[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Linkoeping University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":712},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,48,79,108,143,166,195,224,250,279,307,340,364,395,420,450,477,503,535,569,593,619,639,663,690],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100637703","can-tailored-surgical-incisions-reduce-refractive-error-and-dependence-on-glasses-after-cataract-surgery-100637703",false,"NCT07623317","Can Tailored Surgical Incisions Reduce Refractive Error and Dependence on Glasses After Cataract Surgery?","A Prospective Randomized Controlled Study of How Construction and Placement of Surgical Corneal Incisions May Influence Refractive Errors and Spectacle Dependence After Cataract Surgery","AST-2","Inclusion Criteria:\n\n* Visually disturbing cataract\n* Corneal and refractive astigmatismus more than 1 dioptre\n* Able and willing to undergo study procedures and measurements 3 weeks and 12 weeks after cataract surgery.\n\nExclusion Criteria:\n\n* Declining to participate\n* concomitant disease that prevents detailed objective and subjective investigations (e.g. dementia, serious ocular comorbidity limiting expected postoperative visual acuity to below 20\u002F40)\n* condition damaging structural integrity of cornea (surgical complications, infection, trauma, previous corneal disease)","ALL","40 Years","90 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","Astigmatism is a common cause of continued dependence on glasses after cataract surgery and may lead to patient dissatisfaction with surgical outcomes. As the corneal curvature is the main source for astigmatism after cataract surgery, our aim is to investigate whether postoperative astigmatism can be reduced by tailoring the location of surgical incisions according to the curvature of the cornea. We also wish to investigate whether this in turn reduces the need for glasses following cataract surgery.\n\nIn the planned study, one group of patients with cataracts and concurrent corneal astigmatism will undergo surgery using customized incision placement, while a control group will be operated on using standard incision placement without consideration of corneal astigmatism. Astigmatism will be measured before surgery and again at 3 and 12 weeks postoperatively. We will also assess how tailored incisions affect corneal biomechanics and shape, as well as measure visual quality and the need for glasses during daily activities before and after surgery.\n\nApproximately 160,000 cataract procedures are performed annually in Sweden. Around 40% of these patients (64,000 individuals) have astigmatism greater than 1 diopter and could potentially achieve improved surgical outcomes based on the results of this study. The method is cost-effective and associated with a low risk of complications compared to other approaches for reducing astigmatism.",[29,30],"Cataract (Post-operative Cataract Surgery Follow-up)","Refraction Error",[32,33,34,35],"Cataract","Micro-Incision Cataract Surgery","Astigmatismus","Spectacle dependence","NOT_YET_RECRUITING","2026-05-28",{"date":39,"type":40},"2026-06-03","ACTUAL",{"date":42,"type":23},"2026-09-15",{"date":44,"type":23},"2027-09-30",{"name":46,"class":47},"Linkoeping University","OTHER_GOV",{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100582347","ogtt-at-home-using-cgm-vs-at-the-clinic-100582347","NCT06862128","OGTT at Home Using CGM vs at the Clinic","Oral Glucose Tolerance Test at Home With Continuous Glucose Monitoring vs Standard Clinic-based Testing","OGTT-CGM","Inclusion Criteria:\n\n* Prediabetes indicated by ≥2 of the following values, measured at separate occasions or through different analyses during the past 2 years:\n* \\- Fasting venous plasma glucose ≥6.1 but ≤6.9 mmol\u002FL\n* \\- Non-fasting venous plasma glucose ≥7.8 but ≤11.0 mmol\u002FL\n* \\- HbA1c ≥39 but ≤47 mmol\u002Fmol\n* Access to a smart phone which is compatible with the CGM application and has working Bluetooth connectivity\n* Ability to read and respond to online instructions and questionnaires in Swedish.\n\nExclusion Criteria:\n\n* T2D indicated by ≥2 of the following values, measured at different occasions or through different analyses:\n* \\- Fasting venous plasma glucose ≥7.0 mmol\u002FL\n* \\- Non-fasting venous plasma glucose value ≥11.1 mmol\u002FL\n* \\- HbA1c ≥48 mmol\u002Fmol\n* Previous bariatric surgery e.g., gastric by-pass or gastric sleeve surgery\n* Body mass index \\\u003C20 kg\u002Fm2\n* Body weight \\\u003C43 kg\n* Current pregnancy\n* Need of regular use of GLP-1 receptor agonists, SGLT-2 inhibitors, acetaminophen or ascorbic acid supplements during the study period\n* Fear of needle sticks\n* Shift work during the study period\n* Involvement in the study design, data collection, analysis, or participant recruitment.","18 Years","70 Years",{"count":59,"type":23},75,[26],"This randomized, crossover study evaluates the feasibility and accuracy of a self-administered oral glucose tolerance test (OGTT) at home using continuous glucose monitoring (CGM) compared to a standard clinic-based OGTT. Participants with prediabetes will undergo both home-based and clinic-based OGTTs, with glucose levels measured via CGM and venous plasma glucose. The primary outcome is the correlation between CGM-based glucose values and standard OGTT results. Secondary outcomes include diagnostic agreement, metabolic hormone associations, and feasibility of home-based testing as a diagnostic tool for dysglycemia.",[63,64],"Pre-diabetes","Diabetes",[63,64,66,67,68],"Oral glucose tolerance test","Continuous glucose monitoring","Glucose","RECRUITING","2026-05-15",{"date":72,"type":40},"2026-05-19",{"date":74,"type":40},"2025-06-11",{"date":76,"type":23},"2040-12-31",{"name":46,"class":47},3,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},"100631915","simplified-exercise-based-risk-assessment-in-lung-cancer-100631915","NCT07506889","Simplified Exercise-based Risk Assessment in Lung Cancer","EXercise-based Evaluation of Ventilatory Efficiency for enHanced Risk Assessment in Lungcancer trEatment Using End-tidal CO2: a Multicenter, Prospective Study","EXHALE-CO2","Inclusion Criteria:\n\n* Lung Cancer Diagnosis\n* Age of at least 18 years\n\nExclusion Criteria:\n\n* Not able to perform cycle ergometer exercise\n* Not able to understand spoken or written Swedish",{"count":88,"type":23},500,"1 Year","OBSERVATIONAL","Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment. Ventilatory efficiency during exercise has emerged as a strong predictor of major postoperative complications, so far determined during a maximal cardiopulmonary exercise test. However, this test is limited by its availability and high cost, due to the requirement of high-technological equipment and advanced expertise. The current project aims to evaluate a simplified and accessible method for risk evaluation before decision on treatment in lung cancer. It builds on recent advances in technology and knowledge and combines a simple, low-intensity cycling test with measurement of ventilatory efficiency (end-tidal carbon dioxide pressure) with a handheld monitor. In a prospective, multi-center design the investigators will include patients evaluated for suspected lung cancer. The main objective is to establish threshold values for end-tidal carbon dioxide associated with low respectively high risk of major complications in patients undergoing surgery. In addition, the study aims to determine if end-tidal carbon dioxide can predict severe side-effects during neoadjuvant or curatively aiming systemic therapy. The project is closely linked to clinical practice, and the results can be easily implemented due to the simple and cost-efficient methodology. the suggested simplified approach would also allow access to physiological evaluation where more advanced methods are unavailable.",[93,94,95,96,97,98],"Lung Cancer (Diagnosis)","Lobectomy","Surgery Complications","Neoadjuvant Chemoimmunotherapy","End-Tidal Carbon Dioxide","Exercise","2026-04-02",{"date":101,"type":40},"2026-04-08",{"date":103,"type":23},"2026-04-01",{"date":105,"type":23},"2029-12",{"name":46,"class":47},5,{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":118,"conditions":119,"keywords":129,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},"100630957","a-path-to-prevention-of-elder-abuse-in-long-term-care-prevalence-study-among-staff-in-long-term-care-100630957","NCT07494422","A Path to Prevention of Elder Abuse in Long-term Care. Prevalence Study Among Staff in Long-term Care.","APPEAL","Inclusion Criteria:\n\n* Working in home care services or a long-term care facility in Sweden\n* Working in direct contact with older adults (e.g., providing care, nursing, rehabilitation to older adults)\n\nExclusion Criteria:\n\n* None","69 Years",{"count":117,"type":23},6000,"Globally, studies indicated that 16% of community dwelling older adults have been exposed to some form of abuse in the past 12 months. Furthermore, a global meta-analysis about AOP in long-term care facilities used staff as respondents and found that the pooled estimate of overall self-reported perpetration of staff to resident abuse during the past 12 months was 64.2% (95% CI 53.3-73.9%). Similar findings was also reported in a study from Norway in which the overall prevalence of observed staff-to-resident abuse was 76% and 60% of respondents report self-perpetration of abusive acts during the past 12 months. Resident-to-resident aggression was even more common, observed by 88% of respondents.