. Cognitive disorder that prohibited the pain neuroscience education intervention from being followed .",{"count":82,"type":21},45,[24],"Chronic non-specific neck pain is a common musculoskeletal condition affecting a large proportion of the population worldwide. It is characterized by persistent neck pain lasting more than three months without a specific underlying pathology. Many patients experience ongoing symptoms such as pain, reduced range of motion, functional limitations, and psychological factors like kinesiophobia, which can negatively affect recovery and quality of life.\n\nConventional physiotherapy, including supervised clinic-based rehabilitation, is widely used for the management of chronic non-specific neck pain. These programs typically involve exercise therapy and patient education; however, access to regular in-clinic treatment can be limited due to factors such as travel, cost, and time constraints.\n\nTelerehabilitation has emerged as an alternative approach that allows delivery of physiotherapy services through online platforms, improving accessibility and convenience for patients. In addition, pain neuroscience education (PNE) is an evidence-based strategy that helps patients understand pain mechanisms, reduce fear-avoidance behaviors, and improve treatment outcomes when combined with exercise therapy.\n\nAlthough both telerehabilitation and supervised clinic-based rehabilitation are effective, there is limited evidence directly comparing these two approaches when combined with standardized pain neuroscience education.\n\nTherefore, this randomized controlled trial aims to compare the effects of telerehabilitation with pain neuroscience education and supervised clinic-based rehabilitation with pain neuroscience education on pain intensity, functional disability, and kinesiophobia in individuals with chronic non-specific neck pain.",[86],"Chronic Non-Specific Neck Pain",[88,29,89,66,86],"Pain Neuroscience Education","Supervised Clinic Based Rehab",{"date":69,"type":38},{"date":92,"type":21},"2026-06",{"date":73,"type":21},{"name":43,"class":44},{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":12,"sex":16,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":45},"100618146","comparative-effects-of-back-school-based-intervention-versus-cranio-cervical-muscle-training-in-computer-users-with-cervicogenic-headache-100618146","NCT07327827","Comparative Effects of Back School Based Intervention Versus Cranio-Cervical Muscle Training in Computer Users With Cervicogenic Headache","Effects of Back School Based Intervention Versus Cranio-Cervical Muscle Training on Pain, Posture and Disability in Computer Users With Cervicogenic Headache","Inclusion Criteria:\n\n* Participants of both gender.\n* Participants aged between 19 to 44 years.\n* Participants having unilateral headache without side shift for\\>3 months aggravated by neck movement.\n* Participants with pain intensity ≥3 on a visual analog scale (VAS).\n* Participants working on the computer for an average 32 h per week.\n* Participants having positive cervical flexion rotation test (CFRT).\n* Participants having joint tenderness in at least one of the upper three cervical joints with palpation.\n\nExclusion Criteria:\n\n* If participants having any history of fractures or previous surgery of the vertebral column, any degenerative and inflammatory arthritis, osteoporosis, dislocations, cervical radiculopathy\u002Fmyelopathy and any history of whiplash injury.\n* Participants showing any signs of the five 'D's' or three 'N's.","19 Years","44 Years",{"count":5,"type":21},[24],"The aim of the study is to compare Back School Based Intervention with Cranio- Cervical muscle training in participants with Cervicogenic headache. The study wants to investigate that which intervention helps to mange pain, improve posture and reduce disability. The study aims to answer the question:\n\n* How effective is Back School Based intervention on pain, posture and disability in computer users with Cervicogenic headache compared to Cranio-cervical Muscle Training? Participants will\n* Attend the treatment sessions of the group in which they are placed.\n* Take treatment session two times a week for eight weeks.\n* Participants will be asked about their pain and activities throughout the study.",[108],"Cervicogenic Headache",[108,110,111,30,112,113,114],"Back School Based Program","Cranio-Cervical Muscle Training","Posture","Headache","Disability","2026-06-19",{"date":117,"type":38},"2026-06-24",{"date":119,"type":38},"2026-01-23",{"date":121,"type":21},"2026-07-18",{"name":43,"class":44},{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":12,"sex":16,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":149},"100644434","effects-of-tai-chi-therapy-versus-qi-gong-in-stage-i-parkinsons-patients-100644434","NCT07662837","Effects of Tai Chi Therapy Versus Qi-Gong in Stage-I Parkinson's Patients.","Effects of Tai Chi Therapy Versus Qi-Gong on Postural Control, Functional Balance , and Motor Function in Stage-I Parkinson's Patients.","Inclusion Criteria:\n\nDiagnosis of PD based on the Hoehn \\& Yahr staging system (Stages I). Male or female patients aged between 50-65 years. Currently receiving stable anti-Parkinsonian medication, with no changes in the treatment regimen for at least 3 months. Basic self-care ability with no severe cognitive impairment (Mini-Mental State Examination \\[MMSE\\] score ≥24).\n\nExclusion Criteria:\n\nDepression, as assessed based on a score of \\>16 for the Beck Depression Inventory-II (BDI-II). Recent deep brain stimulation (DBS) treatment. Use of medication that interferes with cognition, alertness, or attention. Current participation in an exercise training program.","50 Years","65 Years",{"count":133,"type":21},50,[24],"This study has important clinical, academic, and practical relevance in neuromuscular rehabilitation. Clinically, it aims to identify effective and tolerable rehabilitation strategies for individuals with Parkinson's disease by comparing Tai Chi Therapy with Qi-Gong there by supporting evidence-based physiotherapy practice and improving patient adherence. Academically, it contributes to the limited literature on comparative effectiveness of these interventions and incorporates patient-centered outcomes such as exercise perception, which are often underreported. From a practical and societal perspective, identifying a more acceptable and effective approach may enhance long-term participation in rehabilitation, potentially slow disease progression, and reduce the overall healthcare burden associated with Parkinson's disease.",[137],"PARKINSON DISEASE (Disorder)",[139,140],"Tai Chi","Qi-Gong","2026-06-17",{"date":143,"type":38},"2026-06-23",{"date":145,"type":38},"2026-05-30",{"date":147,"type":21},"2026-10-10",{"name":43,"class":44},2,{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":172,"locationsCount":45},"100623829","effects-of-modified-clamshell-exercises-in-patients-with-hip-osteoarthritis-grade--100623829","NCT07401719","Effects of Modified Clamshell Exercises in Patients With Hip Osteoarthritis Grade Ⅱ.","Effects Of Modified Clamshell Exercises On Pain, Range Of Motion, And Functional Outcomes In Patients With Hip Osteoarthritis In Grade Ⅱ.","Inclusion Criteria:\n\n* Patients between 45 to 60 years\n* Both male and female patients with hip osteoarthritis grade II were selected for this study\n* Patients with Hip Osteoarthritis grade II\n* Patients with pain more than 6 months\n\nExclusion Criteria:\n\n* Patients with Cardiac disorders\n* Patient with other current lower extremity pathologies (e.g., peripheral vascular disease, septic arthritis)\n\n  * Patients with low back surgery.","60 Years",{"count":159,"type":21},54,[24],"This study focuses on patients diagnosed with Grade II hip osteoarthritis, a degenerative joint condition characterized by pain, reduced range of motion, muscle weakness, and functional limitations. Hip osteoarthritis is commonly assessed using the Kellgren-Lawrence (KL) classification system, with Grade II representing definite osteophyte formation with possible joint space narrowing, where conservative management is strongly recommended. Exercise therapy, particularly strengthening of the hip abductor muscles, plays a key role in improving pelvic stability, reducing pain, and enhancing functional outcomes. Clamshell exercises are widely used to activate the gluteus medius and minimus muscles, while modified clamshell exercises are designed to optimize muscle recruitment and reduce compensatory movements.