[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"MGH Institute of Health Professions\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":280},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,50,72,101,125,150,178,199,222,248],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100619777","fall-risk-intervention-for-stroke-100619777",false,"NCT07349030","Fall Risk Intervention for Stroke","Data-driven Intervention to Reduce Pre-discharge Fall Risk After Stroke","FRISKI","Inclusion Criteria:\n\n* Inpatient rehabilitation admission for diagnosis of stroke\n* Test positive for fall risk at admission (step-test and obstacle-test, \"STOB\", \\>\u002F= 3 out of 8 and\u002For Berg Balance Scale \\\u003C\u002F=43)\n* No pre-stroke history of falls\n* Community dwelling and independent in basic and instrumental activities of daily living prior to stroke\n* Able to follow 1-step verbal command and demonstrate comprehension and decision-making capacity to consent to study participation\n* Able to stand upright for 10 seconds with assistance of no more than one person\n\nExclusion Criteria:\n\n* Brain hemorrhage due to trauma\n* Prior stroke with residual physical or cognitive impairment\n* Use of assistive device for ambulation prior to stroke\n* Diagnosed with dementia\n* Receptive or global aphasia\n* Receiving chemotherapy in last 6 months or any cancer diagnosis with brain metastases","ALL","45 Years","85 Years",{"count":21,"type":22},134,"ESTIMATED","INTERVENTIONAL",[25],"NA","After stroke, falling is a common problem. Falls can lead to injury, as well as fear of future falls. It is important to try to prevent falls from happening after stroke. To goal of this study is to test a new treatment to try to prevent falls after stroke. The people in the study will be patients who are in the hospital receiving care after a stroke. While they are in the hospital, the investigators will provide extra treatment that focuses on helping them not to fall. The investigators will also teach the patients to understand risks for falls and how to avoid them. When they leave the hospital, participants will be sent a text message every day to ask if they have had any falls. The goal is to see if patients who received the extra therapy have fewer falls than patients who did not receive the therapy and education to help avoid falls. If the extra treatment in the hospital can help stop people from falling after they leave the hospital, this will have a positive impact on their lives. By not falling, they will avoid the risk of injury and having to go back to the hospital. This project will help the investigators know how to help people with stroke live longer, healthier lives.",[28],"Stroke",[30,31,32,33,34,35,36],"falls","mobility","rehabilitation","physical therapy","physiotherapy","occupational therapy","speech language therapy","RECRUITING","2026-06-01",{"date":40,"type":41},"2026-06-03","ACTUAL",{"date":43,"type":41},"2026-04-09",{"date":45,"type":22},"2027-12-31",{"name":47,"class":48},"MGH Institute of Health Professions","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":49},"100491400","optimizing-feedback-based-learning-in-children-with-developmental-language-disorder-100491400","NCT05678634","Optimizing Feedback-based Learning in Children With Developmental Language Disorder","Inclusion Criteria:\n\n* English as the primary language Nonverbal intelligence quotient (IQ) score on the Wechsler Intelligence Scale for Children-5th Edition (WISC-V) Standard Score \\>70 Identification Core score on the Test of Integrated Language \\& Literacy Skills (TILLS) equal to or less than 34\n\nExclusion Criteria:\n\n* Hearing loss or other known neurological deficits, or diagnoses (e.g., Autism, Traumatic Brain Injury)\n* Evidence of color blindness as measured by the EnChroma computer base color blindness screening test for children","8 Years","12 Years",{"count":59,"type":22},100,[25],"This project aims to optimize a critical but understudied ingredient of language intervention provided to children with developmental language disorder (DLD) - feedback. The project will bridge a gap between previous findings in our lab of inefficient feedback processing in DLD and clinical practice by identifying the conditions under which feedback-based learning can be improved in DLD. The investigators hypothesize that the effectiveness of feedback can be significantly enhanced for children with DLD when it is tailored to their unique learning strengths. The rationale for this project is based on evidence that feedback-based learning can be improved by enhancing the dominance of an intact learning system. The project will achieve its aim by manipulating (1) the timing of the feedback (immediate vs. delayed) and (2) the level of the learner's involvement in error correction dictated by feedback (active vs. passive correction). Aim 1 will determine the effect of manipulating