\n\nThis study is part of the Swedish national research program APPEAL (A Path to Prevention of Elder Abuse in Long-term care) with the long-term goal to co-create an intervention for abuse of older people (AOP) in nursing homes together with stakeholders, i.e., staff, managers, care recipients and relatives.\n\nStudy design and data collection:\n\nA cross-sectional study design will be used with slightly different data collection modes.\n\n1. Population sample. Statistics Sweden combine data from the Swedish Occupational Register with data about industry codes (SNI-codes) to make a national randomized sample of staff working in home care services (n=12000) and nursing homes (n=11000) in Sweden. Data will be collected through a digital survey. Data will be combined with available register data from Statistics Sweden, including for example sex, age, civil state and occupational related data.\n2. Workplace sample. Sweden has 290 Municipalities. The Swedish Association of Local Authorities and Regions (SALAR) have an official categorization of the municipalities based on e.g., urban area size, proximity to a larger urban area, and commuting patterns. One municipality in each of the nine categories has been randomly selected for participation. In the randomization process, geographical location of the municipalities has been considered to assure national representativeness, meaning that in case several municipalities in the same geographical region were selected a new randomization was conducted. Staff in each selected municipalities will be invited to participate through managers in each organization. Data will be collected through a digital questionnaire. Organizations will be encouraged to set a side time at a staff meeting for completing the questionnaire. If this is not possible, a link to the questionnaire will be sent out by e-mail. Data will be collected anonymously.\n\nMaterial:\n\nThe questionnaire used in the previously mentioned Norwegian study about AOP in long-term care facilities has been translated and culturally adapted. In addition, items about background characteristics of respondents as well as risk factors for AOP on both an individual and system level are included, e.g., workload and perceived support at the workplace and ageist attitudes.\n\nAnalysis:\n\nPrimary outcomes will be proportion of staff reporting different types of abuse (psychological, physical, sexual, financial abuse and neglect) in different relational contexts, i.e., self-perpetrated, staff-to-resident and relative-to resident abuse, and in long-term care facilities resident-to-resident abuse.\n\nSecondary outcome will be staff reported own exposure to different forms of abuse at the workplace, including by residents, co-workers, relatives and managers.\n\nLogistic regression analysis will be used to investigate associations between reporting different forms of abuse and potentially explanatory factors.",[120,121,122,123,124,125,126,127,128],"Abuse Domestic","Abuse Neglect","Abuse Physical","Abuse Verbal","Abuse, Sexual","Violence and Victimization","Elder Abuse","Elder Mistreatment","Long Term Care",[130,131,132,133],"Abuse of older people","Long-term care facilities","Home care","Home health care","2026-03-20",{"date":136,"type":40},"2026-03-27",{"date":138,"type":23},"2026-03-24",{"date":140,"type":23},"2027-04-30",{"name":46,"class":47},1,{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":24,"phases":153,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":165},"100488557","effects-of-exergaming-to-reduce-sedentary-time-in-inactive-patients-with-heart-failure-100488557","NCT05641662","Effects of Exergaming to Reduce Sedentary Time in Inactive Patients With Heart Failure","Heart-eXg Study: Effects of Exergaming to Reduce Sedentary Time in Inactive Patients With Heart Failure: An International Multi-center, Randomized, Parallel-group Study","Heart-eXg","Inclusion Criteria:\n\n1. Diagnosed with symptomatic HF (NYHA II-IV) as diagnosed by cardiologist, (independent of Ejection Fraction: Patients with a preserved ejection fraction (HFpEF), mid-range ejection fraction (HFmrREF) or reduced ejection fraction (HFrEF) can be included.\n2. Clinically stable\n3. Physically inactive\n4. Older than 18 years, there is no upper age limit,\n5. Speak\u002Funderstand the language of the country where the study is taking place.\n6. Wanting to use a smartphone for the study (if patients do not have a smartphone, they can borrow it from the study team for the duration of the study)\n\nExclusion Criteria:\n\n1. Unable to use an exergame due to visual, hearing, cognitive impairment assessed by HF nurse or cardiologist.\n2. Not being able to perform the 6-minute walk test.\n3. Not being able or willing to wear an activity monitor.\n4. Currently included in a rehabilitation program\n5. Lack of willingness to play an exergame.\n6. Co-morbidity that hinders benefitting for this form of exercise (history of stroke, severe cognitive dysfunction, or a life expectancy shorter than 6 months).",{"count":152,"type":23},750,[26],"The goal of this to determine the effect of tailored exergaming for inactive patients with heart failure to reduce their sedentary time, improve their daily physical activity, exercise capacity, decrease frailty and improve health-related quality of life.\n\nParticipants will, on a background of standard guideline-directed medical therapy patients, be randomised to tailored activity advice (control) or the Heart-Exergame (Heart-eXg) intervention for a period of 3 months. Patients randomised to the Heart-eXg group will receive an exergame with feedback and tailoring to adapt the exergaming advice. Patients will also be able to play with a person in their own network.",[156],"Cardiovascular Diseases","2026-03-09",{"date":159,"type":40},"2026-03-10",{"date":161,"type":40},"2022-05-16",{"date":163,"type":23},"2027-07-30",{"name":46,"class":47},12,{"id":167,"slug":168,"hasResults":12,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":24,"phases":175,"briefSummary":176,"conditions":177,"keywords":179,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":142},"100614156","digital-support-program-for-patients-with-heart-failure---a-cluster-randomized-hybrid-type-2-study-100614156","NCT07275931","Digital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 Study","Digital Support Program Via 1177 for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 Study for Evaluation of Effects and Implementation","Inclusion criteria:\n\n* Diagnosed with heart failure with reduced ejection fraction (HFrEF) or heart failure with midrange reduced ejection fraction (HFmrEF) (ejection fraction ≤50%) verified by echocardiography or Magnetic Resonance Imaging\n* Access to BankID, a computer, tablet, or smartphone\n* Aged ≥18 years\n* Able to understand and communicate in Swedish\n* Provided informed consent\n\nExclusion criteria:\n\n* Barriers to participation (e.g., not Swedish-speaking, cognitive impairment, severe mental illness, substance abuse)\n* Life expectancy of less than six months",{"count":174,"type":23},240,[26],"The overall aim of this project is to evaluate the effects of a digital support program for patients with heart failure through a cluster-randomized controlled trial, and to investigate the outcomes of different implementation strategies using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance), PRISM (Practical, Robust Implementation and Sustainability Model) and ERIC (Expert Recommendations for Implementing Change) framework.