\n\nA total of 54 participants with Grade II hip osteoarthritis will be included in the study and allocated into three groups. Group A will receive clamshell exercises along with conventional exercise therapy, Group B will receive modified clamshell exercises in addition to conventional exercise therapy, and Group C will receive a conventional exercise program alone. Pain intensity will be assessed using the Visual Analog Scale (VAS), which ranges from 0 to 10. Hip joint range of motion will be measured using a goniometer, and functional outcomes will be evaluated using the Hip Disability and Osteoarthritis Outcome Score-12 (HOOS-12). The aim of this study is to compare the effects of clamshell exercises, modified clamshell exercises, and conventional exercise programs to determine the most effective intervention for reducing pain, improving hip joint range of motion, and enhancing functional outcomes in patients with Grade II hip osteoarthritis.",[163],"Osteo Arthritis of Hip",[165,166],"Hip Osteoarthritis","Clamshell Exercises",{"date":168,"type":38},"2026-06-22",{"date":170,"type":38},"2025-08-07",{"date":71,"type":21},{"name":43,"class":44},{"id":174,"slug":175,"hasResults":12,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":131,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":181,"briefSummary":182,"conditions":183,"keywords":186,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":197,"locationsCount":149},"100614695","combined-effects-of-soft-robotic-hand-and-electrical-stimulation-on-hand-function-in-stroke-survivors-100614695","NCT07282938","Combined Effects of Soft Robotic Hand and Electrical Stimulation on Hand Function in Stroke Survivors","Inclusion Criteria:\n\n* Diagnosed with their first episode of stroke.\n* Participants with 3-6 months post stroke.\n* Participants with normal cognition on Montreal Cognitive Assessment (MOCA) ≥24.\n* Participants with the ability to extend Metacarpophalangeal (MCP) and Proximal Interphalangeal (PIP) joint to 180 degree passively\n* Modified Ashworth Scale \\\u003C 2.\n* Participants with the score of 10 to 16 on National Institute of Health Stroke Scale Score (NIHSS Score).\n\nExclusion Criteria:\n\n* Presence of other neurological, neuromuscular, orthopedic diseases, or\n* conditions that may interfere with task performance.\n* Participants with sensory disturbances in the fingers",{"count":180,"type":21},64,[24],"Stroke is a clinically delineated syndrome, which is characterised by an acute, focal neurological deficit resulting from vascular injury (infarction or haemorrhage) within the central nervous system. Notably, around 80 percent of stroke survivors experience post-stroke deficits in upper extremity (UE) motor performance, impacting grip strength, dexterity, and functional independence, which greatly hinder the ability of stroke patients to carry out activities of daily living (ADL), and in turn affects their overall quality of life (QOL).One potential solution to these difficulties is the creation of rehabilitation robotic devices that incorporate hand technology and electrical stimulation. Although soft robotic assistive devices and electrical stimulation have each shown positive effects on motor recovery, their combined use has yet to be thoroughly investigated. This study intends to determine if the simultaneous application of these therapies can speed up rehabilitation results in comparison to independent therapies. Stroke Participants will be divided into two groups, Experimental group and Control group. Both the groups will receive intervention for 40 min\u002Fday, 03 days\u002Fweek, for 08 week and measurements will be taken prior to the treatment, after 4 weeks of treatment and 8 weeks post-treatment.",[184,185],"Stroke","Cerebro-vascular Accident",[184,187,188,189,190,191],"hand impairments","soft robotic hand","electrical stimulation","robotic therapy","Cerebrovascular accident",{"date":193,"type":38},"2026-06-18",{"date":195,"type":38},"2025-12-08",{"date":92,"type":21},{"name":43,"class":44},{"id":199,"slug":200,"hasResults":12,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":16,"minAge":206,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":215,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":219,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":223,"locationsCount":45},"100612459","effects-of-hand-and-arm-bimanual-intensive-therapy-including-lower-extremity-in-spastic-cerebral-palsy-100612459","NCT07253857","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity on Motor Function and Cognition in Children With Spastic Cerebral Palsy","HABIT-ILE","Inclusion Criteria:\n\n* Diagnosed with diplegic cerebral palsy\n* CP children with manual ability level 1-3 on manual ability classification system\n* Participants with gross motor function classification system level ranging from 1-3 will be included in the study.\n* With an ability to grasp light objects and lift the more affected arm 15 cm above a table surface.\n* Base line cognition level should be 20 or above assessed through mini mental state exam for children (MMC).\n\nExclusion Criteria:\n\n* Uncontrolled seizures\n* Recent or planned botulinum toxin injections within 6 months\n* Any recent orthopedic interventions that may affect motor function\n* Visual impairments impeding with treatment protocol","6 Years","12 Years",{"count":209,"type":21},42,[24],"Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations. In addition to motor dysfunction, children with CP often experience cognitive impairments affecting decision-making, problem-solving, working memory, selective attention, and inhibitory control. These non-motor challenges contribute to reduced social interaction and quality of life.\n\nHand-Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) has demonstrated improvements in gross motor function among children with spastic CP. However, evidence regarding its impact on cognitive outcomes remains limited. This randomized controlled trial (RCT) aims to evaluate the effects of HABIT-ILE compared with conventional therapy on both motor and cognitive functions in children with spastic diplegic CP. By addressing both upper and lower limb the research seeks to provide a comprehensive therapeutic approach that may yield more significant developmental benefits. Ultimately, the findings could inform the interventions for improving outcomes in pediatric populations affected by diplegic cerebral palsy.\n\nParticipants will receive 90 hours of intervention, with assessments conducted at baseline, mid-intervention, and post-intervention. The study will investigate outcomes across motor domains and cognitive functions such as inhibitory control and working memory. Findings are expected to inform comprehensive therapeutic approaches to improve developmental outcomes and quality of life in pediatric populations affected by spastic diplegic CP.",[213,214],"Cerebral Palsy","Cerebral Palsy, Spastic",[204,216,213,217,218],"Intensive motor therapy","diplegic cerebral palsy with spasticity","Spastic cerebral palsy",{"date":193,"type":38},{"date":221,"type":38},"2025-12-20",{"date":92,"type":21},{"name":43,"class":44},{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":22,"phases":233,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":241,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":45},"100612460","comperative-effects-of-transcutaneous-auricular-and-cervical-vagus-nerve-stimulation-in-subacute-stroke-patients-100612460","NCT07253870","Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients","Comparative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation on Upper Limb Function, Cognition and Quality of Life in Subacute Stroke Patients","Inclusion Criteria:\n\n* First ever ischemic stroke\n* Subacute phase of stroke 3-6 months post onset\n* Fugl-Meyer Assessment-Upper Extremity (FMA-UE) scores ranged from 20 - 50\n\nExclusion Criteria:\n\n* Previous injury or surgical intervention of vagus nerve\n* Patients with cardiac arrest and arrythmias\n* Uncontrolled hypertension\n* Apraxia\n* Other neurologic or musculoskeletal diseases\n* Presence of implanted electronic devices","70 Years",{"count":159,"type":21},[24],"This study aims to determine whether transcutaneous vagus nerve stimulation (tVNS) via