[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lanyue Zhu\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":76},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100595263","the-relationship-between-preoperative-frailty-and-postoperative-aki-and-the-mediating-effect-of-intraoperative-bp-100595263",false,"NCT07030179","The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP","The Relationship Between Preoperative Frailty and Postoperative Acute Kidney Injury in Patients Undergoing Non-cardiac Surgery and the Mediating Effect of Intraoperative Blood Pressure: A Prospective Cohort Study","Inclusion Criteria:\n\n* 18 years old or above\n* Undergo non-cardiac surgery\n\nExclusion Criteria:\n\n* At least one measurement of serum creatinine (SCr) was not conducted before and after the operation\n* End-stage renal disease (ESRD) that has received dialysis within the past year\n* Baseline SCr ≥ 4.5 mg\u002Fdl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)\n* Acute kidney injury occurred within 7 days before the operation\n* No frailty assessment was conducted\n* The surgical procedure is renal surgery\n* The operation time is less than 2 hours","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","1 Year","OBSERVATIONAL","The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.",[25,26],"Postoperative Acute Kidney Injury","Frailty","RECRUITING","2026-03-27",{"date":30,"type":31},"2026-04-02","ACTUAL",{"date":33,"type":31},"2025-07-01",{"date":35,"type":20},"2026-12-31",{"name":37,"class":38},"Lanyue Zhu","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":52,"startDateStruct":53,"completionDateStruct":54,"leadSponsor":55,"locationsCount":39},"100595262","a-machine-learning-prediction-model-for-postoperative-acute-kidney-injury-in-non-cardiac-surgery-patients-100595262","NCT07030166","A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients","A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients: Development, Validation, and the Incremental Value of Frailty Assessment","Inclusion Criteria:\n\n* 18 years old or above\n* Undergo non-cardiac surgery\n\nExclusion Criteria:\n\n* At least one measurement of serum creatinine (SCr) was not conducted before and after the operation\n* End-stage renal disease (ESRD) that has received dialysis within the past year\n* Baseline SCr ≥ 4.5 mg\u002Fdl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)\n* Acute kidney injury occurred within 7 days before the operation\n* The surgical procedure is renal surgery\n* The operation time is less than 2 hours",{"count":48,"type":20},10000,"Primary objectives of this study is to develop and validate a predictive model for acute kidney injury after non-cardiac surgery based on machine learning. Secondary objectives of this study is to incorporate frailty assessment as a new predictor into the model and measure its incremental value was measured.",[51],"Kidney Injury, Acute",{"date":30,"type":31},{"date":33,"type":31},{"date":35,"type":20},{"name":37,"class":38},{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":75,"locationsCount":39},"100604973","impact-of-intraoperative-blood-pressure-components-on-postoperative-aki-a-phenotype-stratified-analysis-100604973","NCT07156474","Impact of Intraoperative Blood Pressure Components on Postoperative AKI: A Phenotype-Stratified Analysis","Risk Assessment of Postoperative Acute Kidney Injury and Personalized Intraoperative Hypotension Threshold Prediction Based on Blood Pressure Components in Non-Cardiac Surgery Patients","Inclusion Criteria:\n\n1. Patients undergoing non-cardiac surgery\n2. Access to intraoperatively available invasive\u002Fnoninvasive blood pressure monitoring data\n\nExclusion Criteria:\n\n1. Patients for Age \\\u003C 18 yr\n2. Patients without preoperative or postoperative creatinine records\n3. Patients undergoing urinary surgeries\n4. Patients with chronic kidney injury before surgery\n5. ASA grade \\> 5 class\n6. Anesthesia duration \\\u003C 60 min\n7. Patients for non-available lowest blood pressure data during surgery\n8. Hemodynamic records loss more than 25% of the total anesthesia duration\n9. Patients for categorical variables records missing",{"count":64,"type":20},44504,"Postoperative acute kidney injury (AKI) is a serious complication often linked to low blood pressure during surgery. This study aims to better protect patients' kidneys by personalizing how blood pressure is managed during an operation.\n\nThe project has two main goals:\n\nFirst, researchers will analyze data from over 44,000 past surgeries to identify which specific blood pressure measurements are the most critical warning signs for kidney damage.\n\nSecond, using this knowledge, they will build a smart tool (a machine learning model) to predict a unique, safe blood pressure target for each individual patient before their surgery begins.\n\nThis personalized approach is intended to give doctors a specific target to maintain during surgery, helping to prevent kidney injury and improve patient safety.",[25,67],"Intraoperative Hypotension","NOT_YET_RECRUITING","2025-09-04",{"date":71,"type":31},"2025-09-05",{"date":73,"type":20},"2025-09-09",{"date":35,"type":20},{"name":37,"class":38},""]