feedback timing on learning in 140 school-age children (8-12 years) with DLD. While immediate feedback is processed by the striatum, which is also implicated in implicit learning, delaying the feedback by a few seconds shifts feedback processing to the mediate temporal lobe (MTL)-based declarative learning system. Evidence that delaying feedback improves learning in DLD would support the hypothesis of the implicit deficit theory that intervention should capitalize on declarative learning mechanisms. The project will test a novel alternative feedback-learning parity hypothesis whereby feedback-based learning is optimized when the timing of the feedback is aligned with the dominant learning system at a given time (i.e., immediate feedback during striatal-based probabilistic learning; delayed feedback during MTL-based declarative learning). Within the same group of children, Aim 2 will compare feedback-based learning in children with DLD when feedback (a) prompts active self-correction or (b) passively exposes learners to error corrections (corrective recast). Children will engage in two nonword-object paired-associate learning tasks. In one task, feedback will promote active self-correction, which is in line with declarative learning. In the other task, feedback will passively expose the learner to corrective feedback in a manner consistent with teaching approaches aiming at reducing awareness of errors. The project will determine whether children with DLD learn better when feedback prompts self-correction or when they are exposed to passive corrections. Electrophysiological measures will indicate whether passive corrections (corrective recast) are processed as negative feedback by children with DLD. For both aims, behavioral indicators of response to feedback will be complemented by electrophysiological measures of feedback processing that can determine the involvement of the striatum and MTL brain systems during the learning process. This work is scientifically and clinically significant because elucidating what manipulations optimize feedback-based learning will enhance our understanding of the impaired learning mechanism in DLD and will provide clinical guidance on what type of feedback to use during an intervention.",[63],"Developmental Language Disorder","2026-05-27",{"date":66,"type":41},"2026-05-29",{"date":68,"type":41},"2023-07-20",{"date":70,"type":22},"2027-10-01",{"name":47,"class":48},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":49},"100444342","speech-treatment-for-minimally-verbal-children-with-asd-and-cas-100444342","NCT05066178","Speech Treatment for Minimally Verbal Children With ASD and CAS","TxMVASD+CAS","Inclusion Criteria:\n\n* Meets criteria for Autism Spectrum Disorder\n* Able to correctly repeat at least 2 syllables\n* Meets criteria for Childhood Apraxia of Speech\n* Lives in an environment where child is exposed to English at least 50% of the time\n\nExclusion Criteria:\n\n* Poorly controlled seizures\n* Factors such as blindness or deafness that contribute to minimally verbal status\n* Lives in an environment where English is not spoken at least 50% of the time\n* Child experiences behavioral challenges that preclude participation in the study","5 Years","18 Years",{"count":82,"type":22},20,[25],"Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech.",[86,87],"Developmental Verbal Dyspraxia","Autism Spectrum Disorder",[89,90,91,92],"childhood apraxia of speech","autism","motor speech disorder","speech development","2026-03-25",{"date":95,"type":41},"2026-03-30",{"date":97,"type":41},"2024-05-01",{"date":99,"type":22},"2030-11-30",{"name":47,"class":48},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":23,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":49},"100630544","optimizing-functional-recovery-after-breast-cancer-treatment-100630544","NCT07489053","Optimizing Functional Recovery After Breast Cancer Treatment","Optimization of a Multicomponent Intervention to Foster Functional Recovery After Breast Cancer Treatment","Inclusion Criteria:\n\n1. Age of 18 years or older,\n2. Diagnosed with Stage 1-3 breast cancer and within one year of completion of locoregional treatment and\u002For adjuvant therapy with curative intent and absence of disease recurrence,\n3. Experiencing reduced participation (i.e., a score of \\> 10 on the Work and Social Adjustment Scale).\n\nExclusion Criteria:\n\n1. Non-English speaking.\n2. Non-correctable hearing loss.\n3. Moderate-severe cognitive impairment indicated by a score \\\u003C 3 on a 6-item cognitive screener.\n4. History of severe mental illness (i.e., schizophrenia, bipolar disorder), current major depressive disorder, active suicidal ideation, or active substance misuse documented within the medical record.",{"count":109,"type":22},352,[25],"The goal of this clinical trial is to determine the best way to promote participation in vocational, social, physical, and instrumental activities of daily living in people who have completed treatment for early stage breast cancer.