auricular or cervical branches enhances recovery when combined with task-specific training in subacute stroke patients. We anticipate finding that both stimulation methods may improve upper limb motor function compared to conventional therapy. The research is expected to reveal specific cognitive domains (attention, memory, executive function) that benefit most from each stimulation approach, while also demonstrating meaningful improvements in patients' quality of life measures. These findings may make a significant practical contribution by providing clinicians with evidence-based guidance on suitable tVNS approach for improving functional independence and quality of life for stroke survivors.",[184,236],"Stroke, Acute",[238,239,240],"Task Specific Training","Upper Limb Function","Cognition",{"date":193,"type":38},{"date":243,"type":38},"2025-11-20",{"date":245,"type":21},"2026-06-20",{"name":43,"class":44},{"id":248,"slug":249,"hasResults":12,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":16,"minAge":255,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":274,"completionDateStruct":275,"leadSponsor":277,"locationsCount":149},"100641120","effects-of-core-stabilization-exercises-and-rotation-angular-breathing-exercises-among-idiopathic-scoliosis-patients-100641120","NCT07601893","Effects of Core Stabilization Exercises and Rotation Angular Breathing Exercises Among Idiopathic Scoliosis Patients","Effects of Core Stabilization Exercises and Rotational Angular Breathing Exercises on Cobb's Angle, Trunk Rotation, Inspiratory Capacity and Spinal Appearance Among Idopathic Scoliosis Patients","CSE RAB IS","Inclusion Criteria:\n\n* Adolescents aged 10-17 years\n* Both male and female participants\n* Diagnosed cases of idiopathic scoliosis\n* Cobb's angle between 10° and 25°\n* Both thoracic and lumbar spine scoliosis patients\n* Both C-shaped or S-shaped curve scoliosis patients\n\nExclusion Criteria:\n\n* Previous spinal surgery\n* Significant neuromuscular disorders (e.g, muscular dystrophy, cerebral palsy)\n* Other medical conditions affecting participation (e.g, respiratory or cardiac)\n* Any contraindication to exercise program","10 Years","17 Years",{"count":258,"type":21},32,[24],"This study is a single-blind, two-arm parallel-group randomized controlled trial designed to evaluate the effects of core stabilization exercises combined with rotational angular breathing exercises on adolescents with idiopathic scoliosis. Participants aged 10-18 years with a Cobb angle between 10° and 25° will be randomly assigned to either an experimental group receiving a structured exercise program or a control group receiving standard care.\n\nThe intervention will be conducted over 12 weeks, with outcomes assessed at baseline, post-intervention, and follow-up periods. Primary outcomes include Cobb angle, angle of trunk rotation, inspiratory capacity, and spinal appearance. The study aims to determine whether the combined exercise approach is more effective than standard care in improving spinal alignment, respiratory function, and physical appearance.",[262,263],"Idiopathic Adolescent Scoliosis","Scoliosis Idiopathic",[265,266,267,268,269,270,271],"Core stabilization exercises","Rotational Angular Breathing Exercises","Cobb's angle","Inspiratory capacity","Idiopathic scoliosis","Spinal Appearance","Trunk rotation","2026-06-16",{"date":193,"type":38},{"date":193,"type":21},{"date":276,"type":21},"2026-11-15",{"name":43,"class":44},{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":282,"acronym":283,"eligibilityCriteria":284,"healthyVolunteers":12,"sex":285,"minAge":52,"maxAge":286,"enrollmentInfo":287,"targetDuration":4,"studyType":22,"phases":289,"briefSummary":290,"conditions":291,"keywords":298,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":301,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":45},"100635561","effects-of-leg-ergometer-versus-arm-ergometer-on-blood-glucose-exercise-tolerance-weight-and-psychological-stress-among-gestational-diabetic-patients-100635561","NCT07554287","Effects of Leg Ergometer Versus Arm Ergometer on Blood Glucose, Exercise Tolerance, Weight, and Psychological Stress Among Gestational Diabetic Patients","GDM","Inclusion Criteria:\n\n1. Female participants aged 18-35 years.\n2. Gestational age 14-28 weeks (second trimester).\n3. Singleton pregnancy (confirmed by obstetric record) only to avoid complications of multiple gestation.\n4. Include both primigravida and multigravida (i.e., first or subsequent pregnancy).\n5. Women with first time GDM in pregnancy.\n6. Women with clinical diagnosis of gestational diabetes according to hospital\u002FWHO criteria or hospital diagnostic test.\n7. Blood glucose levels:\n\n   Random capillary glucose \\\u003C 200 mg\u002FdL at screening (to exclude overt diabetes)\n8. Blood pressure:\n\n   * Systolic BP \\\u003C 140 mmHg and Diastolic BP \\\u003C 90 mmHg (no confirmed gestational hypertension).\n   * If BP ≥140\u002F90 mmHg, confirm with repeat measurement 4 hours apart; exclude if persistent.\n9. Willingness to participate and provide written informed consent.\n10. Medically cleared by obstetrician to participate in moderate aerobic exercise.\n\nExclusion Criteria:\n\n1. Previous Cesarean section or medically indicated bed rest.\n2. Known pre-existing diabetes mellitus (Type 1 or Type 2 prior to pregnancy).\n3. Known major obstetric complications (e.g., placenta previa, severe pre- eclampsia).\n4. Patients having multiple\u002Ftwin\u002Ftriplet pregnancies.\n5. Known major fetal anomaly.\n6. Anemic women with Hb \\\u003C 9 g\u002FdL (excluded to prevent exercise intolerance).\n7. Uncontrolled cardiovascular disease, musculoskeletal, or medical contraindications to exercise.\n8. Psychiatric conditions severe enough to hinder informed consent.\n9. Any other medical condition that, in the opinion of the obstetrician, makes participation unsafe.","FEMALE","35 Years",{"count":288,"type":21},108,[24],"The current study is a single-blind, parallel-group randomized controlled trial involving 108 participants with diabetes during pregnancy. The trial will compare leg ergometer with arm ergometer. Interventions will be delivered three times per week for eight weeks. The primary outcomes are glucose, exercise tolerance, weight, and psychological stress. Assessments will be conducted at baseline and after eight weeks. The trial will be carried out at Jinnah hospital, Services hospital, Sir Ganga Ram Hospital, Lahore. The hypothesis is that the leg ergometer including aerobic exercise will result in greater reduction in glucose and exercise tolerance, weight and stress management than arm ergometer.",[292,293,294,295,296,297],"Diabetes During Pregnancy","Pregnancy Complications","Pregnancy in Diabetes","Gestational Diabetes Mellitus (GDM)","Diabetes Complication","Gestational",[299,300,283,297],"gestational diabetes","diabetes in pregnancy",{"date":193,"type":38},{"date":303,"type":38},"2026-05-26",{"date":305,"type":21},"2026-10-15",{"name":43,"class":44},{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":12,"sex":16,"minAge":130,"maxAge":131,"enrollmentInfo":315,"targetDuration":4,"studyType":22,"phases":317,"briefSummary":318,"conditions":319,"keywords":321,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":331,"locationsCount":45},"100643092","effects-of-progressive-restricted-blood-flow-exercises-in-post-total-knee-arthroplasty-100643092","NCT07601906","Effects of Progressive Restricted Blood Flow Exercises in Post Total Knee Arthroplasty","Effects of Progressive Restricted Blood Flow Exercise on Pain, Range of Motion, Swelling, Proprioception and Kinesiophobia on Patients With Total Knee Arthoplasty","TKA PBFR","Inclusion Criteria:\n\n1. Patients of age 50-65 years.\n2. Primary unilateral TKA due to osteoarthritis.\n3. Individuals with mild to moderate postoperative pain (NPRS score 4-7).\n4. Minimum active knee flexion of 30° \\& an extension lag of no more than 15°.\n5. Patients should be medically stable, cognitively able to follow instructions in Urdu or english, and willing to provide written informed consent\n\nExclusion Criteria:\n\n1. History of deep vein thrombosis within the last six months.\n2. Peripheral vascular disease and active infection.