[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Marquette University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":306},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,45,87,116,141,159,180,206,235,260,282],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100551891","perception-of-speech-in-context-by-listeners-with-healthy-and-impaired-hearing-100551891",false,"NCT06465979","Perception of Speech in Context by Listeners With Healthy and Impaired Hearing","Inclusion Criteria:\n\n* Be able to recognize spoken words in English\n* Be a competent speaker of north American English\n* Be an adult between the age of 18 to 65 years\n* Have normal audiometric thresholds below 25 decibels hearing loss (dB HL) at frequencies between 250 and 8000 Hz OR have audiometric thresholds not exceeding 40 dB HL at frequencies between 250 and 8000 Hz OR have audiometric thresholds not exceeding 55 dB HL at frequencies between 250 and 8000 Hz OR use a cochlear implant\n* Lack language-learning or other cognitive disabilities\n\nExclusion Criteria:\n\n* Inability to recognize spoken words in English\n* Not a competent speaker of north American English\n* Be younger than 18 years of age\n* Be older than 65 years of age\n* Have normal audiometric thresholds exceeding 25 dB HL at frequencies between 250 and 8000 Hz OR have audiometric thresholds exceeding 40 dB HL at frequencies between 250 and 8000 Hz OR have audiometric thresholds exceeding 55 dB HL at frequencies between 250 and 8000 Hz\n* Language-learning or other cognitive disabilities",true,"ALL","18 Years","65 Years",{"count":20,"type":21},680,"ESTIMATED","INTERVENTIONAL",[24],"NA","Recognition of speech sounds is accomplished through the use of adjacent sounds in time, in what is termed acoustic context. The frequency and temporal properties of these contextual sounds play a large role in recognition of human speech. Historically, most research on both speech perception and sound perception in general examine sounds out-of-context, or presented individually. Further, these studies have been conducted independently of each other with little connection across labs, across sounds, etc. These approaches slow the progress in understanding how listeners with hearing difficulties use context to recognize speech and how their hearing aids and\u002For cochlear implants might be modified to improve their perception. This research has three main goals. First, the investigators predict that performance in speech sound recognition experiments will be related when testing the same speech frequencies or the same moments in time, but that performance will not be related in further comparisons across speech frequencies or at different moments in time. Second, the investigators predict that adding background noise will make this contextual speech perception more difficult, and that these difficulties will be more severe for listeners with hearing loss. Third, the investigators predict that cochlear implant users will also use surrounding sounds in their speech recognition, but with key differences than healthy-hearing listeners owing to the sound processing done by their implants. In tandem with these goals, the investigators will use computer models to simulate how neurons respond to speech sounds individually and when surrounded by other sounds.",[27,28],"Hearing","Hearing Loss",[30,31],"speech perception","hearing","RECRUITING","2026-06-01",{"date":35,"type":36},"2026-06-03","ACTUAL",{"date":38,"type":36},"2023-09-19",{"date":40,"type":21},"2028-07-31",{"name":42,"class":43},"Marquette University","OTHER",2,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":15,"sex":16,"minAge":53,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":70,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},"100631596","pain-in-aging-former-athletes-masters-athletes-and-nonathletes-100631596","NCT07502742","Pain in Aging Former Athletes, Master's Athletes, and Nonathletes","Pain in Athletes INtervention (PAIN): A Randomized Crossover Clinical Trial in Aging Former Athletes, Master's Athletes, and Nonathletes","PAIN","Inclusion Criteria (General):\n\n* Age: 35 years through 65 years\n* Current master's athlete, former competitive athletes, or non-athlete control (see details below)\n* Ability to participate in exercise and exercise testing based on the Physical Activity Readiness Questionnaire (PAR-Q+)\n\nExclusion Criteria (General):\n\n* Currently pregnant or planning to become pregnant during the study\n* Currently taking heart rate lowering medications (e.g., betablockers) that would impact exercise testing\n* Contraindications to ice such as Raynaud's, cryoglobulinemia, cold urticaria, and\u002For impaired circulation or sensation\n* Fibromyalgia and\u002For chronic regional pain syndrome (CRPS)\n* Myocardial infarction or pulmonary embolism in the last 12 months, active cancer, a pacemaker, or any additional condition or disease that would preclude the individual from being able to perform the tests safely\n\nParticipants will be