[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mansoura University Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":276},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,50,77,102,128,159,184,210,231,252],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100640891","embolosclerotherapy-versus-deep-dorsal-vein-revascularization-in-venogenic-erectile-dysfunction-100640891",false,"NCT07604194","Embolosclerotherapy Versus Deep Dorsal Vein Revascularization in Venogenic Erectile Dysfunction","Embolosclerotherapy Versus Deep Dorsal Vein Revascularization for Erectile Dysfunction Due to Venous Leak: A Randomized Clinical Study","venogenic ED","Inclusion Criteria:\n\n* Cases with ED reporting difficulty in attaining or maintaining erection for at least 6 months.\n* All participants were sexually active, in a stable and heterosexual partnership, living with their sexual partner for at least the past one year, and have only one sexual partner.\n* The frequency of trying sexual intercourse was ≥1\u002Fweek.\n* Unsatisfactory response to PDE5i medication.\n* All cases suffered venogenic erectile dysfunction diagnosed by color flow Doppler sonography before and after intracavernous injection of vasoactive drugs or Dynamic infusion cavernosometry-cavernosography (selected cases), which indicated veno-occlusive dysfunction.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* Major psychological or psychiatric disorders.\n* Non-vascular causes of ED including penile anatomic defects, any related neurological etiology or spinal cord injury, hypogonadism and hormonal disturbances.\n* History of previous venous surgery, suspected or proven deep venous thrombosis, history of Deep Vein Thrombosis.","MALE","40 Years","80 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Venous leakage is one of the causes of erectile dysfunction and can be managed using different treatment modalities, including surgical ligation and percutaneous embolization. This randomized clinical trial aims to evaluate and compare the efficacy, durability, safety, side effects, and complications of two treatment procedures-embolosclerotherapy of the periprostatic plexus and deep dorsal vein revascularization-in the management of erectile dysfunction caused by venous leak.",[28,29],"Erectile Dysfunction Due to Venous Disorder","Erectile Dysfunction (ED)",[31,32,33,34,35,36,37],"Venogenic erectile dysfunction","Onyx","Endovascular embolization","Venous leak","deep dorsal vein","revascularization","polidocanol","NOT_YET_RECRUITING","2026-05-22",{"date":41,"type":42},"2026-05-27","ACTUAL",{"date":44,"type":22},"2026-06-20",{"date":46,"type":22},"2027-09-20",{"name":48,"class":49},"Mansoura University Hospital","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100586580","slide-tracheoplasty-versus-tracheal-resection-anastomosis-in-acquired-tracheal-stenosis-100586580","NCT06917222","Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis","Inclusion Criteria:\n\n* All patients with grade III, IV acquired tracheal stenosis (e.g., due to trauma, prolonged intubation) regardless their age or sex.\n\n  * Patient with symptomatic high grade II acquired laryngotracheal stenosis after failure of endoscopic interventions.\n  * Clinical indications for surgical intervention (Symptoms of airway obstruction).\n  * Feasible for surgical intervention.\n\nExclusion Criteria:\n\n* congenital tracheal stenosis\n\n  * Malignant stenosis.\n  * Severe comorbidities that contraindicate the surgery.\n  * Patients refusing to sign the consent.","ALL",{"count":58,"type":22},30,[25],"Aim of the Work To compare the clinical outcomes between patients will undergo slide tracheoplasty and those will undergo tracheal resection anastomosis for acquired tracheal stenosis.",[62,63],"Tracheal Stenosis","Subglottic Stenosis",[65,66],"Slide tracheoplasty","Tracheal resection anastomosis","RECRUITING","2025-09-22",{"date":70,"type":42},"2025-09-25",{"date":72,"type":42},"2025-05-01",{"date":74,"type":22},"2026-08-01",{"name":48,"class":49},1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":84,"minAge":4,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":99,"leadSponsor":101,"locationsCount":76},"100602341","demographics-of-lung-cancer-in-females-100602341","NCT07122245","Demographics of Lung Cancer in Females","Demographics of Lung Cancer in Female Patients: A Retrospective Based Analysis","Inclusion Criteria:\n\n* All female patients presented with bronchogenic carcinoma patients and diagnosed at chest diseases department, Oncology Center Mansoura University (OCMU) in last 10 years.