\n3. Severe cardiovascular conditions\n4. Neurological disorders affecting lower limb function",{"count":316,"type":21},48,[24],"Total knee arthroplasty (TKA) is a commonly performed procedure for advanced knee osteoarthritis. Despite successful surgery, many patients experience postoperative impairments including pain, reduced range of motion (ROM), swelling, impaired proprioception, and kinesiophobia, which may delay functional recovery.\n\nConventional physiotherapy is the standard rehabilitation approach following TKA; however, high-load strengthening exercises are often limited in the early postoperative phase due to pain and reduced tolerance.\n\nBlood flow restriction (BFR) exercise is an emerging rehabilitation technique that enables low-load exercise to produce strength adaptations similar to high-intensity training. While evidence supports its effectiveness for improving muscle strength, its effects on other outcomes such as pain, swelling, proprioception, and kinesiophobia are not well established.\n\nThis randomized controlled trial will compare progressive BFR exercise combined with conventional physiotherapy versus conventional physiotherapy alone in patients following unilateral TKA. A total of 48 participants will be randomly allocated to two groups. The intervention will be delivered over 6 weeks with supervised sessions conducted three times per week.\n\nOutcomes will include pain, knee ROM, swelling, proprioception, kinesiophobia, and functional performance. This study aims to determine whether BFR exercise provides additional benefits in postoperative rehabilitation following TKA.",[320],"Total Knee Arthroplasty Recovery",[322,323,324],"Blood Flow Restriction Exercises","Post-Total Knee Arthroplasty","Conventional Physical Therapy","2026-06-05",{"date":327,"type":38},"2026-06-09",{"date":329,"type":38},"2026-05-25",{"date":73,"type":21},{"name":43,"class":44},{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":16,"minAge":286,"maxAge":130,"enrollmentInfo":339,"targetDuration":4,"studyType":22,"phases":341,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":4},"100636207","effect-of-knee-and-heel-off-loader-brace-with-non-weight-bearing-strength-in-knee-osteoarthritis-100636207","NCT07562685","Effect of Knee and Heel Off-Loader Brace With Non Weight Bearing Strength in Knee Osteoarthritis","Effect of Knee and Heel Off-Loader Brace With Non Weight Bearing Strength Training on Pain, Gait Variability, and Functional Outcome in Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinically diagnosed KOA with radiographic Kellgren and Lawrence grade II-III, confirmed within the previous six months\n* History of knee pain for at least three months, consistent with chronic KOA\n* Ability to ambulate independently, with or without assistive devices\n* No change in pharmacological management for KOA during the previous three months\n* Ability to understand instructions and complete self reported outcome measures\n* Willingness to participate and provision of written informed consent\n\nExclusion Criteria:\n\n* Severe venous insufficiency or history of deep vein thrombosis\n* Acute inflammatory knee conditions (e.g., septic arthritis, acute synovitis)\n* Rheumatic or systemic inflammatory joint diseases (e.g., rheumatoid arthritis)\n* Traumatic onset of knee pain within the previous six months\n* History of major lower limb injury or surgery requiring rehabilitation within the past year\n* Neurological or neurodegenerative disorders affecting gait or balance, including Parkinson's disease",{"count":340,"type":21},20,[24],"The current study is a single-blinded, parallel-group pilot randomized controlled trial involving 20 participants diagnosed with knee osteoarthritis (KOA). The trial will compare the effects of a knee and heel off-loader brace combined with non-weight bearing (NWB) strength training versus a conventional knee off-loader brace combined with NWB strength training. Interventions will be delivered three times per week for four weeks.\n\nThe primary outcome of the study is pain intensity, while secondary outcomes include gait variability and functional outcome. Assessments will be conducted at baseline and after completion of the intervention period. The study will be carried out at the outpatient physiotherapy departments of Kaazi Hospital and Ghurki Trust Hospital, Lahore.\n\nThe hypothesis is that the combination of knee and heel off-loader brace with NWB strength training will result in greater reductions in pain, improved gait variability, and enhanced functional outcomes compared to the conventional knee off-loader brace with NWB strength training.",[344],"Knee Osteoarthristis",[346,347,348,349,350],"knee Osteoarthirits","Knee Brace","Offloader Brace","Functional Outcome","Gait Variability","2026-05-24",{"date":353,"type":38},"2026-05-28",{"date":355,"type":21},"2026-05",{"date":357,"type":21},"2026-09",{"name":43,"class":44},{"id":360,"slug":361,"hasResults":12,"nctId":362,"briefTitle":363,"officialTitle":363,"acronym":364,"eligibilityCriteria":365,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":366,"targetDuration":4,"studyType":22,"phases":368,"briefSummary":369,"conditions":370,"keywords":372,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":381,"locationsCount":149},"100633623","combined-effects-of-mulligans-mobilization-with-movement-and-kinetic-control-training-on-pain-range-of-motion-gait-and-functional-disability-among-patients-with-sacroiliac-joint-dysfunction-100633623","NCT07529093","Combined Effects of Mulligan's Mobilization With Movement and Kinetic Control Training on Pain, Range of Motion, Gait and Functional Disability Among Patients With Sacroiliac Joint Dysfunction","MWM KCT SIJD","Inclusion Criteria:\n\n* Both male and female patients\n* Age between 45- 64 years\n* Unilateral non-radiating pain\n* Confirmed diagnosis through at least 3\u002F5 provocative tests Faber test Distraction test Thigh thrust test Gaenslen test Sacral thrust test\n* Pain rating from 4-6 on Numeric Pain Rating Scale\n* Symptoms of SIJD for more than 2 months\n\nExclusion Criteria:\n\n* Patients with history of any surgery at lumbo-sacral or pelvic region\n* Pregnancy, lactation\n* Congenital, postural deformities\n* Acute disc hernia and spinal stenosis that may cause pain in the lower back and hips, piriformis syndrome\n* Rheumatic diseases (fibromyalgia, ankylosing spondylitis, rheumatic arthritis)\n* Acute infections or malignancies\n* Having received manual therapy for the sacroiliac joint in the past 3 months\n* Injection of corticosteroids or anesthesia in the SIJ during the previous 1 month\n* Psychological disorders affecting the subject's ability to follow the instructions",{"count":367,"type":21},55,[24],"Sacroiliac joint dysfunction (SIJD) is a frequent source of low back and pelvic pain and contributes significantly to movement restriction, altered gait patterns, and functional disability in adults. It is associated with impaired lumbopelvic motor control, weakness of key stabilizing muscles, and faulty load transfer across the pelvis. SIJD is prevalent in both physically active individuals and sedentary populations. In addition to its clinical impact, SIJD imposes a considerable socioeconomic burden due to reduced work productivity and long-term disability.\n\nContemporary management of SIJD emphasises on pain reduction, restoration of movement, functional independence, and participation in daily activities. Manual therapy techniques such as Mulligan's Mobilization with Movement (MWM) are widely used to correct positional faults and restore pain-free movement, while kinetic control training targets deficits in motor control of the lumbopelvic stabilizing muscles. Although both approaches are individually supported in the literature, evidence regarding their combined effectiveness on pain, range of motion, gait parameters, and functional disability remains limited. Therefore, this study aims to compare the effects of combined Mulligan's Mobilization with Movement and kinetic control training versus kinetic control training alone in patients with sacroiliac joint dysfunction using validated outcome measures.",[371],"Sacroiliac Joint Dysfunction",[371,373,374,375],"Mulligan's Mobilization with Movement","Kinetic Control Training","Uncontrolled Movement","2026-05-21",{"date":303,"type":38},{"date":379,"type":38},"2026-04-15",{"date":305,"type":21},{"name":43,"class":44},{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":157,"enrollmentInfo":389,"targetDuration":4,"studyType":22,"phases":391,"briefSummary":392,"conditions":393,"keywords":395,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":404,"leadSponsor":405,"locationsCount":4},"100636204","effects-of-two-bar-knee-off-load-brace-with-non-weight-bearing-strength-training-among-knee-osteoarthritis-patients-100636204","NCT07562646","Effects