\n\nOur primary hypothesis is that the digital support program will improve patients' perceived control over their heart failure, measured with the validated Control Attitude Scale.\n\nSecondary hypotheses are that the program will increase patients' health-related quality of life, self-care behaviors, heart failure knowledge, perceived continuity of care, and participation in care, and reduce symptoms of depression.\n\nImplementation aim (based on the RE-AIM, PRISM and ERIC frameworks) The implementation component of the study aims to compare two different implementation strategies: a standard (basic) support package versus a tailored, context-specific support strategy.\n\nHeart failure clinics at hospitals an within primary care will be matched and randomized into two arms. The intervention arm will receive tailored implementation support to implement the support program. The control arm will recive implementation support according to a predefined standard procedure.\n\nResearchers will compare the intervention arm with control arm to see if there are any differences regarding the implementationsuccess between the arms.\n\nThe patients in both arms will have access to the support program during six months.",[178],"Heart Failure With Reduced Ejection Fraction",[180,181,182,183,184,185,186],"Co-design","E-health","support","implementation","RE-AIM","PRISM","ERIC","2026-02-24",{"date":189,"type":40},"2026-02-27",{"date":191,"type":40},"2025-12-15",{"date":193,"type":23},"2029-06-30",{"name":46,"class":47},{"id":196,"slug":197,"hasResults":12,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":24,"phases":204,"briefSummary":205,"conditions":206,"keywords":211,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":142},"100537392","nutrition-care-in-patients-living-with-chronic-pain-100537392","NCT06277232","Nutrition Care in Patients Living With Chronic Pain","Developing Nutrition Care Integrated Into Pain Rehabilitation: a Feasibility and Non-Randomized, Controlled Quasi-Experimental Study","Inclusion Criteria:\n\n* Self reported Body Mass Index (BMI)\\>=25;\n* Written consent to participate and attend to the pain rehabilitation program due to disabling chronic pain (on sick leave or experiencing major interference in daily life due to chronic pain)\n* Agreement not to participate in other parallel treatments for weight reduction\n* Not currently using medications of weight reduction\n* Available to get access to internet via own mobile\u002Fcellphone.\n\nExclusion Criteria:\n\n* Health conditions such as pregnancy, active metabolic disease, rheumatoid arthritis, and serious psychiatric disease (investigator's judgement, eg, psychosis or suicidal ideation);\n* Coagulation disorders with predisposition to bleeding, medication with anticoagulants (low- dose aspirin is permitted);\n* hypersensitivity to anaesthetic\n* Difficulties in understanding the Swedish language.",{"count":203,"type":23},200,[26],"The investigators' purpose is to develop and test the feasibility, usability, and satisfaction of the Diet4painrelief app as a platform for implementing nutrition care in a specialist pain rehabilitation clinic. The Diet4painrelief will consist of two components: a) a screening tool for nutrition status b) an individually tailored behavior change program aiming to improve the dietary habits and behaviors of patients living with chronic pain.\n\nPart I: Included 20 patients with complex chronic pain to examine the feasibility and outcomes of evidence-based Interdisciplinary Pain Rehabilitation Program (IPRP) integrated with nutrition care. The Diet4painrelief includes a screening tool to assess basic nutritional status as well as their intake of key unhealthy and healthy foods and drinks (through three 24hour-dietary recordings or food diary). Thereafter, the patients receive a personalized behavior change program for dietary optimization. The investigators will design and adapt 6 modules in the digital platform (Diet4painrelief app) based on the International Association for the Study of Pain (IASP) recommendations (6 aspects about 'nutrition and pain') and Sweden's food culture. Clinical outcomes using patient-reported data on socio-demographics, pain aspects, psychometric data, physical disability, and quality of life will be measured at three occasions: first appointment (Pre-IPRP), immediately after completing the rehabilitation program (Post-IPRP), and at a 12-month follow-up (FU-IPRP). Blood samples will be taken to identify biomarkers at the same occasions that provide objective information on metabolic and nutritional abnormalities and further to evaluate the effect of the dietary intervention on changing of pain rehabilitation outcomes.\n\nPart II: Included 192 patients with complex chronic pain. Half of the participants receive IPRP and nutrition care (described above) and the other half receive standard IPRP.",[207,208,209,210],"Nutrition Poor","Overweight and Obesity","Mobile Phone Use","Pain, Chronic",[212,213,214,215],"Chronic pain","Nutrition care","Pain rehabilitation","eHealth","2026-02-13",{"date":218,"type":40},"2026-02-18",{"date":220,"type":40},"2024-08-01",{"date":222,"type":23},"2028-12-31",{"name":46,"class":47},{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":24,"phases":233,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":142},"100623046","icbt-for-psychological-symptoms-related-to-economy-100623046","NCT07391540","ICBT for Psychological Symptoms Related to Economy","Ekorostudien - Internet-based Cognitive Behavioral Therapy for Psychological Symptoms Related to Economy","Inclusion Criteria:\n\n* Experience mild to moderate psychological symptoms or problems related to economy\n* 18 years or older\n* Ability to speak, read and write in Swedish\n* Have access to the internet and a smartphone, computer or other device\n\nExclusion Criteria:\n\n* Severe psychiatric or somatic illness that makes participation harder or impossible\n* Ongoing addiction\n* Acute suicidality\n* Other ongoing psychological treatment\n* Recent (within the latest month) changes in the dose of psychotropic medication or planned change of dose during the treatment weeks",{"count":232,"type":23},50,[26],"This study aims to investigate the effects of guided internet-based cogitive behavioral therapy (ICBT) on psychological symptoms related to economy. In this pilot study, the investigators investigate participants' psychological symptoms before and after, and one and two years after, they have received eight weeks of therapist guided ICBT.",[236],"Depression and Anxiety Symptom",[238,239,240,241],"Internet-based cognitive behavioral therapy (ICBT)","Psychological treatment","Economy","Depression","2026-02-02",{"date":244,"type":40},"2026-02-06",{"date":246,"type":40},"2026-01-14",{"date":248,"type":23},"2028-05-31",{"name":46,"class":47},{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":258,"enrollmentInfo":259,"targetDuration":4,"studyType":24,"phases":261,"briefSummary":262,"conditions":263,"keywords":265,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":142},"100538400","pre-operative-exercise-therapy-and-patient-education-before-total-knee-replacement-100538400","NCT06290336","Pre-Operative Exercise Therapy and Patient Education Before Total Knee Replacement","Effect of Prehabilitation Before Total Knee Replacement on Post-operative Patient-reported Joint Awareness, Enablement and Knee Function","PROTEKT","Inclusion Criteria:\n\n* Waiting list for primary unilateral knee replacement surgery\n* Osteoarthritis of the knee being the primary reason for surgery\n* Reside within 60 minutes of travel to the site of the intervention\n\nExclusion Criteria:\n\n* Previous knee replacement surgery in the other knee\n* Other reason than osteoarthritis of the knee as the primary reason for surgery\n* Impaired cognitive function\n* Not being independent speaking and reading in swedish language\n* Chronic illness or disability etc hindering full participation in the intervention","85 Years",{"count":260,"type":23},110,[26],"The goal of this multi-center randomized controlled trial is to investigate the effect of pre-operative exercise therapy and education for patients awaiting knee replacement surgery on subjective knee function, patient satisfaction and enablement compared to standard care.