\n\nExclusion Criteria:\n\n* lung metastasis ( not primary bronchogenic carcinoma)","FEMALE",{"count":86,"type":22},300,"OBSERVATIONAL","Lung cancer has been the most common and fatal type of cancer; indeed worldwide incidence of lung cancer is alarming. It is considered a leading cause of cancer- related deaths among males and females due to environmental pollution, occupational exposure, genetic susceptibility, increasing number of smokers and others.",[90],"Lung Cancer",[92,93,94],"Demographics","lung cancer","female patients","2025-08-07",{"date":97,"type":42},"2025-08-14",{"date":95,"type":42},{"date":100,"type":22},"2026-04-07",{"name":48,"class":49},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":109,"enrollmentInfo":110,"targetDuration":112,"studyType":87,"phases":4,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":76},"100555929","atopy-and-frequency-of-exacerbation-in-chronic-obstructive-pulmonary-disease-patients-100555929","NCT06518473","Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients","The Relation Between Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients","Inclusion Criteria:\n\n* Adults aged 40-70 years diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2024 criteria\n\nExclusion Criteria:\n\n* Patients with known allergic diseases before enrollment\n* Patients with associated other chronic respiratory disorders\n* Patients with significant comorbidities that could influence respiratory function.\n* Recent respiratory infections or use of systemic corticosteroids within the last month before enrollment.","70 Years",{"count":111,"type":22},50,"6 Months","Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production and\u002For exacerbations) due to abnormalities of airways (bronchitis, bronchiolitis) and\u002For alveoli (emphysema) that cause persistent, often progressive, airflow obstruction.\n\nThe presence of non-fully reversible airflow obstruction (FEV1\u002FFVC \\\u003C 0.7 post-bronchodilation) measured by spirometry confirms the diagnosis of COPD",[115],"Chronic Obstructive Pulmonary Disease",[117,118,119],"atopy","frequency of exacerbation","chronic obstructive pulmonary disease","2025-07-30",{"date":122,"type":42},"2025-08-03",{"date":124,"type":42},"2024-07-14",{"date":126,"type":22},"2025-12-15",{"name":48,"class":49},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":136,"sex":56,"minAge":4,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":76},"100511214","phase-4-lactoferrin-use-in-icu-patients-100511214","NCT05936528","Lactoferrin Use in ICU Patients","The Effect of Lactoferrin in Improving Clinical Outcomes in ICU Patients","RCT","Inclusion Criteria:\n\n* The inclusion criteria for patients to participate in this research include adult (age ≥ 18 years) patients admitted to ICU for any reason or disease.\n\nExclusion Criteria:\n\n* inability to give informed consent by patients or their relative,\n* history of hypersensitivity to milk products,\n* history of lactoferrin use in the past 6 months,\n* patients with lactose intolerance,\n* patients with no enteral access to administer LF either orally or by Ryle tube,\n* patients who are expected to die within 48 hours, and\n* patients with poor oral absorption as in case of shock and resected bowel.",true,{"count":138,"type":22},660,[140],"PHASE4","Introduction:\n\nLactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.\n\nAims:\n\nThe objective is to study the effect of lactoferrin on improving clinical outcomes in ICU patients, and also to evaluate its safety.\n\nPatients and populations:\n\nA sample of 660 patients (330 patients in both groups A, and B) who will be admitted to ICU departments in Mansoura university hospital will be used to represent the population in ICU.\n\nMethods:\n\nA sample of 660 participants was randomized 1:1 into two groups (group A (330 patients), and group B (330 patients)).\n\nThis study is a single blind, randomized controlled clinical trial. Randomization was performed by independent clinical pharmacists working in hospital ICU departments.",[143],"Critical Illness",[145,146,147,148,149,150],"Clinical outcomes","ICU patients","Lactoferrin","Antioxidant therapy","Anti-inflammatory therapy","Antimicrobial therapy","2025-07-23",{"date":153,"type":42},"2025-07-28",{"date":155,"type":22},"2025-12-29",{"date":157,"type":22},"2027-12-29",{"name":48,"class":49},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":84,"minAge":4,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":168,"conditions":169,"keywords":171,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":76},"100595519","diffusion-coefficient-and-micro-calcifications-to-kaiser-score-in-evaluation-of-bi-rads-4-breast-lesions-100595519","NCT07033507","Diffusion Coefficient and Micro-calcifications to Kaiser Score in Evaluation of BI-RADS 4 Breast Lesions","Diagnostic Performance of Combining Apparent Diffusion Coefficient and Micro-calcifications to Kaiser Score in Evaluation of BI-RADS 4 Breast Lesions","Inclusion Criteria:\n\n* Patients with BI-RADS 4 lesion.