[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":280},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,48,75,101,131,158,183,207,233,259],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100640762","effect-of-high-flow-nasal-oxygen-on-laryngoscopic-view-100640762",false,"NCT07575776","Effect of High-Flow Nasal Oxygen on Laryngoscopic View","Effect of Different Flows Using High-Flow Nasal Oxygen (HFNO) on Laryngoscopic View Quality During Videolaryngoscopy","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled for endotracheal intubation under general anesthesia\n* Use of videolaryngoscopy\n\nExclusion Criteria:\n\n* Anticipated difficult airway\n* Emergency intubation\n* Contraindications to HFNO\n* Inability to obtain adequate video recording","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","OBSERVATIONAL","This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing general anesthesia. Each patient will serve as their own control, with repeated measurements obtained at three different HFNO flow settings (0, 40, and 60 L\u002Fmin). The study will assess objective and subjective parameters of glottic visualization using standardized scoring systems.",[24,25,26,27,28,29],"High Flow Nasal Canula","Laryngoscopy","Airway Anesthesia","Airway Complication of Anaesthesia","Difficult Airway","Difficult \u002F Failed Intubation",[31,32,33,34,35],"high flow nasal canula","thrive","difficult airway","airway management","anaesthesia","NOT_YET_RECRUITING","2026-05-04",{"date":39,"type":40},"2026-05-08","ACTUAL",{"date":42,"type":20},"2026-09-01",{"date":44,"type":20},"2027-12-01",{"name":46,"class":47},"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100632680","three-dimensional-gait-analysis-and-electromyography-after-stabilisation-of-thoracolumbar-spine-fractures-focusing-on-possible-temporal-diferences-in-physiological-gait-recovery-through-comparison-of-open-and-minimally-invasive-approaches-100632680","NCT07516834","Three Dimensional Gait Analysis and Electromyography After Stabilisation of Thoracolumbar Spine Fractures Focusing on Possible Temporal Diferences in Physiological Gait Recovery Through Comparison of Open and Minimally Invasive Approaches.","3D Gait Analysis and Electromyography After Instrumented Stabilisation of Thoracolumbar Spine Fractures - Comparison Between Open and Minimally Invasive Approach","Inclusion Criteria:\n\n* fracture of thoracic or lumbar spine indicated for spine stabilization\n\nExclusion Criteria:\n\n* neurological deficits as a consequence of the primary spine trauma","20 Years","75 Years",{"count":58,"type":20},20,"INTERVENTIONAL",[61],"NA","We prospectively enrolled patients with a thoracic or lumbar spine fracture indicated for instrumented posterior stabilization. We consequently randomized the patient for either a conventional open approach procedure or minimally invasive surgery. 3DGA analysis was carried out at specific time points after surgery together with electromyography of deep-plane back muscles.",[64],"Spine Fracture","RECRUITING","2026-04-01",{"date":68,"type":40},"2026-04-08",{"date":70,"type":40},"2022-02-20",{"date":72,"type":20},"2026-07",{"name":46,"class":47},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100631612","rotem-interpretation-ai-vs-experts-100631612","NCT07502950","ROTEM Interpretation AI vs Experts","Artificial Intelligence Versus Expert Interpretation of ROTEM: A Prospective Study of Agreement and Clinical Decision-Making","ROTEMAI","Inclusion Criteria:\n\nAdult patients (age ≥18 years)\n\n* ROTEM analysis performed using a ROTEM Sigma device as part of routine clinical care\n* Availability of complete ROTEM output (graphical and numerical data)\n* ROTEM measurement obtained in a clinical context where assessment of coagulation status is indicated (e.g., perioperative setting, trauma, or critical illness)\n\nExclusion Criteria:\n\n* ROTEM measurements performed using the HEPTEM channel\n* Incomplete or missing ROTEM data preventing standardized evaluation\n* ROTEM measurements obtained under non-standardized or technically unreliable conditions",{"count":84,"type":20},400,"This prospective multicenter observational study aims to evaluate the agreement between artificial intelligence (AI)-based interpretation and expert interpretation of rotational thromboelastometry (ROTEM) findings in clinically relevant settings. ROTEM is widely used to guide hemostatic therapy in perioperative and critically ill patients, but its interpretation is complex and subject to interobserver variability.