[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Masaryk University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":445},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,43,75,97,131,165,190,221,251,284,310,341,367,390,416],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100636070","non-invasive-stimulation-of-deep-brain-structures-to-modulate-working-memory-100636070",false,"NCT07560904","Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory","DEEPBRAIN","Inclusion Criteria:\n\n* normal cognitive performance as assessed by a cognitive screening for healthy subjects\n* possible or probable MCI-LB or with PD-MCI, collectively called MCI-LBD, described as: presence of PD , and level II criteria for MCI (i.e. based on comprehensive neuropsychological examination), or the level II criteria for MCI , and at least two of four core DLB features including parkinsonism, visual hallucinations, attention\u002Fcognitive function fluctuation, and REM sleep behavioral disorder, or at least 1 core clinical feature and 1 indicative biomarker (probable MCI-LB).\n\nExclusion Criteria:\n\n* Psychiatric disorders including major depression, major vascular lesions, or other brain pathologies that might present with cognitive decline.",true,"ALL","60 Years","80 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities. Currently, there is no effective treatment for impairments in these functions. The study will evaluate the effects of non-invasive electrical stimulation in both healthy older adults and individuals with mild impairment of these functions.\n\nThe study combines magnetic resonance imaging (MRI) with non-invasive brain stimulation targeting deep brain structures. Its aim is to improve understanding of the neural mechanisms underlying these cognitive functions and their impairments, as well as to explore the mechanisms of non-invasive brain stimulation for potential future therapeutic applications.",[28,29],"Older Adults (60 - 85 Years Old)","Mild Cognitive Impairment (MCI)","RECRUITING","2026-04-28",{"date":33,"type":34},"2026-05-01","ACTUAL",{"date":36,"type":34},"2026-03-01",{"date":38,"type":22},"2026-07",{"name":40,"class":41},"Masaryk University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":51,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":42},"100627475","effect-of-striatal-temporal-interference-stimulation-on-language-processing-in-neurodegenerative-diseases-100627475","NCT07449117","Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases","Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases","Inclusion Criteria:\n\n* Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI).\n\nExclusion Criteria:\n\n* Any severe psychiatric disorder.\n* History of other neurological diseases affecting the central nervous system.\n* Severe head trauma.\n* Uncompensated internal or oncological disease.\n* Presence of MRI-incompatible metal in the body (e.g., pacemaker).",{"count":21,"type":22},[25],"The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.",[54,55,56],"Mild Cognitive Impairment (MCI) Amnestic","Lewy Body Disease With Mild Cognitive Impairment","Parkinson's Disease With Mild Cognitive Impairment",[58,59,60,61,62,63,64,65,66],"Temporal Interference Stimulation","Functional Magnetic Resonance Imaging","Sentence Comprehension","Language Processing","Brain Connectivity","Striatum","Fronto-striatal Circuit","Mild Cognitive Impairment","Neurodegenerative Diseases","2026-02-27",{"date":69,"type":34},"2026-03-04",{"date":71,"type":22},"2026-03",{"date":73,"type":22},"2028-12",{"name":40,"class":41},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":42},"100504413","language-and-lewy-body-diseases-sentence-comprehension-problems-and-modifying-noninvasive-brain-stimulation-treatment-100504413","NCT05847985","Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment","LANG-LBD","Inclusion Criteria:\n\n* right-handedness\n* Czech as their first language\n* age (60-80 years)\n* presence of PD-MCI (Litvan et al. 2012) or MCI-LB (McKeith et al. 2020) for LBD subjects\n\nExclusion Criteria:\n\n* cardio pacemaker\n* any MRI-incompatible metal in the body\n* epilepsy\n* any diagnosed psychiatric disorders\n* alcohol\u002Fdrug abuse\n* for HC group the presence of LBDs or other neurodegenerative disorder or MCI\u002Fdementia",{"count":83,"type":22},90,[25],"Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting in cell death. LBDs consists of two major clinical entities - Parkinson's disease (PD) and dementia with LB (DLB). Vast majority of patients with LBDs either already have mild cognitive impairment (MCI) at the time of the diagnosis or will develop it during the course of the disease. Language dysfunctions in LBDs patients with MCI are often unrecognized, which are difficult to treat, but even subtle changes might lead to impairment of social and occupational functioning with profound effect on their quality of lives. Current