enrolled into one of the following three mutually exclusive groups according to the following criteria:\n\n1. Former Competitive Athlete: Prior participation in competitive sports at the Tier 3 level or above as per McKay et al. (2022): i.e., \"national-level representatives who are performing structured and\u002For periodized training and are developing proficiency in skills required to perform their sport at the highest level; this tier includes individuals participating in Provincial\u002FState or Academy Programs\" or higher participation in sport; Not currently participating in any recreational or competitive sports over the last 5 years (Tier 2 or above)\n2. Master's Athlete: Currently (within the past year) participating in sports at the Tier 2 level or above (i.e., committed to sports-specific training at least 3 times per week with the intent to compete)(McKay et al., 2022)\n3. Nonathlete Control: No prior participation in sport at the Tier 3 (Highly Trained\u002FNational) Level or above and not currently participating in any competitive sports (i.e., Tier 2 or above) (McKay et al., 2022) for at least 5 years","35 Years",{"count":55,"type":21},90,[24],"The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes.\n\nThe main questions this study aims to address are:\n\n1. How do former athletes, master's athletes, and nonathletes experience pain?\n2. How do different types of moderate-intensity exercise (strength versus aerobic exercise) influence pain in former athletes, master's athletes, and nonathletes?\n\nParticipants will complete 3 different testing sessions:\n\n1. Baseline testing including assessments of strength, cardiorespiratory fitness, and pain;\n2. Strength exercise: pain assessments will occur before and after moderate-intensity strength training exercise;\n3. Aerobic exercise: pain assessments will occur before and after moderate-intensity aerobic exercise.\n\nThere will be a washout period of approximately one week or greater between each of the three different testing sessions. The order of conditions (strength versus aerobic exercise) will be randomized (crossover randomized trial design).",[59,60,61,62,63,64,65,66,67,68,69],"Pain","Pain Management","Athlete","Exercise Training","Sports Medicine","Strength Training Effects","Aerobic Exercise","Strength Training","Aging","Quality of Life","Sports",[71,72,59,73,74,75,76,67,77],"Former Athlete","Master's Athlete","Quantitative Sensory Testing","Randomized Crossover Clinical Trial","Exercise","Rehabilitation","Sport","2026-03-27",{"date":80,"type":36},"2026-03-31",{"date":82,"type":36},"2026-03-02",{"date":84,"type":21},"2028-05",{"name":42,"class":43},1,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":86},"100465690","life-after-sport-prior-injury-and-sedentary-behavior-as-mechanisms-of-later-poor-health-100465690","NCT05344001","Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health","Please see cohorts for specific inclusion\u002Fexclusion criteria\n\nInclusion Criteria:\n\n* Age 18-25 years OR age 40-64 years\n* Current or former collegiate varsity athlete OR non-athlete control\n\nExclusion Criteria:\n\n* Neurologic (e.g., stroke, Parkinson's) and\u002For degenerative disease that impairs function\n* Pregnancy\n* Lower extremity joint replacement (e.g., hip or knee replacement)","64 Years",{"count":95,"type":21},450,"OBSERVATIONAL","Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.",[67,99,100,101],"Athletic Injuries","Physical Inactivity","Knee Injuries and Disorders",[63,103,61,77,104,105,106,107],"Injury","Physical Activity","Function","Health","Knee","2026-02-23",{"date":110,"type":36},"2026-02-25",{"date":112,"type":36},"2022-04-18",{"date":114,"type":21},"2027-08",{"name":42,"class":43},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":86},"100621558","wound-healing-following-extraction-and-ridge-preservation-in-smokers-and-non-smokers-100621558","NCT07372183","Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers","Inclusion Criteria:\n\n* Adult patients (18-75 years)\n* Good general health (controlled conditions)\n* Smokers (≥10 cigarettes\u002Fday for ≥5 years) and never smokers. Confirmation of smoking status will be done via use of a smokerlyzer. The cut-off point for distinguishing smokers from non-smokers is 8 carbon monoxide parts per million (ppm).