[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mattienne van der Kamp\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100537502","cohort-multiple-randomized-controlled-trial-in-pediatric-asthma-100537502",false,"NCT06278662","Cohort Multiple Randomized Controlled Trial in Pediatric Asthma","Cohort Multiple Randomized Controlled Trial in Pediatric Asthma: Infrastructure to Assess the Long- and Short-term Effects of (eHealth) Interventions.","CIRCUS","Inclusion Criteria:\n\n* Is 4 to 18 years old\n* Is patient at the children's department at Medisch Spectrum Twente at moment of inclusion\n* Is diagnosed with asthma by a pediatrician following the Global Initiative for Asthma(GINA) guidelines 2022 \\[8\\]:\n\n  \\*Medical history fitting asthma diagnosis:\n* Based on (typical) symptoms: (nighttime) wheezing, dyspnea, coughing (triggered by either viral infections, exercise, allergens or weather changes)\n* (Possibly) supplemented with a family history\u002Fatopy\n\nAND\n\n\\*Spirometry variable expiratory airflow limitation by at least one of these criteria:\n\n* FEV1\u002FFVC reduced compared to lower limit of normal(Z-score ≤ -1.64)\n* Positive bronchodilator responsiveness(increase FEV1\\>12%)\n* Positive Exercise Challenge Test (ECT)(decrease FEV1≥ 13%)\n* Excessive variation in lung function (LF) between tests from different dates (variation FEV1\\>12% pred)\n\nExclusion Criteria:\n\n* The child and\u002For parent(s) has\u002Fhave insufficient command of the Dutch language resulting in the insufficient ability to understand and\u002For answer questions","ALL","4 Years","18 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","The overarching goal of this study is to optimize pediatric asthma care and to continuously evaluate variations\u002Finnovations of the care (including transformation to remote eHealth care).\n\nPrimary Objectives within cmRCT cohort:\n\n* Provide a framework for multiple randomized (eHealth) interventions for asthmatic children\n* Generate short- and long-term data on Quality of life (QoL), asthma outcomes (asthma control, lung function), quality of care, self-management capacity, healthcare use, and therapy compliance in a representative secondary care pediatric asthma cohort.\n\nSecondary Objectives within cmRCT cohort:\n\n* Evaluate current pediatric asthma care at the Pediatric department of Medisch Spectrum Twente, in order to explore possible improvements for the pediatric asthma care.\n* Compare the short and long-term asthma outcomes between the eHealth care path and the outpatient care path.\n* Compose patient risk profiles that include both personal, clinical and exposome markers and clinical asthma endpoints (for example clinical admission\u002Fexacerbations).",[28],"Pediatric Asthma",[30,31,32,33],"asthma","child","cohort studies","telemedicine","RECRUITING","2024-11-22",{"date":37,"type":38},"2024-11-26","ACTUAL",{"date":40,"type":38},"2024-04-01",{"date":42,"type":22},"2034-04-01",{"name":44,"class":45},"Mattienne van der Kamp","OTHER",""]