[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lancaster University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":126},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,74,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100635499","chemotherapy-induced-hearing-loss-and-health-inequality-100635499",false,"NCT07553481","Chemotherapy-Induced Hearing Loss and Health Inequality","CANHEAR","Inclusion Criteria:\n\n* Patients receiving platinum-based chemotherapy drugs\n* Living and treated within North West England\n* Able to complete an online hearing and cognitive test\n* Fluent in English\n\nExclusion Criteria:\n\n* Following cancer types: brain tumour\u002Fmetastasis, head + neck, skin cancers around the ear, and adenoid cystic carcinoma of the auditory cortex\n* World Health Organisation performance status score of 3 or more\n* Stage 4 cancer\n* History of childhood deafness\n* Current or recent ear infections\n* Cochlear implant user\n* Known neurological impairment (e.g., stroke, traumatic brain injury, dementia)\n* Patients who look capacity to consent or complete study tasks","ALL","18 Years",{"count":19,"type":20},172,"ESTIMATED","OBSERVATIONAL","This project aims to understand how platinum-based chemotherapy affects hearing function in cancer patients from different socioeconomic backgrounds in the North West of England. Platinum-based chemotherapy drugs, such as cisplatin, are ototoxic, meaning that they cause permanent damage to the hair cells of the ear, resulting in hearing loss. Patients from more deprived backgrounds face additional risk factors to their hearing health, including limited healthcare access, greater occupational noise exposure, and poorer overall health, making them more vulnerable to hearing loss.\n\nThis is especially concerning as hearing loss can make communication more challenging, which creates a greater reliance on cognitive processes such as thinking and memory to navigate social interactions. This challenge is exacerbated when individuals experience cognitive dysfunction related to chemotherapy, commonly referred to as 'chemo brain'. Addressing these communication difficulties is crucial for promoting healthy ageing and maintaining social engagement. It is expected that cancer patients from the most deprived backgrounds would experience greater hearing loss following chemotherapy than those from less deprived backgrounds.\n\nAs a secondary aim, this study will also investigate how hearing loss may affect cognitive function. Specifically, it will assess whether differences in speech-in-noise performance from pre- to post-treatment predict cognitive performance post-treatment, to understand if changes in hearing over time are associated with changes in cognition. The study will also explore how socioeconomic deprivation, cumulative chemotherapy dose, and treatment duration influence these relationships. By identifying disparities in hearing loss and possible associations with cognition, this research will help guide future hearing screening and intervention strategies for cancer patients.",[24,25,26,27],"Cancer","Chemo Brain","Chemotherapy","Hearing",[24,29,26,27],"Chemo brain","NOT_YET_RECRUITING","2026-04-20",{"date":33,"type":34},"2026-04-28","ACTUAL",{"date":36,"type":20},"2026-05-02",{"date":38,"type":20},"2028-09-01",{"name":40,"class":41},"Lancaster University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":42},"100624489","the-perceived-point-of-muscular-discomfort-vs-the-point-of-failure-in-the-ageing-population--a-pilot-study-100624489","NCT07410299","The Perceived Point of Muscular Discomfort vs the Point of Failure in the Ageing Population- a Pilot Study","The Perceived Point of Moderate Muscular Discomfort vs the Point of Technical Failure in the Ageing Population- a Pilot Study.","Inclusion Criteria:\n\n* Aged 60-80 years of age.\n* Physically capable of resistance training.\n* Able to walk unassisted.\n\nExclusion Criteria:\n\n* Major cardiovascular (e.g. myocardial infarction, angioplasty within the last year, coronary artery bypass graft), neurological (e.g. Parkinson's disease, Alzheimer's, major anxiety or depressive disorders), muscular (e.g., muscular dystrophies, myopathies, myositis) or uncontrolled metabolic conditions (e.g. Type 1 or 2 diabetes).\n* Severe obesity (BMI \\>39).\n* Have undertaken regular resistance exercise in the last 12 months.\n* Any upper or lower body musculoskeletal injury that impairs the participants ability to perform a repetition as fast as possible.\n* Acute or terminal illnesses (e.g. severe locals or systemic infections, cancer).\n* Current residence being within a setting of care.\n* Experience of muscle pain from taking statins.",true,"60 Years","80 Years",{"count":54,"type":20},15,"INTERVENTIONAL",[57],"NA","This is an investigation into the differences in muscle activation and numerical difference in reps between the feeling of moderate discomfort and technical failure during a set of bodyweight resistance exercise.\n\nThe investigators know that resistance training is an essential tool for older people to maintain muscle function, valuable independence and autonomy in daily tasks. The idea of completing a set of resistance training activity to the point of failing a repetition due to fatigue regularly has been shown to not be appealing and could be a reason why there are low participation rates among older people for in weight training regularly.\n\nResearch has also shown that it is not necessary to train to failure (being unable to continue to complete repetitions of an exercise with the proper technique due to fatigue), but the investigators would like to know if training to a point of moderate discomfort can also allow for the muscles to gain the positive changes associated with weight training, potentially making it more accessible and enjoyable.