[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Liverpool Heart and Chest Hospital NHS Foundation Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":105},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100637045","dynamic-voltage-mapping-to-personalise-the-ventricular-tachycardia-substrate-100637045",false,"NCT07573579","Dynamic Voltage Mapping to Personalise the Ventricular Tachycardia Substrate","DYNAMITE-VT","Inclusion Criteria:\n\n* Scheduled for clinically indicated VT ablation (due to sustained VT episodes or ICD therapies).\n* Willing and able to give informed consent for participation in the trial\n* Male or female aged between 18-85\n* Ischaemic and non-ischaemic cardiomyopathy\n* ICD insitu\n\nExclusion Criteria:\n\n* Unable or unwilling to consent\n* NYHA Class IV (end stage heart failure)\n* Metastatic cancer\n* End stage renal disease\n* Pregnant or breast feeding\n* Severe frailty","ALL","18 Years","85 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder and one of the commonest causes of heart-related sudden death. It often affects people who have had a heart attack or other structural heart damage. VT occurs when abnormal electrical circuits develop within and around scar tissue in the heart.\n\nPeople at risk are usually offered an implantable cardiac defibrillator (ICD), a device that can detect VT and deliver a lifesaving shock. While effective, these shocks can be sudden, painful and distressing. Medications such as amiodarone can also help, but they are often unsuitable for long-term use due to their potential side effects on the liver, lungs and thyroid gland.\n\nAn alternative is catheter ablation. Thin tubes (catheters) are threaded from a blood vessel in the groin to the heart, allowing the cardiologist to identify scar tissue and abnormal electrical circuits, which can be destroyed using heat, freezing or electrical energy.\n\nAlthough ablation can help many patients, VT can return in up to one in three people after the procedure. This is because it can be difficult to precisely identify the scar and surrounding tissue that sustain the abnormal circuits, making it challenging to know exactly where to apply ablation treatment.\n\nDynamic Voltage Mapping, is a technique which the investigators believe can more accurately identify scar and the critical bordering tissue during ablation. Initial data collected suggests that the approach accurately predicts the VT circuit and helps guide ablation.\n\nIn this study, the investigators wish to recruit 40 participants undergoing VT ablation to determine how effective Dynamic Voltage Mapping is in real-world procedures.",[27],"Ventricular Tachycardia (VT)",[29,30,31],"Catheter Ablation","Electroanatomical Mapping","Ventricular Tachycardia","NOT_YET_RECRUITING","2026-04-30",{"date":35,"type":36},"2026-05-07","ACTUAL",{"date":38,"type":21},"2026-08-03",{"date":40,"type":21},"2029-08-01",{"name":42,"class":43},"Liverpool Heart and Chest Hospital NHS Foundation Trust","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100612461","a-study-to-understand-the-accuracy-of-a-new-breathing-device-compared-to-standard-testing-for-asthma-and-copd-100612461","NCT07253883","A Study to Understand the Accuracy of a New Breathing Device Compared to Standard Testing for Asthma and COPD","A Diagnostic Accuracy Study: N-Tidal Assessment for Respiratory Diagnosis Compared to Using Standard Testing","STARDUST","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Referred for respiratory diagnostic testing with a clinical suspicion of asthma or COPD\n* Participant is willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Referred for respiratory diagnostic testing for a condition other than asthma or COPD, with no mention in the referral of a clinical suspicion of COPD or asthma\n* Participants who, in the opinion of the chief investigator, or their delegate, are unlikely to comply with the requirements of the study\n* Inability to give written informed consent\n* Participants who are acutely unwell\n* Patients unable to breathe through their mouths e.g. tracheostomy patients","110 Years",{"count":55,"type":21},1200,"OBSERVATIONAL","The diagnosis of either asthma or chronic obstructive pulmonary disease (COPD) is currently based on a combination of symptoms, different lung tests and sometimes a 'trial by treatment'. Both COPD and Asthma tests currently include forced breathing using a test known as spirometry which can be difficult and uncomfortable for people to perform and needs expert interpretation. Asthma can require multiple tests in sequence which can make the process of diagnosis long and inconvenient for patients. In the UK, there have been challenges providing enough testing for COPD and asthma, in part because the tests are challenging to provide in the community to everyone who needs one.\n\nThe STARDUST study aims to test and develop new ways of diagnosing asthma and COPD that are quick, accurate and easy for patient and healthcare professionals to perform. People who have been referred for routine lung testing will breathe normally in and out into a handheld device called the N-Tidal Handset for 75 seconds. This device measures how the level of carbon dioxide (CO2) changes in the breath as people breath through it. The information gathered on the N-Tidal Handsets, called breath records or capnograms, will not be used to alter the diagnosis of any participants in the study.\n\nAfter the capnograms have been collected, the research team will test 'algorithms' that have been developed using artificial intelligence, to see if they can accurately identify the correct diagnosis. Information collected in the study will also be used to make improvements in these algorithms.\n\nIf confirmed to be accurate, these algorithms could be used in clinical practice to help healthcare professionals make faster, more accessible and accurate diagnoses, especially in settings like GP clinics in the community where access to specialist tests may be limited.",[59,60],"Asthma (Diagnosis)","COPD (Chronic Obstructive Pulmonary Disease)",[62,63,64,65,66],"Asthma","COPD","End tidal CO2","Diagnostics","Machine learning","2026-04-21",{"date":69,"type":36},"2026-04-24",{"date":71,"type":21},"2026-04-01",{"date":73,"type":21},"2027-05-19",{"name":42,"class":43},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":91,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":44},"100583381","the-radiation-protection-for-dose-reduction-in-the-cardiac-catheter-lab-study-the-reduce-trial-100583381","NCT06875583","The Radiation ProtEction for Dose RedUction in the Cardiac CathEter Lab Study: The REDUCE Trial","REDUCE","Inclusion Criteria:\n\n* All procedures involving adult patients (\\>18 year of age)\n* Male or female patients\n* Planned to undergo either an elective or urgent coronary intervention procedure involving ionising radiation in the cardiac catheter lab, via the right and or left radial arteries.\n\nExclusion Criteria:\n\n* Procedures involving patients less than 18 years of age\n* Patients unable to give valid consent\n* Pregnancy\n* Femoral approach procedure",{"count":83,"type":21},100,[24],"Doctors and nurses who perform heart procedures using X-ray guidance are exposed to radiation, which can be harmful over time. This exposure increases the risk of certain health problems, including cancers, eye damage (cataracts), and DNA damage. Although protective lead clothing is used to reduce exposure, it is heavy, uncomfortable, and can cause muscle and joint problems for those who wear it daily.\n\nA new radiation protection device, called RAMPART, may help reduce radiation exposure for heart specialists and their teams. It could also allow them to wear lighter protective gear-or none at all-making their work safer and more comfortable.\n\nThis study will compare the radiation levels received by doctors and nurses during heart procedures when using RAMPART versus standard protection. By doing so, we hope to find out if this new device can better protect medical teams from radiation, improving both their safety and well-being.",[87,88,89,90],"Radiation Exposure","Radiation Exposure to Operator","Radiation Injuries","Radiation Safety",[92,93,94,95],"radiation exposure","radiation exposure to operator","radiation injuries","radiation safety","RECRUITING","2025-11-19",{"date":99,"type":36},"2025-11-24",{"date":101,"type":36},"2025-08-29",{"date":103,"type":21},"2026-03-01",{"name":42,"class":43},""]