\n* Periodontal status: periodontal health, gingivitis on intact or reduced periodontium, treated periodontitis\n* Intact post-extraction bony walls or less than 50% bone dehiscence\n* Distance at least 8 mm of vertical bone height between bone crest and anatomical structures (i.e. sinus floor, inferior alveolar nerve (IAN) canal, mental foramen)\n* Extracted tooth root in the same three-dimensional position as the future implant placement so that the bone core biopsy can be taken from a site totally within the confines of the former tooth socket without inclusion of surrounding native alveolar bone\n* Scheduled for single tooth extraction with bone graft placement and membrane\n\nExclusion Criteria:\n\n* Uncontrolled periodontal disease\n* Uncontrolled systemic disease\n* Pregnancy\n* Use of therapy and\u002For medication that impairs wound healing (e.g., bisphosphonates, steroids, chemotherapy, radiotherapy etc.)","75 Years",{"count":124,"type":21},12,"The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.",[127,128,129,130,131],"Smoking, Cigarette","Alveolar Bone Grafting","Wound Healing","Bone Healing","Tooth Extraction Site Healing","NOT_YET_RECRUITING","2026-01-20",{"date":135,"type":36},"2026-01-28",{"date":137,"type":21},"2026-01-25",{"date":139,"type":21},"2028-10-01",{"name":42,"class":43},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":122,"enrollmentInfo":147,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":86},"100564116","determinants-of-bone-dimensional-changes-after-extraction-and-alveolar-ridge-preservation-100564116","NCT06624982","Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation","Inclusion Criteria:\n\n* Adult patients (18-75 years)\n* Good general health (controlled conditions)\n* Controlled periodontal disease\n* Scheduled for single tooth extraction with bone graft placement and resorbable membrane\n* Tooth to be extracted must have adjacent teeth\n* Socket wall integrity\n\nExclusion Criteria:\n\n* Smoking\n* Pregnancy\n* Active periodontal disease\n* Systemic conditions that affect healing\n* Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.",{"count":148,"type":21},160,"The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.",[128,130,131,129],"2025-11-13",{"date":153,"type":36},"2025-11-17",{"date":155,"type":36},"2025-10-08",{"date":157,"type":21},"2027-10-01",{"name":42,"class":43},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":86},"100541430","cuped-an-approach-to-motor-recovery-post-stroke-not-compensation-100541430","NCT06329765","CUped: An Approach to Motor Recovery Post-Stroke, Not Compensation","Inclusion Criteria:\n\n* Single, unilateral stroke in adulthood.\n* Cortical, subcortical stroke. Individuals with cortical lesions affecting sensory and motor structures in the gray matter of the brain will be included. Individuals subcortical white matter lesions affecting the internal capsule and corona radiata will be included.\n* Ischemic, hemorrhagic stroke. Individuals with ischemic and hemorrhagic strokes will be admitted. Because ischemic stroke is more common than hemorrhagic, the investigators expect a smaller proportion of volunteers from the latter group.\n* Chronic stroke. Individuals with chronic stroke, defined as \\>6 months post infarct, will be included.\n* Able to walk 10 m. Stroke survivors capable of walking 10 m overground will be admitted. Canes, walkers, braces, and other devices will be allowed. This study examines the effect of CUped on gait kinematics and kinetics; therefore, the ability to walk is imperative.\n* Unilateral motor impairment consistent with hemiparesis.\n* Learned non-use of the paretic limb. Non-use will be verified by comparing paretic limb work (W) during unilateral and bilateral coupled pedaling. Participants with non-use will be identified as those who produce significantly \\\u003C50% of the total W of bilateral coupled pedaling with their paretic limb but are capable of unilateral pedaling with the paretic limb at a workload equivalent to 50% of the total W of bilateral coupled pedaling. (Significance will be determined using a 1-sample t-test or corresponding non-parametric test in the case of non-normality).\n* No contraindications for exercise. Contraindications to exercise include but may not be limited to recent electrocardiogram changes or recent myocardial infarction, uncontrolled arrhythmia, unstable angina, third degree heart block, acute progressive heart failure, uncontrolled hypertension, and orthopedic conditions (e.g., severe muscle contracture, arthritis, acute limb injury) that may interfere with pedaling.\n* Age ≥18. All participants must be at least 18 years of age. The investigators are studying adult not childhood stroke. Recovery mechanisms are different between adult and childhood stroke survivors.\n* Able to commit to 27 visits to the lab (pre-, mid-, post-test, plus 24 training sessions).\n\nExclusion Criteria:\n\n* More than 1 stroke. Individuals with more than one clinically apparent stroke, as evidenced by residual impairments and\u002For medical imaging, will be excluded. Individuals with history of transient ischemic attack (TIA) resulting in no residual impairments or brain damage will NOT be excluded.\n* Stroke in the cerebellum or basal ganglia. Individuals with stroke affecting primarily the cerebellum or basal ganglia will be excluded. The cerebellum has an important role in motor learning. Given that CUped depends on motor learning, people with cerebellar strokes may not benefit. Basal ganglia strokes can cause tremor, which is not the target of CUped. However, individuals with predominantly internal capsule lesions that also affect the basal ganglia will be included.\n* Dementia or other cognitive impairment that interferes with learning and\u002For the ability to consent.