\n\nExclusion Criteria:\n\n* Patients on chemotherapy or related treatment.\n* Patients who have contraindications to do MRI as patients with cardiac pace maker, patients with cochlear implant and ocular foreign body, claustrophobia.",{"count":167,"type":22},80,"Breast cancer is the most commonly diagnosed cancer worldwide and is the leading cause of cancer-related deaths in women. Mammography, breast ultrasonography (US), and breast magnetic resonance imaging (MRI) are essential for the diagnosis and follow-up of breast cancer. The American College of Radiology Breast Imaging- Reporting and Data System (ACR BI-RADS), which is used worldwide, provides the standard terminology for breast imaging (Jajodia et al., 2021). The ACR BI- RADS lexicon categorizes breast imaging findings into seven BIRADS categories of 0, 1, 2, 3, 4(4a, 4b, 4c), 5, and 6 according to the probability of malignancy. Breast imaging findings assigned as BI-RADS 4 require tissue sampling and histopathological examination. However, the likelihood of malignancy of lesions classified as BI-RADS 4 ranges widely, from 3% to 94%. Categorization of lesions according to BI-RADS is related to the experience of the radiologist, with experienced radiologists performing better than inexperienced radiologists",[170],"Breast Neoplasms",[172,173,174,175],"BI-RADS 4 breast lesions","diffusion coefficient","micro-calcifications","Kaiser Score","2025-06-14",{"date":178,"type":42},"2025-06-24",{"date":180,"type":42},"2024-06-01",{"date":182,"type":22},"2026-01-01",{"name":48,"class":49},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":193,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":76},"100564467","bronchoscopic-lung-volume-reduction-in-management-of-localized-emphysema-100564467","NCT06629558","Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema","Efficacy and Safety of 0.5% w\u002Fv Nano- Silver Nitrate Versus Silver Nitrate Solution for Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema: Prospective Interventional Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* COPD of grade III and IV according to GOLD 2024 staging of COPD with localized (heterogeneous) emphysema as determined by high resolution computerized tomography (HRCT) of the chest with area of destruction \\>-950 Hounsfield units (HU) and respiratory symptoms despite optimal medical therapy with the following criteria: Patient less than 75 years of age not candidate for or had refused lung volume reduction surgery but fit for fibro-optic bronchoscope (FOB). Lung volumes criteria: FEV1 less than 60% of predicted value, Residual volume (RV) more than 100% of predicted value, Total lung capacity (TLC) more than 100% of predicted value, 6 MWT of less than 450 meters.\n\nExclusion Criteria:\n\n* Significant co-morbidities that limits exercise capacity or prognosis as cardiovascular diseases (heart failure, arrhythmia, ischemic heart disease) and lung cancer.\n* Patients unfit or refused FOB.\n* Homogenous emphysema.\n* More than 75 years of age.\n* Associated lung fibrosis.\n* FEV1 \\> 60%.\n* Current smoker.","75 Years",{"count":58,"type":22},[25],"Emphysema is a progressive phenotype of chronic Obstructive Pulmonary Disease (COPD), poses a significant global health burden characterized by irreversible lung parenchymal destruction and airspace enlargement.\n\nIn recent years, bronchoscopic lung volume reduction (BLVR) has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema.\n\nBLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents. Many techniques are available for BLVR as coil, endo-bronchial valve, and biological as thrombin, autologous blood and chemicals as silver nitrate solution.",[196],"Bronchoscopic Lung Volume Reduction",[198,199,200,201],"bronchoscopic lung volume reduction","Nano-silver nitrate","Localized Emphysema","Silver nitrate","2025-05-27",{"date":204,"type":42},"2025-05-29",{"date":206,"type":42},"2024-10-01",{"date":208,"type":22},"2026-03-01",{"name":48,"class":49},{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":56,"minAge":217,"maxAge":4,"enrollmentInfo":218,"targetDuration":112,"studyType":87,"phases":4,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":230,"locationsCount":76},"100551822","diaphragmatic-thickening-fraction-as-a-predictor-of-successful-weaning-100551822","NCT06465082","Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning","Role of Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning From Mechanical Ventilation","Inclusion Criteria:\n\n* Adult patients \\>18 years old, who are in need for mechanical ventilation as: Life threatening hypoxia, Respiratory rate \\> 30 breath\u002Fmin, Disturbed conscious level.