pharmacological or surgical strategies are effective for tackling the motor issues of LBDs with very limited effects on other symptoms such as language dysfunctions. Therefore, non-pharmacological approaches are gaining more attention. One of these non-pharmacological strategies is the use of noninvasive brain stimulation (NIBS) techniques that are able to modulate the brain functions with the effects on human nervous system plasticity. In this proposed project the investigators aim to first describe specific alterations in the language domain in LBDs patients with MCI as compared to healthy controls (HC) and identify the neural underpinnings of these changes using novel combination of advanced multimodal imaging techniques and various analytical methods. Secondly, the investigators aim to use NIBS as a supervised and individualized home-based therapeutical approach to tackle the language dysfunctions.",[87,88],"Lewy Body Disease","Healthy Aging","2026-02-02",{"date":91,"type":34},"2026-02-04",{"date":93,"type":34},"2023-05-01",{"date":95,"type":22},"2026-12-31",{"name":40,"class":41},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":104,"enrollmentInfo":105,"targetDuration":104,"studyType":107,"phases":4,"briefSummary":108,"conditions":109,"keywords":115,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},"100615699","motor-development-and-early-predictors-of-psychomotor-outcomes-in-preterm-and-term-infants-assessed-by-mos-r-and-caregiver-questionnaire-at-18-and-36-months-100615699","NCT07296003","Motor Development and Early Predictors of Psychomotor Outcomes in Preterm and Term Infants Assessed by MOS-R and Caregiver Questionnaire at 18 and 36 Months","A Longitudinal Observational Study of Early Spontaneous Motor Activity, Postural Control, and Motor Optimality Score (MOS-R) as Predictors of Psychomotor, Cognitive, and Sensory Development at 18 and 36 Months in Preterm and Term Infants, With Consideration of Early Therapeutic Intervention","Inclusion Criteria:\n\n* The child was born either preterm or full-term. Both groups are included in the study.\n* The child completed a video recording of early movements during routine check-ups in the first months of life.\n* The parents or legal guardians agree to participate and give informed consent.\n* The child will be available for follow-up at around 18-36 months of age, when parents will complete a developmental questionnaire.\n\nExclusion Criteria:\n\n* There is no usable video recording of the child's early spontaneous movements from the neonatal or early infant period.\n* The child has a diagnosed medical condition that makes movement assessment impossible (for example, severe congenital anomalies or conditions preventing typical movement).\n* Parents do not wish to participate or withdraw their consent.\n* The child is not available for follow-up, meaning that the developmental questionnaire at 18-36 months cannot be completed.","3 Years",{"count":106,"type":22},60,"OBSERVATIONAL","This study examines how early motor behavior in infants relates to their later psychomotor development. Researchers will observe both preterm and full-term infants during the first months of life, using video-based assessments to evaluate spontaneous movements and early postural control. These early motor patterns will be scored with the Motor Optimality Score - Revised (MOS-R).\n\nWhen the children reach 18 and 36 months of age, their development in areas such as motor skills, communication, sensory processing, and social behavior will be evaluated through a caregiver-completed questionnaire.\n\nThe purpose of the study is to determine whether early motor quality can predict later developmental outcomes, whether preterm and full-term infants with similar motor scores develop differently, and whether early therapy may improve outcomes for infants with low MOS-R results.",[110,111,112,113,114],"Neurodevelopmental Disorders","Motor Skills Disorders","Infant, Premature Development","Infant, Term Development","Postural Balance",[116,117,118,119,120,121],"General Movements Assessment","Motor Optimality Score Revised","Postural Control","Full-Term Infants","Preterm Infants","Neurodevelopmental Outcomes","2026-01-02",{"date":124,"type":34},"2026-01-06",{"date":126,"type":34},"2024-04-19",{"date":128,"type":22},"2027-07-30",{"name":40,"class":41},3,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":16,"sex":138,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":42},"100595154","evaluation-of-catching-skills-in-preschoolers-with-motor-difficulties-100595154","NCT07028762","Evaluation of Catching Skills in Preschoolers With Motor Difficulties","Motor Coordination During Catching of a Moving Object in Preschool Children as the Indicator of Motor Development","Inclusion Criteria:\n\n* Age between 4.0 and 7.0 years (preschool age)\n* Male sex\n* Motor performance within the defined inclusion range based on the Movement Assessment