\n* Communication impairments, such as receptive aphasia, that prevent safe participation. Expressive aphasia is not an exclusion criterion. Participants will be included as long as they have a method to communicate willingness to participate, discomfort, and\u002For the desire to start or stop a study activity.\n* Orthopedic impairments that interfere with pedaling.\n* Cardiovascular contraindications to exercise.\n* Inability to walk 10 m overground. Participants will be excluded in they are not able to walk 10 m overground our cannot do so safely.\n* Neurological disorder other than stroke. Individuals with history or signs of any neurologic disease or injury other than stroke will be excluded. Such conditions may include head trauma, cerebral palsy, epilepsy, brain tumor, diabetic neuropathy, dementia, multiple sclerosis, Parkinson's disease, or Alzheimer's disease.\n* Other conditions that interfere with safe participation or data integrity. Participants will be excluded if, at any point in the recruitment or enrollment process, the investigators become aware of a condition that increases risk beyond that indicated in our IRB protocols. Exclusion will also occur if the investigators become aware of a condition that introduces an experimental variable that could confound the results of the study.\n* Failure to meet any inclusion criteria listed above.","100 Years",{"count":124,"type":21},[24],"The goal of lower limb rehabilitation after stroke is recovery of independent walking at home and in the community. Few stroke survivors achieve this goal. Suboptimal outcomes are due to the serious and intransigent nature of movement impairments caused by stroke and the scarcity of feasible and effective therapies that restore movement lost to stroke. Our team has developed a novel exercise intervention called CUped (pronounced cupid, like the Roman god) to address barriers to recovery and improve walking after stroke. CUped is so called because it compels use of the paretic limb during a movement that resembles pedaling. This project will examine safety, acceptability, and tolerance to CUped, characterize its therapeutic effects, and identify dose-response relationships. Results will provide preliminary data for an R01 to support a randomized controlled trial (RCT). CUped is designed to help stroke survivors recover lower limb movement lost to stroke, thereby improving walking. It is intended to be used as an adjunct to gait training. CUped uses a robotic technology that eliminates compensatory movements that interfere with recovery, compels use of the paretic lower limb, and targets 3 key movement impairments caused by stroke: decreased muscle output from the paretic limb, inappropriate paretic muscle timing, and abnormal interlimb coordination. Exercise is done in sitting which enables high repetition practice. Like walking, CUped requires continuous, reciprocal use of both lower limbs; effects are likely to transfer to walking. The risk-reward profile of this proposal is ideal for an R21, which is an NIH funding opportunity intended to encourage exploratory\u002Fdevelopmental research by providing support for the early and conceptual stages of project development. CUped is a novel therapy grounded in a physiologic premise and based on prior observations from our laboratory. The investigators have pilot data suggesting that CUped fulfills its design specifications, and this study will be the first to test its therapeutic effects. In this Stage 1 rehabilitation trial, The investigators will support or quickly refute the hypothesis that CUped is safe, acceptable, and capable of eliciting a therapeutic response in stroke survivors. The investigators will also examine tolerance to CUped and dose-response effects. If our hypotheses are supported, the investigators will be poised to run an RCT to isolate the effects of CUped and compare them to standard care. Future work will investigate physiologic mechanisms underlying the effects of CUped.",[170,171],"Stroke","Hemiplegia","2025-09-25",{"date":174,"type":36},"2025-09-30",{"date":176,"type":36},"2023-08-07",{"date":178,"type":21},"2027-04-04",{"name":42,"class":43},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":16,"minAge":187,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":194,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":86},"100308663","use-of-sensory-substitution-to-improve-arm-control-after-stroke-100308663","NCT03298243","Use of Sensory Substitution to Improve Arm Control After Stroke","Augmenting Kinesthetic Feedback to Improve Hemiparetic Arm Control After Stroke","Inclusion Criteria:\n\n* stroke survivors who can perform our stabilization and grip modulation tasks and who\n* had a single ischemic or hemorrhagic stroke of the middle cerebral artery (MCA) in the chronic state of recovery (\\> 6 months post-stroke).\n* ability to give informed consent and be able to follow two-stage instructions.