[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lincoln University College\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":106},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100611336","the-effects-of-mir-shakeel-teleintegrated-therapy-plan-in-patients-undergoing-total-knee-arthroplasty-100611336",false,"NCT07239258","The Effects of Mir Shakeel Teleintegrated Therapy Plan in Patients Undergoing Total Knee Arthroplasty","The Effects of Mir Shakeel Teleintegrated Therapy Plan and Conventional Physical Therapy on Pain, Range of Motion, Gait, Functional Outcomes and Quality of Life in Patients Undergoing Total Knee Arthroplasty","RCT","Inclusion Criteria:\n\n* Patients who have underwent a primary unilateral total knee arthroplasty due to osteoarthritis\n* Able to participate in a rehabilitation program, either telerehabilitation or in-person, and demonstrate sufficient mobility with or without assistive devices (e.g., crutches, walker) as deemed appropriate for post-TKA therapy.\n* Participants must have reliable access to a smartphone, tablet, or computer with internet connectivity and the ability to engage in video calls.\n* Willing and able to provide informed consent, and to comply with all study protocols, including scheduled therapy sessions and follow-up assessments.\n\nExclusion Criteria:\n\n* Presence of significant comorbidities or complications that could interfere with safe participation in rehabilitation, such as severe cardiovascular disease, or conditions causing significant immobility (e.g., severe osteoarthritis in other joints or Rheumatoid Arthritis.\n* Previous knee replacement or other significant knee surgeries on the same knee, as this may impact the standardization of rehabilitation outcomes.\n* Currently enrolled in another physical therapy or rehabilitation trial, or engaging in additional rehabilitation outside the study protocol.\n* Cognitive impairment or severe visual or hearing impairments that would prevent them from following therapy instructions or engaging with telerehabilitation technology.\n* Any other conditions or factors that, in the opinion of the investigators, could hinder compliance with the study procedures or put the participant at undue risk.","ALL","50 Years","65 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial aims to evaluate the effectiveness of a newly developed Modified Structured Telerehabilitation Intervention Protocol (MSTITP) compared with conventional in-person physical therapy in patients recovering from Total Knee Arthroplasty (TKA). The study also explores whether a hybrid rehabilitation approach may further optimize patient outcomes.\n\nA total of eligible participants aged 50-65 years who have undergone primary TKA will be randomly assigned to one of two groups:\n\nGroup A (Intervention): Telerehabilitation-based structured exercise program (MSTITP) delivered through digital platforms with remote supervision.\n\nGroup B (Control): Standard conventional face-to-face physiotherapy in a clinical setting.\n\nBoth groups will receive rehabilitation programs of equal duration focusing on pain management, range of motion (ROM), muscle strengthening, gait training, and functional mobility.\n\nThe primary objective is to compare the effectiveness of telerehabilitation and conventional therapy in improving pain, ROM, and gait performance. Secondary objectives include evaluation of exercise adherence, kinesiophobia, functional outcomes, quality of life, and patient satisfaction. Additionally, the study will explore whether integrating telerehabilitation with conventional rehabilitation could provide superior outcomes.\n\nOutcome assessments will be conducted using validated tools including pain scales (VAS), goniometric ROM measurements, gait analysis, functional performance tests, and standardized questionnaires for quality of life, exercise adherence, and fear of movement.\n\nThis study addresses the increasing burden of osteoarthritis and the growing number of TKA procedures in Pakistan. Telerehabilitation may offer a cost-effective, accessible, and scalable rehabilitation model that ensures continuity of care and improved access to physiotherapy services, particularly in resource-limited settings.