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years.\n* Pregnancy\n* Surgical incisions likely to interfere with ultrasound examination.\n* Hepato-splenomegaly, Ascites\n* Neuromuscular disease as Myasthenia gravis, kypho-scoliosis\n* Diaphragmatic Paralysis (paralyzed diaphragm exhibiting abnormal paradoxical movement, i.e., moving in a cranial direction during inspiration","18 Years",{"count":219,"type":22},55,"The aim of this study is to assess the validity of the diaphragmatic thickening Fraction measured by ultrasound as a predictor for successful weaning from mechanical ventilation.",[222],"Weaning From Mechanical Ventilation",[224,225],"mechanical ventilation.","diaphragmatic thickening Fraction",{"date":204,"type":42},{"date":228,"type":42},"2024-09-05",{"date":126,"type":22},{"name":48,"class":49},{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":56,"minAge":217,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":23,"phases":239,"briefSummary":240,"conditions":241,"keywords":243,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":247,"startDateStruct":248,"completionDateStruct":249,"leadSponsor":251,"locationsCount":76},"100552367","breathing-exercises-on-lung-function-100552367","NCT06472167","Breathing Exercises on Lung Function","Impact of Breathing Exercises on Lung Function in Chronic Airway Diseases","Inclusion Criteria:\n\n* The patients fulfilled the criteria for COPD: the presence of a post bronchodilator FEV1 \\\u003C 80% predicated together with an FEV1\u002FFVC \\\u003C0.70confirm the presence of airflow limitation that is not fully reversible.\n* COPD patients ranging from mild to severe according to GOLD \\[stages I-IV\\].\n* Asthmatic patients receive medical treatment for at least 6 months; and clinically stable (i.e., no exacerbation or changes in medication for ≥30 days).\n* None of the individuals had been engaged in any exercise-training program before participating in the study.\n* Optimized medical therapy according to GOLD \\& Global Initiative for Asthma (GINA)\n* Clinically stable COPD and asthmatic patients (not suffering from a recent respiratory tract infection).\n* All patients are Ex-smoker\n\nExclusion Criteria:\n\n* Age \\\u003C18 years.\n* Pregnancy\n* Current Smokers\n* Patients that are incapable of exercising; unable to understand any questionnaire\n* Multiple co- morbidity (e.g., cardiovascular diseases, active cancer)\n* Neuromuscular disease as Myasthenia gravis, kypho-scoliosis\n* Diaphragmatic Paralysis (paralyzed diaphragm exhibiting abnormal paradoxical movement, i.e., moving in a cranial direction during inspiration).",{"count":111,"type":22},[25],"aim of this study is to evaluate the efficacy of pulmonary rehabilitation program as a non-pharmacological treatment method to: Improve functional capacity as assessed by six-minute walking distance (6MWD) test. Improve dyspnea level as assessed by Medical Research Council (MRC) dyspnea scale. Improve pulmonary function tests and arterial blood gas.",[242],"Breathing Exercises",[244,245,246],"Breathing exercises","lung function","Chronic airway diseases",{"date":204,"type":42},{"date":180,"type":42},{"date":250,"type":22},"2025-12-10",{"name":48,"class":49},{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":136,"sex":56,"minAge":217,"maxAge":19,"enrollmentInfo":258,"targetDuration":112,"studyType":87,"phases":4,"briefSummary":260,"conditions":261,"keywords":263,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":76},"100558254","patients-quality-of-life-and-functional-changes-after-fistula-surgery-100558254","NCT06548724","Patient's Quality of Life and Functional Changes After Fistula Surgery","Inclusion Criteria:\n\n* both genders\n* Age :between 18-65 years\n* cryptoglandular anal fistula\n* need intervention\n\nExclusion Criteria:\n\n\\- Patients with associated anorectal pathology (anal fissure, hemorrhoids, rectal prolapse, neoplasm, solitary rectal ulcer, inflammatory bowel diseases.)",{"count":259,"type":22},70,"This is a prospective observational study that will monitor the effects of surgery for anal fistula on the patient quality of life using many valid questionnaires",[262],"Anal Fistula",[264,265,266,267],"quality of life","incontinence","preoperative","postoperative","2024-08-09",{"date":270,"type":42},"2024-08-12",{"date":272,"type":42},"2021-08-01",{"date":274,"type":22},"2024-12",{"name":48,"class":49},""]