[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Leeds Beckett University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":191},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,54,98,145,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100598614","probiotic-impact-on-cognitive-performance-and-metabolic-outcomes-in-overweight-young-adults-with-impaired-glucose-regulation-100598614",false,"NCT07073781","Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation","A Double-blind Placebo-controlled Exploratory Trial to Assess the Impact of Daily Lab4P Probiotic Supplementation on Cognitive Performance and Metabolic Regulation in Overweight Young Adults With Impaired Glucose Regulation","ProCog","Inclusion Criteria\n\n* Aged 18-40 years\n* Body Mass Index (BMI) between 25.0 and 29.9 kg\u002Fm² (classified as overweight)\n* In good general health (self-reported)\n* Normal self-reported sleep patterns, with no history of diagnosed sleep disorders\n* Willing and able to provide informed consent\n* Able to comply with study procedures, including fasting and oral glucose tolerance testing\n\nExclusion Criteria:\n\n* Diagnosed diabetes (any type).\n* Diagnosed sleep disorders.\n* Fasting glucose \\>6.9 mmol\u002FL during screening.\n* History of bariatric surgery (e.g., gastric bypass, sleeve gastrectomy).\n* Major surgery, significant illness, trauma, infection, or myocardial infarction within the past 6 weeks.\n* Current use of medications affecting glucose metabolism or probiotics\n* Pregnancy or actively trying to conceive\n* Night shift work within the past month","ALL","18 Years","40 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight adults aged 18 to 40 with impaired glucose tolerance, a preclinical condition where blood glucose regulation is mildly disrupted. Seventy participants will be randomly assigned to receive either Lab4P or a placebo. The study will assess changes in memory, executive function, and processing speed, along with blood glucose control, cardiovascular function, cholesterol levels, body composition, and markers of inflammation. The study will also analyse changes in the gut microbiome and evaluate the safety and tolerability of the probiotic.",[28,29,30,31,32,33],"Impaired Glucose Regulation","Impaired Glucose Tolerance (Prediabetes)","Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)","Overweight (BMI > 25)","Cognitive Dysfunction","Neurovascular Coupling Mechanism and Cognitive Function",[35,36,37,38,39,40],"Probiotic supplementation","Psychobiotic","Cognitive performance","Metabolic function","Impaired glucose tolerance","Gut-brain axis","RECRUITING","2026-03-25",{"date":44,"type":45},"2026-03-31","ACTUAL",{"date":47,"type":45},"2025-08-15",{"date":49,"type":22},"2026-08-20",{"name":51,"class":52},"Leeds Beckett University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":19,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":53},"100603339","the-effects-of-resistance-training-and-a-plant-based-supplement-on-perimenopausal-symptoms-and-muscle-health-100603339","NCT07135232","The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.","The Effects of Resistance Training and a Sarmentosin - L-theanine Supplement on Perimenopausal Symptoms and Musculoskeletal Health: A Randomised Controlled Trial","Inclusion criteria\n\n1. Perimenopausal women between 40 - 55 years\n2. Not currently engaging in consistent structured resistance training (defined as \\>3 resistance training sessions per week for 4 consecutive weeks, in the past six months).\n3. Not on any HRT or hormonal contraception for at least one year before initiation of the study.\n4. Able to attend laboratory visits and commit to the intervention schedule for 6 months.\n5. Willing to provide blood samples\n6. Not regularly consuming any dietary supplements containing concentrated sarmentosin, L-theanine or other compounds that may interfere with the study intervention.\n7. Willing to limit dietary intake of Sarmentosin (e.g. Blackcurrant) and L-theanine (e.g. green tea\u002F black tea).\n8. Willing and able to provide written informed consent\n\nExclusion criteria\n\n1. Diagnosed cardiovascular disease (CVD), uncontrolled hypertension (\\>160\u002F100 mmHg), or other conditions that prevent safe exercise participation.\n2. Clinically diagnosed mental health disorders (e.g., bipolar disorder, schizophrenia, severe depression requiring medication adjustment within the last 6 months).\n3. Neurological conditions affecting cognitive function (e.g., Parkinson's disease, multiple sclerosis, epilepsy).\n4. Endocrine disorders that could impact hormonal fluctuations or metabolism (e.g., uncontrolled diabetes, thyroid dysfunction).\n5. History of major musculoskeletal injuries (e.g., fractures, joint replacement) within the past 6 months\n6. Regular use of medications that could interfere with study outcomes, including antidepressants, corticosteroids, beta-blockers.\n7. Obesity (BMI \\>30 or for South Asian Ethinicity BMI\\> 27.5)\n8. Food allergy or intolerance to study products.\n9. Use of illicit drugs.\n10. Alcohol intake exceeding the government guidelines of 14 standard units per week (Equivalent of 6 standard drinks).\n11. Pregnant or planning to conceive during the trial.