[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Maidstone & Tunbridge Wells NHS Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100601543","pavlik-harness-treatment-vs-monitoring-for-treatment-of-developmental-dysplasia-of-the-hip-ddh-in-babies-diagnosed-with-graf-type-2-hips-100601543",false,"NCT07111858","Pavlik Harness Treatment vs Monitoring for Treatment of Developmental Dysplasia of the Hip (DDH) in Babies Diagnosed With Graf Type 2 Hips","Pavlik Harness Treatment Versus Monitoring for Treatment of Graf Type 2b and 2c Hip Developmental Dysplasia of the Hip (DDH)","Inclusion Criteria:\n\n•Infants from birth to 16 weeks with Graf type 2b or 2c hip dysplasia on ultrasound\n\nExclusion Criteria:\n\n* associated neuromuscular, genetic or neurological condition which may complicate the course of treatment\n* babies who have unstable hips on clinical examination","ALL","0 Weeks","16 Weeks",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","Developmental Dysplasia of the Hip (DDH) is thoroughly manageable if treated correctly. While the standard treatment is using a Pavlik harness, there is not enough research regarding those patients who have stable but immature Graf type 2b and 2c hips and whether a harness is needed.\n\nAt Maidstone and Tunbridge Wells NHS Trust, all babies who present with Graf type 2b and 2c hip dysplasia are treated using a Pavlik harness, which is worn 24 hours a day for up to 12 weeks. Although the harness is usually very comfortable, it can result in stress and anxiety for parents, and may make caregiving activities such as bathing, feeding and carrying more difficult.\n\nOur aim is to run a feasibility trial, recruiting babies with type 2b and 2c hip dysplasia, to determine whether there is any difference in a group which is treated with Pavlik harnessing, or whether these hips do in fact mature on their own. We would like to ensure that Pavlik harness treatment is indeed necessary in these groups.\n\nBabies randomised to the comparator group with type 2b and 2c hips would be treated using a Pavlik Harness and following the usual protocol with ultrasound scans at 3 weeks, 8 weeks and 12 weeks post start of treatment, and harness duration is determined by the scan at 8 weeks.\n\nBabies randomised to the Intervention group would be monitored via ultrasound scans at 3 weeks, 6 weeks, 8 weeks and 12 weeks post diagnosis, and should it be determined that their hips are not maturing spontaneously, they will be placed in a harness immediately, and follow the treatment-group protocol. Since the scans are done so frequently, and their hips are stable, there is no risk to these babies.\n\nBabies in both groups would have x-rays at 9 months and 15 months to determine longer-term outcome.\n\nThe trial will last for 15 months after diagnosis for each patient, and the end-point of the study would be on achieving a 15-month x-ray for the last recruited patient.\n\nPatients will be informed of the results of the study.",[27],"Developmental Hip Dysplasia",[29],"DDH","RECRUITING","2026-03-18",{"date":33,"type":34},"2026-03-23","ACTUAL",{"date":36,"type":34},"2023-08-02",{"date":38,"type":21},"2027-06",{"name":40,"class":41},"Maidstone & Tunbridge Wells NHS Trust","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":42},"100469665","living-donor-allograft-for-anterior-cruciate-ligament-reconstruction-study-100469665","NCT05395767","LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study","A Prospective Cohort Study of Skeletally Immature Patients Requiring Endoscopic Anterior Cruciate Ligament Reconstruction, Using Living Donor Hamstring Allograft From a Parent","LivD_ACLR","Inclusion Criteria:\n\n* Patients aged 8 to 17 years inclusive and have a clinically and radiologically confirmed ACL rupture that requires reconstruction.\n* Patients who have had previous surgery for meniscal pathology .\n* Patients with current meniscal pathology\n* The child and their responsible adult are in agreement with the choice to undergo anterior cruciate ligament reconstruction using living donor allograft.\n* Donors has not previously undergone tendon harvest on the chosen donor limb\n* Patients are willing to attend follow up appointments and agree to fill in knee questionnaires and allow instrumented knee ligament testing.\n\nExclusion Criteria:\n\n* Patients who have previously undergone ACL surgery on the same limb (and therefore require revision surgery)\n* Patients who are immunosuppressed, or receiving immunosuppressive therapy\n* Patients who are unable to attend follow-up appointments for continued research purposes.\n* Donors who have previously undergone hamstring tendon surgery on the donor limb\n* Patients and donors who have a positive screening blood test for any of the transmissible infections tested\n* Donors whose answers to the 'Donor Documentation Questionnaire' indicate that there could be a risk of transmissible infection, may not included\n* Donors who are not considered healthy enough to undergo a tenotomy under General anaesthetic",true,"8 Years","17 Years",{"count":55,"type":21},40,[24],"The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients. The current advice in younger patients is usually to undergo ACL reconstruction. The choice of an ideal graft in children is difficult\n\nThis study will use a technique involves the use of hamstring tendons from a living donor, where the adult (usually a parent) agrees to donate their hamstring tendons, which are dissected out of them and implanted into the child",[59],"ACL","2025-05-20",{"date":62,"type":34},"2025-05-23",{"date":64,"type":34},"2021-09-15",{"date":66,"type":21},"2028-09",{"name":40,"class":41},""]