\n\nThe primary objective is to determine whether AI-based interpretation achieves agreement comparable to variability between expert clinicians. Secondary objectives include comparison of interpretation time, assessment of consistency of AI outputs, and evaluation of potential differences in clinical decision-making.\n\nROTEM datasets will be independently assessed by multiple expert anesthesiologists and by an AI-based model using standardized input. Agreement between methods and variability of interpretation will be analyzed.\n\nThe study aims to determine whether AI-assisted interpretation could serve as a reliable decision-support tool and reduce variability in ROTEM-guided clinical practice.",[87,88,89],"Coagulopathy","Thromboelastography","Agreement",[91,92,93],"ROTEM","thromboelastography","coagulopathy","2026-03-25",{"date":96,"type":40},"2026-03-31",{"date":42,"type":20},{"date":99,"type":20},"2027-07-01",{"name":46,"class":47},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":59,"phases":111,"briefSummary":112,"conditions":113,"keywords":118,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":125,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100630606","nurse-vs-physician-artery-cannulation-100630606","NCT07489859","Nurse vs Physician Artery Cannulation","Nurse-performed Versus Physician-performed Radial Artery Cannulation: a Multicenter Randomized Non-inferiority Trial","ARTEDU","Inclusion Criteria:\n\n* Nurse with successful completion of the predefined radial artery catheterization educational module\n* Czech board certified anaesthesiologist with obtained competency for radial artery catheterization.\n\nExclusion Criteria:\n\n* Absence of competency for radial artery catheterization.",{"count":110,"type":20},560,[61],"This prospective controlled clinical trial evaluates the effectiveness and safety of radial artery cannulation using the Seldinger technique under ultrasound guidance when performed by two different operator groups: experienced physicians and trained registered nurses. The study aims to determine whether a structured, competency-based training program enables nurses without prior experience in arterial cannulation to achieve comparable outcomes to physicians in terms of first-attempt success rate, procedural efficiency, and complication rates.",[114,115,116,117],"Educational Problems","Catheterization","Education Nursing","Simulation Based Medical Education",[119,120,121,122,123,124],"education","nurse competency","arterial catheterization","seldinger method","competency based education","simulation based medical education",{"date":96,"type":40},{"date":127,"type":20},"2026-05-01",{"date":129,"type":20},"2028-08-01",{"name":46,"class":47},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":141,"conditions":142,"keywords":147,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":156,"leadSponsor":157,"locationsCount":4},"100629395","fluid-vs-weight-24-hour-balance-100629395","NCT07474116","Fluid vs Weight 24 Hour Balance","More Than a Number: Why Daily Fluid Balance Alone Should Not Guide Clinical Decision-Making in the ICU: A Prospective Observational Study","Bilance24","Inclusion criteria:\n\n\\- adult (age ≥ 18 years) patients admitted to intensive care unit.\n\nExclusion criteria:\n\n* age \\\u003C18 years\n* pregnancy\n* inability to obtain standardized daily body weight using the ICU bed scale\n* incomplete 24-hour fluid balance data preventing calculation of cumulative balance\n* absence of an indwelling urinary catheter, extracorporeal life support (ECMO) or other extracorporeal circulation\n* open abdomen\n* open chest\n* lavage or irrigation procedures during the assessment interval\n* surgery during the assessment\n* massive bleeding\n* diarrhoea during the assessment period\n* massive transfusion protocol during the 24-hour interval and ICU stay shorter than 24 hours.",{"count":140,"type":20},55,"Daily Fluid Balance vs Weight Change",[143,144,145,146],"Weight Bias","Weight Change","Fluid Balance","Fluid Accumulation",[148,149,150,151],"fluid balance","weight change","fluid accumulation","fluid deresuscitation","2026-03-11",{"date":154,"type":40},"2026-03-16",{"date":127,"type":20},{"date":42,"type":20},{"name":46,"class":47},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":168,"conditions":169,"keywords":173,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":179,"completionDateStruct":180,"leadSponsor":182,"locationsCount":4},"100629331","incidence-and-characteristic-of-crt-persistent-after-catheter-extraction-in-icu-patients-100629331","NCT07473284","Incidence and Characteristic of CRT Persistent After Catheter Extraction in ICU Patients","Incidence and Characteristics of Venous Catheter-related Thrombosis Persisting After Catheter Removal in Intensive Care Unit Patients.","CRT-PERSIST","Inclusion Criteria:\n\n* age over 18 years\n* ICU hospitalization\n* signed informed consent\n* an indwelling central venous catheter planned for extraction\n\nExclusion Criteria:\n\n* age under 18 years\n* local pathology precluding ultrasound examination\n* disagreement with participation in the study",{"count":167,"type":20},300,"The goal of this observational study is to describe characteristics of catheter related thrombosis (CRT) that persists after catheter extraction in condition of intensive care unit. The main questions it aims to answer are:\n\n1. What is the incidence of CRT that persists after catheter extraction in patients hospitalized in the intensive care unit?