\n\nThe findings of this trial are expected to provide evidence for developing standardized, technology-assisted rehabilitation protocols to improve post-TKA recovery outcomes and reduce healthcare burden.",[28,29],"Total Knee Anthroplasty","Total Knee Arthroplasty Recovery",[31,32,33,34,35,36,37],"pain","range of motion","gait","functional outcomes","quality of life","conventional physical therapy","total knee arthroplasty","RECRUITING","2026-05-09",{"date":41,"type":42},"2026-05-13","ACTUAL",{"date":44,"type":42},"2025-06-26",{"date":46,"type":22},"2026-06",{"name":48,"class":49},"Lincoln University College","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100618868","effect-of-knee-extensor-training-on-the-lumbar-spine-100618868","NCT07337213","Effect of Knee Extensor Training on the Lumbar Spine","Knee Extensor-Focused Biomechanical Intervention for Pain, Posture, and Disability in Non-Specific Low Back Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\nI. Males aged 40 to 60 years, II. nonsmokers, III. with normal body mass index IV. of Saudi nationality, V. office workers, VI. suffering from chronic NLBP for 12 weeks or more with a moderate disability according to the Oswestry Disability Index (score of 21 - 40%) moderate activity level according to the Arabic version of the International Physical Activity Questionnaire short form .\n\nExclusion Criteria:\n\nI. Previous spinal surgery, fracture, deformity, or disease. II. Neurological deficit and Lower limb deformity or fracture, or disease. III. Mental or psychological illness. The Arabic version of the Self-Reporting Questionnaire (SRQ-20) developed by the World Health Organization (WHO) to screen for common mental disorders such as depression and anxiety, uses a cut-off score to distinguish between individuals with and without significant psychological distress. A score of 7 or below is generally considered \"normal\", indicating no significant psychological distress (Al-Subaie et al., 1998).\n\nIV. Systematic chronic illnesses such as hypertension, cardiac and respiratory disorders, and diabetes mellitus.","MALE","40 Years","60 Years",{"count":62,"type":22},128,[25],"The goal of this clinical trial is to learn if knee extensor training with different protocols works to treat LBP in adults.. The main questions it aims to answer are:\n\nWhat are the comparative effects of open and closed kinetic chain knee extensor strengthening exercises versus lumbar stabilization exercises on lumbar curvature, postural control, and disability in individuals with non-specific low back pain? 1.4.2. How does open kinetic chain knee extensor strengthening affect pain, functional capacity, and lumbar spine stability compared to closed kinetic chain exercises in individuals with non-specific low back pain? 1.4.3 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.4 What is the effect of closed kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.5 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.6 What is the effect of close kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.7 What is the effect of conventional lumbar extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain Researchers will compare three different exercise protocols to a control group (will not receive exercise) to see if knee extensor training has an effect on problems associated with LBP.\n\nParticipants will:\n\n* Exercise three times per week for 8 weeks\n* Be assessed before, 4 weeks after, and 8 weeks after intervention",[66],"Non Specific Low Back Pain","NOT_YET_RECRUITING","2026-01-06",{"date":70,"type":42},"2026-01-13",{"date":72,"type":22},"2026-02-01",{"date":74,"type":22},"2026-06-01",{"name":48,"class":49},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":50},"100611654","effects-of-steroid-dextrose-prolotherapy-and-platelet-rich-plasma-injections-in-knee-joint-oa-patients-100611654","NCT07243392","Effects of Steroid, Dextrose Prolotherapy, and Platelet-Rich Plasma Injections in Knee Joint OA Patients","A Comparative Study on Effects of Steroid, Dextrose Prolotherapy, and Platelet-Rich Plasma Injections to Lessen Pain in Knee Osteoarthritis Patients","Inclusion Criteria:Inclusion criteria include patients aged 40-80 years, diagnosed with knee OA having Kellgren- Lawrence grades 2-4(Gelber, 2024) having history of persistent knee pain from at least last six months -\n\nPatients Exclusion reporting with history of recent knee surgery, patients suffering from inflammatory joint diseases for example rheumatoid arthritis, having any active body infection, diabetic patients with de ranged HbA1c, pregnant and breast-feeding females will be excluded.:\n\n\\-","80 Years",{"count":85,"type":22},72,[25],"The novelty of thisstudy lies in its comparative assessment of three latest intra-articular injection therapies including steroid injections, dextrose prolotherapy, and PRP, for knee OA associated impairments, with a focus on long-term efficacy and safety profile. While prior studies may have assessed one or two of these treatments individually therefore this protocol is systematically designed.",[89],"Knee Osteoarthritis",[91,92,31,93,94,95,96,97],"Osteoarthristis","Osteoarthritis, Knee","steroids","Platelet-Rich Plasma","Injections, Intra-Articular","Regenerative Medicine.","Prolotherapy","2025-11-17",{"date":100,"type":42},"2025-11-21",{"date":102,"type":22},"2025-11-28",{"date":104,"type":22},"2026-09-01",{"name":48,"class":49},""]