\n* mild-to-moderate motor impairment as assessed using the upper extremity (UE) portion of the Fugl-Meyer Motor Assessment (FM); i.e., UE-FM score between 28 and 50 (inclusive) out of a possible 66.\n* proprioceptive deficit at the elbow in the more involved (contralesional) arm.\n* preserved tactile sensation in either the ipsilesional arm and\u002For thigh.\n* a minimal active wrist extension of 5°.\n\nExclusion Criteria:\n\n* Inability of subjects to give informed consent or follow two-stage instructions.\n* subjects with a bleeding disorder.\n* subjects with fixed contractures or a history of tendon transfer in the involved limb.\n* subjects with a diagnosis of myasthenia gravis, amyotrophic lateral sclerosis or any disease that might interfere with neuromuscular function.\n* subjects who are currently using or under the influence of aminoglycoside antibiotics, curare-like agents, or other agents that may interfere with neuromuscular function.\n* subjects with a history of epilepsy.\n* history of other psychiatric co-morbidities (e.g. schizophrenia).\n* malignant or benign intra-axial neoplasms.\n* concurrent illness limiting the capacity to conform to study requirements.\n* Cardiac pacemaker, cardiac arrhythmia or history of significant cardiovascular or respiratory compromise.\n* subjects with profound atrophy or excessive weakness of muscles in the target area(s) of testing.\n* subjects with a systemic infection.","21 Years",{"count":189,"type":21},30,[24],"Supplementing or augmenting sensory information to those who have lost proprioception after stroke could help improve functional control of the arm. Thirty subjects will be recruited to a single site to evaluate the ability of supplemental kinesthetic feedback (a form of vibrotactile stimulation) to improve motor function. Participants will be tested in performing reaching movements as well as more functional tasks such as simulated drinking from a glass",[170,193],"Proprioceptive Disorders",[195,196,197],"stroke","proprioception","sensory substitution","2025-09-24",{"date":200,"type":36},"2025-09-29",{"date":202,"type":36},"2023-07-17",{"date":204,"type":21},"2026-05-31",{"name":42,"class":43},{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":15,"sex":16,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":221,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":86},"100542286","exercise-training-in-children-with-communication-impairments-100542286","NCT06340893","Exercise Training in Children With Communication Impairments","Exercise as Treatment in Children With Communication Impairments","Inclusion Criteria:\n\nChildren with a diagnosis of developmental language disorder (DLD) or typically developing controls will be included.\n\nAll children will meet following inclusion criteria:\n\n* (1) between 5 and 9 years old at enrollment\n* (2) from homes where the primary language spoken is English\n* (3) normal hearing based on parent report and audiometric screening\n* (4) typical nonverbal cognition as determined by a T-score within 1.5 standard deviations of the mean on nonverbal subtests of the Reynolds Intellectual Assessment Scales\n\nExclusion Criteria:\n\nExclusionary Criteria are:\n\n* (1) diagnosis of disorder that significantly affects social interactions (e.g., autism), as per referral diagnosis or which is identified during initial screening or assessment phase\n* (2) vision impairments that prevent participation in our experimental protocol\n* (3) inability for any reason to participate in assessment and\u002For treatment protocols","5 Years","9 Years",{"count":216,"type":21},40,[24],"This clinical trial study has two goals. The first goal is to establish fitness levels, participation in physical activities, and fine\u002Fgross motor abilities for children with development language disorder (DLD). DLD occurs in 1\u002F13 children and children with DLD often have poorer fine\u002Fgross motor skills than those with typical development. The second goal is to determine whether physical exercise helps children with DLD and typical development to learn better and improve fitness and fine\u002Fgross motor abilities more than participating in restful play activities.\n\nAll children (DLD and typically developing) will undergo communication, fine\u002Fgross motor and fitness testing. Children will be randomly assigned to participate in an exercise program (n =20) or to a restful play program (n = 20). Both programs will take place 3x\u002Fweek for 6 weeks and children will only participate in one of the two programs.\n\nChildren in the exercise program will do activities to train cardiovascular fitness, agility, balance, strength, and endurance while children in the restful play condition will do things like play with legos and color.