[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Lucie Bréchet\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100493657","improvement-of-memory-in-mild-cognitive-impairment-100493657",false,"NCT05708001","Improvement of Memory in Mild Cognitive Impairment","Improvement of Memory in Mild Cognitive Impairment (MCI) Using Transcranial Alternating Current Stimulation (tACS) Guided by EEG and MRI: a Randomized, Sham-controlled, Parallel-arm, Double-blind Study","Inclusion Criteria:\n\nMild Cognitive Impairment (MCI) patients\n\n* age ≥ 55 years old\n* clinical diagnosis of mild cognitive impairment (MCI) based on a comprehensive clinical assessment and standard neuropsychological examination including tests of language, visuospatial thinking, executive functions, and memory\n* confirmation of diagnosis will be made by Prof. Paul Unschuld, the study MD, based on a participant's cognitive evaluation and history\n* understanding of the informed consent\n* able and willing to comply with all study requirements\n* informed consent form was signed\n* women of childbearing potential (WOCBP) must perform a pregnancy test during screening\n\nCaregiver\n\n* minimum 21 years of age\n* self-reported computer\u002Ftablet proficiency\n* willingness to learn how to use tACS\n* availability during the study period to administer tACS to the participant\n* informed consent form was signed\n* women of childbearing potential (WOCBP) must perform a pregnancy test during screening\n\nExclusion Criteria:\n\nMild Cognitive Impairment (MCI) patients\n\n* age \\\u003C 55 years old\n* any current diagnosis of a psychiatric disorder (e.g., schizophrenia, bipolar disorder, depressive disorder)\n* other than MCI, any history of other progressive or genetic neurologic disorder (e.g., Parkinson's disease, multiple sclerosis, tubular sclerosis) or acquired neurological disease (e.g., stroke, traumatic brain injury, tumor), including intracranial lesions\n* history of head trauma resulting in prolonged loss of consciousness\n* current history of poorly controlled headaches including chronic medication for migraine prevention\n* history of fainting spells of unknown or undetermined etiology that might constitute seizures\n* history of seizures, diagnosis of epilepsy\n* any unstable medical condition or chronic uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)\n* contraindication for undergoing MRI or receiving tACS\n* any metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g., MRI compatible joint replacement)\n* any skin problems, such as dermatitis, psoriasis, or eczema\n* any electrically, magnetically, or mechanically activated implanted devices such as a pacemaker, intracranial electrodes, implanted defibrillators, medication pumps, nerve stimulators, vascular clips, or any other prosthesis in the brain\n* any serious life-threatening disease such as congestive heart failure, pulmonary obstructive chronic disease, or active neoplasia\n* pregnant women\n* adults lacking capacity for consent\n\nCaregiver\n\n* insufficient understanding of study procedures\n* poor eyesight, severe arthritis in the hands, pain, deformity or other condition that interferes with successful administration of tACS",true,"ALL","55 Years","85 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","The Clinical Trial will systematically examine the feasibility of remote, caregiver-led tACS for older adults with memory deficits and evaluate whether repeated tACS leads to sustained improvement of neuronal activity and memory functions.",[28],"Mild Cognitive Impairment",[30,31,32,33],"autobiographical memory (ABM)","memory and cognition","transcranial alternating current stimulation (tACS)","high-density electroencephalography (hdEEG)","RECRUITING","2025-07-09",{"date":37,"type":38},"2025-07-15","ACTUAL",{"date":40,"type":38},"2023-02-01",{"date":42,"type":22},"2027-12-01",{"name":44,"class":45},"Lucie Bréchet","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":19,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":46},"100493852","understanding-brain-mechanisms-involved-in-autobiographical-memory-100493852","NCT05710549","Understanding Brain Mechanisms Involved in Autobiographical Memory","Understanding Brain Mechanisms Involved in Autobiographical Memory Using High-density Electroencephalography and Transcranial Alternating Current Stimulation","Inclusion Criteria:\n\nCognitively-Unimpaired Younger and Older Adults\n\n* Age 18 to 35 years old (younger adults)\n* Age 55+ years old (older adults)\n* without any cognitive impairment (based on the Montreal Cognitive Assessment: MoCA)\n* willing and capable to give informed consent for participation in the study after it has been thoroughly explained able\n* willing to comply with all study requirements informed consent form was signed\n\nMild Cognitive Impairment (MCI) patients\n\n* Age 55+ years old\n* Clinical Diagnosis of MCI\n* Confirmation of diagnosis will be made by the study MD based on a holistic consideration of the participant's cognitive evaluation and history\n* Mini-Mental State Examination (MMSE) ≥ 18 (Mild AD ≥ 21)\n* CDR ≥ .5\n* Demonstration or history of autobiographical memory impairments\n* On a stable dose of medications for memory loss including cholinesterase inhibitors (e.g. donepezil, rivastigmine) or memantine as defined as 6 consecutive weeks of treatment at an unchanging dose\n* Minimum of completed 8th-grade education\n* willing and capable to give informed consent for participation in the study after it has been thoroughly explained - note that to ensure this in the case of the MCI participants, a cut-off of MOCA score \\>18 will be applied\n* able and willing to comply with all study requirements informed consent form was signed\n\nExclusion Criteria:\n\nCognitively-Unimpaired Younger and Older Adults\n\n* any cognitive impairment captured by the Montreal Cognitive Assessment (MoCA) - score \\\u003C 26\n* major psychiatric co-morbidity including major depressive disorder, schizophrenia, or psychosis\n* blindness or other disabilities that prevent task performance\n* Contraindication for undergoing MRI\n* Any metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g. MRI compatible joint replacement)\n\nMild Cognitive Impairment (MCI) patients\n\n* Age \\\u003C 55 years old\n* Any current diagnosis of a major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depressive disorder)\n* Other than MCI, any history of other progressive or genetic neurologic disorder (e.g. Parkinson's disease, multiple sclerosis, tubular sclerosis) or acquired neurological disease (e.g. stroke, traumatic brain injury, tumor), including intracranial lesions\n* History of head trauma resulting in prolonged loss of consciousness\n* Current history of poorly controlled headaches including chronic medication for migraine prevention\n* History of fainting spells of unknown or undetermined etiology that might constitute seizures\n* History of seizures, diagnosis of epilepsy, or immediate (1st-degree relative) family history of epilepsy with the exception of a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist\n* Any unstable medical condition or chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.) or study complication\n* contraindications to tACS, as recorded on a standardized screening questionnaire, which include a reported seizure within the past two years, use of neuroactive drugs, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, pacemaker, etc.), or the presence of any active dermatological condition, such as eczema, on the scalp\n* Contraindication for undergoing MRI or receiving tACS\n* Any metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g. MRI compatible joint replacement)\n* Any devices such as a pacemaker, medication pump, nerve stimulator, TENS unit, ventriculoperitoneal shunt unless cleared by the responsible covering MD","18 Years",{"count":56,"type":22},120,[25],"The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.",[28,60,61],"Alzheimer Disease","Memory Loss",[30,63,64,65,32],"high-density electroencephalography (EEG)","magnetic resonance imaging (MRI)","non-invasive brain stimulation (NIBS)",{"date":37,"type":38},{"date":68,"type":38},"2022-04-25",{"date":70,"type":22},"2027-08-01",{"name":44,"class":45},""]