\n12. High habitual caffeine intake (\\>400 mg\u002Fday which is approximately 4-5 cups of coffee)",true,"FEMALE","55 Years",{"count":65,"type":22},72,[25],"The aim of this clinical trial is to determine if resistance training and a newly developed plant-based nutritional supplement can improve the symptoms and musculoskeletal health of perimenopausal women.\n\nThe main questions it aims to evaluate are:\n\n1. Can resistance training and the nutritional supplement - both independently and in combination - improve perimenopausal symptoms (e.g. cognition, mood, sleep) and musculoskeletal outcomes (e.g. strength, muscle mass)?\n2. What are the acute effects of the nutritional supplement on cognitive function and mood in perimenopausal women, and is this response altered following long-term intake (12 weeks)?\n3. What mechanisms may be contributing to the results?\n\nParticipants will be split into four groups to allow the researchers to answer the above questions. These are:\n\n1. The nutritional supplement + resistance training\n2. The nutritional supplement only\n3. The placebo supplement (A look alike capsule that contains no active ingredients) and resistance training\n4. The Placebo supplement only.\n\nParticipants will:\n\n* Take their allocated supplement daily and perform home-based strength exercise 3 times per week (for exercise groups), for 12 weeks.\n* Attend the laboratory at the beginning and end of the 12 weeks to assess cognitive function and mood following acute intake of the supplement.\n* Attend the laboratory every 4 weeks during the 12 week period, for assessment of cognitive function, symptom severity and muscle health.\n* Provide a blood sample at each visit for assessment of mechanistic pathways.",[69,70],"Perimenopause","Menopause",[72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89],"Mood","Depression","Cognition","Resistance Training","Sarmentosin - L-theanine","Bioactive supplement","perimenopause symptoms","menopause","lifestyle","muscle","health","exercise","perimenopause","symptoms","hot flashes","vasomotor","anxiety","stress","2026-03-23",{"date":92,"type":45},"2026-03-27",{"date":94,"type":22},"2026-03-01",{"date":96,"type":22},"2027-04-01",{"name":51,"class":52},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":61,"sex":62,"minAge":19,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":127,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":53},"100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476","NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.","60 Years",{"count":107,"type":22},40,[25],"The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[111,112,113,114,115,116,117,118,119,73,120,121,122,123,124,125,126],"Cognitive Assessment","Working Memory","Executive Function (Cognition)","Sustained Attention","Inhibitory Control","Cognitive Flexibility","Cortisol","Stress","Anxiety","Sleep Quality","Blood Pressure","Heart Rate","Mental Fatigue","Physical Fatigue","Productivity","Effort",[128,129,130,131,132,133,134,135,136],"Cognitive Performance","Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","2025-12-19",{"date":139,"type":45},"2026-01-06",{"date":141,"type":22},"2025-12-15",{"date":143,"type":22},"2026-08-31",{"name":51,"class":52},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":61,"sex":152,"minAge":18,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":23,"phases":156,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":53},"100605770","exploring-the-cognitive-benefits-of-a-blackcurrant-based-supplement-in-normobaric-hypoxia-100605770","NCT07166835","Exploring the Cognitive Benefits of a Blackcurrant-Based Supplement in Normobaric Hypoxia","The Efficacy of a Blackcurrant-based Nootropic Drink to Support Cognitive Functioning Under Normobaric Simulated High Altitude","Inclusion Criteria:\n\n* Willing and able to provide written informed consent (in English)\n* Aged 18-35\n* Male\n* Residing at a low altitude (\\\u003C500m)\n\nExclusion Criteria:\n\n* Diagnosed food allergy or intolerance to the investigational products or control products. (Blackcurrant, food allergen\u002F pine, tree-derived allergen\u002F l-theanine tree allergen (camellia sinensis))\n* Significant past medical and psychiatric history and ongoing chronic conditions such as, cardiovascular disease, respiratory disease, endocrine disorder (e.g. Diabetes mellites) and neurological and psychiatric conditions including brain injury or are colourblind.\n* Significant medication history or current prescription of medication or supplements known to affect cognition such as. Sedatives, stimulants, or herbal supplements high in anthocyanin and polyphenol content.\n* A positive result from the pre-screening sickle cell trait blood test.\n* An abnormal ECG reading.\n* A resting heart rate above 100bmp.\n* A blood pressure reading above 140\u002F90mmHg.\n* Subjects not willing and\u002F or not able to comply with the scheduled visits required for the study.\n* Not willing to provide blood samples.