[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lakeland Regional Health Systems, Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":51},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100613165","phase-4-urine-sodium-driven-diuretic-adjustment-strategy-in-acute-decompensated-heart-failure-100613165",false,"NCT07263035","Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure","US-DASH","Inclusion Criteria:\n\n* The study will target adults 18 years of age or older admitted to Lakeland Regional Medical Center who:\n\n  * Have a primary diagnosis of acute decompensated heart failure, and\n  * Have at least one of the following signs of hypervolemia:\n\n    * Bilateral lower extremity pitting edema\n    * Jugular venous distension\n    * Hepatojugular reflex\n    * Crackles on pulmonary exam, or\n    * Chest x-ray demonstrating pulmonary edema or pleural effusions\n\nExclusion Criteria:\n\n* Exclusion criteria include:\n\n  * Admission to the intensive care unit\n  * Presence of ST-elevated myocardial infarction\n  * Presence of type 1 non-ST elevated myocardial infarction\n  * Dyspnea primarily due to non-cardiac cause as judged by the emergency medicine physician or admitting physician\n  * Use of supplemental oxygen totaling at least 3 L per minute or greater at baseline\n  * Anuria\n  * End-stage renal disease per KDIGO criteria\n  * Dialysis use","ALL","18 Years",{"count":19,"type":20},600,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care.\n\nThe main questions it aims to answer are:\n\n1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis?\n2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions?\n3. Does targeting a higher urine sodium goal reduce hospital length of stay?\n\nResearchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice.\n\nParticipants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.",[26,27,28,29],"Heart Failure","Heart Failure - NYHA II - IV","Heart Failure Acute","Acute Heart Failure (AHF)",[31,32,33,34,35,36,37,38],"Urine sodium","Diuretics","Lasix","heart failure","Acute CHF","acute HFrEF","Acute HFpEF","Natriuresis","RECRUITING","2026-04-06",{"date":42,"type":43},"2026-04-09","ACTUAL",{"date":45,"type":43},"2026-04-01",{"date":47,"type":20},"2027-09-01",{"name":49,"class":50},"Lakeland Regional Health Systems, Inc.","OTHER",""]