[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lancashire Teaching Hospitals NHS Foundation Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":65},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100538256","enteral-feeding-of-fibre-to-improve-microbiota-100538256",false,"NCT06288464","Enteral Feeding of Fibre to Improve Microbiota","Does Distal Enteral Feeding of Fibre Positively Affect the Microflora in the Distal Limb of Loop Ileostomy Patients?","Inclusion Criteria:\n\n* Any individual that has been identified for distal (stoma) feeding that is able to understand verbal and written English to provide informed consent.\n* Participants must be undergoing ileostomy or colostomy reversal surgery.\n\nExclusion Criteria:\n\n* Not undergoing ileostomy or colostomy reversal.\n* Persons who might not adequately understand verbal explanations or written information given in English","ALL","18 Years",{"count":19,"type":20},15,"ESTIMATED","INTERVENTIONAL",[23],"NA","Following surgical removal of diseased bowel, patients often require a temporary redirection of bowel contents to a stoma, to allow healing prior to re-joining of the remaining bowel at a later date. Some patients may experience complications, either during or after reversal surgery, and this may be due to changes in the 'friendly' bacteria that live in our bowels. Previous research shows that the distal section of bowel that is non-functioning undergoes tissue-wasting and the 'friendly' bacteria that help our digestion die. Data shows that patients that have a reduction in their microflora are more likely to experience side effects. This study investigates a method of replenishing the microflora prior to surgery.",[26,27,28],"Bowel Dysfunction","Colon Disease","Ileum--Diseases","RECRUITING","2025-04-04",{"date":32,"type":33},"2025-04-06","ACTUAL",{"date":35,"type":33},"2023-01-09",{"date":37,"type":20},"2025-12-01",{"name":39,"class":40},"Lancashire Teaching Hospitals NHS Foundation Trust","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":41},"100536368","neurofrailty-a-study-of-late-onset-epilepsy-and-its-associations-100536368","NCT06263920","Neurofrailty: A Study of Late-onset Epilepsy and Its Associations","A Prospective Population-based Longitudinal Observational Cohort Study of Late-onset Epilepsy, and Subsequent Stroke and Dementia.","Inclusion criteria for case participants includes:\n\n* diagnosis of LOE or first seizure after the age of 18.\n* diagnosis confirmed or established at a tertiary neurology centre.\n* sequential cases will be used; in the unlikely event that eligible cases outstrip capacity, an annual cap of the first 150 patients per year per cohort will be used.\n\nInclusion criteria for control participants includes:\n\n* established diagnosis of migraine.\n* with or without therapeutic medications with antiepileptic properties.\n\nExclusion Criteria\n\nExclusion criteria for case participants includes:\n\n* a 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma, vascular or congenital abnormality of likely aetiological significance.\n* people with migraine or headache syndrome can be included in case group - the presence or absence of a seizure syndrome is mutually exclusive between case and control groups, not the presence or absence of migraine.\n\nExclusion criteria for control participants includes:\n\n* diagnosis of epilepsy or confirmed seizure.\n* 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma.",{"count":50,"type":20},360,"60 Months","OBSERVATIONAL","There is not much known about why some people develop seizures in adulthood, but some researchers think that it might be a warning from the body to highlight something may be wrong with the brain. A small number of people with first seizure in adulthood go on to experience problems like stroke or dementia later in life. However, stroke and dementia are common diseases, so it is not know whether there is a real association between these conditions. When people develop their first seizure in adult life, this is sometimes called Late-Onset Epilepsy. The NeuroFrailty study, will observe 'brain health' over the years following the onset of a seizure, to provide more information about people with these kinds of seizures.",[55,56,57],"Late Onset Epilepsy","Stroke","Dementia",{"date":59,"type":33},"2025-04-08",{"date":61,"type":33},"2022-05-05",{"date":63,"type":20},"2027-01-12",{"name":39,"class":40},""]