Battery for Children - 2nd Edition (MABC-2)\n* Typically developing children (as assessed by educators or therapists), or\n* Children identified as having motor coordination difficulties\n\nExclusion Criteria:\n\n* Children with intellectual disability\n* autism spectrum disorder\n* uncorrected vision impairment\n* hearing loss\n* neurological or psychiatric conditions, behavioral disorders, or orthopedic limitations will be excluded.","MALE","4 Years","7 Years",{"count":142,"type":22},40,"This research project investigates the development of predictive and online motor control in preschool-aged boys with typical development and those with motor difficulties, specifically children at risk for Developmental Coordination Disorder (DCD). The study is being conducted as part of a doctoral dissertation at the Faculty of Sports Studies, Masaryk University in Brno, in cooperation with the integration and rehabilitation center Lentilka in Pardubice.\n\nThe aim of the study is to assess how children plan, initiate, and adjust their movements in response to a dynamic, time-sensitive task-catching a horizontally moving object (pendulum) under two different time constraints. By comparing performance between typically developing children and those identified as being at risk for motor difficulties, the study aims to improve our understanding of motor control development and support the creation of more effective diagnostic and educational strategies.\n\nParticipants in this study will be preschool boys from two age groups: 4.6 to 5.0 years and 6.5 to 7.0 years. Each age group will include 10 children with typical motor development and 10 children with motor difficulties, defined as scoring below the 16th percentile on the Movement Assessment Battery for Children - Second Edition (MABC-2). In total, the study aims to recruit 40 participants. Children with intellectual disabilities, autism spectrum disorder, uncorrected visual impairments, hearing loss, psychiatric or neurological conditions, or significant behavioral or orthopedic problems will be excluded from participation.\n\nEach child will complete two parts of the study protocol. The first involves a standardized motor assessment using the MABC-2, which evaluates both fine and gross motor skills, including tasks such as threading beads, catching, and balance activities. The second part is an experimental task requiring interception of a swinging foam ring attached to a horizontal pendulum. The children will attempt to stop the pendulum at a precise moment under two time conditions: either on its first pass through the target zone (approximately 0.750 seconds after release) or on its second pass (approximately 1.5 seconds after release). The task will be performed using both the dominant and non-dominant hand, with multiple repetitions in each condition.\n\nDuring the experiment, children will stand on a pressure-sensitive mat (CONFORMat® Tekscan), which records shifts in their center of pressure (COP). Upper limb movement will be captured using reflective markers placed on anatomical landmarks (shoulder, elbow, wrist, and hand), and recorded by four video cameras (two sagittal, two frontal). Movement data will be analyzed using Dartfish software.\n\nThe study will focus on several key outcome measures: anticipatory postural adjustments (APAs) based on COP movement prior to arm motion, spatial accuracy of the stopping movement (angular deviation), trajectory and velocity of COP displacement, timing of movement initiation based on radial styloid marker velocity, joint angles and segmental velocity, and overall smoothness of upper limb motion. All data and recordings will be pseudonymized, securely stored, and used exclusively for research purposes. Recordings will be deleted upon project completion.\n\nThis study aims to clarify the developmental trajectory of anticipatory and online motor control strategies in early childhood and to distinguish between typical and atypical motor patterns. The findings are expected to contribute to early screening practices and the development of targeted educational and therapeutic interventions for children with motor coordination difficulties. Ethical approval for the study has been granted by the Research Ethics Committee of Masaryk University. Participation is voluntary, and parents will receive individualized feedback on their child's motor performance after assessment.",[145,146],"Development Coordination Disorder","Motor Disabilities",[148,149,150,151,152,153,154,155,156],"motor control","predictive control","feedback control","developmental coordination disorder -DCD","anticipatory postural adjustments- APA","interception task","preschool children","MABC-2","center of pressure - COP","2025-11-30",{"date":159,"type":34},"2025-12-02",{"date":161,"type":34},"2025-03-31",{"date":163,"type":22},"2026-12",{"name":40,"class":41},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":16,"sex":17,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":189,"locationsCount":42},"100594460","esskaesma-acl-injury-prevention-program-in-czech-sport-100594460","NCT07019727","ESSKA\u002FESMA