\n\nThe main question it aims to answer is: Which of the intervention components, alone or in combination, most effectively promote participation in vocational, social, physical, and instrumental activities of daily living?\n\nParticipants will be asked to try one of 8 combination of three intervention components that have been shown to promote activity participation: (1) priority elicitation, (2) education, and (3) guided application involving goal setting, problem-solving and action planning.",[113],"Breast Neoplasms",[115,116,32],"randomized controlled trial","factorial experiment","NOT_YET_RECRUITING","2026-03-21",{"date":93,"type":41},{"date":121,"type":22},"2027-01-01",{"date":123,"type":22},"2030-09-30",{"name":47,"class":48},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":137,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":49},"100526591","phase-4-dalfampridine-combined-with-physical-therapy-for-mobility-impairment-in-multiple-sclerosis-100526591","NCT06136728","Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis","Dalfampridine Combined With Physical Therapy for Mobility Impairment in People With Multiple Sclerosis","AmpPT","Inclusion Criteria:\n\n* Confirmed diagnosis of MS\n* Expanded Disability Status Scale (EDSS) 6.5 or less\n* Timed 25-Foot Walk 6-45 seconds (average of 2 trials)\n* Able to stand unsupported for at least 10 seconds\n* Montreal Cognitive Assessment 23 or higher\n* Relapse free for at least 3 months\n* Not currently taking dalfampridine or not previously taken and discontinued due to adverse reactions\n* Not currently receiving physical therapy\n\nExclusion Criteria:\n\n* Co-existing neurological disorders or orthopedic conditions affecting mobility and physical activity\n* Unable to follow a 3-step verbal command in English\n* Hospitalization for any reason in the last 3 months\n* Uncontrolled hypertension or diabetes\n* History of seizures\n* Renal impairment\n* Women who are breastfeeding, pregnant, or trying to become pregnant\n* Contraindications to magnetic resonance imaging (MRI; to be excluded from MRI procedures but may participate if all other criteria are met)","25 Years","75 Years",{"count":136,"type":22},48,[138],"PHASE4","The goal of this clinical trial is to evaluate if combining a medication that can help improve walking in people with multiple sclerosis (MS) with a physical therapy program is better for improving walking than either treatment alone. The main questions this study will answer are:\n\n* Does combining dalfampridine with physical therapy improve mobility more than physical therapy without concurrent dalfampridine?\n* Is the combined treatment associated with better outcomes than the medication (dalfampridine) on its own?\n* How do the individual treatments (dalfampridine, physical therapy) alone compare to each other?\n\nParticipants with MS-related mobility deficits will:\n\n* Receive 6 weeks of dalfampridine treatment to assess the effects of this treatment.\n* After stopping the medication for 2 weeks, the investigators will re-evaluate walking, then randomly assign individuals to a 6-week physical therapy program.\n* Half of the participants will receive physical therapy while resuming dalfampridine treatment. The other half of the participants will receive physical therapy without resuming the medication.\n\nResearchers will compare the combination treatment group (medication plus physical therapy) to the physical therapy only group to see if the combined treatment improves walking-related function. Approximately 3 months after finishing the physical therapy program, participants will undergo a final evaluation to see if the treatment effects have been maintained.",[141],"Multiple Sclerosis","2026-02-25",{"date":144,"type":41},"2026-02-27",{"date":146,"type":41},"2024-06-12",{"date":148,"type":22},"2026-12",{"name":47,"class":48},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":157,"sex":17,"minAge":158,"maxAge":19,"enrollmentInfo":159,"targetDuration":4,"studyType":23,"phases":161,"briefSummary":162,"conditions":163,"keywords":166,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":49},"100446615","effects-of-neuromodulation-in-laryngeal-dystonia-100446615","NCT05095740","Effects of Neuromodulation in Laryngeal Dystonia","The Effects of Neuromodulation on Phonatory Function in Laryngeal Dystonia","Inclusion Criteria:\n\n* Age range is 21-85 years\n* Diagnosis of Laryngeal Dystonia (LD)\n* Subject is able to give informed consent\n* Symptoms at worst severity if receiving botulinum toxin injections\n* Subject has signed the consent form\n\nExclusion Criteria:\n\n* Other forms of dystonia\n* Vocal fold pathology or paralysis\n* Essential tremor\n* Laryngeal cancer or other neurologic conditions with medications affecting the central