of Two Bar Knee Off-Load Brace With Non Weight Bearing Strength Training Among Knee Osteoarthritis Patients","Effects of Two Bar Knee Off-Load Brace With Non Weight Bearing Strength Training on Pain, Stiffness, and Satisfaction Among Knee Osteoarthritis Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 45-60 years\n* Have a confirmed diagnosis of KOA of grade II to III according to Kellgren and Lawrence classification\n* Participants must have had no changes in pharmacological treatment and not received any intra-articular knee injection (glucocorticosteroids with analgesics) during the last three months\n* Patient must be able to understand instructions and complete self-reported questionnaires\n\nExclusion Criteria:\n\n* Participants will be excluded if they have severe venous insufficiency\n* Acute inflammatory knee conditions (septic arthritis, gout, pseudogout)\n* Systemic disease (rheumatoid arthritis, fibromyalgia)\n* Traumatic onset of knee pain\n* Individuals with a major lower-limb injury requiring surgery or physiotherapy within the past year",{"count":390,"type":21},18,[24],"The current study is a single-blind, parallel-group randomized controlled trial involving 18 participants with knee osteoarthritis. The trial will compare a program of two-bar knee off-load brace combined with non-weight bearing strength training with a program of standard knee off-loader brace combined with non-weight bearing strength training. Interventions will be delivered three times per week for six weeks. The primary outcomes are pain, stiffness, and patient satisfaction. Assessments will be conducted at baseline and after six weeks. The trial will be carried out at Water and Power Development Authority Hospital Complex and Fatima Memorial Hospital, Lahore. The hypothesis is that the two-bar knee off-load brace combined with non-weight bearing strength training will result in greater reductions in pain and stiffness as well as improved patient satisfaction compared with the standard knee off-loader brace with non-weight bearing strength training.",[394],"Knee Osteoarthritis",[394,396,397,398,399],"Knee Pain","Stiffness","Patient Satisfaction","Brace","2026-04-24",{"date":402,"type":38},"2026-05-01",{"date":355,"type":21},{"date":357,"type":21},{"name":43,"class":44},{"id":407,"slug":408,"hasResults":12,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":286,"enrollmentInfo":413,"targetDuration":4,"studyType":22,"phases":415,"briefSummary":416,"conditions":417,"keywords":419,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":429,"leadSponsor":430,"locationsCount":4},"100635747","effects-of-tele-rehabilitation-versus-supervised-rehabilitation-among-computer-users-with-non-specific-neck-pain-100635747","NCT07556705","Effects of Tele-rehabilitation Versus Supervised Rehabilitation Among Computer Users With Non-specific Neck Pain","Effects of Tele-rehabilitation Versus Supervised Rehabilitation on Neck Pain, Disability and Exercise Adherence Among Computer Users With Non-specific Neck Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-35 years.\n* Neck pain that worsens with movement in at-least one direction\n* Computer users with neck pain for at-least 12 weeks\n* Neck pain with Visual Analog score of 3 to 8 out of 10\n* Participants with forward head posture (FHP)\n* Working \\>35h per week at a desk or computer in a sedentary manner\n\nExclusion Criteria:\n\n* Individuals with any neurological or vascular disease\n* A history of shoulder or spine injuries or surgeries\n* Participants with history of regular participation or training programs\n* Participants with body mass index over 30\n* Participants having undergone physical therapy or other medical treatments for neck pain in the previous 6 months",{"count":414,"type":21},62,[24],"The current study is a single-blinded, two-arm parallel-group randomized controlled trial involving 62 participants with non-specific neck pain among computer users. The trial aims to compare the effects of tele-rehabilitation and supervised rehabilitation on neck pain, disability, and exercise adherence. Both groups will receive the same structured exercise program along with postural correction instructions. The tele-rehabilitation group will perform exercises remotely with digital guidance, reminders, and follow-ups, while the supervised group will receive in-clinic physiotherapy sessions under professional supervision. Interventions will be carried out three times per week for a duration of six weeks, with each session lasting approximately 40 minutes. Outcome measures will include neck pain (VAS), neck disability (NDI), and exercise adherence (ATEMPT tool).Assessments will be conducted at baseline and at the end of treatment at 8th week.The study will be conducted at the Physical Therapy Department of Sehat Medical Complex Lake City, and the University of Lahore Teaching Hospital. The hypothesis is that tele-rehabilitation will be more effective than supervised rehabilitation in reducing neck pain and disability, and may result in better exercise adherence due to its convenience and accessibility.",[418],"Non Specific Neck Pain",[420,29,421,422,423,424],"Neck pain","Supervised exercise therapy","Computer users","Exercise adherence","Musculoskeletal pain assessment tool","2026-04-22",{"date":427,"type":38},"2026-04-29",{"date":355,"type":21},{"date":357,"type":21},{"name":43,"class":44},{"id":432,"slug":433,"hasResults":12,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":437,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":16,"minAge":439,"maxAge":17,"enrollmentInfo":440,"targetDuration":4,"studyType":22,"phases":442,"briefSummary":443,"conditions":444,"keywords":445,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":45},"100625635","comparative-effects-of-two-rehabilitation-approaches-on-lumbopelvic-function-in-sacroiliac-joint-dysfunction-100625635","NCT07425197","Comparative Effects of Two Rehabilitation Approaches on Lumbopelvic Function in Sacroiliac Joint Dysfunction","Effects of Dynamic Neuromuscular Stabilization Verses Core Stability Exercises on Pain and Lumbopelvic Stability Among Patients With Sacroiliac Joint Dysfunction","DNS CSE SIJD","Inclusion criteria\n\n1. Age between 30 and 45 years\n2. Confirmed diagnosis by at least three positive provocation tests\n\n   * FABER\n   * Gaenslen's, Thigh Thrust\n   * Compression\n   * Distraction\n3. Pain lasting three months or longer\n4. NPRS score between 4 and 7\n\nExclusion criteria:\n\n1. Other spinal conditions such as, spinal stenosis or tumors\n2. Prior history of spinal or pelvic surgery\n3. Patients with neurological disorders or systemic diseases such as rheumatoid arthritis\n4. Pregnant women\n5. Patients with cardiopulmonary conditions","30 Years",{"count":441,"type":21},40,[24],"This research compares two rehabilitation strategies for people with sacroiliac joint dysfunction (SIJD): Dynamic Neuromuscular Stabilization (DNS) and Core Stability Exercises (CSE). SIJD is presented as a biomechanical source of low-back, buttock and leg pain caused by altered joint mechanics, muscle control problems, or asymmetric pelvic alignment; diagnosis relies on clinical provocation tests and exclusion of other causes. The study aims to determine which of the two exercise-based approaches better reduces pain and improves lumbopelvic control. The trial is a single-blinded, parallel randomized controlled trial conducted in an outpatient physiotherapy setting with supervised sessions over four weeks. Adults aged 20-50 with at least three positive SIJ provocation tests and moderate, chronic pain were included; important exclusions were prior spinal\u002Fpelvic surgery, systemic inflammatory disease, pregnancy, cardiopulmonary limitation or poor session attendance. Each participant received a baseline conventional physiotherapy package; one arm received a DNS program (breathing-based and developmental movement patterns) and the other performed progressive core-stability training emphasizing transversus abdominis and multifidus activation. Primary outcomes are pain (Numeric Pain Rating Scale) and lumbopelvic stability measured with a pressure biofeedback