ACL Injury Prevention Program in Czech Sport","Anterior Cruciate Ligament Injury Prevention Program ESSKA\u002FESMA: A Comprehensive Approach to Reducing the Incidence of Knee Joint Injuries in Czech Sport","Inclusion Criteria:\n\n* Age group: Participants aged 17-20 years\n\nSports activity: Individuals actively engaged in sports with a high risk of ACL injury\n\nHealth status: Participants with no or minimal previous knee joint injuries that do not limit their current physical activity\n\nWillingness to participate: Agreement to take part in the prevention program, including regular training and assessments\n\nInformed consent: Signed informed consent for participation in the program and testing procedures; for minors, consent must be signed by legal guardians\n\nExclusion Criteria:\n\nCurrent injury: Individuals with a current knee joint injury requiring treatment or surgery\n\nChronic conditions: Participants with chronic diseases or conditions that may affect the outcome of injury prevention (e.g., congenital abnormalities, neuromuscular disorders, or cardiovascular diseases)\n\nInsufficient consent: Individuals who are unable or unwilling to provide written informed consent\n\nIrregular participation: Individuals who do not comply with regular participation in the training program or assessments","17 Years","20 Years",{"count":175,"type":22},100,[25],"This study aims to address the rising incidence of ACL injuries, particularly among adolescents, by developing and implementing a comprehensive prevention program based on the evidence-based \"ACL Prevention for ALL\" framework recommended by ESSKA-ESMA. The project focuses on muscle strengthening, flexibility, coordination, proper movement techniques, and a multidisciplinary approach involving coaches, physiotherapists, and physicians. Through targeted exercise modules, education, and dynamic evaluation-including 2D motion analysis-the study seeks to reduce ACL injuries, enhance movement safety, and enable individualized training plans by identifying and correcting muscle and biomechanical imbalances.",[179,180,181,182],"Double Leg Vertical Jump (DLVJ)","Single Leg Squat (SLS)","Single Leg Drop Landing (SLDL)","Drop Jump Test (DJ Test)","2025-09-29",{"date":185,"type":34},"2025-09-30",{"date":187,"type":34},"2025-06-12",{"date":95,"type":22},{"name":40,"class":41},{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":197,"targetDuration":198,"studyType":107,"phases":4,"briefSummary":199,"conditions":200,"keywords":208,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":219,"locationsCount":220},"100605729","ultrasound-evaluation-of-hematoma-risk-after-needle-emg-in-patient-on-doac-therapy-100605729","NCT07166302","Ultrasound Evaluation of Hematoma Risk After Needle EMG in Patient on DOAC Therapy","U-HAND","Inclusion Criteria:\n\n* Subjects must understand the nature of the study and must provide signed and dated written informed consent prior to conducting any study-related procedures\n* Willing and able to comply with all protocol procedures\n* subjects confirmed the daily (and recent) intake od direct anticoagulants in strandard dosing.\n* no other antitrombotic drug therapy (e.g. acetylsalicyl acid, clopidogrel, ticagralol, low molecular weight heparin or second direct anticoagulant) is taken.\n\nExclusion Criteria:\n\n* Any clinically significant medical or psychiatric condition or medical history that, in the opinion of the investigator, would interfere with the subject's ability to participate in the study or increase the risk of participation for that subject\n* other antitrombotic drug therapy (e.g. acetylsalicyl acid, clopidogrel, ticagralol, low molecular weight heparin or second direct anticoagulant) is recently taken.",{"count":21,"type":22},"7 Days","Approximately 30 minutes after needle EMG, patients who are taking direct oral anticoagulants (DOACs) will undergo an ultrasound examination to evaluate for the presence of possible intramuscular hematomas at the muscles where the EMG needle was inserted. These hematomas are considered a potential adverse effect of needle EMG.