nervous system\n* History of laryngeal surgery\n* Adults lacking the ability to consent or complete the assessments and intervention\n* Seizure in the last 2 years\n* Contraindications to rTMS",true,"21 Years",{"count":160,"type":22},25,[25],"Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life. Individuals with LD often experience episodic breathy voice, decreased ability to sustain vocal fold vibration, frequent pitch breaks and in some cases, vocal tremor. While neuroimaging investigations have uncovered both cortical organization and regional connectivity differences in structures in parietal, primary somatosensory and premotor cortices of those with LD, there remains a lack of understanding regarding how the brains of those with LD function to produce phonation and how these might differ from those without LD. Intervention options for people with LD are limited to general voice therapy techniques and Botulinum Toxin (Botox) injections to the posterior cricoarytenoid (PCA) and\u002For TA (thyroarytenoid) often bilaterally, to alleviate muscle spasms in the vocal folds. However, the effects of injections are short-lived, uncomfortable, and variable. To address this gap, the aim of this study is to investigate the effectiveness of repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, in assessing cortical excitability and inhibition of laryngeal musculature. Previous work conducted by the investigator has demonstrated decreased intracortical inhibition in those with adductor laryngeal dystonia (AdLD) compared to healthy controls. The investigators anticipate similar findings in individuals with with other forms of LD, where decreased cortical inhibition will likely be noted in the laryngeal motor cortex. Further, following low frequency (inhibitory) rTMS to the laryngeal motor brain area, it is anticipated that there will be a decrease in overactivation of the TA muscle. To test this hypothesis, a proof-of-concept, randomized study to down-regulate cortical motor signal to laryngeal muscles will be compared to those receiving an equal dose of sham rTMS. Previous research conducted by the investigator found that a single session of the proposed therapy produced positive phonatory changes in individuals with AdLD and justifies exploration in LD.",[164,165],"Laryngeal Dystonia","Focal Dystonia",[167,168,169],"transcranial magnetic stimulation","randomized control trial","rTMS","2026-02-19",{"date":172,"type":41},"2026-02-20",{"date":174,"type":41},"2021-06-10",{"date":176,"type":22},"2026-12-31",{"name":47,"class":48},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":157,"sex":17,"minAge":56,"maxAge":185,"enrollmentInfo":186,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":49},"100583776","training-inner-speech-in-children-with-developmental-language-disorder-100583776","NCT06880731","Training Inner Speech in Children With Developmental Language Disorder","Training Verbal Mediation to Support Executive Function in Children With Developmental Language Disorder","Inclusion criteria (children with developmental language disorder; DLD):\n\n* Age 8;0-9;11 years English as the primary language\n* Pass hearing screen bilaterally (20 dB HL, at 1K, 2K, \\& 4K)\n* TILLS Identification Core Score \\\u003C 34\n\nInclusion criteria (children with typical development; TD):\n\n* Age 8;0-9;11 years English as the primary language\n* Pass hearing screen bilaterally (20 dB HL, at 1K, 2K, \\& 4K)\n* TILLS Identification Core Score \\> or = 34\n\nExclusion criteria (DLD \\& TD groups):\n\n* KBIT-2 Fluid Subtest Standard Score \\\u003C 70\n* ADHD, Autism, TBI, or other neurological deficits or disorders","10 Years",{"count":187,"type":22},75,[25],"The complex and unclear relationship between language and executive function (EF) creates barriers to developing effective interventions for children with developmental language disorder (DLD) whose language difficulties often co-occur with impaired EF. Children and adults with typical language development (TD) facilitate their EF by using self-directed language, or verbal mediation, to guide conscious reflection and override habitual behaviors. Conversely, children with DLD do not use verbal mediation to support EF efficiently or effectively. Promising evidence suggests that language-based training can shape verbal mediation and improve EF task performance in children with TD, which makes it pertinent to determine whether verbal mediation training benefits children with DLD. Specifically, modeling interventions have been shown to promote learning of language forms without taxing the cognitive resources required for learning such as attention or working memory, which are known to be impaired among children with DLD. The long-term goal of the proposed work is to optimize intervention outcomes for children with DLD by elucidating the complex relationship between language and executive functions. The