\n\nThe main questions it aims to answer are:\n\n* Does pre-operative exercise therapy and education lead to better subjective knee function compared to standard care one year after surgery?\n* Does pre-operative exercise therapy and education lead to a higher level of patient satisfaction compared to standard care one year after surgery?\n* Does pre-operative exercise therapy and education lead to better patient enablement compared to standard care six weeks after surgery?\n* Does pre-operative exercise therapy and education lead to better objective knee function compared to standard care six weeks after surgery?\n\nParticipants will be randomized stratified by age (≤ 67 years, \\> 67 years) to either pre-operative supervised individualized exercise therapy combined with education two sessions\u002Fweek (intervention group) or to standard care (control group). The intervention will be continuously ongoing for at least eight weeks from the point of decision for surgery until as close to the surgery as possible.",[264],"Knee Osteoarthritis",[266,267,268,269,270],"Knee replacement","Exercise therapy","Education","Knee function","Satisfaction","2026-01-30",{"date":273,"type":40},"2026-02-03",{"date":275,"type":40},"2024-02-26",{"date":277,"type":23},"2027-12-30",{"name":46,"class":47},{"id":280,"slug":281,"hasResults":12,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":287,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":24,"phases":290,"briefSummary":291,"conditions":292,"keywords":294,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":306},"100587729","artificial-intelligent-decision-support-for-skin-cancer-diagnostics-in-primary-care-100587729","NCT06932172","Artificial Intelligent Decision Support for Skin Cancer Diagnostics in Primary Care","Artificial Intelligent Decision Support for Skin Cancer Diagnostics in Primary Care - a Multicentre Randomized Controlled Trial.","AI-DSSC","Inclusion Criteria:\n\n* Patients attending a primary care facility in order to have one or more skin lesions checked for skin cancer, or patients presenting with one or more skin lesions raising suspicion of skin cancer when noticed by the primary care physician.\n* Willingness and ability to provide informed consent.\n\nExclusion Criteria:\n\n* Individuals with skin type V and VI according to the Fitzpatrick's scale (darker brown or black coloured skin)",true,{"count":289,"type":23},3000,[26],"Background: Artificial intelligence has in numerous studies shown high accuracy in detecting skin cancer when trained on various databases of dermatoscopic images. However, there are very few prospective studies conducted in real clinical settings directed at patients seeking healthcare for assessment of skin lesions, and nosuch studies at all in primary care, where the majority of patients are managed.\n\nProject aim: To study the accuracy, reliability, and clinical utility of an AI-based decision support system (Dermalyser), developed for primary care, in distinguishing skin cancer from benign lesions.\n\nMethod: Cluster-randomized controlled trial at approx. 30 primary care centers in Sweden, Germany, Scotland, the Netherlands and Australia. At study start, the participating primary care centres in each country are equally randomised to either be enabled to use the Dermalyser (intervention phase) or to assess patients according to the standard clinical procedure (control phase). When half of the intended sample size (i.e. 1500 of 3000 participants) have been included, the primary care centres switch phase from intervention to control, or vice versa. During the intervention phase, the physicians may use (if found indicated) Dermalyser as a part of their clinical evaluation, whereas during the control phase the physicians follow their ordinary diagnostic routine without support from Dermalyser. This will direct the participants to either an intervention or a control cohort. Both groups will be followed for up to 5 years, with regard to the tumour diagnoses, proportions of skin cancer\u002Fbenign lesions, and morbidity and mortality in skin cancer. Possible between-group differences will be investigated statistically.\n\nPotential benefits: If the Dermalyser prooves to be safe and diagnotically reliability, it could enhance the chance of detecting skin cancer in early stage in primary care, and to reduce the proportion of benign skin lesion unnecessarily excised or referred to dermatologist.",[293],"Skin Cancer",[295,296,297],"Artificial Intelligence (AI)","Primary care","Diagnostics","2026-01-08",{"date":300,"type":40},"2026-01-12",{"date":302,"type":40},"2025-11-04",{"date":304,"type":23},"2031-12-31",{"name":46,"class":47},8,{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":287,"sex":18,"minAge":315,"maxAge":316,"enrollmentInfo":317,"targetDuration":4,"studyType":24,"phases":319,"briefSummary":320,"conditions":321,"keywords":326,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":339,"locationsCount":142},"100603411","healthy-older-adults-through-movement-and-engagement-100603411","NCT07136168","Healthy Older Adults Through Movement and Engagement","Healthy Ageing - an Interdisciplinary Randomised Study of Health Dialogues in Primary Care","HOME","Inclusion Criteria:\n\n* Living in Borgholm municipality or in one of 7 matched Demographical Statistical Area in Kalmar county\n* Age between 67-84 years\n\nExclusion Criteria:\n\n* Living in a nursing home\n* Not speaking or understanding swedish language","67 Years","84 Years",{"count":318,"type":23},2952,[26],"The HOME Project evaluates the effects of structured health dialogues with individuals aged 67-84 years in the municipality of Borgholm, Sweden. A combination of registry data and survey responses will be used to monitor quality of life, morbidity, healthcare needs, and lifestyle factors over a six-year period. Outcomes will be compared between randomized groups within Borgholm municipality and a matched control group from seven other municipalities in Region Kalmar.\n\nThe project also includes an analysis of cost-effectiveness and the reach of the intervention. A qualitative interview study will explore participants' perceptions of their health, their motivations for health improvement, and their experiences of how the health dialogues may influence these aspects.\n\nIn a substudy, machine learning models will be developed to predict functional decline and high healthcare needs among older adults. These models will be validated against established risk assessment tools such as the Adjusted Clinical Groups (ACG) system and the Charlson Comorbidity Index. Digital motion analysis using Skeleton Avatar Technology will be employed both independently and in combination with other variables to support model development.",[322,323,324,325],"Frailty","Ageing Well","Prevention Intervention","Health Related Quality of Life",[327,328,329,330,331,332],"health dialogue","frailty","cost-effectiveness","ageing well","primary care","health related quality of life","2025-10-01",{"date":335,"type":40},"2025-10-07",{"date":337,"type":40},"2025-08-25",{"date":304,"type":23},{"name":46,"class":47},{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":24,"phases":350,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":362,"leadSponsor":363,"locationsCount":142},"100514340","digital-diabetes-treatment---the-healthy-eating-healthy-patients-trial-100514340","NCT05977218","DIgitAl diabeTES Treatment - the Healthy Eating, heaLthy Patients Trial","DIATEST-HELP","Inclusion criteria:\n\n* Age between 18 and 75 years\n* Self-reported type 2 diabetes with a duration of ≥2 years\n* Regularly grocery shopping\n\nExclusion criteria:\n\n* No access to BankID (a digital identification system commonly used in Sweden)\n* Failure to complete eligibility screening and run-in periods","75 Years",{"count":349,"type":23},900,[26],"This randomized controlled trial will assess the impact of the FoodSwitch mobile app, which provides interpretive front-of-pack labelling via barcode scanning, in 900 Swedish adults with type 2 diabetes. Participants will be randomized to app + standard advice or standard advice alone. The primary outcome is change in HbA1c at 6 months; secondary outcomes include anthropometrics, quality of life, medication use, hospitalizations, and mortality.",[353],"Type 2 Diabetes",[355,356,357],"Diet","Mobile