\n\nThe aim of the study is to determine whether needle EMG can be considered a safe procedure in this group of patients, without posing a risk of intramuscular hematoma formation.",[201,202,203,204,205,206,207],"Direct Acting Anticoagulant Adverse Reaction","Needle Injury","EMG","Peripheral Neuropathies","Mononeuropathies","Polyneuropathies","Neuromuscular Diseases (NMD)",[209,210,211,212],"electromyography","hematoma","ultrasonography","anticoagulants","2025-09-03",{"date":215,"type":34},"2025-09-10",{"date":217,"type":22},"2025-09",{"date":95,"type":22},{"name":40,"class":41},2,{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":17,"minAge":228,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":231,"conditions":232,"keywords":237,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":42},"100599496","the-role-of-cutibacterium-acnes-in-the-development-of-degenerative-lumbar-intervertebral-disc-disease-100599496","NCT07085247","The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease","The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease and the Clinical Effect of Microdiscectomy","Inclusion Criteria:\n\n* minimum age of 18 years\n* MRI of the lumbosacral spine performed one month ± 2weeks before surgery showing a disc protrusion, herniation, or free nucleus pulposus sequestration\n* matching physical examination findings including positive straight leg raise test, dermatomal sensory deficits, myotome motor deficits, and diminished deep tendon reflexes.\n\nExclusion Criteria:\n\n* antibiotics or corticosteroid use the month before surgery\n* ongoing bacterial or viral infection\n* immunocompromised patient\n* trauma\n* undefined radiological mass\n* inflammatory arthritis\n* other rheumatologic diseases.","18 Years",{"count":230,"type":22},400,"The goal of this study is to clarify the role of the bacterium Cutibacterium acnes in the development of degenerative disc disease in patients with lumbar disc herniation who underwent microdiscectomy as part of their regular medical care.",[233,234,235,236],"Lumbar Disc Herniation","Lumbar Disc Degeneration","Cutibacterium Acnes","Low Back Pain",[238,239,240,241,242],"Cutibacterium acnes","Degenerative disc disease","Low back pain","Microdiscectomy","Clinical outcome","2025-08-26",{"date":245,"type":34},"2025-08-27",{"date":247,"type":34},"2025-06-01",{"date":249,"type":22},"2028-12-31",{"name":40,"class":41},{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":261,"conditions":262,"keywords":264,"overallStatus":275,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":42},"100585764","psychophysiological-stress-response-in-medical-students-during-simulation-based-communication-training--study-protocol-100585764","NCT06906614","Psychophysiological Stress Response in Medical Students During Simulation-Based Communication Training -Study Protocol","Analysis of Predictors of Stress Reactions in Medical Students During Simulation-Based Training","SIMU2025","Inclusion Criteria\n\n* Enrollment as a 3rd-year medical student at the Faculty of Medicine, Masaryk University.\n* Participation in the Medical Psychology and Psychosomatics course.\n* Active involvement in simulation-based communication training sessions.\n* Signed informed consent provided before the start of the study.\n* Willingness to wear physiological monitoring devices (e.g., chest strap) during simulations.\n\nExclusion Criteria\n\n* Inability or unwillingness to complete all phases of data collection, including pre- and post-simulation assessments.\n* Absence of a smartphone with Bluetooth connectivity.",{"count":260,"type":22},150,"In this study, researchers will examine key predictors of stress reactions in medical students participating in simulation-based communication training. By using psychometric questionnaires and physiological measurements, the study will assess how psychological traits, resilience, and self-efficacy impact stress responses during simulated patient interactions. These simulations use live actors to portray emotionally challenging scenarios, such as communicating with anxious or aggressive patients. The results aim to identify factors that contribute to heightened stress, ultimately guiding the development of targeted stress-management strategies to improve students' readiness for real-world clinical settings.",[263],"Stress",[265,266,267,268,269,270,271,272,273,274],"Medical Student Stress","Simulation-Based Training","Psychological Predictors of Stress","Physiological Stress Responses","Heart Rate Variability (HRV)","Patient Communication Skills","Resilience and Self-Efficacy","High-Fidelity Simulation","Stress Management in Medical Education","Psychometric Assessments in Training","NOT_YET_RECRUITING","2025-04-02",{"date":278,"type":34},"2025-04-03",{"date":280,"type":22},"2025-04-01",{"date":282,"type":22},"2025-12-31",{"name":40,"class":41},{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":298,"overallStatus":275,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":307,"leadSponsor":309,"locationsCount":42},"100584272","point-of-care-ultrasound-in-chronic-heart-failure-100584272","NCT06887179","Point-of-Care Ultrasound in Chronic Heart Failure","The Role of Point-of-Care Ultrasound in the Management of Chronic Heart Failure","POCUS-HF","Inclusion Criteria:\n\n* Patients after hospitalization for acute heart failure (AHF)\n* Symptoms (shortness of breath, oedema, decreased exercise tolerance, increase in abdominal circumference)\n* Clinical signs (jugular vein distention, hepatojugular reflux, third heart sound, wet lung crackles, pitting