unit (PBU). Data were collected at baseline and after four weeks; the analysis plan uses SPSS with paired and independent t-tests, ANCOVA to adjust for baseline differences, and effect sizes\u002Fconfidence intervals to interpret clinical relevance. Safety, informed consent, assessor blinding and standard ethical safeguards are described. The synopsis notes a gap in direct RCT evidence comparing DNS and CSE for SIJD and positions this trial to address that gap with clinical and mechanistic outcomes.",[371],[446,447,448,449],"SIJD","DNS","Core stability","lumbopelvic stability","2026-03-16",{"date":452,"type":38},"2026-03-19",{"date":454,"type":21},"2026-03-18",{"date":456,"type":21},"2026-09-27",{"name":43,"class":44},{"id":459,"slug":460,"hasResults":12,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":464,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":16,"minAge":206,"maxAge":207,"enrollmentInfo":466,"targetDuration":4,"studyType":22,"phases":467,"briefSummary":468,"conditions":469,"keywords":471,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":45},"100629449","loaded-and-task-specific-training-in-spastic-diaplegic-cp-to-improve-gait-and-functional-mobility-100629449","NCT07474818","Loaded and Task Specific Training in Spastic Diaplegic CP to Improve Gait and Functional Mobility.","Effects of Loaded Treadmill and Task Specific Training on Gait and Functional Mobility in Children With Spastic Diplegic Cerebral Palsy","ELTTS-GFM-SDCP","Inclusion Criteria:\n\n* Confirmed diagnosis of Spastic Diplegic Cerebral Palsy\n* 6 to 12 years\n* Gross Motor Function Classification System Level I to III\n* Stand independently or with support\n\nExclusion Criteria:\n\n* Diagnosed with any type other then Spastic Diplegic\n* Presence of Comorbidities\n* Severe Cognitive and Communicative impairments\n* Classified as Gross Motor Function Classification System Level IV and V",{"count":159,"type":21},[24],"Cerebral Palsy is a non-progressive condition caused by early brain injury that affects movement, posture, and muscle tone. Spastic diplegia mainly involves the lower limbs, leading to stiffness, weakness, and abnormal gait patterns.\n\nThese impairments reduce functional independence and increase caregiver burden. Loaded Treadmill Training and Task Specific Training are two rehabilitation approaches used to improve strength and Gait function.\n\nThis study compares their effectiveness in improving gait and functional mobility in children with spastic diplegic CP.",[470],"Spastic Diplegia Cerebral Palsy",[472,473,474,475,238,476],"Spastic Cerebral Palsy","Gait Training","Functional Mobility","Loaded Treadmill Training","Gross Motor Function","2026-03-14",{"date":479,"type":38},"2026-03-17",{"date":481,"type":21},"2026-04-01",{"date":483,"type":21},"2026-07-31",{"name":43,"class":44},{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":489,"acronym":4,"eligibilityCriteria":490,"healthyVolunteers":12,"sex":16,"minAge":491,"maxAge":492,"enrollmentInfo":493,"targetDuration":4,"studyType":22,"phases":494,"briefSummary":495,"conditions":496,"keywords":498,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":510,"locationsCount":45},"100628313","effects-of-pain-neuroscience-education-on-pain-kinesiophobia-in-patients-with-non-specific-low-back-pain-100628313","NCT07460011","Effects of Pain Neuroscience Education on Pain, Kinesiophobia in Patients With Non Specific Low Back Pain","Inclusion Criteria:\n\n\\-\n\nParticipants included in this study were male and female patients aged between 20 and 55 years diagnosed with chronic non-specific low back pain of mechanical origin lasting three months or more.\n\nIndividuals experiencing pain localized between the costal margin and gluteal folds without radiating symptoms or specific pathological causes were considered eligible.\n\nParticipants with low back pain that has persisted for more than three months reported pain intensity of greater than three months.\n\nThe study will involve those who have mechanical low back pain, which is defined as pain that is impacted by posture, movement, and physical activity but does not have a specific cause\n\nExclusion Criteria:\n\n* Participants with a history of spinal fractures, previous spine injury, malignant tumors, spondylolisthesis, or spondylolysis were excluded from this study.\n\nThe conditions associated with structural instability, neurological involvement, or serious underlying pathology.\n\nIndividuals with a history of malignant tumors involving the spine were excluded because cancer-related pain.\n\nPregnant women were also excluded from the study due to physiological, hormonal, and bio-mechanical changes that occur during pregnancy, which may alter spinal loading, pain perception, and movement patterns","20 Years","55 Years",{"count":414,"type":21},[24],"Chronic non-specific low back pain (NSLBP) is a highly prevalent musculoskeletal condition and a leading cause of disability worldwide. Psychological factors such as fear-avoidance beliefs and kinesiophobia significantly contribute to pain chronicity, reduced physical activity, and functional limitations. Pain Neuroscience Education (PNE) is a biopsychosocial educational approach designed to reconceptualize pain as a protective output of the nervous system rather than solely a marker of tissue damage.\n\nThis randomized controlled trial aims to determine the effect of Pain Neuroscience Education combined with Core Stabilization Exercises on pain intensity and kinesiophobia in patients with chronic non-specific low back pain. A total of 62 participants aged 20-55 years with mechanical low back pain lasting ≥3 months will be randomly allocated into two groups: (1) Core Stabilization Exercises plus PNE (experimental group) and (2) Core Stabilization Exercises alone (control group). The intervention duration will be four weeks, with three sessions per week.\n\nPrimary outcomes include pain intensity measured by the Numeric Pain Rating Scale (NPRS) and kinesiophobia measured using the Fear-Avoidance Beliefs Questionnaire (FABQ). Assessments will be conducted at baseline and post-intervention. The study hypothesizes that the addition of PNE will produce greater reductions in fear-avoidance beliefs and pain intensity compared to exercise therapy alone.",[497],"Non Specific Low Back Pain",[30,66,499,500,501,502],"Pain neuroscience education","Core stabilization","Numeric pain rating scale","Fear avoidance belief questionnaire","2026-03-04",{"date":505,"type":38},"2026-03-10",{"date":507,"type":21},"2026-03-02",{"date":509,"type":21},"2026-09-02",{"name":43,"class":44},{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":518,"sex":519,"minAge":52,"maxAge":520,"enrollmentInfo":521,"targetDuration":4,"studyType":22,"phases":522,"briefSummary":523,"conditions":524,"keywords":526,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":539,"locationsCount":4},"100628187","effects-of-plyometric-versus-resistance-band-training-on-agility-and-rate-of-perceived-exertion-among-recreational-football-players-100628187","NCT07458373","Effects of Plyometric Versus Resistance Band Training on Agility and Rate of Perceived Exertion Among Recreational Football Players","Effects of Plyometric Versus Resistance Band Training on Agility and Rate of Perceived Exertion Among Recreational Football Players: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Population selected: Male recreational footballers.\n* Participants who were football players had been actively participating in football academies for more than 6 months.\n* Participants must be active and are in good health.\n\nExclusion Criteria:\n\n* Participants with any neurological and spinal impairments, cardiopulmonary diseases and musculoskeletal disorders.\n* Participants with history of any lower limb surgeries that affect lower limb function\n* Participants not regularly attending the training programs.