objective of this project is to determine the impact of modeling verbal mediation on shifting task performance in school-aged children with DLD. Shifting, also known as cognitive flexibility, is the ability to alternate between operations or mental sets. It is an important EF because it is the pivot point between multiple goal-directed tasks when language use is critical for guiding action. Children aged 8-10 years will complete three versions of a shifting task over three phases: pre-intervention, intervention, and post-intervention. During the intervention phase, half of the participants with DLD will be exposed to a task model with verbal mediation (training), while the other half will be exposed to a silent task model (control). The investigators will determine the effect of modeling verbal mediation on the subsequent use of verbal mediation (Aim 1) and behavioral and electrophysiological measures of shifting ability (Aim 2). Indirect measures of shifting (i.e., accuracy and reaction time) will be supplemented with an electrophysiological marker of shifting that reflects real-time cue processing. This combination of methods provides insight to changes in processing following intervention that may precede and predict subsequent changes in behaviors. Our central hypothesis is that modeling verbal mediation will facilitate more effective use of verbal mediation and improve shift cue processing in children with DLD. The project will provide a theoretical framework for the role of language in shaping goal-directed behavior and the first examination of electrophysiological change in shifting following a verbal mediation intervention. Results will have a significant impact on clinical practice by advancing knowledge about a promising language-based intervention to support EF and other goal-directed tasks.",[63],"2025-12-12",{"date":193,"type":41},"2025-12-15",{"date":195,"type":41},"2025-11-21",{"date":197,"type":22},"2028-03",{"name":47,"class":48},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":211,"conditions":212,"keywords":214,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":221,"locationsCount":49},"100554079","employment-support-after-hematopoietic-stem-cell-transplantation-100554079","NCT06494423","Employment Support After Hematopoietic Stem Cell Transplantation","Supportive Care Intervention Development to Address Employment Concerns After Allogeneic Hematopoietic Stem Cell Transplantation","WorkS","Inclusion Criteria:\n\n* Received an allogeneic HSCT within the past six months to treat a hematological malignancy.\n* Screen positive for work-related concerns (i.e., responds \"yes\" to the question, \"Are you concerned about your ability to return to work in the coming six months?\")\n\nExclusion Criteria:\n\n* Patients with acute psychiatric or cognitive conditions which the treating clinician believes prohibits informed consent or compliance with the study procedures\n* We will not enroll the following special populations: adults unable to consent, individuals not yet adults, pregnant women, and prisoners.","70 Years",{"count":209,"type":22},35,[25],"This is a feasibility study of a Work Support (WorkS) intervention designed to ameliorate employment challenges for people preparing to return to work after allogeneic stem cell transplantation. The aim of this study is to evaluate \"proof of concept\" by:\n\n1. examining the feasibility and acceptability of the WorkS intervention and the study procedures, and\n2. exploring the preliminary effects of WorkS for improving patient-reported return-to-work self-efficacy, work status, quality of life, and financial toxicity.",[213],"Hematopoietic Stem Cell Transplantation",[215],"Return to Work",{"date":217,"type":41},"2025-12-19",{"date":219,"type":41},"2024-07-31",{"date":45,"type":22},{"name":47,"class":48},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":230,"minAge":80,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":49},"100520124","strength-after-breast-cancer-100520124","NCT06052488","Strength After Breast Cancer","Strength After Breast Cancer: Clinical Implementation of an Evidence-based Group Exercise Intervention for Breast Cancer Survivors","SABC","Inclusion Criteria:\n\n* ≥18 years of age\n* Diagnosed with Stage I-III breast cancer, having completed primary cancer treatment (e.g., surgery, chemotherapy, radiation therapy); hormonal therapies and adjuvant targeted therapies will be permitted\n\nExclusion Criteria:\n\n* Any injury or medical condition that would prohibit being able to safely perform exercise as indicated by the Physical Activity Readiness Questionnaire (i.e., atrial fibrillation, chest pain or angina, uncontrolled high blood pressure or hypertension, loss of balance due to dizziness in the past 12 months, or loss of consciousness in the past 12 months).