oedema) or signs of congestion on CT, X-ray or ultrasound\n* NT-proBNP \\>450 pg\u002FmL \\\u003C55 years old, \\>900 pg\u002FmL 55-75 years old, \\>1800 pg\u002FmL \\>75 years old\n* Increase in oral diuretic therapy or need for IV diuretics\n\nExclusion Criteria:\n\n* pregnancy or lactation\n* under 18 years of age,\n* current AHF due to a transient cause (Takotsubo syndrome, neurogenic myocardial stunning, septic cardiomyopathy, cardiac tamponade, pulmonary embolism with acute cor pulmonale, thyrotoxicosis, bradycardia \\\u003C40\u002Fmin)\n* planned surgical treatment of the HF cause, CRT implantation or valvular repair ≤ 30 days ago, STEMI or coronary angiography with PCI or CABG ≤ 30 days ago, untreated AV block III. and II. degree type 2, planned or previous heart transplantation, myocarditis ≤ 6 months ago, complex congenital heart disease, cardiac amyloidosis, hypertrophic and restrictive cardiomyopathy, constrictive pericarditis\n* BMI over 40 kg\u002Fm2, cognitive deficit with MMSE \\\u003C18 points, life expectancy \\\u003C 12 months, progressive oncological disease, chronic liver failure Child-Pugh C, chronic kidney disease with eGFR \\\u003C0.25 ml\u002Fs\n* current participation in another study or relative of investigators",{"count":293,"type":22},112,[25],"This study aims to determine whether Point-of-Care Ultrasound (POCUS)-guided treatment is non-inferior to standard NT-proBNP-based care in ambulatory patients following hospitalization for heart failure (HF) over a 12-month follow-up period.",[297],"Cardiovascular Diseases",[299,300,301,302],"Heart failure","Diuretic therapy","Congestion","Point-of-Care Ultrasound","2025-03-20",{"date":305,"type":34},"2025-03-25",{"date":280,"type":22},{"date":308,"type":22},"2029-12-31",{"name":40,"class":41},{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":17,"minAge":228,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":23,"phases":321,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":220},"100583283","non-invasive-brain-stimulation-to-prepare-the-patient-for-bariatric-surgery-rebas-100583283","NCT06874309","Non-invasive Brain Stimulation to Prepare the Patient for Bariatric Surgery (REBAS)","Non-invasive Brain Stimulation to Prepare the Patient for Bariatric Surgery","REBAS","Inclusion Criteria:\n\n* Subjects with severe or morbid obesity (determined by BMI \\> 35 or 40 kg\u002Fm2, respectively) eligible for BS treatment in compliance with the current guidelines\n* Subjects who meet reduced control over eating behavior (disinhibition) criteria in the Eating Habits Questionnaire\n\nExclusion Criteria:\n\n* Subjects unable to provide informed consent and those unable to understand and cooperate with study-related procedures (based on the physician's discretion)\n* Subjects with a personal history of ischemic heart disease, myocardial infarction, stroke, heart failure, and atrial fibrillation\n* Subjects who have already undergone BS treatment in the past\n* Pregnant subjects or subjects that plan on becoming pregnant during the study.\n* Subjects deemed unsuitable for the study based on expert evaluation (e.g., by a physician or neuropsychologist) will be excluded.\n* Subjects with dreadlocks (problematic for the EEG)","65 Years",{"count":320,"type":22},65,[25],"Obesity is a chronic metabolic condition characterized by excessive accumulation of body fat, which triggers physiological mechanisms that increase the risk of a wide range of health problems. The most effective treatment for severe obesity is metabolic-bariatric surgery, which can lead to a 15-20% weight reduction, significantly lowering the risks of illness and death. However, the success of this surgery can be threatened by poor eating habits after the procedure. The main goal of this study is to enhance the long-term effectiveness of bariatric surgery by combining it with non-invasive brain stimulation (tDCS) targeting inhibitory centers before the operation. Additionally, the investigators aim to comprehensively monitor patients before and after surgery, focusing on investigating changes in brain function associated with the achieved weight loss.",[324],"Obesity",[326,327,328,329,330,331,332],"bariatric surgery","obesity","brain stimulation","tDCS","cognitive control","impulsivity","eating behavior","2025-03-11",{"date":335,"type":34},"2025-03-13",{"date":337,"type":34},"2024-05-01",{"date":339,"type":22},"2027-12-31",{"name":40,"class":41},{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":16,"sex":17,"minAge":228,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":350,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":42},"100558145","cyp1a2-and-adora2a-genotypes-and-endurance-performance-100558145","NCT06547307","CYP1A2 and ADORA2A Genotypes and Endurance Performance.","Effects of Caffeine, CYP1A2 and ADORA2A Genotypes on Cycling Endurance Performance.","Inclusion Criteria:\n\n* healthy person\n* any training