\n2. What are the risk factors for this phenomenon?\n3. What is the fate of such a thrombus, including recanalization or the development of complications such as pulmonary embolism or post-thrombotic syndrome?",[170,171,172],"Catheter Thrombosis","Post Thrombotic Syndrome","Pulmonary Embolism (Diagnosis)",[174,175,176],"CRT","Persistent thrombosis","Thrombotic complication","2026-03-10",{"date":154,"type":40},{"date":66,"type":20},{"date":181,"type":20},"2028-01-01",{"name":46,"class":47},{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":59,"phases":193,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":204,"leadSponsor":206,"locationsCount":4},"100620701","comparison-of-video-and-classic-laryngeal-mask-airways-100620701","NCT07361042","Comparison of Video and Classic Laryngeal Mask Airways","Comparison of Video and Classic Laryngeal Mask Airways: A Prospective Randomized Trial","VLMA vs LMA","Inclusion Criteria\n\n* Patient without predicted difficult airway (MACOCHA score ≤ 2), undergoing a planned surgical procedure under general anesthesia with an indication for airway management using a laryngeal mask.\n* Patient aged 18 years or older.\n\nExclusion Criteria\n\n* Patient younger than 18 years.\n* Patient with predicted difficult airway (MACOCHA score \\> 2).\n* Patient with a history of difficult airway.\n* Patient requiring airway management with a method other than a laryngeal mask.\n* Refusal or failure to sign the informed consent for study participation. • Patient undergoing emergency surgery.\n* Administration of muscle relaxants for LMA insertion.\n* State Entropy value below 30 during LMA insertion.\n* State Entropy value above 60 during LMA insertion.",{"count":192,"type":20},417,[61],"The goal of this study is to evaluate the performance of the new video laryngeal masks for securing airway in patients undergoing general anaesthesia. Main goal is to evaluate the first insertion attempt success rate, time to adequate ventilation, sealing pressures and adverse events.",[196],"Supraglottic Airway",[198,199,34],"supraglottic airway","laryngeal mask","2026-02-27",{"date":202,"type":40},"2026-03-03",{"date":66,"type":20},{"date":205,"type":20},"2027-09-30",{"name":46,"class":47},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":16,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":59,"phases":216,"briefSummary":217,"conditions":218,"keywords":222,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":230,"leadSponsor":232,"locationsCount":74},"100620713","percutaneous-transcatheter-genicular-embolization-in-osteoarthritis-100620713","NCT07361198","Percutaneous Transcatheter Genicular Embolization in Osteoarthritis","Inclusion Criteria:\n\n* Adults aged 40 to 80 years\n* Clinical symptoms consistent with chronic knee pain\n* Radiographically confirmed knee osteoarthritis of Kellgren-Lawrence grade II-IV or persistent knee pain following total knee arthroplasty\n* Insufficient pain relief after standard conservative treatment (e.g., pharmacological therapy, physical therapy, or injections)\n* Ability to understand the study procedures and provide written informed consent \\_ Willingness and ability to comply with the study procedures and follow-up schedule\n\nExclusion Criteria:\n\n* Active local or systemic infection\n* Known coagulation disorders or ongoing anticoagulation that cannot be safely interrupted\n* Significant peripheral arterial disease affecting the lower limbs\n* Known allergy or contraindication to iodinated contrast agents\n* Severe renal impairment\n* History of fibromyalgia or other generalized chronic pain syndromes that may confound pain assessment\n* Pregnancy or breastfeeding","40 Years","80 Years",{"count":58,"type":20},[61],"This clinical study investigates a minimally invasive treatment called percutaneous transcatheter embolization of knee arteries for patients with chronic knee pain caused by advanced knee osteoarthritis or persistent pain after total knee replacement. Osteoarthritis of the knee is a common degenerative condition that can lead to long-term pain, reduced mobility, and decreased quality of life, and some patients do not achieve sufficient relief with standard treatments.