[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Linda Malan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100599181","iron-absorption-and-losses-in-young-south-african-women-living-without-and-with-overweight-and-obesity-100599181",false,"NCT07081152","Iron Absorption and Losses in Young South African Women Living Without and With Overweight and Obesity","Long-term Iron Absorption and Losses in Young South African Women Living Without and With Overweight and Obesity","RAYON","Inclusion Criteria:\n\n* Of African descent\n* BMI of 18.5 to 24.9 kg\u002Fm2 for participants living without OW\u002FOB and BMI ≥ 28 kg\u002Fm2 for participants living with OW\u002FOB\n* Having low to moderate inflammation-adjusted iron stores (ferritin ≤50 µg\u002FL)\n* Absence of low-grade inflammation (CRP\\\u003C2 mg\u002Fl) for participants living without OW\u002FOB and presence of low-grade inflammation CRP 2-20 mg\u002Fl) for participants living with OW\u002FOB\n* Planning to reside in the study area for at least 2 years\n\nExclusion Criteria:\n\n* Hemoglobin \\\u003C 11 g\u002Fdl\n* Treated or self-reported chronic or malabsorptive disorder\n* Current use of chronic anti-inflammatory medication, like corticosteroids or non-steroidal anti-inflammatory medication\n* Pregnancy or planning to become pregnant in the next 2 years\n* Lactation\n* Fear of needles or experiencing vaso-vagal episodes when exposed to blood\n* Difficulty drawing blood due to poor quality veins\n* Blood donation in the past 4 months or plans to donate blood during the study\n* On a weight-loss diet or program or planning to start the same during the study\n* Smoking\n* Unwillingness to stop taking iron and \u002For vitamin C-containing supplements during phase 1 of the study\n* Regular use of antacids, proton pump inhibitors or H2 blockers\n\nAdditional inclusion criteria applicable to phase 2 of the study\n\n* Labelled with stable iron isotope (tracer) for a minimum of one year\n* Willingness not to start or stop contraceptive use during the 6 months\n* BMI ≥ 18.5 to 24.9 kg\u002Fm2 for participants living without OW\u002FOB and BMI ≥ 28 kg\u002Fm2 for participants living with OW\u002FOB\n\nAdditional exclusion criteria applicable to phase 2 of the study\n\n\\- Blood transfusion, intravenous iron infusion, blood donation or significant blood loss during the equilibration period",true,"FEMALE","18 Years","35 Years",{"count":22,"type":23},70,"ESTIMATED","INTERVENTIONAL",[26],"NA","Young women living with obesity (OB) have a greater risk of developing iron deficiency. Plus, the risk of anemia and\u002For ID in young women living with overweight (OW) and obesity (OB) is further increased by inadequate dietary intake and\u002For poor bioavailability of iron, as well as gastrointestinal and menstrual iron losses. It is not certain whether women living with OW\u002FOB can meet their iron requirements from their day-to-day diet.\n\nThe aim of this study is to compare iron absorption and losses over a long period between women living with and without OW and OB. Secondary outcomes include iron and inflammation status, as well as dietary iron intake.",[29,30,31],"Obesity","Iron Deficiency","Inflammation","RECRUITING","2026-03-19",{"date":35,"type":36},"2026-03-23","ACTUAL",{"date":38,"type":36},"2025-07-24",{"date":40,"type":23},"2027-06-30",{"name":42,"class":43},"Linda Malan","OTHER",""]