status\n* within age limits\n* without contraindications to perform the test on a bicycle trainer\n* No contraindications to caffeine intake\n\nExclusion Criteria:\n\n* Pregnancy\n* Breast feeding\n* Cardiovascular disease\n* Hypertension\n* Liver disease in the previous two months\n* Taking drugs that can affect liver function\n* Illness in the period of 14 days before the start of the research\n* Use of caffeine during research","35 Years",{"count":106,"type":22},[25],"The aim of this randomized, double-blind, placebo-controlled experiment will be to assess the potential effect of the selected gene polymorphism (CYP1A2, ADORA2A) on performance after caffeine ingestion.",[353],"Healthy",[355,356,357,358],"endurance","genotype","caffeine","ergogenic effect","2024-08-07",{"date":361,"type":34},"2024-08-09",{"date":363,"type":22},"2024-08",{"date":365,"type":22},"2025-03",{"name":40,"class":41},{"id":368,"slug":369,"hasResults":11,"nctId":370,"briefTitle":371,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":375,"conditions":376,"keywords":378,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":42},"100507783","delirium-in-the-neurointensivecritical-care-in-the-adult-and-paediatric-czech-populations-100507783","NCT05891873","Delirium in the (Neuro)Intensive\u002FCritical Care in the Adult and Paediatric Czech Populations","Inclusion Criteria:\n\n* Neurointensive\u002Fneurocritical group (N-ICU): patients with acute ischaemic or haemorrhagic stroke admitted to the Stroke Unit or ICU of the Department of Neurology, University Hospital Brno (NK-UHB).\n* Paediatric intensive\u002Fcritical group (P-ICU): children aged 6-18 years, admitted to the Paediatric ICU - Department of Paediatric Anaesthesiology and Intensive Care (KDAR-UHB) with a stay of at least 24 hours (including postoperative care).\n\nExclusion Criteria:\n\n* (N-ICU) severe trauma with short life expectancy (days)\n* duration of the ICU stay shorter than 24 hours",{"count":374,"type":22},700,"Intensive and critical care in the intensive care unit (ICU) is often associated with ICU delirium and post-ICU dementia, regardless of the nature of the primary disease or insult. Optimal practical management of ICU delirium including its screening, prevention, and treatment, is an integral part of the current recommendations for optimal ICU care, but there are large gaps in the knowledge about the optimal and most effective prevention and treatment of this complication. Information on the actual implementation of these recommendations in the Czech Republic is lacking. The diagnosis of delirium is particularly challenging in neurointensive care patients (due to overlap with symptoms of primary brain lesions) and in a paediatric population. A complementary multicentre observational 4-year follow-up study, performed in an adult neurointensive\u002Fcritical care stroke cohort and in a paediatric intensive\u002Fcritical care cohort in centres following currently recommended preventive measures (Delusion-deep-cz) will investigate the incidence of ICU delirium and post-ICU dementia and their modifiable and non-modifiable predisposing and precipitating risk factors. Objectives are to determine the optimal methods for diagnostic screening of these complications and for the differential diagnosis of conditions mimicking delirium (non-convulsive epileptic state) or symptoms hindering its diagnosis (aphasia), and to study the association between sleep disturbances and ICU delirium to verify the role of sleep in the pathophysiology of delirium.",[377],"Delirium",[379,380,381],"delirium","delirium screening","ICU delirium","2023-10-18",{"date":384,"type":34},"2023-10-23",{"date":386,"type":34},"2023-09-07",{"date":388,"type":22},"2027-12",{"name":40,"class":41},{"id":391,"slug":392,"hasResults":11,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":11,"sex":17,"minAge":228,"maxAge":4,"enrollmentInfo":397,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":399,"conditions":400,"keywords":403,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":414,"locationsCount":415},"100426581","covid-19-vaccines-safety-tracking-covast-100426581","NCT04834869","COVID-19 Vaccines Safety Tracking (CoVaST)","COVID-19 Vaccines Safety Tracking: Global Consortium Study","Inclusion Criteria:\n\n* HCW, OA and ST who received COVID-19 vaccine.\n* Participating subjects should be at least 18-year-old and able to give their informed consent independently.