[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Marina Castel Sánchez\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100625473","exergame-based-upper-limb-rehabilitation-in-adults-with-chronic-stroke-100625473",false,"NCT07423091","Exergame-Based Upper-Limb Rehabilitation in Adults With Chronic Stroke","A Randomized Controlled Trial Assessing the Efficacy, Feasibility, and Usability of an Exergame-Based Semi-Autonomous Upper-Limb Rehabilitation Program in Individuals With Chronic Stroke","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Confirmed diagnosis of chronic stroke with more than 6 months of evolution.\n* Ability to maintain independent sitting and standing (with or without assistive devices).\n* Upper-limb functional capacity ranging from limited to moderate, defined as an ARAT score between 11 and 54 points.\n* Ability to understand and follow simple instructions (Mini-Mental State Examination ≥ 23).\n* Ability to provide informed consent personally or through a legal representative.\n\nExclusion Criteria:\n\n* Acute illness, musculoskeletal pathology, or pain that interferes with the performance of rehabilitation exercises.\n* Uncompensated sensory deficits, including significant visual or hearing impairments.\n* Disruptive behavior or neuropsychiatric conditions that may limit participation.\n* Active epilepsy or any medical contraindication to physical exercise.\n* Botulinum toxin treatment affecting the upper limb within the previous 6 months.","ALL","18 Years",{"count":19,"type":20},32,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study is a randomized controlled trial designed to evaluate the effectiveness of a semi-autonomous upper-limb rehabilitation program based on exergames in adults with chronic stroke. Participants will be randomly assigned (1:1) to either an exergame-based intervention or an individually delivered conventional home-based therapy program. The primary outcome is upper-limb functionality as measured by the Action Research Arm Test (ARAT). Secondary outcomes include upper-limb motor function and quality of life. The study also examines adherence, usability, and the feasibility of remote monitoring for long-term implementation.",[26],"Chronic Stroke",[26,28,29,30,31],"Upper Limb Rehabilitation","Exergames","Serious Games","Telerehabilitation","NOT_YET_RECRUITING","2026-02-18",{"date":35,"type":36},"2026-02-20","ACTUAL",{"date":38,"type":20},"2026-04",{"date":40,"type":20},"2026-12",{"name":42,"class":43},"Marina Castel Sánchez","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":66,"locationsCount":67},"100626040","home-based-exergame-rehabilitation-for-upper-limb-function-in-people-with-multiple-sclerosis-100626040","NCT07430462","Home-Based Exergame Rehabilitation for Upper Limb Function in People With Multiple Sclerosis","Effectiveness and Feasibility of a Home-Based Exergame Rehabilitation Protocol for Upper Limb Function in Individuals With Multiple Sclerosis: A Randomized Controlled Pilot Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Clinical diagnosis of Multiple Sclerosis with EDSS score between 2.0 and 6.5, with upper-limb involvement.\n* Ability to maintain independent sitting and to stand with or without assistive devices.\n* Upper-limb functional capacity between 11 and 54 points on the ARAT, indicating limited to substantial impairment.\n* Cognitive ability to understand and follow simple instructions, demonstrated by a Mini-Mental State Examination score ≥ 23.\n* Provision of written informed consent by the participant or legally authorized representative.\n\nExclusion Criteria:\n\n* Acute illness, musculoskeletal injury, or pain interfering with the ability to perform the intervention exercises.\n* Uncompensated visual or hearing impairments that limit participation.\n* Disruptive behavior or other conditions that significantly hinder participation in the rehabilitation program.\n* Active epilepsy or any medical contraindication to physical exercise.\n* Botulinum toxin treatment in the upper limb within the previous 6 months.",{"count":52,"type":20},40,[23],"This randomized pilot clinical trial aims to evaluate the effectiveness, feasibility, and cost-effectiveness of a semi-autonomous upper-limb rehabilitation program based on therapeutic exergames in people with Multiple Sclerosis (MS). The intervention integrates intensive motor practice, multisensory feedback, and cognitively demanding tasks to enhance upper-limb function, dexterity, and patient autonomy. Participants will be randomly assigned to either an exergame-based home rehabilitation program with remote physiotherapist supervision or a dose-matched conventional home-based physiotherapy program.\n\nThe primary outcome is upper-limb functionality measured by the Action Research Arm Test (ARAT). Secondary outcomes include motor function, manual ability, quality of life, usability, adherence, and digital performance metrics related to the execution of motor and cognitive tasks. Follow-up at 16 weeks will assess the sustainability of treatment effects.\n\nThis study seeks to generate evidence on whether exergame-based rehabilitation can serve as an accessible, scalable, and patient-centered alternative to conventional home-based upper-limb rehabilitation for individuals with MS.",[56],"Multiple Sclerosis",[56,28,29,58,59,60,61],"Home-Based Rehabilitation","Virtual Reality Rehablitation","Cost-effectiveness","Usability",{"date":63,"type":36},"2026-02-24",{"date":38,"type":20},{"date":40,"type":20},{"name":42,"class":43},1,""]