health","HbA1c","2025-09-19",{"date":360,"type":40},"2025-09-25",{"date":337,"type":40},{"date":304,"type":23},{"name":46,"class":47},{"id":365,"slug":366,"hasResults":12,"nctId":367,"briefTitle":368,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":12,"sex":370,"minAge":56,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":24,"phases":372,"briefSummary":373,"conditions":374,"keywords":376,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":4},"100583818","effectiveness-of-a-smartphone-app-primi-to-promote-healthy-diet-and-physical-activity-after-pregnancy-in-migrant-women-100583818","NCT06881277","Effectiveness of a Smartphone App (PRIMI) to Promote Healthy Diet and Physical Activity After Pregnancy in Migrant Women","Inclusion Criteria:\n\n* First-generation migrant women\n* Given birth ≤ 6 months ago\n* Age ≥ 18 years\n* Able to receive health-related information in Arabic, Somali, English, or Swedish\n\nExclusion Criteria:\n\n* Swedish-born women\n* Age \\\u003C 18 years\n* Given birth \\> 6 months ago","FEMALE",{"count":203,"type":23},[26],"The PRIMI trial (Promoting Reproductive health In MIgrant women) is a randomized controlled trial evaluating the effectiveness of a smartphone app designed to promote a healthy diet, physical activity, and health literacy among first-generation migrant women after pregnancy. The study will recruit 200 women within six months after pregnancy and randomize them into an intervention group, receiving access to the PRIMI app for six months, or a wait-list control group. The primary outcomes are diet quality and moderate-to-vigorous physical activity, while secondary outcomes include health literacy, body mass index, self-efficacy, and self-rated health. The intervention is expected to provide accessible and culturally tailored support to improve postpartum health behaviors.",[375],"Postpartum",[377,378,379,380,381,382,383,384,385,386],"mHealth","app","randomized controlled trial","postpartum","pregnancy","migration","migrant health","diet","physical activity","health literacy","2025-09-10",{"date":389,"type":40},"2025-09-16",{"date":391,"type":23},"2025-09-15",{"date":393,"type":23},"2026-12-31",{"name":46,"class":47},{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":402,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":404,"conditions":405,"keywords":408,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":418,"locationsCount":419},"100501396","quality-of-care-in-relationship-to-aborted-cancer-surgery-100501396","NCT05808712","Quality of Care in Relationship to Aborted Cancer Surgery","Developing Patient-centered Interventions to Improve the Quality of Care in Relationship to Aborted Cancer Surgery","Inclusion Criteria:\n\n* \\>18 years\n* cancer patients with different gastrointestinal cancer diagnosis\n\nExclusion Criteria:\n\n\\- not able to answer the questionnarie SCNS-SF34 in Swedish.",{"count":403,"type":23},350,"Surgery is often a central curative treatment for gastrointestinal tumors. Surgical treatment of diagnosed cancer tumors is decided after a comprehensive assessment of the patient's physical status, radiological assessments and after careful evaluation at the multidisciplinary conference. Despite the careful preoperative assessment of patients for curative surgery, the planned operation may unexpectedly need to be canceled. Of the patients who were planned for curative resection for pancreatic cancer in 2021 in Sweden, 90% received the intended surgery, and 10% of planned surgery was canceled. The reason for this was disseminated cancer or locally advanced disease in which radical resection is considered impossible to carry out. A systematic review of knowledge reveals a significant lack of evidence regarding patient-centered research and aborted cancer surgery.\n\nThe studies in the project have different study designs and methods, and include focus group interviews with staff, translation and validation of a questionnaire to measure care needs, estimation of supportive care needs and patient experiences.\n\nAn improved understanding and knowledge of patients' preferences and needs is needed to design interventions that can improve health-related quality of life. This project is dedicated to studying patients undergoing aborted cancer surgery, with the aim of improving the quality of care and meeting patients' care needs.",[406,407],"Cancer","Gastrointestinal Cancer",[409,410,411],"cancer nursing,","patient preferences","patient-centered care","2025-06-04",{"date":414,"type":40},"2025-06-08",{"date":416,"type":40},"2023-03-01",{"date":222,"type":23},{"name":46,"class":47},2,{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":426,"eligibilityCriteria":427,"healthyVolunteers":287,"sex":18,"minAge":428,"maxAge":4,"enrollmentInfo":429,"targetDuration":4,"studyType":24,"phases":431,"briefSummary":432,"conditions":433,"keywords":436,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":142},"100573604","enhancing-prevention-of-injuries-in-community-youth-and-adult-amateur-football-players-100573604","NCT06748443","Enhancing Prevention of Injuries in Community Youth and Adult Amateur Football Players","Enhancing Prevention of Injuries in Community (EPIC) Youth and Adult Amateur Football Players - Design of a Type 3 Hybrid Implementation-effectiveness Cluster Randomised Controlled Trial","EPIC","Inclusion Criteria:\n\n* Male and female, youth and adult amateur football teams\n* Teams participating in series for players 10 years or older\n* Teams with scheduled training at least twice per week during the season\n* All eligible players in the team are invited to participate, regardless of whether they have an injury or not at study start\n\nExclusion Criteria:\n\n* Players with long-term injuries not planning to take part in match play in the 2025 season","10 Years",{"count":430,"type":23},1600,[26],"This is a type 3 hybrid cluster randomised controlled trial, where implementation of the intervention is the primary outcome and preventive effectiveness is the secondary outcome.\n\nThe overall purpose of this study is to evaluate the added value of implementation support on the use and preventive effectiveness of the injury prevention exercise programme Knee Control+ in male and female, youth and adult amateur football teams.\n\nResearch questions\n\n1. Does use and injury preventive effect of Knee Control+ differ between teams randomised to an intervention group receiving additional support for Knee Control+ use and teams randomised to a control group with standard access to digital Knee Control+ programme material?\n2. Does coach self-efficacy to use Knee Control+, player motivation and player training dosage differ between the intervention and control groups?\n3. What are the mediators and moderators that influence use of Knee Control+?\n4. How well do the intervention and control groups adhere to Knee Control+ recommended use and is there an association between adherence and preventive efficacy?\n5. How are different components of the support material used by the intervention group teams, and how is the implementation support perceived by administrators, coaches and players in the clubs (end-users) and by fitness coaches who educate coaches about the programme (intervention deliverers)?\n6. How do coaches perceive their engagement to lead Knee Control+ training with their players and has this changed after having used the implementation support material?\n\nFootball teams will be randomised before the 2025 season to an intervention group receiving additional support for the implementation of Knee Control+ or to a control group without this support. All teams will have access to digital programme material via the Swedish Football Association.