\n\nThe study is based on the hypothesis that targeted embolization of small arteries supplying the inflamed tissues of the knee can safely reduce abnormal blood flow associated with inflammation, leading to pain relief and improved knee function. During the procedure, a thin catheter is guided through the blood vessels to the affected area of the knee, where a temporary embolic agent is administered to reduce pathological blood supply.\n\nThe aim of the study is to evaluate the safety and effectiveness of this procedure by assessing changes in pain intensity, knee function, and quality of life over a follow-up period of up to 24 months. The results of this study may help determine whether this minimally invasive approach can offer a new treatment option for patients who have limited alternatives for managing chronic knee pain",[219,220,221],"Osteoarthritic Knee Pain","Osteo Arthritis of the Knee","Osteoarthitis",[223,224,225],"genicular artery embolisation","osteoarthritis","MSK embolisation","2026-02-02",{"date":228,"type":40},"2026-02-04",{"date":226,"type":40},{"date":231,"type":20},"2029-12-01",{"name":46,"class":47},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":241,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":242,"targetDuration":244,"studyType":21,"phases":4,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100614692","intraoperative-lung-protective-ventilation-in-czech-republic-100614692","NCT07282899","Intraoperative Lung Protective Ventilation in Czech Republic","Overview of Intraoperative Lung Protective Ventilation in Czech Republic","IOLPVCZ","Inclusion Criteria:\n\n* anaesthesiologist practiting in Czech republic\n\nExclusion Criteria:\n\n* not lincensed anaesthesiologist\n* anaesthesiologist outside Czech republic",true,{"count":243,"type":20},800,"20 Days","This questionnaire-based study aims to evaluate the adherence to and current clinical practices regarding intraoperative lung-protective ventilation (IOLPV) among anesthesiologists in the Czech Republic. Despite the established role of IOLPV in reducing postoperative pulmonary complications in selected populations, its routine application during general anesthesia for elective surgeries remains variable. The survey focuses on identifying common ventilation strategies, attitudes toward lung recruitment maneuvers, tidal volume selection, use of PEEP, and awareness of existing recommendations. The results will provide insight into national practice patterns, perceived barriers, and educational needs, helping to inform future guidelines, training initiatives, and efforts to enhance patient safety and postoperative outcomes across Czech anesthesia departments.",[247],"Intraoperative Lung Protective Ventilation",[249,250],"general anaesthesia","intraoperative lung protective ventilation","2025-12-02",{"date":253,"type":40},"2025-12-15",{"date":255,"type":20},"2026-02-01",{"date":257,"type":20},"2026-08-01",{"name":46,"class":47},{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":59,"phases":268,"briefSummary":269,"conditions":270,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":74},"100594567","serratus-posterior-plane-block-vs-erector-spine-plane-block-100594567","NCT07021131","Serratus Posterior Plane Block vs Erector Spine Plane Block","Continuous Serratus Posterior Plane Block Versus Continuous Erector Spine Plane Block for Video-assisted Thoracoscopic Surgery: a Prospective Randomized Non-inferiority Trial","Inclusion Criteria:\n\n* Patiens undergoing VATS-surgery\n\nExclusion Criteria:\n\n* Age \\\u003C 20 years\n* Body Mass Index \\>35 kg\u002Fm2\n* Technical difficulties with the nerve block administration and\u002For subsequent bolus application\n* Abnormal course of the surgery (e.g. conversion to thoracotomy) or the postoperative phase (e.g. surgical revision of the chest)\n* Patient's refusal",{"count":267,"type":20},100,[61],"Analgesia related to the administration of local anesthetic solution into the fascia of erector spinae muscle is mediated by the effect of local anesthetic on the posterior and lateral branches of the anterior part of the spinal nerve. Comparable analgesic efficiency after the administration of both nerve blocks would reject the widespread theory of the paravertebral site of effect of the local anesthetic in ESPB.",[271],"Regional Anesthesia","2025-06-06",{"date":274,"type":40},"2025-06-13",{"date":276,"type":20},"2025-07-01",{"date":278,"type":20},"2026-07-01",{"name":46,"class":47},""]