[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Laurenz Kopp Fernandes\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":37},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":5},"100644791","extracellular-vesicles-for-rejection-monitoring-in-cardiac-transplantation-100644791",false,"NCT07673536","Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation","ExoRejeCT","Inclusion Criteria:\n\n* Subject is either on the heart transplant waiting list or is still hospitalised following HTx surgery.\n* Age of subject is ≥ 18 years.\n* Subject is female or male.\n* Capacity to consent.\n* Signed written informed consent.\n* For female subjects:\n\n  1. Confirmed post-menopausal state, defined as amenorrhea for at least 12 months, or\n  2. If being of childbearing potential: Negative highly sensitive urine or serum pregnancy test before inclusion.\n\nExclusion Criteria:\n\n* Concurrent multiple solid organ or tissue transplants.\n* Prior history of any organ or cellular transplantation.\n* Subject suffers from an addiction or from a disease that prevents the subject from recognising nature, scope, and consequences of the study.\n* Subject shows an inability to comply with all the study procedures and follow-up visits.\n* Subject is legally detained in an official institution.\n* Subjects who are unwilling to consent to saving and propagation of pseudonymised medical data for study reasons.\n* Subject is financially dependent on the investigators or the study site.","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","This study will analyze extracellular vesicle (EV)-derived protein profiles in heart transplantated patients during the first 15 months post-transplantation to investigate, if there are distinct EV-derived proteins or protein patterns that allow early and reliable diagnosis of acute cardiac allograft rejection. Additionally, it will explore temporal changes in the EV-derived protein profile during the early postoperative period irrespective of acute allograft rejection, and will investigate, if there are correlations between EV protein markers and imaging findings.",[24],"Rejection Heart Transplant","RECRUITING","2026-06-30",{"date":28,"type":29},"2026-07-01","ACTUAL",{"date":31,"type":29},"2026-06-18",{"date":33,"type":20},"2028-11-30",{"name":35,"class":36},"Laurenz Kopp Fernandes","OTHER",""]