\n\nData on implementation of Knee Control+ and injuries (players only) will be collected weekly (coaches) and monthly (players) throughout the season using web-based questionnaires. Behavioural outcomes: for coaches self-efficacy, action and coping planning and perceived support from the club, and for players autonomous motivation, basic psychological needs and basic need support, will also be analysed.",[434,435],"Injury Prevention in Sports","Adherence",[437,438,439,440,441],"amateur sports","injury prevention exercise programme","adherence","co-design","support for coaches","2025-04-24",{"date":444,"type":40},"2025-04-27",{"date":446,"type":40},"2025-03-25",{"date":448,"type":23},"2026-06",{"name":46,"class":47},{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":456,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":24,"phases":460,"briefSummary":461,"conditions":462,"keywords":464,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":142},"100572499","effect-of-non-invasive-lung-fluid-monitoring-for-heart-failure-management-in-primary-care-100572499","NCT06734065","Effect of Non-Invasive Lung Fluid Monitoring for Heart Failure Management in Primary Care","Effect of Non-Invasive Lung Fluid Monitoring Using ReDS Technology for Heart Failure Management in Primary Care Settings: A Randomized Controlled Trial","LiLAC-HF","Inclusion Criteria:\n\n* Age ≥ 18 years, there is no upper age limit\n* Diagnosed with heart failure regardless of left ventricular ejection fraction\n* Having New York Heart Association (NYHA) Class III\u002FIV irrespective of prior hospitalisation for heart failure, or NYHA II with a history of at least one hospitalisation for heart failure within the previous 12 months\n* Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) within 12 months: (a) ≥450 pg\u002Fml for patients under 50 years; (b) ≥900 pg\u002Fml for patients aged 50-75 years; (c) ≥1800 pg\u002Fml for patients over 75 years.\n\nExclusion Criteria:\n\n* NYHA I\n* Life expectancy \\\u003C6 months\n* Physical characteristics that prevented use of the ReDS (body mass index \\\u003C 22 or \\>39, and height less than 155 cm or higher than 195 cm)\n* Implantation of a left ventricular assist device or cardiac transplantation.",{"count":459,"type":23},330,[26],"Remote dielectric sensing (ReDS) technology offers a non-invasive method for assessing lung congestion. This randomized controlled trial aims to evaluate the effectiveness and processes of the ReDS-guided heart failure management program in primary care settings for patients with heart failure.",[463],"Heart Failure",[465,296,466,467,468,469],"Heart failure","Nursing","Monitoring","Self-care","Community","2025-04-23",{"date":444,"type":40},{"date":473,"type":40},"2025-04-16",{"date":475,"type":23},"2030-12",{"name":46,"class":47},{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":483,"eligibilityCriteria":484,"healthyVolunteers":287,"sex":18,"minAge":485,"maxAge":4,"enrollmentInfo":486,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":488,"conditions":489,"keywords":491,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":495,"lastUpdatePostDateStruct":496,"startDateStruct":498,"completionDateStruct":500,"leadSponsor":502,"locationsCount":142},"100573988","co-regulation-and-interaction-in-the-nicu-100573988","NCT06753435","Co-regulation and Interaction in the NICU","Development of the Premature Infant's Stress System. Focus on Parent-infant Co-regulation and Interaction","CORI","Inclusion Criteria:\n\n* Swedish- or English-speaking parents aged over 18, born in Europe, and their infants born between gestational weeks 30+0 and 34+6.\n\nExclusion Criteria:\n\n* Parents with conditions or taking medications affecting the hormone system. Additionally, infants with major malformations or complex care needs that impede interaction possibilities are excluded.","2 Days",{"count":487,"type":23},105,"Preterm infants are exposed to multiple stressors each day, posing a risk of toxic stress that can impact their developing brains during a critical period of sensitivity. Elevated levels of the stress hormone cortisol can impede neuronal connectivity and communication, thereby increasing the likelihood of cognitive impairment and behavioural problems. Synchronized social-emotional mother-infant interaction holds promise in buffering stress reactivity and mitigating long-term stress effects.\n\nOur previous research has shown that preterm infants exhibit higher baseline saliva cortisol levels than full-term infants, along with blunted cortisol reactivity to stressors, irregular cortisol circadian rhythms, and delayed cortisol co-regulation between mother and infant. Another potential stress marker is saliva alpha-amylase (α-amylase), which has garnered increasing interest in adult research. However, there remains a significant gap in the literature concerning saliva α-amylase as a stress marker in preterm infants, warranting further investigation. The overall aim is to study development and relationships between three systems of parent-infant synchrony in preterm infants and their parents and elucidate potential confounding factors for a synchronous correlation. This will be done in relation to standardised care procedures commonly performed in the neonatal intensive care unit.\n\nThis observational study will involve 35 families undergoing three video-recorded procedures in the NICU. Saliva will be collected from infants and both parents before and after each procedure so we can analyse co-regulation of cortisol and alpha-amylase. Parent-infant interaction will be analysed from the videos using validated scales.\n\nThis study will be the first to document biological co-regulation and social-emotional parent-infant interaction simultaneously involving preterm infants and both parents in the NICU setting. Such insights are pivotal for the future design and implementation of tailored nursing interventions aimed at early stress mitigation, thereby reducing the risk of stress-related consequences.",[490],"Preterm",[492,493,494],"Preterm infant","Stress system","Family","2025-03-04",{"date":497,"type":40},"2025-03-07",{"date":499,"type":40},"2025-01-07",{"date":501,"type":23},"2031-12",{"name":46,"class":47},{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":509,"eligibilityCriteria":510,"healthyVolunteers":12,"sex":511,"minAge":56,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":24,"phases":514,"briefSummary":515,"conditions":516,"keywords":522,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":530,"completionDateStruct":532,"leadSponsor":534,"locationsCount":142},"100574995","internet-based-support-for-adjustment-to-prostate-cancer-100574995","NCT06766526","Internet-based Support for Adjustment to Prostate Cancer","Internet-based Support for Adjustment to Prostate Cancer (ISAC) - A Randomized Controlled Trial of ICBT for Distress Related to Prostate Cancer","ISAC","Inclusion Criteria:\n\n* Subjectively reported psychological symptoms and problems that have come about after a prostate cancer diagnosis.\n* A sum score above 19 on the primary outcome measure (Kessler-10).\n* An age of 18 or older.\n* Ability to speak, read, and write Swedish.\n* Access to a computer\u002Flaptop\u002Ftablet\u002Fsmartphone and internet access.\n* Sufficient computer profiency to be able to use the treatment platform.\n\nExclusion Criteria:\n\n* Planned medical treatment or planned change in medication related to the prostate cancer during the treatment period.\n* Recently finished (within the past six months) medical treatment for prostate cancer.\n* Severe psychiatric or somatic conditions that impedes participation in the study.\n* Ongoing substance use problems.\n* Acute suicidality.\n* Other ongoing psychological treatment.\n* Psychopharmaceutic treatment that has been changed within the past month or with planned changes during the treatment phase.","MALE",{"count":513,"type":23},180,[26],"The study aims to study the efficacy of internet-based cognitive behavior therapy (ICBT) in reducing subjective distress and comorbid psychiatric symptoms in men diagnosed with prostate cancer. Participants who have been diagnosed with prostate cancer and are currently not undergoing or scheduled to undergo medical treatment will be recruited. Once recruited, they will be randomized to receive either a tailored, eight-week long ICBT intervention or an attention control group. Both group receive weekly support by a trained therapist.",[517,518,519,520,521],"Psychological Distress","Depression - Major Depressive Disorder","Insomnia","Anxiety","Prostate Cancer",[523,524,406,525,526],"Psychological distress","Prostate cancer","ICBT","Cognitive behavior therapy","2025-02-21",{"date":529,"type":40},"2025-02-24",{"date":531,"type":40},"2025-01-05",{"date":533,"type":23},"2026-12",{"name":46,"class":47},{"id":536,"slug":537,"hasResults":12,"nctId":538,"briefTitle":539,"officialTitle":539,"acronym":540,"eligibilityCriteria":541,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":542,"targetDuration":4,"studyType":24,"phases":543,"briefSummary":544,"conditions":545,"keywords":555,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":564,"startDateStruct":565,"completionDateStruct":566,"leadSponsor":568,"locationsCount":419},"100576742","co-occurence-of-mental-illness-and-problematic-alcohol-use-an-internet-based-cognitive-behavior-therapy-intervention-100576742","NCT06789250","Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention","CoMiT","Inclusion Criteria:\n\n* Age ≥18 years\n* AUDIT ≥ 6 points for women and ≥ 8 points for men\n* Symptoms of depression, anxiety disorder and\u002For stress-related illness\n* Adequate ability to speak, read and write Swedish\n* Having access to the internet and a smartphone, computer or other device.