\n* Not classified as low risk based on the ACSM guidelines.","MALE","35 Years",{"count":155,"type":22},27,[25],"This study investigates the cognitive effects of Ārepa, a blackcurrant-based drink, under simulated high-altitude conditions (4,500m normobaric hypoxia for \\~180 minutes). Using a double-blind, randomised, placebo-controlled crossover design, participants will consume either the nootropic blackcurrant-based drink or a taste-matched placebo. Cognitive testing (\\~80 minutes) includes Trail-making, Stroop, N-back, Serial 7s\u002F3s, and RVIP tasks. Physiological measures (heart rate, SpO₂, blood) and biomarkers (MAO-B, BDNF, hsCRP, S100B, Prolactin, C3G, Sarmentosin) will be assessed. Scales will evaluate mood, wellbeing, and perceived effects. The aim is to determine if the nootropic drink can support cognitive function in hypoxic environments.",[128,113,112,159,72],"Hypoxia Induced Cognitive Impairment","NOT_YET_RECRUITING","2025-09-03",{"date":163,"type":45},"2025-09-10",{"date":165,"type":22},"2025-09-01",{"date":167,"type":22},"2027-10-01",{"name":51,"class":52},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":61,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":177,"targetDuration":4,"studyType":179,"phases":4,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":53},"100551405","the-bowel-movement-monitoring-bomomo-study-100551405","NCT06459661","The Bowel Movement Monitoring (BoMoMo) Study","The Bowel Movement Monitoring (BoMoMo) Study: An Exploration of the Relationship Between Intake of Unrefined, Intact Plant Foods and Faecal Output","BoMoMo","Inclusion Criteria:\n\n* Age: 18-60 years.\n* Healthy as determined from self-reported medical history or when no relevant medical condition exists.\n* Stool frequency of 3 to 21 times per week.\n* Able to attend a session in person at City Campus or Headingley Campus, Leeds Beckett University, or City Campus, Sheffield Hallam University.\n* For women: Use of contraceptive methods or not planning to become pregnant for the duration of the study.\n* Able to understand and be willing to sign the informed consent form, and to follow all the study procedures and requirements.\n\nExclusion Criteria:\n\n* Food allergy or intolerance\n* Currently dieting to lose weight\n* For women: Pregnancy, lactation\n* Bowel disease\n* Use of medicine causing constipation\n* Abnormal gastro-intestinal (gut) function or structure such as malformation, angiodysplasia or active peptic ulcer\n* History of gastro-intestinal surgery with permanent effect (e.g., surgical treatment of obesity)\n* Active inflammatory bowel disease, coeliac disease, chronic pancreatitis, or other disorder potentially causing malabsorption\n* Currently experiencing or been diagnosed with gastro-intestinal symptoms (e.g., abdominal pain\u002Fcramps, heartburn, stomach acid\u002Freflux, nausea, vomiting, abdominal rumbling, bloating, belching, excess gas\u002Fwind)\n* Active constipation (i.e., currently constipated).\n* Active Irritable Bowel Syndrome\n* Currently experiencing disordered eating\n* Current use of laxatives\n* Current use or within the previous 3 months use of prescription or over-the-counter medication that has the potential of affecting gut bacteria including food supplements (specific medications will be assessed on an individual basis).\n* Use of antibiotics or pain medication containing opiates or morphine currently or within the previous 3 months.\n* Use of opioid drugs of abuse (e.g., heroin, fentanyl) currently or within the previous 3 months.\n* Consumption of more than 21 units of alcohol per week (men)\u002F more than 14 unit of alcohol per week (women).\n* Malignancy\u002Fcancer which is currently active or in remission for less than 2 years after treatment.\n* Currently experiencing a psychiatric disorder or a condition related with your mental health that impacts on your daily life (e.g., major depression, bipolar disorders).\n* Currently engaging in intense physical activity more than 3 times per week (assessed on an individual basis).\n* Presenting a psychological or linguistic incapability to sign the informed consent\u002F Investigator considers the subject unlikely to comply with study procedures, restrictions, and requirements.\n* Parallel participation in another research project which involves dietary intervention\u002Fother clinical trial.",{"count":178,"type":22},24,"OBSERVATIONAL","The link between what people eat and how it affects faecal output (poo) has been understudied. Most of the research that has looked at the link between diet, bowel movements and overall health has studied different types of fibre extracted from foods (e.g., fibre extracted from carrots), rather than foods in the form that they are consumed.\n\nIt is necessary for scientists to investigate the relationship between food as people usual eat it (e.g., a carrot) and bowel movements, as this information is key to understanding the relationship between what people eat and overall health.\n\nThe investigators would like to understand the relationship between intake of certain foods and faecal output. This will help to develop a chart, similar to the United Kingdom National Health Service urine colour hydration chart. The chart will allow people to know, by looking at their poo, whether they are eating enough of the foods that will keep them healthy. By monitoring and measuring participants' bowel movements, and providing information about diet, participants will provide the data we need for this research.",[182],"Dietary Exposure","2024-06-14",{"date":185,"type":45},"2024-06-17",{"date":187,"type":45},"2024-05-01",{"date":189,"type":22},"2024-06-30",{"name":51,"class":52},""]