\n* Participants with history of any lower limb fracture and ligament sprain.",true,"MALE","25 Years",{"count":441,"type":21},[24],"The goal of the current study is to evaluate the plyometrics and resistance band training in recreational football players, aged 18-25 years. The main question it aims to answer are:\n\nDoes the plyometrics significantly improve agility and reduce Rate of Perceived Exertion (RPE)? Does the resistance band training significantly improve agility and reduce RPE? Participants will be assigned to either an experimental group receiving plyometrics or arm comparator group receiving resistance band training, and will complete standardized assessment of agility and RPE before and after the intervention.",[525],"Recreational Football Players",[527,528,529,530,531,532],"Plyometrics","Resistance Band","Agility","Perceived Exertion Rate","Recreational Players","Illinois Agility Test","2026-03-03",{"date":535,"type":38},"2026-03-09",{"date":537,"type":21},"2026-04",{"date":92,"type":21},{"name":43,"class":44},{"id":541,"slug":542,"hasResults":12,"nctId":543,"briefTitle":544,"officialTitle":544,"acronym":545,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":547,"enrollmentInfo":548,"targetDuration":4,"studyType":22,"phases":550,"briefSummary":551,"conditions":552,"keywords":554,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":149},"100627430","comparative-effects-of-functional-electrical-stimulation-and-mirror-therapy-for-foot-clearance-among-patients-with-sub-acute-stroke-100627430","NCT07448532","Comparative Effects of Functional Electrical Stimulation and Mirror Therapy for Foot Clearance Among Patients With Sub-acute Stroke","FES MT CVA","Inclusion Criteria:\n\n* Patient aged 18-85 years of age, who experienced stroke within ≤6 months.\n* The Fugl-Meyer motor assessment of lower extremity (FMA-LE) was conducted by physiotherapist in the hospital, and score required to be ≥ 20 points.\n* Participants possessed healthy nerves, neuromuscular junctions, muscles tissues, and a sufficient range of motion in dorsiflexor and plantarflexion.\n* The subjects could walk independently on a treadmill for at least 2 min without without experiencing adverse reaction to FES.\n* Patients who received more 24 scores on Mini Mental State Exam and could comprehend and follow the information researcher provides.\n* No orthopedic diseases in upper and lower extremities.\n* Patients with functional ambulation classification (FAC) score of 3 or 4 were included (FAC is a scale of 0-5, where 3 indicates supervision or standby guarding and 4 indicates independent on level surfaces.\n* Patients with inadequate ankle dorsiflexion during the swing phase of gait.\n* Patients with adequate minimal stability at the ankle during stance with stimulation.\n\nExclusion Criteria:\n\n* Patients with cardiac pacemaker, those with skin lesions, who could not be treated due to spasticity within the last three months, and vestibular and cerebellar lesions or deaf- blindness were excluded.\n* Patients with past or current epilepsy, uncontrolled seizure disorder, mental disorders and all neurological disorders except stroke.\n* Patients with severe edema of lower extremities or patients of vascular disorders like deep vein thrombosis or thromboembolisms and severe atheroscelerosis of lower extremities.\n* Subjects with any musculoskeletal dysfunction that would potentially affect gait and causes risk of falls.\n* We excluded patients with pregnancy, plantar flexion contracture, and severe hemi-neglect.\n* Subjects with hip or knee prostheses made of metal on the lower limb were excluded.","85 Years",{"count":549,"type":21},38,[24],"This study aims to evaluate the effectiveness of two rehabilitation techniques- Functional Electrical Stimulation (FES) and Mirror Therapy (MT)-in improving motor recovery among stroke survivors. Stroke often results in long-term impairments, particularly in foot clearance, which is critical for daily activities. Although current rehabilitation strategies help, more effective solutions are needed to enhance recovery. Participants, aged 18- 85 years old with subacute stroke and foot clearance impairments, will be randomized into two groups: Group A will receive functional electrical stimulation (FES) with routine physical therapy; and Group B will receive mirror therapy (MT) with routine physical therapy. The interventions will take place three times a week for 4 weeks, and participants will undergo motor function assessments, including the Fugl-Meyer Assessment and Functional Independence Measure, before and after the intervention. The study will compare the effects of each intervention on motor recovery, specifically focusing on tibialis anterior function and motor control. The findings could lead to improved rehabilitation protocols, offering stroke survivors better therapeutic options and enhancing their quality of life.",[553],"Stroke (Subacute)",[555,556,557,558,559,560,561,562],"Fugl-Meyer Assessment","Functional Independence Measure","Lower limb rehabilitation","Stroke (subacute)","Foot Clearance","Neuromuscular Rehabilition","Mirror therapy (MT)","Functional Electrical Stimulation (FES)","2026-02-26",{"date":503,"type":38},{"date":566,"type":38},"2026-01-22",{"date":568,"type":21},"2026-06-27",{"name":43,"class":44},{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":576,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":16,"minAge":207,"maxAge":439,"enrollmentInfo":578,"targetDuration":4,"studyType":22,"phases":580,"briefSummary":581,"conditions":582,"keywords":584,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":4},"100623828","effects-of-vestibular-rehabilitation-and-routine-physical-therapy-in-athletes-with-post-concussion-syndrome-100623828","NCT07401706","Effects of Vestibular Rehabilitation and Routine Physical Therapy in Athletes With Post Concussion Syndrome","Effects of Vestibular Rehabilitation in Comparison With Routine Physical Therapy on Stability, Kinesiophobia and Return to Sports in Athletes With Post Concussion Syndrome","PCS BESS IPRRS","Inclusion Criteria:\n\n1. Age 12 to 30 years\n2. Fulfil the criteria of post concussion syndrome as highlighted by Tator et al.(2016)which requires presence of at least 3 or more persistent symptoms from standardized list\n3. Sustained a mTBI in past 3 to 12 weeks\n4. Having ongoing symptoms from list in PCSS that started 72 hrs or less after an impact\n5. Exhibit objective deficits on standardized baseline examination enabling vestibular and ocular dysfunction\n\nExclusion Criteria:\n\n* Have a chronic infectious disease.\n\n  * Uncontrolled hypertension.\n  * Other neurological disorders (not attributed to their primary diagnosis).\n  * Cancer treatment (other than basal cell carcinoma), craniotomy, or refractory subdural hematoma.\n  * Those on long term use of psychoactive drugs that compromise their ability to perform study activities\n  * Those with pacemakers or elevated cardiovascular risk.\n  * Ongoing litigation surrounding their injury.\n  * Have been diagnosed with a severe brain injury prior to enrollment, or their post concussive symptoms have persisted beyond 12",{"count":579,"type":21},34,[24],"This randomized controlled trial with a parallel design was conducted over six months at Ghurki Trust Teaching Hospital to compare the effects of Vestibular Rehabilitation and Routine Physical Therapy on stability, kinesiophobia, and return to sports in athletes with post-concussion syndrome. A total of 34 participants aged 12 to 30 years were enrolled based on specific diagnostic criteria. Non probability convenient sampling was used, followed by random allocation into experimental and control groups through computer generated sequencing and sealed envelope concealment. Single blinding was done, with participants unaware of their assigned intervention.