[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":121},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,70,97],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100633896","radiographic-head-and-neck-positional-changes-in-response-to-usage-of-low-powered-prismatic-lenses-100633896",false,"NCT07532642","Radiographic Head and Neck Positional Changes in Response to Usage of Low-powered Prismatic Lenses","Radiographic Head and Neck Positional Changes in Response to Oculomotor Muscles Tonic Modification Using Low-powered Prismatic Lenses","Inclusion Criteria:\n\nPresentation of diagnostic criteria for Postural Deficiency Syndrome comprising of\n\n* Two or more cardinal signs of Postural Deficiency Syndrome\n* Clinical presentation of asymmetrical stance and head extension and rotation\n* Presence of typical directional pseudoscotoma described in this syndrome\n\nExclusion Criteria:\n\n* Vision under 8\u002F10, strabismus or nistagmus;\n* Previous eye or vestibular surgery;\n* Known disease affecting the central nervous system or inner ear;\n* Medication with known interference with balance and posture and\n* treatment for postural and movement disorders in the previous year.","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to investigate the short-term modifications in head and neck positioning by usage of low-powered prismatic lenses in patients with Postural Deficiency Syndrome (PDS). A matched pair observation study was designed. Evaluation is carried out using low dose biplanar radiography before treatment and 15 minutes after lenses application.",[26,27,28],"Postural Neck Pain","Postural Imbalance","Postural Disorders","RECRUITING","2026-04-13",{"date":32,"type":33},"2026-04-16","ACTUAL",{"date":35,"type":33},"2023-03-27",{"date":37,"type":20},"2026-05-31",{"name":39,"class":40},"Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa","NETWORK",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},"100632214","up-study---decipher-persistent-critical-illness-through-in-deep-clinical-phenotyping-100632214","NCT07510776","UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.","UPSt_UCI","Inclusion Criteria:\n\n* Adult patients aged 18 years or older;\n* ICU length of stay equal to or greater than 5 days.\n\nExclusion Criteria:\n\n* Patients with an ICU stay \\\u003C 5 days;\n* Patients discharged from the ICU early due to lack of ward availability, rather than clinical recovery;\n* Patients who do not survive the early phase of critical illness (i.e., early ICU deaths).",{"count":50,"type":20},7000,"OBSERVATIONAL","Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients. A recent Portuguese study found that more than 14% of ICU patients stayed longer than 14 days. PCI is often associated with ongoing need for life support, such as mechanical ventilation or medications to maintain blood pressure. However, patients may also experience severe muscle weakness, repeated infections, or other complications, which makes this group very diverse.\n\nOne of the main risk factors for prolonged ICU stay is sepsis, a severe infection that affects the whole body. Other factors-such as prior health conditions, use of corticosteroids, sedation practices, early versus late mobilization, fluid and antibiotic management, and delirium treatment-may also influence the development and course of PCI.\n\nThis study aims to identify different clinical patterns (\"clusters\") among critically ill patients who remain in the ICU for more than 10 days. Patients will be followed until hospital discharge, and up to one year if data are available. Understanding these different patterns will help develop more personalized and effective care strategies for each patient profile.\n\nThe study is a multicenter retrospective cohort including adult patients (≥18 years) admitted to participating ICUs for more than 5 days between 2021 and 2023. Data collected will include demographic, clinical, and laboratory information, details of organ support (such as mechanical ventilation or vasopressors), medications, nutrition, and rehabilitation practices.\n\nStatistical and machine learning methods will be used to identify groups of patients with similar clinical trajectories and to assess how these groups are related to outcomes such as survival, recovery of organ function, or long-term disability.\n\nExpected results are the identification of distinct clinical clusters of PCI that combine clinical and laboratory data, and the development of tailored management strategies to improve recovery and outcomes for patients with PCI.",[54,55,56,57,58],"Critical Illness","Recovery Outcomes","Critical Care, Intensive Care","Critical Care","Critical Care Medicine",[60,61,54],"Persistant Critical Illness","Critical care","2026-04-08",{"date":30,"type":33},{"date":65,"type":33},"2025-01-13",{"date":67,"type":20},"2027-12-31",{"name":39,"class":40},7,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},"100624885","cardiac-remodelling-following-endovascular-repair-of-the-aorta-100624885","NCT07415447","Cardiac Remodelling Following Endovascular Repair of the Aorta","EVACaRe","Inclusion Criteria:\n\n\\- Patients over 18-year-old, with degenerative arch, descending thoracic or abdominal aortic aneurysms, penetrating aortic ulcers or intramural hematomas managed with total EVAR in elective setting.\n\nExclusion Criteria:\n\n* Heart failure with an ejection fraction \\\u003C35 vs 50% or New York Heart Association (NYHA) class III and IV.\n* LV wall motion abnormality.\n* Moderate to severe valve disease.\n* History of (or expected within the study period) cardiac\u002Faortic surgery.\n* Coronary artery disease.\n* Atrial fibrillation.\n* Congenital heart disease.\n* Connective tissue disorders.\n* Chronic kidney disease (eGFR \\\u003C30 mL\u002Fmin\u002F173 m2).\n* Moderate to severe pulmonary disease as indicate either by post bronchodilator FEV1 (%predicted) \\\u003C50% or Modified Medical Research Council Dyspnoea Scale (mMRC) 3-4.\n* CMR contraindications (non-compatible pacemakers and metal implants, and claustrophobia).",{"count":78,"type":20},40,"To assess the effects of endovascular aortic repair on cardiac morphology and function",[81,82],"Cardiac Failure","Aortic Disease",[84,85,86,87],"cardiac","failure","aortic","disease","2026-02-12",{"date":90,"type":33},"2026-02-17",{"date":92,"type":33},"2025-09-01",{"date":94,"type":20},"2027-09-01",{"name":39,"class":40},2,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":96},"100574402","the-triad-of-nutrition-intestinal-microbiota-and-rheumatoid-arthritis-tasty-100574402","NCT06758817","The Triad of Nutrition, Intestinal Microbiota and Rheumatoid Arthritis (TASTY)","TASTY","Inclusion Criteria:\n\n* RA patients (ACR\u002FEULAR2010 criteria)\n* Age \\>18-years\n* Disease duration \\>1-year\n* Active disease (DAS28 \\> 2.6units)\n* On stable medication for 12 weeks\n* Low\u002Fmedium MedDiet adherence (PREDIMED\\\u003C10)\n* Willing to comply with study protocol\n\nExclusion Criteria:\n\n* Prednisolone dose ≥ 7.5 mg\u002Fday\n* Antibiotic therapy 4-weeks prior to baseline\n* Persistent use of NSAID's\n* Inflammatory or irritable bowel disease\n* Celiac disease\n* Chronic diarrhea\n* Diabetes\n* Other immune-mediated inflammatory diseases besides RA\n* Major organ dysfunction\n* Cancer diagnosed in the last five years\n* Health conditions which may difficult participation (cognitive impairment\u002Fpsychiatric disease)\n* Pregnant or lactating individuals",true,{"count":106,"type":20},100,[23],"The main goal of this trial is to investigate whether a dietary intervention based on a typical Mediterranean Diet enriched with fermented foods (MedDiet+) can impact gut microbiota and RA-related outcomes.",[110],"Diet Interventions",[110,112],"rheumatoid arthritis","2024-12-27",{"date":115,"type":33},"2025-01-06",{"date":117,"type":33},"2023-01-02",{"date":119,"type":20},"2025-12-31",{"name":39,"class":40},""]