\n* Non-English speaking","FEMALE",{"count":232,"type":22},40,[25],"The goal of this study is to explore whether a group exercise program called Strength After Breast Cancer can be delivered in an outpatient physical therapy clinic to improve physical function among women after treatment for breast cancer.\n\nThe main questions this study aims to answer are:\n\n* Can the Strength After Breast Cancer program and the associated outcome battery be successfully delivered in an outpatient physical therapy clinic at Massachusetts General Hospital and do participants find the program practical?\n* What are the barriers to and facilitators of delivering the group exercise program in a clinical setting and what changes need to be made to the program to improve sustainability and to facilitate implementation at other clinical sites?\n\nParticipants will complete study questionnaires before and after engaging in the group exercise program and they will participate in interviews following participation in the program.",[236],"Breast Cancer",[238,239],"Physical Therapy","Exercise Program","2025-10-15",{"date":242,"type":41},"2025-10-20",{"date":244,"type":41},"2024-01-02",{"date":246,"type":22},"2027-03",{"name":47,"class":48},{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":256,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":23,"phases":259,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":49},"100539466","telehealth-and-onsite-maintenance-exercise-in-chronic-lung-disease-100539466","NCT06304207","Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease","Comparison of Telehealth and Onsite Supervised Maintenance Exercise Program for Adults With Chronic Lung Disease: A Pilot Randomized Controlled Trial","CLD","Inclusion Criteria:\n\n* All adult patients 40 years and older with physician diagnosed Chronic Lung Disease within 2 months of discharge following completion of a traditional onsite outpatient rehabilitation or physical therapy or exercise program for their condition\n* Able to walk independently with or without mobility devices\n* Able to complete a six-minute walk test at discharge with or without supplemental oxygen maintaining an oxygen saturation at or above 85%\n* Able to follow commands and instructions in the English language\n* Have ability to connect to the internet\n\nExclusion Criteria:\n\n* • Those with significant mobility limitations such as those with a history of stroke, neurological comorbidities such as Parkinson's disease or relapsing multiple sclerosis, or significant degenerative osteoarthritis, or any other joint impairments that compromise ability to walk independently with or without an assistive device.\n\n  * Patients who primarily rely on a wheelchair for mobility\n  * Patients with or without supplemental oxygen who are unable to complete a walking test without a drop in oxygen saturation to below 85% at discharge from traditional outpatient rehabilitation\n  * Patients with baseline hemodynamic compromise, unstable angina, a recent myocardial infarction within a week, uncontrollable atrial fibrillation not managed with medications, advanced stage heart failure (New York Heart Association class 4), or those with mechanical circulatory assist devices for the heart such a ventricular assist device (VADs)\n  * Inability to communicate in the English language","40 Years",{"count":258,"type":22},30,[25],"The goal of this pilot clinical trial is to compare telehealth and onsite supervised maintenance exercise program for adults with Chronic Lung Disease.\n\nThe specific aims of the study are:\n\n* To compare 8-week supervised maintenance program delivered onsite and via tele-rehab with no maintenance for patients with Chronic Lung Disease following discharge from traditional exercise or physical therapy or onsite outpatient rehabilitation programs on clinical outcomes (dyspnea, exercise capacity, physical function, physical activity, and quality of life) at 8 weeks and 4-months post-intervention.\n* To compare the differences in dyspnea, exercise capacity, physical function, physical activity, and quality of life between an 8-week maintenance program delivered onsite and via tele-rehab at 8-weeks and 4-months post-intervention in patients with Chronic Lung Disease following discharge from traditional onsite outpatient rehabilitation.\n\nParticipants in both intervention groups (onsite and tele-rehab) will undergo a baseline onsite assessment followed by an 8-week supervised exercise intervention either onsite or in a telehealth setting. Control group will receive biweekly check in calls, but no active intervention.",[262,263,264,265,266,267,268,269,270,271],"Copd","COPD Exacerbation","COPD Bronchitis","Emphysema or COPD","Chronic Lung Disease","Pulmonary Fibrosis","Interstitial Lung Disease","Bronchiectasis","Chronic Asthma","Chronic Asthmatic Bronchitis","2024-07-30",{"date":274,"type":41},"2024-08-01",{"date":276,"type":41},"2023-09-01",{"date":278,"type":22},"2026-03-01",{"name":47,"class":48},""]