\n\nThe experimental group received a Vestibular Rehabilitation program consisting of balance training, habituation exercises, and gaze stabilization, while the control group underwent Routine Physical Therapy involving ankle strategies and elliptical training. Both interventions were administered for 30 minutes, three times per week, over four weeks. Outcomes were measured pre- and post-intervention using validated tools: the Balance Error Scoring System (BESS) for postural stability, the Urdu version of the Tampa Scale of Kinesiophobia (TSK), and the Injury Psychological Readiness to Return to Sport Scale (I-PRRS). Data analysis was performed using SPSS version 26, employing appropriate parametric or non-parametric tests based on normality, with significance set at p \\\u003C 0.05. Ethical approval was obtained, informed consent was secured, and all procedures adhered to established ethical standards.",[583],"Post Concussion Syndrome",[585,586,587,588,589,590,591,592,593,594],"TAMPA","BESS","IPRRS","RPT","Athletes","Post concussion syndrome","vestibular rehabilitation","stability","kinesiophobia","return to sports","2026-02-03",{"date":597,"type":38},"2026-02-10",{"date":599,"type":21},"2026-03-22",{"date":601,"type":21},"2026-07-22",{"name":43,"class":44},{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":609,"eligibilityCriteria":610,"healthyVolunteers":12,"sex":16,"minAge":491,"maxAge":53,"enrollmentInfo":611,"targetDuration":4,"studyType":22,"phases":612,"briefSummary":613,"conditions":614,"keywords":616,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":621,"startDateStruct":623,"completionDateStruct":625,"leadSponsor":627,"locationsCount":4},"100623324","comparison-of-integrated-neuromuscular-inhibition-technique-init-and-active-release-technique-art-in-patients-with-upper-trapezius-trigger-points-100623324","NCT07395154","Comparison of Integrated Neuromuscular Inhibition Technique (INIT) and Active Release Technique (ART) in Patients With Upper Trapezius Trigger Points","COMPARATIVE EFFECT OF INTEGRATED NEUROMUSCULAR INHIBITION TECHNIQUE AND ACTIVE RELEASE TECHNIQUE ON PAIN, RANGE OF MOTION AND FUNCTIONAL DISABILITY IN PATIENTS WITH UPPER TRAPEZIUS TRIGGER POINTS","INIT ART","Inclusion Criteria:\n\n* Presence of active trigger points in the upper trapezius muscle.\n* Forward Head Posture (measured by craniovertebral angle).\n* Pain duration less than 3 months.\n\nExclusion Criteria:\n\n* History of trauma or surgery involving the cervical spine or shoulder\n* Neurological disorders (e.g., cervical radiculopathy)\n* Systemic conditions like diabetes or rheumatoid arthritis\n* Use of corticosteroids\n* Fibromyalgia, Thoracic Outlet Syndrome, Temporomandibular Joint Disorders",{"count":180,"type":21},[24],"The goal of this clinical trial is to determine whether two manual therapy techniques-Integrated Neuromuscular Inhibition Technique (INIT) and Active Release Technique (ART)-can reduce pain, improve neck range of motion, and decrease functional disability in adults with upper trapezius myofascial trigger points.\n\nThe main questions it aims to answer are:\n\nDoes INIT reduce pain, improve ROM, and reduce functional disability more effectively than ART?\n\nDoes ART provide similar or different treatment benefits compared to INIT?\n\nResearchers will compare INIT with ART to see which technique produces greater improvements in pain, ROM, and functional disability.\n\nParticipants will:\n\nReceive treatment sessions of either INIT or ART.\n\nUndergo assessment of pain, cervical range of motion, and functional disability before and after the intervention.",[615],"Myofascial Pain Syndrome",[617,618,619,620],"Integrated Neuromuscular Inhibition Technique","Active Release Technique","Muscle Energy Technique","Ischemic Compression",{"date":622,"type":38},"2026-02-09",{"date":624,"type":21},"2026-02-15",{"date":626,"type":21},"2026-06-30",{"name":43,"class":44},{"id":629,"slug":630,"hasResults":12,"nctId":631,"briefTitle":632,"officialTitle":633,"acronym":634,"eligibilityCriteria":635,"healthyVolunteers":12,"sex":16,"minAge":130,"maxAge":636,"enrollmentInfo":637,"targetDuration":4,"studyType":22,"phases":639,"briefSummary":640,"conditions":641,"keywords":643,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":649,"lastUpdatePostDateStruct":650,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":654,"locationsCount":45},"100616629","comparative-effects-of-virtual-reality-and-proprioceptive-neuromuscular-facilitation-in-patients-with-parkinsons-disease-100616629","NCT07308093","Comparative Effects of Virtual Reality and Proprioceptive Neuromuscular Facilitation in Patients With Parkinson's Disease","Effects of Virtual Reality and Proprioceptive Neuromuscular Facilitation on Upper Limb Sensorimotor Control Among Patients With Parkinson's Disease.","VR PNF RPT PD","Inclusion Criteria:\n\n1. Idiopathic Parkinson's Disease according to Gelb's criteria\n2. Stage II-IV Hoehn \\&Yahr scale\n3. Intact cognition status (MMSE \\> 24)\n4. 50-80 years of age\n\nExclusion Criteria:\n\n1. History of PD surgery\n2. Phobia of virtual gaming systems\n3. Visual anomalies\n4. Cardiovascular problems\n5. Severe dyskinesia or \"on-off\" fluctuations","80 Years",{"count":638,"type":21},28,[24],"Parkinson's Disease is a chronic neurodegenerative disorder marked by the progressive loss of dopaminergic neurons in the substantia nigra and accumulation of α-synuclein (Lewy bodies).It impacts both motor and non-motor systems, with growing global prevalence-affecting 7-10 million people, mostly men over 60 years-due to increasing life expectancy and demographic shifts.\n\nPD shows motor symptoms like tremors and bradykinesia, along with non-motor issues like depression, REM sleep disorder, and cognitive decline. Diagnosis is often delayed due to subtle early signs like constipation or shoulder pain and atypical cases lacking classical tremors.\n\nVR offers immersive, task-specific therapy that enhances motor learning and neuroplasticity in a safe, engaging environment. By integrating sensory feedback and real-time motion tracking, VR reduces tremors, promotes cortical reorganization (notably in the sensorimotor cortex and cerebellum), and increases rehabilitation motivation through gamified experiences.\n\nPNF is a hands-on therapy using tactile, auditory, and proprioceptive cues to improve coordination, strength, and movement patterns. Especially useful in Parkinson's rehabilitation, PNF targets rigidity, bradykinesia, tremors, and postural instability by reinforcing neuromuscular coordination and improving movement execution in functional, diagonal planes.\n\nSensorimotor control is the dynamic integration of sensory input, motor planning, and execution, which becomes disrupted in PD due to impaired proprioception and feedback loops. Patients rely excessively on visual feedback, making movement effortful, highlighting the need for focused upper limb rehabilitation strategies.",[642],"Parkinson Disease",[642,644,645,646,647,648],"Sensorimotor Control","Virtual Reality Therapy","Proprioceptive Neuromuscular Facilitation","Upper Limb Rehabilitation","Neuroplasticity","2026-01-30",{"date":595,"type":38},{"date":652,"type":21},"2026-01-31",{"date":483,"type":21},{"name":43,"class":44},{"id":656,"slug":657,"hasResults":12,"nctId":658,"briefTitle":659,"officialTitle":659,"acronym":4,"eligibilityCriteria":660,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":157,"enrollmentInfo":661,"targetDuration":4,"studyType":22,"phases":662,"briefSummary":663,"conditions":664,"keywords":665,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":670,"lastUpdatePostDateStruct":671,"startDateStruct":673,"completionDateStruct":675,"leadSponsor":676,"locationsCount":45},"100622274","effects-of-core-strengthening-with-pelvic-proprioceptive-neuromuscular-facilitation-on-trunk-control-and-balance-in-patients-with-sub-acute-stroke-100622274","NCT07381491","Effects of Core Strengthening With Pelvic Proprioceptive Neuromuscular Facilitation on Trunk Control and Balance in Patients With Sub-acute Stroke","Inclusion Criteria:\n\n* Participants between the ages of 45 and 60 years.\n* Sub-acute phase of unilateral ischemic stroke.\n* More than two weeks but no more than six months were included.\n* Participants should be able to walk with or without support for 2-4 min.\n* Participants with modified Ashworth scale grade 1 or grade 2.\n* Participants should be able to understand and follow simple verbal instructions (Mini-Mental Status Examination \\[MMSE\\]≥24).\n\nExclusion Criteria:\n\n* Participants with recurrent stroke; brainstem or cerebellar stroke or hemorrhagic stroke.\n* Participants with modified Ashworth scale grade ≥3 (severe spasticity).",{"count":549,"type":21},[24],"Purpose of this study was to investigate the effectiveness of core stabilization with pelvic proprioceptive neuromuscular facilitation on trunk control and balance which will be provided an evidence-based selection of the best possible intervention to improve trunk function and balance as compared to the trunk control exercises such as Rhythmic stabilization, Bridging, Side-Lying Trunk Lifts, Quadruped, Kneeling and modified plantigrade positioning, which one can provide the better balance and trunk control in sub-acute stroke patients.",[184],[184,666,667,668,669],"PNF","Core Strengthening","Trunk control","Balance Impairment","2026-01-27",{"date":672,"type":38},"2026-02-02",{"date":674,"type":38},"2025-11-25",{"date":145,"type":21},{"name":43,"class":44},""]