\n\nExclusion Criteria:\n\n* Non HCW, OA and ST who received the COVID-19.",{"count":398,"type":22},30000,"This project aims to monitor the side effects of COVID-19 vaccines worldwide actively. The primary objectives of the project include a) to estimate the prevalence of each local and systemic side effect of each COVID-19 vaccine among healthcare workers (HCW), old adults over +65 (OA), and schoolteachers (ST); b) to evaluate the potential demographic and medical risk factors for side effects frequency and intensity; c) to evaluate the long-term consequences of COVID-19 vaccines. The secondary objectives include a) to evaluate the relative safety of COVID-19 vaccines compared to each other; b) to evaluate the impact of palliative drugs used by the recently vaccinated individuals on their short-term side effects resolution.",[401,402],"Adverse Reaction to Vaccine","COVID19 Vaccine",[404,405,406,407],"COVID-19","Vaccines","Safety","Side Effects","2022-04-05",{"date":410,"type":34},"2022-04-06",{"date":412,"type":34},"2021-04-01",{"date":95,"type":22},{"name":40,"class":41},14,{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":422,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":17,"minAge":228,"maxAge":424,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":427,"briefSummary":428,"conditions":429,"keywords":431,"overallStatus":275,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":444,"locationsCount":42},"100434318","prediction-of-vagal-nerve-stimulation-efficacy-in-drug-resistant-epilepsy-100434318","NCT04935567","PRediction of Vagal Nerve Stimulation EfficaCy In Drug-reSistant Epilepsy","PRediction of Vagal Nerve Stimulation EfficaCy In Drug-reSistant Epilepsy: Prospective Study for Pre-implantation Prediction","PRECISE","Inclusion Criteria:\n\n* Drug-resistant epilepsy indicated to VNS based on clinical decision.\n* Drug-resistant epilepsy is defined as a failure of adequate trials of two tolerated, appropriately chosen, and used antiepileptic drug schedules (whether as monotherapy or in combination) to achieve sustained seizure freedom (Kwan et al., 2010).\n* Age ≥ 18 years\n* Availability to record 20 minutes of EEG with photic stimulation, hyperventilation, and eye-opening\u002Fclosing according to the pre-defined protocol.\n* Availability of seizure diaries at least three months before VNS implantation OR reliable information about seizure frequency at least three months before VNS implantation\n* The ability of a patient\u002Ffamily member\u002Fcaregiver to record seizures precisely into seizure diaries OR the ability of a patient\u002Ffamily member\u002Fcaregiver to report seizures precisely different ways.\n* In cases with very high seizure frequency (several seizures per day), it is acceptable to report only the days without any seizures.\n\nExclusion Criteria:\n\n* The indication and planning of resection brain surgery as a treatment option for drug-resistant epilepsy. If a patient clearly demonstrates his refusal of resection surgery, he\u002Fshe can be included in the study.\n* The presence of psychogenic non-epileptic seizures which cannot be reliably distinguished from epileptic seizures by a patient\u002Ffamily member\u002Fcaregiver.\n* The presence of other condition which can resemble epileptic seizures which cannot be reliably distinguished from epileptic seizures by a patient\u002Ffamily member\u002Fcaregiver.\n* Metabolic condition or other diseases, in which the increase of seizure frequency is expectable.\n* The inability of a patient to take regular visits which are required for VNS parameters settings or the study\n* Life expectancy shorter than two years","85 Years",{"count":426,"type":22},120,[25],"Vagal nerve stimulation (VNS) can be indicated in patients with drug-resistant epilepsy who are not eligible for resective epilepsy surgery with responders rates about 50% (≥50% seizure reduction). At the moment, there is not a widely-accepted possibility to predict VNS efficacy in a given patient based on pre-implantation data, which can lead to unnecessary surgery and improper allocation of financial resources. The principal aim of PRECISE (PRediction of vagal nerve stimulation EfficaCcy In drug-reSistant Epilepsy) study is to verify the predictability of VNS efficacy by analysis of pre-implantation routine EEG. The PRECISE relies on the results of our previous work, which developed a statistical classifier for VNS response (responders vs. non-responders) based on differences in EEG power spectra dynamics (Pre-X-Stim). PRECISE is designed as a prospective multicentre study in which patients indicated to VNS therapy will be recruited. Patients will be classified as predicted responders vs. predicted non-responders using pre-implantation EEG analyses. After the first and the second year of the study, the real-life outcome (responder vs. non-responder) will be determined. The real-life outcome and predicted outcome will be compared in terms of accuracy, specificity, and sensitivity. In the meantime, the patients will be managed according to the best clinical practice to obtain the best therapeutical response.",[430],"Drug Resistant Epilepsy",[432,433,434,435,436,437],"Drug-resistant epilepsy","Vagal nerve stimulation","Efficacy predictability","Responders","Non-responders","EEG","2021-06-22",{"date":440,"type":34},"2021-06-23",{"date":442,"type":22},"2021-12-01",{"date":95,"type":22},{"name":40,"class":41},""]