\n\nExclusion Criteria:\n\n* Ongoing psychological treatment.\n* Ongoing medication for AUD\n* Recent changes (within the past three months) in psychiatric medication or planned changes during the treatment period. New medication prescribed during the study shall be reported but will not lead to exclusion\n* Severe psychiatric disorders based on a Mini-International Neuropsychiatric Interview (MINI) interview and reported medical history\n* Severe medical conditions that may impede participation in the study\n* Severe cognitive impairment\n* Current suicidality\n* Severe alcohol addiction where specialized treatment is more appropriate\n* Risk for severe alcohol withdrawal symptoms with a need for medical treatment. Participation is possible after completing alcohol withdrawal treatment within the ordinary health-care system, accessible to the Swedish population.\n* Substance use disorder, other than alcohol or nicotine, within the past six months.",{"count":174,"type":23},[26],"The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression, anxiety, stress or disturbed sleep.\n\nThe main questions the study aims to answer are:\n\n* Does the ICBT program lower the self-rated suffering from mental illness?\n* Does the ICBT program lower the self-reported alcohol intake? Researchers will compare the ICBT program to the participants who are rancomized to a control grout that receives weekly attention from the research team, to see if the treatment works. In both groups, the participants will have the opportunity to ask for support from a therapist during the week days.\n\nParticipants are adults living in Sweden. They will:\n\n* Receive an ICBT program supported by a trained therapist. It consists of modules that the participants will work with on their computer for 10 weeks. Some modules will be compulsory and other optional for the participants.\n* Fill out forms to rate their mental illness and alcohol intake at the start and the end of the study as well as once every week during treatment.\n\nPrimary outcome measures are depression, anxiety and stress symptoms (measured with Depression Anxiety and Stress Scale 21 (DASS-21)) and alcohol intake measured with self-reported amounts. Other, secondary, outcome measures used will for example be about insomnia symptoms and disability assessment. Pre-treatment measurement, post-treatment measurement and 6-months and 12-months follow up is planned to be collected through an online survey.",[546,547,548,549,550,551,552,553,554],"Alcohol Drinking Related Problems","Alcohol Use Disorders","Depressive Disorders","Mental Illness","Mental Stress","Mental and Behavioral Disorders","Sleep Problems","Stress Disorders","Anxiety Disorder\u002FAnxiety State",[556,241,520,557,558,238,559,560,561,562,563],"Internet intervention","Individually tailored","Transdiagnostic","Stress","Sleeping disorders","Mental illness","Harmful alcohol use","Alcohol addiction",{"date":529,"type":40},{"date":531,"type":40},{"date":567,"type":23},"2026-05",{"name":46,"class":47},{"id":570,"slug":571,"hasResults":12,"nctId":572,"briefTitle":573,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":24,"phases":577,"briefSummary":578,"conditions":579,"keywords":581,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":142},"100578806","internet-based-acceptance-based-psychotherapy-as-an-adjunct-to-chronic-pain-rehabilitation-100578806","NCT06816082","Internet-based Acceptance Based Psychotherapy As an Adjunct to Chronic Pain Rehabilitation","Inclusion Criteria:\n\n* Participants must be adults with sufficient understanding of Swedish to speak and read, have internet access, and currently be a patient at the Pain and Rehabilitation Clinic in Linköping.\n\nExclusion Criteria:\n\n* Severe cognitive problems, or severe mental illness such as a psychotic episode",{"count":576,"type":23},15,[26],"The goal of this clinical trial is to evaluate how an acceptance based internet-delivered psychological treatment (IACT) tailored to patients with chronic pain is perceived, and if it meets the needs and expectations of those enrolled.\n\nThe main question it aims to answer is:\n\nWhat are the expectations of patients with chronic pain prior to IACT treatment, and how do they experience IACT during and after treatment?\n\nParticipants will be offered a 7 week long treatment with therapist support. They will be interviewed before treatment starts, once during treatment, and again after treatment is completed.",[580],"Chronic Pain",[582,583,584],"chronic pain","acceptance and commitment therapy","internet delivered treatment","2025-02-03",{"date":587,"type":40},"2025-02-10",{"date":589,"type":40},"2025-01-22",{"date":591,"type":23},"2026-10",{"name":46,"class":47},{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":370,"minAge":601,"maxAge":4,"enrollmentInfo":602,"targetDuration":4,"studyType":24,"phases":604,"briefSummary":605,"conditions":606,"keywords":609,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":618,"locationsCount":419},"100518426","strength-and-aerobic-training-against-hot-flushes-in-postmenopausal-women-100518426","NCT06030388","Strength and Aerobic Training Against Hot Flushes in Postmenopausal Women","STrength and AeRobic Training Against Vasomotor Symptoms (START) in Postmenopausal Women","START","Inclusion Criteria:\n\n* Postmenopausal women (one of: ≥ 12 months since last menstruation; amenorrhea due to intrauterine device or hysterectomy and Follicle Stimulating Hormone (FSH) \\>30 mIU\u002Fml; bilateral oophorectomy; induced menopause due to chemotherapy or radiation and ≥2 years amenorrhea);\n* ≥ 28 moderate to severe hot flushes per week during a 2-week screening period, registered through a daily VMS diary;\n* Age ≥45 years;\n* Physical ability to participate in strength training or high intensity aerobic exercise for 60 minutes, 3 times\u002Fweek during 15 weeks;\n* Understand Swedish orally and in writing\n\nExclusion Criteria:\n\n* Regular physical activity \\>30 minutes per week of vigorous intensity or ≥150 minutes of moderate intensity or combined activities representing maximum 150 minutes of moderate intensity;\n* Use of systemic menopausal hormone therapy the last 2 months;\n* Use of natural preparations such as herbal preparations for VMS, or other medications for VMS the last 2 months;\n* Capillary hemoglobin \\\u003C110 g\u002Fl;\n* Blood pressure \\>160 mmHg systolic or \\>100 mmHg diastolic;\n* Unstable medical condition with a potential to affect VMS (like unregulated thyroid disease);\n* Medical condition that by a physician is judged not appropriate (because of potential to affect VMS or risk of injury with vigorous exercise)","45 Years",{"count":603,"type":23},90,[26],"The goal of this randomised controlled trial is to investigate the effects of and compare two modes of physical exercise (strength training and high-intensity aerobic exercise) to unchanged physical activity on vasomotor symptoms (hot flushes) in postmenopausal women. The main question it aims to answer is the effect of 15 weeks of strength training vs high intensity aerobic training vs unchanged physical activity on frequency and severity of hot flushes. Participants will be randomised to:\n\n1. strength training\n2. high-intensity aerobic training\n3. untreated control group.