\n\nResearchers will compare changes in learning tasks and fitness levels for children (DLD and typically developing) who participated in the exercise program vs. restful play program.",[220],"Developmental Language Disorder",[222,223,224,225,226],"developmental language disorder","exercise","learning","word learning","fitness","2025-05-16",{"date":229,"type":36},"2025-05-21",{"date":231,"type":36},"2024-07-02",{"date":233,"type":21},"2026-05-15",{"name":42,"class":43},{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":22,"phases":244,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":259,"locationsCount":86},"100582052","mental-imagery-to-improve-quadriceps-strength-post-anterior-cruciate-ligament-reconstruction-a-feasibility-study-100582052","NCT06858293","Mental Imagery to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility Study","Mental Imagery of Open and Closed Chain Exercises to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility Study","Inclusion Criteria:\n\n* post anterior cruciate ligament reconstruction (ACLR) surgery\n* cleared to participate in physical therapy\n* currently in physical therapy related to ACLR\n\nExclusion Criteria:\n\n* greater than 9 months post ACLR surgery\n* history of lower back of hip pain that would limit lower limb motor testing\n* current neurological condition that limits muscle strength\n* history of substance abuse in the last 5 years\n* any uncontrolled medical condition\n* inability to follow 2-step commands",{"count":243,"type":21},20,[24],"The goal of this clinical trial is to understand if people recovering from anterior cruciate ligament reconstruction (ACLR) surgery will complete mental imagery training and if this will improve their injured leg's strength. The main questions are:\n\n* Will people complete a five-day mental imagery exercise schedule while in physical therapy for ACLR?\n* Does mental imagery exercise help raise leg strength during ACLR recovery? Researchers will also compare if different mental imagery exercises involving leg extension or squats will change leg strength.\n\nParticipants will be asked to:\n\n* Participate in two testing sessions to make measurements of leg function\n* Complete about 10 minutes of mental imagery exercises once per day for five days at home and write down whether they complete the exercises.",[247],"Anterior Cruciate Ligament Reconstruction",[249,250,251,252],"Mental Imagery","knee","strength","physical therapy","2025-03-05",{"date":255,"type":36},"2025-03-10",{"date":257,"type":36},"2025-02-14",{"date":135,"type":21},{"name":42,"class":43},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":22,"phases":269,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":86},"100509923","phase-4-preemptive-ibuprofen-effects-on-pain-perception-following-extraction-and-bone-graft-100509923","NCT05919745","Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft","Patient Perception of Pain Following Extraction and Bone Graft Surgery With or Without Preemptive Ibuprofen: A Randomized Clinical Trial","Inclusion Criteria\n\n* Age \\>18 years\n* Good general health (controlled conditions)\n* Fluent in English\n* Treatment-planned for single site extraction and bone graft surgery\n\nExclusion criteria\n\n* Pregnancy\n* Site with active infection i.e purulence, abscess formation\n* Patients experiencing pain pre-operatively\n* Oral surgery in more than one site\u002Fquadrant in the same session\n* Patients receiving surgery under sedation\n* Patients with any contraindication for oral bone grafting surgery (e.g., on anticoagulants, medication-related osteonecrosis of the jaw, etc.)\n* Patients experiencing acute or chronic oral pain due to conditions or previous interventions\n* Patients with diseases or taking medications that affect hard and soft tissue wound healing such as poorly controlled diabetes, bisphosphonate use, corticosteroid use, chemotherapy, immunosuppressive therapy, etc.\n* Current or chronic (≥4 weeks) use of anti-inflammatory, analgesic, corticosteroid or sedative medications in the past 6 months\n* Health conditions that contraindicate the use of NSAIDs, such as stomach ulcers, bleeding disorders, renal disfunction, liver cirrhosis or acute liver disease, etc.\n* Intake of medications that interact with NSAIDs or whose actions can be affected by NSAIDs, such as anticoagulant\u002Fantiplatelet medications, ACE inhibitors, diuretics, etc.\n* Allergy to ibuprofen, acetaminophen and\u002For aspirin, and study materials (e.g., sutures, grafts, membranes?).\n* Patients having 3 or more alcoholic beverages daily\n* Patients who are planned to undergo heart surgery or had heart surgery less than 6 months prior\n* Not fluent in English",{"count":268,"type":21},50,[270],"PHASE4","The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery.\n\nThe primary question it aims to answer is:\n\n• Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo?\n\nSecondary questions are:\n\n* Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo?\n* Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?",[273,68],"Pain, Post Operative","2024-09-25",{"date":276,"type":36},"2024-09-27",{"date":278,"type":36},"2023-10-19",{"date":280,"type":21},"2026-12",{"name":42,"class":43},{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":122,"enrollmentInfo":288,"targetDuration":4,"studyType":22,"phases":290,"briefSummary":291,"conditions":292,"keywords":294,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":44},"100495783","high-intensity-dynamic-stability-gait-training-in-people-with-multiple-sclerosis-100495783","NCT05735691","High-Intensity, Dynamic-stability Gait Training in People With Multiple Sclerosis","Inclusion Criteria:\n\n1. Participants must have a clinical diagnosis of MS according to the revised McDonald Criteria. Participants with an EDSS score of 2.0-6.5 will be included but must have a stable disease course without worsening more than 1.0 EDSS point over the last 3 months and no MS exacerbation within the preceding 4 weeks, as determined by interview and review of medical records.\n2. Participants will have stable MS disease treatments. All medications will be consistent for at least 1 month prior to enrollment. No corticosteroids for at least 1 month and no botulinum toxin injections above the knee for at least 3 months prior to enrollment.\n3. Participants will be between the age of 18 and 65 and have a body mass of less than 135kg (maximum mass for treadmill equipment).\n4. Participants will be able to follow three commands, as determined by the three step command test of the Mini Mental State Exam.\n5. Participants must have had no myocardial infarction in the past month, must not have uncontrolled hypertension (blood pressure must be \\\u003C 190\u002F110 mmHg at rest), must not have a symptomatic fall in blood pressure when standing and must not have documented, uncontrolled diabetes.\n6. Participants will be medically stable, with absence of concurrent severe medical illness including: existing infection, known significant cardiovascular or metabolic disease that limits exercise participation, significant osteoporosis (as indicated by known history of fractures), known history of vascular claudication or pitting edema, and known history of pulmonary complications that limits exercise capacity, including significant obstructive and\u002For restrictive lung diseases.\n7. All participants must be able to perform walking training with passive range of motion within the limits of normal locomotor function, including: 0-30 +\u002F- 10 degrees ankle plantarflexion, knee flexion from 0 to 90 +\u002F- 10 degrees, hip flexion to 0-90 +\u002F- 10 degrees.\n8. Individuals who are undergoing concurrent physical therapy or supervised exercise by a trained professional will be excluded from the study to eliminate confounding effects of additional physical interventions. Other therapies, such as occupational or speech therapies, will be allowed as prescribed by their physician. Individuals will be allowed and encouraged to continue their normal exercise routines during the course of the intervention.\n9. Participants must have no other concomitant neurological diseases, no history of epileptic seizures, peripheral nerve injury in lower legs or traumatic brain injury.\n10. Participants must have adequate hearing (whisper test) and vision (minimum 20\u002F80 corrected vision on a Snellen chart).\n11. Participants must be able to walk for 10 meters at their preferred walking speed. For participants that require assistive devices to walk overground, minimal assistance will be provided to enable training until participants recover enough that they are not needed. The use of braces or orthoses is allowed in the proposed study to assure orthopedic safety. Participants will be excluded if they have factors that preclude stepping exercise, such as severe spasticity, excessive fatigue or exercise intolerance.\n12. Women of childbearing potential will not be excluded, although women who are pregnant or who are considering becoming pregnant will be excluded due to the trunk and pelvis restraints required for safety during treadmill training.\n13. Participants must be willing to commit to the treadmill training program schedule and participate in all of the assessments. They must be able to provide informed written consent and willing to be randomized to any of the 4 study arms.\n\nExclusion Criteria:\n\nSee inclusion criteria.",{"count":289,"type":21},150,[24],"The goal of this clinical trial is to improve walking speed, balance, and walking in the community for people with multiple sclerosis. This trial involves intense exercise combined with walking on a shaky treadmill. Walking on a shaky treadmill helps to practice balance and intense exercise promotes the ability to walk faster and farther. In this study, participants will train with a combination of high or low intensity, and with a stable or shaky treadmill. Walking speed and endurance, balance while walking and the number of steps taken in the community will be measured before, half way through the training (15 sessions), after training (30 sessions) and six months after training.",[293],"Multiple Sclerosis",[295,296,297,75],"Walking","Balance","Treadmill","2024-06-03",{"date":300,"type":36},"2024-06-05",{"date":302,"type":36},"2023-01-01",{"date":304,"type":21},"2027-06-30",{"name":42,"class":43},""]