\n\nUsing bodyweight exercises (a squat pattern and a push up pattern) the investigators will see how many repetitions after the point of perceived moderate discomfort is stated at which the point of failure is. the investigators will also measure muscle activation in the quadriceps and triceps with EMG (a device that can detect the muscles' electrical activity\u002F how hard it is working) to see at which point the muscle is working the hardest.",[60],"Muscle Fatigue Caused by Repetitive Muscle Exercise",[62,63,64,65],"fatigue","Ageing population","resistance exercise","electromyography","2026-02-07",{"date":68,"type":34},"2026-02-13",{"date":70,"type":20},"2026-02-10",{"date":72,"type":20},"2026-03-10",{"name":40,"class":41},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":50,"sex":81,"minAge":17,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":4},"100623685","investigating-the-effects-of-time-of-day-and-menstrual-cycle-phase-low-and-high-progesterone-on-females-cognitive-and-strength-performance-100623685","NCT07399847","Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance","Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance","Inclusion Criteria:\n\n* Female (assigned at birth)\n* Aged 18-30 years\n* Tier 2 athlete which requires the participants to identify with a specific sport, train with a purpose to compete, regularly train \\~3 times per week and compete at a local level (for example being a member of a BUCS sport and competing regularly with that sport)\n* Regular menstrual cycle - considered between 21-35-day cycles with at least 9 periods a year.\n\nExclusion Criteria:\n\n* The current\u002Fprevious (in the last 3 months) use of any contraceptive method that alter the menstrual cycle\n* The use of the emergency contraceptive pill either 3 months prior to the study or during the study\n* Diagnosis of menstrual disorders including (but not exclusively) endometriosis and Polycystic Ovary Syndrome (PCOS)\n* A formal diagnosis of sleep disorders such as insomnia\n* Consume \\>400mg\u002Fday of caffeine\n* A musculoskeletal injury in the past 3 months\n* A formal diagnosis of neurological or psychiatric disorders such as Attention-Deficit\u002FHyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Dyslexia or schizophrenia\n* Taking prescribed medication that may affect sleep for example stimulants such as Methylphenidate\n* No regular night shift work\n* No trans-meridian travel within 10 days of their expected participation dates (travel that will cause jetlag)\n* Have given blood in the last 12 weeks - this is not strictly an exclusion; participants will just need to wait until after 12 weeks before taking part in the study","FEMALE","30 Years",{"count":84,"type":20},30,"This study is designed to determine whether time-of-day and menstrual cycle phase influence athletic performance and is expected to contribute valuable insight into how both time-of-day, and hormonal factors can influence performance and expand existing research. This study aims to support more inclusive, effective and personalised approaches to training and competition schedules for female athletes.\n\nThe study will involve two testing days that require a participant to complete a compilation of tests at 07:00, 12:00 and 18:00 hours. The testing days will be arranged for when a participant is in phase 1 (lowest levels of progesterone in the menstrual cycle) and phase 4 (highest level of progesterone in the menstrual cycle). The tests will examine a participant's executive function and physical strength.\n\nThis study will aim to recruit thirty 18-30-year-old females from Lancaster University who identify with a sport that they train \\~3 times a week for with a purpose to compete. The females recruited must have a regular menstrual cycle and no history of sleep disorders.\n\nAim: To investigate the effects of time-of-day and menstrual cycle phase (low and high progesterone levels) on executive function and strength in females.\n\nObjectives:\n\n1. To determine the effects of time-of-day on executive function and strength tests.\n2. To determine the effects of menstrual cycle phase on executive function and strength tests.\n3. To examine if there is an interaction between time-of-day and menstrual cycle phase on executive function and strength tests.",[87,88,89,90,91,92],"Circadian Rhythm","Menstrual Cycle Phase","Female Athletes","Executive Function (Cognition)","Eumenorrhea","Strength","2026-02-05",{"date":70,"type":34},{"date":96,"type":20},"2026-02",{"date":98,"type":20},"2026-09",{"name":40,"class":41},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":42},"100593820","the-facial-study-pilot-100593820","NCT07011407","The FACIAL Study Pilot","Facial Recognition in Acute Illness - The FACIAL Study","Inclusion Criteria:\n\n* Aged 18 to 35\n* Male or female\n* Capable of completing a maximal exercise test\n* Answer \"NO\" to all variables in the Physical Activity Readiness questionnaire (PAR-Q)\n\nExclusion Criteria:\n\n* Musculoskeletal injury\n* Cardiovascular disease\n* Neurological disease, stroke, or other disease that may affect facial expressions","35 Years",{"count":54,"type":20},"Facial recognition is a non-invasive method for analysing facial characteristics and changes in facial expressions. There is evidence to suggest there may be a link between physiological health and facial expression patterns. Many medical conditions are associated with specific facial characteristics, with some related to inherited genetic conditions and others that have been acquired as a result of medical conditions such as stroke, nerve injuries and dementia. If successful, this technology could prove useful for studies evaluating the monitoring of acute or chronic illness. The proposed study will ask participants to do a maximal exercise test that will challenge the body, as a proof-of-principle, to see how this correlates with facial expressions. Depending on the study outcomes and future work, it could prove to be a useful tool and clinical application in healthcare for evaluating and tracking patient health and well-being. The investigators want to conduct a proof-of-principle study where physically stressed young and healthy participants (in the form of a maximal exercise test), whilst recording facial expressions, will be used to determine the relationship between physiological stress and changes in facial parameters.",[111],"Healthy Adult",[113,114,115,116,117],"Facial Characteristics","Exercise","Thermal Patterns","Facial Expression","Maximal Exercise Test","2025-05-30",{"date":120,"type":34},"2025-06-08",{"date":122,"type":20},"2025-06-01",{"date":124,"type":20},"2025-12-31",{"name":40,"class":41},""]