\n\nResearchers will compare strength training, high-intensity aerobic training and untreated control group to see if training can reduce hot flushes.",[607,608],"Postmenopausal Symptoms","Hot Flashes",[610,611],"aerobic training","strength training","2025-01-20",{"date":589,"type":40},{"date":615,"type":40},"2023-09-12",{"date":617,"type":23},"2032-12",{"name":46,"class":47},{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":347,"enrollmentInfo":626,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":628,"conditions":629,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":638,"locationsCount":78},"100463122","functioning-in-individuals-with-cervical-radiculopathy-after-posterior-cervical-decompression-100463122","NCT05310578","Functioning in Individuals with Cervical Radiculopathy After Posterior Cervical Decompression","Functioning in Individuals with Cervical Radiculopathy After Posterior Cervical Decompression: a Prospective Multicenter Observational Study with a 2 Year Follow-up.","Inclusion Criteria:\n\n* Cervical radiculopathy, confirmed by MRI images (or alternative neuroradiological imaging if MRI contraindicated) compatible with clinical findings of nerve root compression (neurological examination performed by a neurosurgeon\u002Forthopedic surgeon)\n* Posterior cervical decompression as foraminotomy with our without laminectomy\n* At least 3 months of persistent arm pain\n* Age 18-75 years\n\nExclusion Criteria:\n\n* Nurick score 2 or more (to exclude individuals with moderate to high myelopathy)\n* Previous surgery of cervical spine\n* Previous fracture or dislocation of the cervical spine\n* Malignancy or benign spinal tumor (eg, neuromas)\n* Spinal infection\n* Previous spondylodiscitis\n* Servere mental disorder\n* Known alcohol or drug abuse\n* Lack of ability to write\u002Fcomprehend\u002Fexpress oneself in Swedish",{"count":627,"type":23},154,"Compression on structures, as spinal nerves, in the cervical spine can cause cervical radiculopathy which leads to pain, disability, and reduced quality of life for the affected individual. Cervical foraminotomy with our without laminectomy are common posterior decompression surgical techniques for treating cervical radiculopathy. There is a lack of knowledge regarding function in patients with cervical radiculopathy after posterior cervical decompression.\n\nThe aim with this study is to study pain, function, psychosocial factors, and health related quality of life after posterior cervical decompression in patients with cervical radiculopathy.\n\nThis is a prospective multicenter longitudinal observational cohort study with follow-up at three, 12- and 24 months postoperative. A total of 154 individuals scheduled to undergo foraminotomy with our without laminectomy due to cervical radiculopathy will be included. Primary outcome is neck-specific function measured with the Neck Disability Index. Data will be collected preoperatively and at three, 12 and 24 months with electronic questionnaire.",[630],"Cervical Radiculopathy","2024-11-21",{"date":633,"type":40},"2024-11-25",{"date":635,"type":40},"2022-08-22",{"date":637,"type":23},"2025-12-31",{"name":46,"class":47},{"id":640,"slug":641,"hasResults":12,"nctId":642,"briefTitle":643,"officialTitle":643,"acronym":4,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":645,"targetDuration":4,"studyType":24,"phases":647,"briefSummary":648,"conditions":649,"keywords":651,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":655,"lastUpdatePostDateStruct":656,"startDateStruct":658,"completionDateStruct":660,"leadSponsor":662,"locationsCount":142},"100567217","internet-based-affect-focused-psychodynamic-therapy-for-neuroticism-a-randomized-controlled-trial-100567217","NCT06665321","Internet-based Affect Focused Psychodynamic Therapy for Neuroticism: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Score 5 points or more on either the PHQ-9 or GAD-7\n* 18 years or older\n* Ability to speak, read and write in Swedish\n* Have access to the internet and a smartphone, computer or other device\n\nExclusion Criteria:\n\n* Severe psychiatric or somatic illness that makes participation difficult or impossible\n* Ongoing addiction\n* Acute suicidality\n* Other ongoing psychological treatment\n* Recent (within the latest month) changes in the dose of psychotropic medication or planned change of dose during the treatment weeks",{"count":646,"type":23},108,[26],"The purpose of the study is to investigate if internet delivered affect-focused psychodynamic therapy (IPDT) leads to lowered levels of trait neuroticism compared to a wait-list control condition. The target group is adults (18+) who experience mild to moderate symptoms of anxiety and\u002For depression. The IPDT treatment consists of 8 modules that the participants will work with for 9 weeks, with therapist support. Participants will be recruited in Sweden with nationwide recruitment.",[650],"Trait Neuroticism",[652,653,654],"Trait neuroticism","Internet-delivered psychodynamic therapy","Internet Intervention","2024-11-08",{"date":657,"type":40},"2024-11-12",{"date":659,"type":23},"2025-01",{"date":661,"type":23},"2025-06",{"name":46,"class":47},{"id":664,"slug":665,"hasResults":12,"nctId":666,"briefTitle":667,"officialTitle":668,"acronym":4,"eligibilityCriteria":669,"healthyVolunteers":12,"sex":370,"minAge":4,"maxAge":4,"enrollmentInfo":670,"targetDuration":4,"studyType":24,"phases":672,"briefSummary":673,"conditions":674,"keywords":677,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":688,"locationsCount":689},"100482343","can-the-use-of-a-next-generation-partograph-improve-neonatal-outcomes-picrino-100482343","NCT05560802","Can the Use of a Next Generation Partograph Improve Neonatal Outcomes? (PICRINO)","Can the Use of a Next Generation Partograph Based on WHO's Latest Intrapartum Care Recommendations Improve Neonatal Outcomes? a Stepped-wedge Cluster Randomized Trial (PICRINO)","Inclusion Criteria:\n\n-All women in active labor\n\nExclusion Criteria:\n\n-No exclusion criteria",{"count":671,"type":23},120000,[26],"The overall aim is to evaluate the impact of the use of two different guidelines for monitoring labor progress, the WHOs LCG versus standard care, on neonatal and maternal outcomes. The hypothesis is that the use of LCG will reduce adverse neonatal outcomes and decrease the number of intrapartum Cesarean sections compared with standard care.\n\nSecondly, other perinatal interventions and complications will be compared between the LCG and standard care groups, as well as economic considerations. This will be investigated using a multicenter, stepped-wedge cluster randomized trial design.\n\nIn addition, the project will explore a series of quantitative and qualitative research questions to gain in-depth knowledge about experiences and perceptions about childbirth and the use of LCG. These research questions will be investigated using questionnaires, focus group and individual interviews with providers, partners and women that have gone through childbirth.",[675,676],"Neonatal Complication","Labor (Obstetrics)--Complications",[678,679,680],"neonatal outcomes","obstetric outcomes","labour care guide","2024-10-19",{"date":683,"type":40},"2024-10-22",{"date":685,"type":40},"2023-11-15",{"date":687,"type":23},"2027-09",{"name":46,"class":47},24,{"id":691,"slug":692,"hasResults":12,"nctId":693,"briefTitle":694,"officialTitle":695,"acronym":696,"eligibilityCriteria":697,"healthyVolunteers":287,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":698,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":700,"conditions":701,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":704,"lastUpdatePostDateStruct":705,"startDateStruct":707,"completionDateStruct":709,"leadSponsor":711,"locationsCount":419},"100560706","the-role-of-a-mycobacterium-growth-inhibition-assay-to-quantify-host-immune-control-of-m-tuberculosis-100560706","NCT06580639","The Role of a Mycobacterium Growth Inhibition Assay to Quantify Host Immune Control of M. Tuberculosis","The Role of a Mycobacterium Growth Inhibition Assay to Quantify Host Immune Control of M. Tuberculosis From Healthy Blood Donors and Patients With Latent or Active Tuberculosis.","MGIA","Inclusion Criteria: Healthy blood donors or subjects who will get vaccinated.\n\nExclusion Criteria:Known HIV infection, not Swedish citizen, chronic liver och kidney disease,immunosuppression from treatment or disease.",{"count":699,"type":23},280,"The goal of this observational study is to learn about how the blood leucocytes from patients with and without exposure or disease from tuberculosis (TB) are able to kill live mycobacteria (M. tuberculosis). The main question it aims to answer is:\n\nIs intracellular growth suppression of M. tuberculosis in peripheral blood mononuclear cells variable among healthy blood donors and higher than in patients with latent TB compared to active TB?",[702,703],"Tuberculosis","Immunologic Activity Alteration","2024-08-28",{"date":706,"type":40},"2024-08-30",{"date":708,"type":40},"2020-08-01",{"date":710,"type":23},"2025-12-01",{"name":46,"class":47},""]